Home Metabolism PPAR agonist 2,4-Thiazolidinedione

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2,4-Thiazolidinedione PPAR agonist

Cat.No.E1775

2,4-Thiazolidinedione (Thiazolidinedione), an insulin sensitizer, is a specific agonist of peroxisome proliferator-activated receptor (PPAR)γ. Thiazolidinedione treatment corrects impaired muscle insulin action in vivo.
2,4-Thiazolidinedione PPAR agonist Chemical Structure

Chemical Structure

Molecular Weight: 117.13

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Quality Control

Batch: E177501 DMSO]23 mg/mL]false]Water]23 mg/mL]false]Ethanol]23 mg/mL]false Purity: 99.56%
99.56

Solubility

In vitro
Batch:

DMSO : 23 mg/mL (196.36 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 23 mg/mL

Ethanol : 23 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 117.13 Formula

C3H3NO2S

 Storage (From the date of receipt)
CAS No. 2295-31-0 Download SDF Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
PPARγ
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03791580 Unknown status
Fall|Congestive Heart Failure|Chronic Kidney Failure|Adverse Drug Event
RAND|Northwestern University|University of California Los Angeles|University of Southern California|University of Pittsburgh|National Institute on Aging (NIA)
 February 11 2019 Not Applicable
NCT00432809 Completed
Diabetes Mellitus Type 2|Obesity
The Cleveland Clinic|Ethicon Endo-Surgery|LifeScan
 February 2007 Not Applicable

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