L-Glutamine

For research use only.

Catalog No.S1749

2 publications

L-Glutamine Chemical Structure

CAS No. 56-85-9

L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.

Selleck's L-Glutamine has been cited by 2 publications

Purity & Quality Control

Biological Activity

Description L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.
In vitro

L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4]

In vivo L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5]

Protocol

Solubility (25°C)

In vitro Water 29 mg/mL (198.43 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.14
Formula

C5H10N2O3

CAS No. 56-85-9
Storage powder
in solvent
Synonyms N/A
Smiles C(CC(=O)N)C(C(=O)O)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04785989 Not yet recruiting Other: [U-13C]glucose|Other: [13C5]glutamine Chronic Lymphocytic Leukemia University of Wisconsin Madison October 2021 Early Phase 1
NCT04634539 Recruiting Drug: Gemcitabine|Drug: Nab-paclitaxel|Drug: L-glutamine Advanced Pancreatic Adenocarcinoma|Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma Jun Gong MD|Emmaus Medical Inc.|Cedars-Sinai Medical Center May 13 2021 Phase 1
NCT04684381 Recruiting Drug: L-glutamine Sickle Cell Disease|Pharmacokinetics Emmaus Medical Inc. January 4 2021 Phase 4
NCT00922688 Unknown status Drug: Dipeptide Alanyl-Glutamine|Drug: Placebo Colon Carcinoma Medical Center Alkmaar December 2010 Not Applicable
NCT01179217 Completed Drug: L-glutamine|Drug: Placebo Sickle Cell Anemia|Sickle ß0-Thalassemia Emmaus Medical Inc. May 2010 Phase 3
NCT00125788 Completed Drug: L-glutamine|Drug: Placebo Sickle Cell Anemia|Thalassemia Emmaus Medical Inc.|FDA Office of Orphan Products Development March 2004 Phase 2

Tech Support

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID