CAS No. 1614-12-6

Batch: Purity:99.99
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1-Aminobenzotriazole Chemical Structure
Chemical Structure
Check the 1-Aminobenzotriazole product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name benzotriazol-1-amine
CAS Number 1614-12-6
Molecular Formula
C6H6N4
Molecular Weight (MW) 134.14
SMILES N[N]1N=NC2=CC=CC=C12
InChIKey JCXKHYLLVKZPKE-UHFFFAOYSA-N

Ordering Information

Biological Activity

1-Aminobenzotriazole (ABT) is a nonselective and irreversible inhibitor of cytochrome P450 (CYP) enzymes. It acts as a suicide substrate that covalently inactivates CYP isoforms, thereby blocking P450-mediated xenobiotic metabolism and oxidative clearance pathways. Additionally, ABT serves as a substrate and inhibitor of N-acetyltransferase (NAT). These activities impair xenobiotic biotransformation and suppress the metabolic clearance of co-administered substrates in functional assays. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 27 mg/mL (201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 27 mg/mL
Ethanol 27 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.