For research use only.
CAS No. 56-85-9
L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.
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|Description||L-Glutamine (Gln) is one of the 20 amino acids encoded by the standard genetic code and also a major respiratory fuel and substrate for nucleic acid synthesis in mammalian intestinal cells.|
L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells.  L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC.  L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells.  L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. 
|In vivo||L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. |
-  Sessa WC, et al. Proc Natl Acad Sci U S A,?990, 87(21), 8607-8611.?
-  Rhoads JM, et al. Am J Physiol,?994, 266(5 Pt 1), G828-838.
-  Hecker M, et al. Br J Pharmacol,?990, 101(2), 237-239.
|In vitro||Water||29 mg/mL (198.43 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04785989||Not yet recruiting||Other: [U-13C]glucose|Other: [13C5]glutamine||Chronic Lymphocytic Leukemia||University of Wisconsin Madison||October 2021||Early Phase 1|
|NCT04634539||Recruiting||Drug: Gemcitabine|Drug: Nab-paclitaxel|Drug: L-glutamine||Advanced Pancreatic Adenocarcinoma|Pancreatic Cancer|Pancreatic Ductal Adenocarcinoma||Jun Gong MD|Emmaus Medical Inc.|Cedars-Sinai Medical Center||May 13 2021||Phase 1|
|NCT04684381||Recruiting||Drug: L-glutamine||Sickle Cell Disease|Pharmacokinetics||Emmaus Medical Inc.||January 4 2021||Phase 4|
|NCT00922688||Unknown status||Drug: Dipeptide Alanyl-Glutamine|Drug: Placebo||Colon Carcinoma||Medical Center Alkmaar||December 2010||Not Applicable|
|NCT01179217||Completed||Drug: L-glutamine|Drug: Placebo||Sickle Cell Anemia|Sickle ß0-Thalassemia||Emmaus Medical Inc.||May 2010||Phase 3|
|NCT00125788||Completed||Drug: L-glutamine|Drug: Placebo||Sickle Cell Anemia|Thalassemia||Emmaus Medical Inc.|FDA Office of Orphan Products Development||March 2004||Phase 2|
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