Amlodipine

Catalog No.S1905 Batch:S190503

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Technical Data

Formula

C20H25ClN2O5
Molecular Weight 408.88 CAS No. 88150-42-9
Solubility (25°C)* In vitro DMSO 82 mg/mL (200.54 mM)
Ethanol 82 mg/mL (200.54 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5% DMSO 95% Corn oil

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 6.000mg/ml (14.67mM) Taking the 1 mL working solution as an example, add 50 μL of 120 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 6.000mg/ml (14.67mM) Taking the 1 mL working solution as an example, add 50 μL of 120 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Amlodipine (UK-48340) is a long-acting calcium channel blocker, used to lower blood pressure and prevent chest pain.
Targets
Calcium channel [1]
In vitro Amlodipine causes a dose-dependent increase in nitrite production. This compound also increases nitrite production in large coronary arteries and in aorta. It is attributed to distinct membrane physico-chemical interactions. This chemical contributes to distinct membrane biophysical interactions that lead to potent lipid antioxidant effects, independent of calcium channel modulation. It increases plaque smooth muscle cell content (P<0.05), whereas atenolol decreases plaque inflammation. This compound attenuates intracellular neuronal Ca2+ increases elicited by KCl depolarization but does not affect Ca2+ changes triggered by N-methyl-D-aspartate receptor activation. It also inhibits free radical-induced damage to lipid constituents of the membrane in a dose-dependent manner, independent of Ca2+ channel modulation.
In vivo Amlodipine results in regression of cardiovascular hypertrophy and amelioration of endothelial dysfunction in spontaneously hypertensive rats. This compound significantly reduces aortic hypertrophy, endothelial dysfunction, LOX-1 expression, aortic O(2)(-) and ONOO(-) production, and plasma free 8-F(2)alpha-isoprostane levels in Ang II-infused rats. It has antihypertensive and antioxidant activity in vivo, which effectively inhibits many of the oxidative stress-dependent mechanisms involved in Ang II-mediated cardiovascular injury.

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/9494028/
  • https://pubmed.ncbi.nlm.nih.gov/10072734/
  • https://pubmed.ncbi.nlm.nih.gov/18391092/
  • https://pubmed.ncbi.nlm.nih.gov/10098848/
  • https://pubmed.ncbi.nlm.nih.gov/9797191/
  • https://pubmed.ncbi.nlm.nih.gov/14751660/

Selleck's Amlodipine Has Been Cited by 18 Publications

Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways [ Cell Death Discovery, 2025 Oct 27, 492] PubMed: 41145413
Amlodipine exerts inhibitory effects against glioma stem cells through degrading EGFR and down-regulating its downstream pro-survival pathways [ Cell Death Discovery, 2025, 492] PubMed: 41145413
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
Targeting the core program of metastasis with a novel drug combination [ Cancer Medicine, 2024, e7291] PubMed: 38826119
Targeting the core program of metastasis with a novel drug combination [ Cancer Med, 2024, 13(11):e7291] PubMed: 38826119
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer [ Acta Pharmaceutica Sinica B, 2023, 4217-4233] PubMed: 37799381
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer [ Acta Pharm Sin B, 2023, 13(10):4217-4233] PubMed: 37799381
Anticancer Effects of Amlodipine Alone or in Combination With Gefitinib in Non-Small Cell Lung Cancer [ Frontiers in Pharmacology, 2022, 902305] PubMed: 20573926
Anticancer Effects of Amlodipine Alone or in Combination With Gefitinib in Non-Small Cell Lung Cancer [ Front Pharmacol, 2022, 13:902305] PubMed: 35721193
Repurposing screen identifies Amlodipine as an inducer of PD-L1 degradation and antitumor immunity [ Oncogene, 2021, 1128-1146]

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.