Home Microbiology HIV inhibitor Dimercaprol For research use only.

Dimercaprol

Synonyms: Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol

Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.

Dimercaprol Chemical Structure

Dimercaprol Chemical Structure

CAS: 59-52-9

Purity & Quality Control

Batch: Purity: 99.67%
99.67

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Biological Activity

Description Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
Targets
HIV-1 tat [1]
In vitro
In vitro

Dimercaprol exerts its acrolein scavenging capability, significantly protects PC-12 cells from acrolein-mediated cell death in a dose dependent manner.[3]
Cell Research Cell lines PC-12 cells
Concentrations 10, 25, 50 and 100 μM
Incubation Time 4 h
Method

Cell viability was tested by WST-1 ([2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium]) assay. Both dimercaprol and acrolein were dissolved in Hank’s Balanced Salt Solution (HBSS). The final concentration of acrolein was 100 μM. The final concentrations of dimercaprol were 10, 25, 50 and 100 μM. PC-12 cells were seeded in 12-well plates at the concentration of 105 cells/well. After overnight incubation, acrolein was added into each well of acrolein group and treatment groups. Equal volumes of HBSS were added into wells of the negative control group. After incubation for 15 minutes, dimercaprol was added at the desired final concentrations (10, 25, 50 and 100 μM) into wells of treatment groups and equal volume of HBSS was added into other wells. The initial 15-minute incubation in acrolein was designed to mimic pathological conditions by allowing acrolein to enter the cells. WST-1 assay solution was added into every well after incubating 4 h, and then allowed to incubate for an additional 2 h.
In Vivo
In vivo

Dimercaprol could significantly reduce acrolein contents in spinal cord tissue following a spinal cord contusion injury in rats.[3]
Animal Research Animal Models Male Sprague–Dawley rats of spinal cord contusion injury model
Dosages 5 mg/kg
Administration i.p
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06093867 Recruiting
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
National Heart Lung and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC)
 January 12 2024 --
NCT05989399 Not yet recruiting
Antisynthetase Syndrome
Central Hospital Nancy France
 January 1 2024 --

Chemical Information & Solubility

Molecular Weight 124.22 Formula

C3H8OS2
CAS No. 59-52-9 SDF --
Density 1.239 g/mL
Smiles OCC(S)CS
Storage (From the date of receipt) 2 years -20°C liquid

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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