Apoptosis related Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S2412	Genipin	Genipin((+)-Genipin) is an active aglycone derived from an iridoid glycoside called geniposide, which is found in the fruit of Gardenia jasminoides Ellis.	World J Diabetes, 2023, 10.4239/wjd.v14.i9.1349 Commun Biol, 2022, 5(1):105 Front Pharmacol, 2022, 13:1038802
E2631	Colcemid	Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor which can incuces cell apoptosis and can be used for cancer research.	Cell Prolif, 2023, e13486. Cell Proliferation, 2023, e13486 Cellular Physiology and Biochemistry, 2018, 489-504
E4789	Bleomycin hydrochloride	Bleomycin hydrochloride is a natural antibiotic, an inhibitor of DNA synthesis. It binds to nuclear DNA, targeting and killing dividing cells in G2 and M phases. It exhibits anticancer activity, showing efficacy against squamous cell carcinoma (SCC) with an IC50 of 4.0 nM in the UT-SCC-19A cell line.	Nat Commun, 2025, 16(1):1303 Adv Sci (Weinh), 2025, 12(34):e13017 Front Aging Neurosci, 2024, 16:1450337
E1327	CWI1-2 hydrochloride	CWI1-2 hydrochloride is an inhibitor of IGF2BP2 that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.	Cell Biol Toxicol, 2025, 41(1):92 Cell Biology and Toxicology, 2025, 92
S9562	Pomolic acid	Pomolic acid is a pentacyclic triterpene isolated from Euscaphis japonica, and is highly effective in inhibiting cell growth and induces apoptosis.	J Microbiol, 2022, 60(6):649-656
E3523	Antrodia cinnamomea Extract	Antrodia Cinnamomea Extract is extracted from Antrodia Cinnamomea, which is a novel anticancer agent in tamoxifen-resistant breast cancer management.
E1223	RGX-202	RGX-202 is an SLC6A8 transporter inhibitor which suppress the colon cancer tumor. In addition to significantly reducing intracellular phosphocreatine and ATP levels and inducing tumour apoptosis, this compound also inhibits creatine import both in vitro and in vivo.
E3535	Japanese ardisia Extract	Japanese Ardisia Extract is extracted from Ardisia japonica, which induces apoptosis and inhibits proliferation in human pancreatic cancer cells.
E3536	Pleurotus ostreatus Extract	Pleurotus ostreatus Extract is extracted from Pleurotus ostreatus, which decreases the proliferation of leukaemia cells through apoptosis.
E0808	BI-6C9	BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (AIF) release and caspase-independent cell death in neurons.
S3267	Nicotiflorin (Kaempferol-3-O-rutinoside)	Nicotiflorin (Kaempferol-3-O-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
E3844	Polygonatum Odoratum Extract	Polygonatum Odoratum Extract is extracted from Polygonatum odoratum, which inhibits high glucose-induced tubular epithelial cell apoptosis and reduces oxidative stress.
E3095	Pyrethrum Extract	Pyrethrum Extract is extracted from Pyrethrum, which can induce apoptosis in HCT cells, and therefore, it can be used as a novel therapeutic for colorectal cancer treatment.
E3884	Galium Aparine Extract	Galium Aparine Extract is extracted from Galium aparine, which may have a potential anti-cancer effect against breast cancer cells without impairing normal breast epithelial cells.
E3266	Black Carrot Extract	Black Carrot Extract is extrcated from Daucus carota ssp. sativus var. atrorubens, which is a neuroprotective agent.
E4519^New	Lumichrome	Lumichrome is a natural photodegradation product of riboflavin present endogenously in humans that potently inhibits lung cancer cell growth and induces p53-dependent apoptosis via mitochondrial pathways while suppressing AKT/β-catenin signaling critical for cancer stem cell maintenance.
E3348	Capsella bursa-pastoris Extract	Capsella Bursa-Pastoris Extract is extracted from Capsella Bursa-Pastoris, which aids in fever, improving eyesight and calming the liver.
E3376	Saw palmetto Extract	Saw Palmetto Extract is extrcated from Serenoa repens, which has anti-androgenic, pro-apoptotic, and anti-inflammatory effects.
E7972	Isosilybin A	Isosilybin A is a flavonolignan isolated from silymarin that exhibits anti-prostate cancer (PCA) efficacy with an IC50 of 32 μM in DU145 cells. It induces growth inhibition, G1 arrest, and apoptosis in PCA cells by targeting the Akt-NF-κB-AR axis, highlighting its potential as a therapeutic agent in clinical prostate cancer (PCA) management.
S5045	Nomilin	Nomilin is a triterpenoid present in common edible citrus fruits with putative anticancer properties.
E3436	Liquidambar formosana Extract	Liquidambar Formosana Extract is extracted from the dried and mature fruits of Liquidambar Formosana, which can inhibit sarcoma cancer cells by inducing apoptosis.
E3148	Euphorbiae Humifusae Herba Extract	Euphorbiae Humifusae Herba Extract is extracted from Euphorbiae Humifusae, which induces apoptosis in Hep3B hepatocarcinoma cells and can be a treatment for hepatocellular carcinoma.
E3455	Puff-ball Extract	Puff-Ball Extract is extracted from Calvatia, which has inhibitory effects on the proliferation of breast cancer cells through apoptosis.
E7531	Necrostatin 2	Necrostatin-2 is a potent inhibitor of necroptosis with an EC50 of 50 nM in FADD-deficient Jurkat T cells treated with TNF-α.
E1232	Concanavalin A	Concanavalin A is a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics.
S8037	Necrostatin-1 (Nec-1)	Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.	Cell Res, 2025, 10.1038/s41422-025-01167-8 Signal Transduct Target Ther, 2025, 10(1):341 Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
S1077	SB202190	SB202190 is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. This compound inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. It significantly suppresses Erastin‐dependent ferroptosis.	Cancer Cell, 2025, S1535-6108(25)00271-5 Nat Cancer, 2025, 6(2):259-277 Nat Metab, 2025, 7(10):2018-2032
S7033	GSK2656157	GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. This compound decreases apoptosis and inhibits excessive autophagy.	EMBO J, 2025, 44(4):1107-1130 J Adv Res, 2025, S2090-1232(25)00385-6 J Clin Invest, 2024, 135(1)e179874
S2923	Salubrinal	Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.	Cell Discov, 2025, 11(1):80 Cell Metab, 2025, 37(8):1715-1731.e11 EMBO J, 2025, 44(4):1107-1130
S3654	Tauroursodeoxycholic Acid (TUDCA)	Tauroursodeoxycholic acid (TUDCA) is the taurine conjugate of ursodeoxycholic acid (UDCA) and acts as a mitochondrial stabilizer and anti-apoptotic agent in several models of neurodegenerative diseases, including AD, Parkinson's diseases (PD), and Huntington's diseases (HD).	Nat Commun, 2025, 16(1):50 Toxicol Appl Pharmacol, 2025, 499:117333 Cell Mol Life Sci, 2024, 81(1):299
S2872	GW5074	GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted. This compound inhibits LK-induced apoptosis.	Cancers (Basel), 2025, 17(18)2958 Aging Cell, 2024, e14320. University of Central Florida, 2022,
S1386	Nafamostat mesilate (FUT-175)	Nafamostat mesilate (FUT-175) is a synthetic serine protease inhibitor used as an anticoagulant during hemodialysis. It blocks activation of SARS-CoV-2 and is investigated as a new treatment option for COVID-19. This compound also attenuates inflammation and apoptosis.	J Immunother Cancer, 2024, 12(11)e009805 Cell Death Dis, 2024, 15(2):109 CNS Neurosci Ther, 2024, 30(6):e14822
S8632	BML-277 (Chk2 Inhibitor II)	BML-277 (Chk2 Inhibitor II) is an ATP-competitive inhibitor of Chk2 with IC50 of 15 nM, and it is 1000-fold more selective toward Chk2 serine/threonine kinase than for Chk1 and Cdk1/B kinases. This compound dose dependently protects human CD4(+) and CD8(+) T-cells from apoptosis due to ionizing radiation.	BMC Cancer, 2025, 25(1):1520 Sci Adv, 2025, 11(30):eadu9555 Int J Mol Sci, 2024, 25(17)9473
S9668	PKR-IN-C16	PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). This compound prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.	Immunity, 2025, 58(10):2489-2504.e8 Experimental & Molecular Medicine, 2024, 408-421 Exp Mol Med, 2024, 56(2):408-421.
S1132	3-Aminobenzamide	3-Aminobenzamide (3-ABA , 3-Amino Benzamide, 3-AB) is a potent inhibitor of Poly(ADP-ribose)polymerase (PARP) and inhibits cell apoptosis after SCI (Spinal Cord Injury) in caspase-independent way.	J Biol Chem, 2024, S0021-9258(24)02608-5 Int J Mol Sci, 2023, 24(2)1667 Psychopharmacology (Berl), 2022, 10.1007/s00213-022-06188-4
S1733	Methylprednisolone	Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis.	iScience, 2025, 114293 Food Chem Toxicol, 2024, 188:114665 Clinical Cancer Research, 2022, 4444-4455
S3275	Senkyunolide I	Senkyunolide I (SEI, SENI) is an orally active compound isolated from Ligusticum chuanxiong with analgesic, anti-migraine, neuroprotective, anti-oxidation and anti-apoptosis activities. This compound up-regulates the phosphorylation of Erk1/2 and induces Nrf2 nuclear translocation with enhanced HO-1 and NQO1 expressions. It also promotes the ratio of Bcl-2/Bax and inhibits the expressions of cleaved caspase 3 and caspase 9.	Blood Sci, 2025, 7(3):e00246 iScience, 2024, 27(7):110367 World J Emerg Med, 2024, 15(3):206-213
S8974	GSK2795039	GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) with pIC50 of 6.57 for NOX2-mediated activation of HRP/Amplex Red. This compound inhibits reactive oxygen species (ROS) production, NADPH consumption and reduces apoptosis.	Phytomedicine, 2024, 136:156283 Open Med (Wars), 2024, 19(1):20240898 Int J Mol Sci, 2023, 24(18)14369
S6812	Z-Guggulsterone	Z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. This compound exhibits anti-inflammatory effects in microglia. It induces apoptosis in gastric cancer cells through the intrinsic mitochondria-dependent pathway.	Journal of Animal Science and Biotechnology, 2025, Article number: 16 International Journal of Biological Sciences, 2023, 3456-3471 Int J Biol Sci, 2023, 19(11):3456-3471
S3294	Demethyl-Coclaurine	Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. This compound stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.	Signal Transduct Target Ther, 2024, 9(1):243
S7274	HLY78	HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway.	Haematologica, 2025, 10.3324/haematol.2025.288464
S0411	BAM 15	BAM 15 is a novel mitochondrial protonophore uncoupler capable of protecting mammals from acute renal ischemic-reperfusion injury and cold-induced microtubule damage. This compound is also a potent AMPK activator. It attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.	Neuroscience, 2012, 223:238-45
S0231	NSC15364	NSC 15364 (compound 59) is an inhibitor that directly interacts with VDAC1 and prevents VDAC1 oligomerization, concomitant with an inhibition of apoptosis.	Exp Cell Res, 2024, 434(2):113874
S3236	Mesaconitine	Mesaconitine, one of the aconite alkaloids in Aconiti tuber, increases the [Ca2+]i level in endothelial cells by influx of Ca2+ from extracellular spaces.
S3269	Acetylcorynoline	Acetylcorynoline, a major alkaloid component derived from Corydalis bungeana which is a traditional Chinese medical herb, shows anti-inflammatory properties. This compound may decrease egl-1 expression to suppress apoptosis pathways and increase rpn5 expression to enhance the activity of proteasomes.
S0947	Cafestol	Cafestol is a natural diterpenes extracted from coffee beans. It induces apoptosis and regulates a variety of inflammatory mediators to reduce inflammation. This compound inhibits the PI3K/Akt pathway and can also reduce the production of ROS in the leukemia cell line HL60.
S0539	BTZO-1	BTZO-1 binds to macrophage migration inhibitory factor (MIF) with Kd of 68.6 nM. This compound activats antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro.
E0020	Lupenone	Lupenone (Lup-20(29)-en-3-one, lupeone) is an isolated compound exhibiting anti-oxidative, anti-inflammation, and anti-diabetic activities. This compound can protect SH-SY5y cells against METH-induced neuronal apoptosis through the PI3K/Akt pathway.
S5973	Methylprednisolone Acetate	Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
E0129	Oxysophocarpine	Oxysophocarpine (OSC) is an alkaloid extracted from Sophora alopecuroides. This compound inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC) by targeting the Nrf2/HO-1 axis. It protects cells against apoptosis and inflammatory responses and compromised miR-155 activity by attenuating MAPK and NF-κB pathways.