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Endogenous Metabolite Inhibitors

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S5259 β-nicotinamide mononucleotide (NMN) Nicotinamide mononucleotide (β-NM, NMN), one of the key precursors of NAD+ and products of the NAMPT reaction , is converted to NAD+ by nicotinamide mononucleotide adenylyltransferase.
Nat Commun, 2025, 16(1):212
MedComm (2020), 2025, 6(3):e70075
PLoS Pathog, 2025, 21(5):e1013163
S9793 4-HNE (4-Hydroxynonenal) 4-HNE (4-Hydroxynonenal) is one of the major end products of lipid peroxidation and has been widely accepted as an inducer of oxidative stress.
Circulation, 2024, 1752-1769
Nature Communications, 2022, 5545
Nat Commun, 2022, 13(1):5545
S5992 Heparan Sulfate Heparan sulfate (HS, Heparitin sulfate, Alpha-idosane, HHS 5, N-Acetylheparan Sulfate, Suleparoid, Tavidan), a constituent of HS proteoglycans (HSPGs), is a linear polysaccharide present on the cell surface. Heparan sulfate influences the binding affinity of intestinal epithelium cells (IECs) to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating regeneration of small intestinal crypts after epithelial injury.
Mol Ther Methods Clin Dev, 2025, 33(1):101426
iScience, 2024, 27(6):110120
bioRxiv, 2024, 2024.05.23.595417
S2935 Nicotinamide Riboside Chloride (NR-Cl) Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
bioRxiv, 2025, 2025.07.10.663928
bioRxiv, 2025, 2025.01.06.631511
Front Physiol, 2023, 14:1164287
S4707 Oleic acid (cis-9-Octadecenoic acid) Oleic acid (Oleate, 9-Octadecenoic Acid, Elaidoic acid) is a fatty acid that occurs naturally in various animal and vegetable fats and oils. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator.Oleic Acid can be used to induce animal models of Renal Failure.
Life Sci, 2025, 374:123687
Sci Rep, 2025, 15(1):28774
J Ovarian Res, 2025, 18(1):180
S5260 ATP (Adenosine 5'-triphosphate) ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.
Adv Sci (Weinh), 2025, 12(40):e09838
Stem Cell Res Ther, 2025, 16(1):206
Cell Rep, 2024, 43(2):113779
S5109 Ademetionine (S-Adenosylmethionine) Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.
Pharmaceuticals (Basel), 2025, 18(9)1395
J Oral Microbiol, 2024, 16(1):2292375
Nat Metab, 2023, 10.1038/s42255-023-00861-4
S6010 Sodium L-lactate Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent.
Cell Commun Signal, 2025, 23(1):104
J Transl Med, 2025, 23(1):69
EMBO Rep, 2024, 25(12):5599-5619
S5790 Folinic acid (Leucovorin) Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.
Nat Cell Biol, 2024,
Nat Commun, 2022, 13(1):6308
E4473 DL-Lactic acid Lactate (Lactic acid) is the product of glycolysis, produced due to lack of oxygen in contracting skeletal muscle in vivo, and can be utilised under fully aerobic conditions. It plays a key role as a metabolic intermediate and can be used as hemodynamic marker and resuscitation endpoint in several cohorts of critically ill patients.
PeerJ, 2025, 13:e18887
iScience, 2024, 27(8):110238