L-Glutamine

Catalog No.S1749

L-Glutamine Chemical Structure

Molecular Weight(MW): 146.14

L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.

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Biological Activity

Description L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.
In vitro

L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4]

In vivo L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5]

Protocol

Solubility (25°C)

In vitro Water 29 mg/mL (198.43 mM)
DMSO Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 146.14
Formula

C5H10N2O3

CAS No. 56-85-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02053350 Terminated Clostridium Difficile Infection University of Virginia April 2015 Phase 2
NCT02215083 Withdrawn Peripheral Neuropathy Eastern Regional Medical Center|TSPC America Inc. August 2014 Phase 1
NCT03015077 Completed Head and Neck Cancer Kaohsiung Medical University Chung-Ho Memorial Hospital July 2014 Not Applicable
NCT01832636 Completed Malnutrition|Environmental Enteropathy|Diarrhea Children''s Hospital Medical Center Cincinnati|Universidade Federal do Ceara October 2013 Phase 3
NCT01353638 Terminated End Stage Renal Disease Christoph Aufricht|Medical University of Vienna April 2011 Phase 1|Phase 2
NCT01250782 Unknown status Trauma ICU Patients Hospital Universitari Son Dureta October 2010 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID