CAS No. 520-34-3

Batch: Purity:99.92
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Diosmetin Chemical Structure
Chemical Structure
Check the Diosmetin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
CAS Number 520-34-3
Molecular Formula

C16H12O6
Molecular Weight (MW) 300.26
SMILES COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
InChIKey MBNGWHIJMBWFHU-UHFFFAOYSA-N

Ordering Information

Biological Activity

Diosmetin is a bioflavonoid that acts as a selective inhibitor of cytochrome P450 1A1 (CYP1A1) and CYP1B1 enzymes. It modulates key intracellular pathways by suppressing the activation of the NF-kB and MAPK signaling cascades. Downstream, diosmetin reduces the production of pro-inflammatory cytokines, inhibits cell proliferation and migration, and induces apoptosis in various cancer cell lines. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.