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2',3'-Dideoxyadenosine HIV inhibitor

Name: 2',3'-Dideoxyadenosine
Brand: Selleck Chemicals
SKU: S5979
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S5979

2',3'-Dideoxyadenosine (ddA, ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication.

Chemical Structure

Molecular Weight: 235.24

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Batch: S597901 DMSO]47 mg/mL]false]Water]47 mg/mL]false]Ethanol]Insoluble]false Purity: 99.98%

99.98

Related Targets	Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HCV Protease SARS-CoV HIV Protease Influenza Virus β-lactamase Integrase HBV CMV Neuraminidase HCV Thioredoxin Reductase HSV RSV Enterovirus 3C-Like Protease Ribosomal Peptidyl Transferase HPV
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Chemical Information, Storage & Stability

Molecular Weight	235.24	Formula	C₁₀H₁₃N₅O₂	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	4097-22-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	ddA, ddAdo			Smiles	NC1=C2N=C[N](C3CCC(CO)O3)C2=NC=N1

Solubility

In vitro
Batch:

DMSO : 47 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 47 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	HIV ^[1] HBV ^[1]
References	[1] https://pubmed.ncbi.nlm.nih.gov/9237655/ [2] https://pubmed.ncbi.nlm.nih.gov/7969062/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06405386	Not yet recruiting	Diabetes type1\|Diabetes Mellitus Type 1\|Diabetes Autoimmune\|Diabetes Mellitus\|Distress Emotional	University of North Carolina Chapel Hill\|American Diabetes Association	May 2024	Not Applicable
NCT06405373	Not yet recruiting	Diabetes type1\|Diabetes Mellitus Type 1\|Diabetes Autoimmune\|Diabetes Mellitus\|Distress Emotional	University of North Carolina Chapel Hill\|American Diabetes Association	May 2024	Not Applicable
NCT05815342	Completed	Type2 Diabetes	Insulet Corporation\|Jaeb Center for Health Research	April 11 2023	Not Applicable
NCT05523362	Completed	Type 2 Diabetes	Ian J. Neeland MD\|DexCom Inc.\|University Hospitals Cleveland Medical Center	January 15 2022	Not Applicable
NCT04821336	Completed	Thyroid Cancer	Institut Claudius Regaud\|Cancer Research Center of Toulouse	April 15 2021	--

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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