Home Microbiology HIV inhibitor Dimercaprol

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Dimercaprol HIV inhibitor

Cat.No.S4446

Dimercaprol (Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol) is an acrolein scavenger that inhibits HIV-1 tat activity, viral production, and infectivity in vitro.
Dimercaprol HIV inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 124.22

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability

Quality Control

Chemical Information, Storage & Stability

Molecular Weight 124.22 Formula

C3H8OS2

 Storage (From the date of receipt) 2 years -20°C liquid
CAS No. 59-52-9 -- Storage of Stock Solutions

Synonyms Bal, 2,3-Dimercapto-1-propanol, Dithioglycerol Smiles OCC(S)CS

Solubility

In vitro
Batch:

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
HIV-1 tat [1]
In vitro

Dimercaprol exerts its acrolein scavenging capability, significantly protects PC-12 cells from acrolein-mediated cell death in a dose dependent manner.[3]
In vivo

Dimercaprol could significantly reduce acrolein contents in spinal cord tissue following a spinal cord contusion injury in rats.[3]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06317909 Recruiting
Mild Allergic Asthma
Fraunhofer-Institute of Toxicology and Experimental Medicine
 June 1 2024 Not Applicable
NCT06381739 Not yet recruiting
COVID-19 Infection
McMaster University|Canadian Institutes of Health Research (CIHR)
 June 2024 Phase 2
NCT06376617 Not yet recruiting
Bronchial Asthma
Mansoura University
 April 25 2024 Not Applicable
NCT03482245 Recruiting
Pneumonia|Necrotizing Soft Tissue Infection|Intraabdominal Infections|Infection Joint
Washington University School of Medicine|National Institute of General Medical Sciences (NIGMS)
 April 16 2024 Not Applicable
NCT06093867 Recruiting
Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
National Heart Lung and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC)
 April 8 2024 --

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