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HIV Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S0958 Zingibroside R1 Zingibroside R1, isolated from rhizomes of Panax zingiberensis Wu et Feng (Araliaceae), has some anti-HIV-1 activity. This compound shows the inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells with IC50 of 91.3 µM and the growth of MT-4 cells with CC50 of 46.2 µM.
E0005 Enfuvirtide Acetate Enfuvirtide Acetate (T20 Acetate, DP178 Acetate) is an HIV fusion inhibitor with ic50s of 13.63  nM and 30.21  nM on infection by HIV-1IIIB in MT-2 cells and HIV-1Bal in M7 cells, respectively.Solutions are unstable and should be fresh-prepared.
S4861 Oxindole Oxindole (2-indolone, 2-Oxindole, Indolin-2-one) is an aromatic heterocyclic organic compound which causes sedation, muscle weakness, hypotension, and coma when dosed in excess. This compound has anti-cancer, anti-HIV, anti-diabetic, antibacterial and other pharmacological activities.
S9626 Nelfinavir Nelfinavir (AG-1341) is a potent inhibitor of HIV protease and induces endoplasmic reticulum (ER) stress, autophagy, and apoptosis in vitro and in vivo. It also inhibits Streptolysin S (SLS) production, a key virulence factor of Streptococcus pyogenes, with IC50 of 6 µM.
E0797 WAY-383487 WAY-383487 is one of the Tat peptide derivatives and inhibits HIV-1 long terminal repeat-activated transcription.
S5979 2',3'-Dideoxyadenosine 2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication.
E4891 Fostemsavir Tris Fostemsavir Tris(BMS-663068 Tris) is a phosphonooxymethyl prodrug of BMS-626529, formulated as a tris(hydroxymethyl)aminomethane salt. It inhibits human immunodeficiency virus type 1 (HIV-1) by binding to the gp120 protein, preventing the virus from attaching to CD4+ T-cells.
E1138 CQ31 CQ31, a small molecule, selectively activates caspase activation and recruitment domain-containing 8 (CARD8).
S4446 Dimercaprol Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
S9630 Tipranavir Tipranavir(PNU-140690) is a nonpeptidyl inhibitor of HIV protease with high potency Ki of 0.008 nM and IC50 of 0.03 μM, it also inhibited HIV-2 protease with Ki of < 1 nM. It is administered in combination antiretroviral therapy to treat HIV-1 infection and AIDS.
S1009 Dactolisib (BEZ235) Dactolisib (BEZ235, NVP-BEZ235) is a dual ATP-competitive PI3K and mTOR inhibitor for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively. It inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell, induces autophagy, and suppresses HIV-1 replication. Phase 2.
Adv Mater, 2025, e12810.
Nat Commun, 2025, 16(1):8189
Nat Commun, 2025, 16(1):4502
Verified customer review of Dactolisib (BEZ235)
S1230 Flavopiridol (Alvocidib, HMR-1275) Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.
Mol Cell, 2025, S1097-2765(25)00042-5
Cell Rep Med, 2025, S2666-3791(25)00231-9
Dev Cell, 2025, S1534-5807(25)00537-4
Verified customer review of Flavopiridol (Alvocidib, HMR-1275)
S1117 Triciribine (API-2) Triciribine (API-2) is a DNA synthesis inhibitor that also inhibits Akt in PC3 cell line and HIV-1 in CEM-SS, H9, H9IIIB, U1 cells with IC50 of 130 nM and 20 nM, respectively; it does not inhibit PI3K/PDK1 and is 5000-fold less active in cells lacking adenosine kinase. Phase 1/2.
Mol Psychiatry, 2025, 10.1038/s41380-025-02917-1
Transl Oncol, 2025, 58:102434
J Cell Sci, 2023, 136(4)jcs259788
Verified customer review of Triciribine (API-2)
S7015 Birinapant (TL32711) Birinapant is a SMAC mimetic antagonist, mostly to cIAP1 with Kd of <1 nM in a cell-free assay, less potent to XIAP. This compound helps to induce apoptosis in latent HIV-1-infected cells. Phase 2.
Cell, 2025, S0092-8674(25)01233-4
Nat Commun, 2025, 16(1):7360
EMBO Mol Med, 2025, 10.1038/s44321-025-00201-x
Verified customer review of Birinapant (TL32711)
S2679 Flavopiridol (Alvocidib) HCl Flavopiridol (Alvocidib) HCl competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM in cell-free assays. It is 7.5-fold more selective for CDK1/2/4/6 than CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol HCl induces autophagy and ER stress. Flavopiridol HCl blocks HIV-1 replication. Phase 1/2.
Elife, 2024, 13e80684
Int J Biol Macromol, 2023, 258(Pt 1):128776
Mol Cell Biol, 2023, 43(1):1-21
Verified customer review of Flavopiridol (Alvocidib) HCl
S3013 Plerixafor (AMD3100) 8HCl Plerixafor (AMD3100, JM 3100,Plerixafor Octahydrochloride,AMD3100 octahydrochloride,SID791 octahydrochloride) 8HCl is the hydrochloride of Plerixafor, a chemokine receptor antagonist for CXCR4 and CXCL12-mediated chemotaxis with IC50 of 44 nM and 5.7 nM in cell-free assays, respectively. Plerixafor can be used as an anti-HIV agent.
Angiogenesis, 2025, 28(3):26
bioRxiv, 2025, 2025.08.29.673113
bioRxiv, 2025, 2025.05.28.656643
Verified customer review of Plerixafor (AMD3100) 8HCl
S1848 Curcumin Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase（IC50~25 μM）and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
J Biol Chem, 2025, 301(7):110305
Mol Pain, 2025, 21:17448069251323668
BMC Immunol, 2025, 26(1):67
Verified customer review of Curcumin
S1400 Tenofovir Disoproxil Fumarate Tenofovir Disoproxil Fumarate belongs to a class of antiretroviral drugs, it inhibits the activity of HIV reverse transcriptase by competing with the natural substrate deoxyadenosine 5’-triphosphate and, after incorporation into DNA, by DNA chain termination.
Clin Immunol, 2024, 260:109915
Antiviral Res, 2024, 231:106010
Front Cell Infect Microbiol, 2024, 14:1334126
Verified customer review of Tenofovir Disoproxil Fumarate
S1351 Ivermectin Ivermectin is a glutamate-gated chloride channel (GluCls) activator, used as a broad-spectrum antiparasitic drug. This compound is a specific positive allosteric effector of P2X4 and α7 nicotinic acetylcholine receptors (nAChRs). It is a specific inhibitor of Impα/β1-mediated nuclear import and has potent antiviral activity towards both HIV-1 and dengue virus. This chemical induces autophagy through the AKT/mTOR signaling pathway and mitophagy.
Nat Commun, 2025, 16(1):7156
J Adv Res, 2025, S2090-1232(25)00874-4
Biomed Pharmacother, 2025, 189:118248
S1704 Emtricitabine (FTC) Emtricitabine (FTC) is a new nucleoside agent that has activity against both human immunodeficiency virus (HIV) and hepatitis B virus. It is a reverse transcriptase inhibitor, and its intracellular half-life is 39 h.
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
HIV Med, 2025, 26(2):285-294
Immunity, 2024, 57(12):2928-2944.e6
S8512 Cenicriviroc Cenicriviroc is a potent, orally active dual inhibitor of CC chemokine receptor 2 (CCR2) and CCR5. This compound also inhibits HIV-1 and HIV-2 with potent anti-inflammatory and antiinfective activity.
Nature, 2025, 10.1038/s41586-024-08535-1
Int J Biol Sci, 2023, 19(8):2572-2587
Stem Cells, 2023, 41(6):672-683
S5144 Neferine Neferine ((R)-1,2-Dimethoxyaporphine), a natural component of Nelumbo nucifera, has antitumor efficiency. It induces apoptosis in renal cancer cells. This compound prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells. It strongly inhibits NF-κB activation. It possesses a number of therapeutic effects such as anti-diabetic, anti-aging, anti-microbial, anti-thrombotic, anti-arrhythmic, anti-inflammatory and even anti-HIV.
J Cosmet Dermatol, 2024, 10.1111/jocd.16587
Bone Res, 2022, 10(1):27
Cell Death Dis, 2022, 13(11):1000
S5959 Tenofovir Disoproxil Tenofovir Disoproxil (Bis(POC)-PMPA, GS 4331) is a prodrug of tenofovir, which is metabolised intracellularly to its active anabolite tenofovir diphosphate, a competitive inhibitor of HIV-1 reverse transcriptase and terminates the growing DNA chain.
J Virol, 2022, JVI0173021
Front Microbiol, 2018, 9:278
S6848 3'-Fluoro-3'-deoxythymidine (Alovudine) 3'-Fluoro-3'-deoxythymidine (Alovudine, CL 184824, FddThd, FLT, MIV-310) is a potent inhibitor of polymerase γ and reverse transcriptase that can be used in the treatment of HIV infection. It is also a marker of DNA synthesis that can be used as an early response biomarker in the chemotherapy of pancreatic cancer.
Toxicol Lett, 2025, 406:31-37
S3500 Pentosan Polysulfate Sodium Pentosan Polysulfate Sodium (PPS, Elmiron) is an orally bioavailable, semi-synthetic medication with anti-inflammatory and pro-chondrogenic properties. This compound also exhibits anti-HIV-1 activity.
S9064 Trilobatin Trilobatin (P-Phlorizin), a natural flavonoid lipid molecule, is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope and exihibits anti-oxidant and anti-inflammatory effect.