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Apoptosis related Chemicals

Cat.No. Product Name Information Product Use Citations Product Validations
S4777 Plumbagin Plumbagin (Plumbagine, Plumbaein, Plumbagone), a quinoid constituent isolated from the root of the medicinal plant Plumbago zeylanica L, exerts anticancer and antiproliferative activities in animal models and in cell culture.
PLoS One, 2025, 20(9):e0333127
Free Radic Biol Med, 2023, 203:1-10
Exp Ther Med, 2022, 24(2):501
S3836 6-Gingerol 6-Gingerol is the active constituent of fresh ginger known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
Animals (Basel), 2023, 1315
Animals (Basel), 2023, 13(8)1315
J Biochem Mol Toxicol, 2020, e22609
E4022 Sodium propionate Sodium propionate (sodium propanoate), a short chain fatty acid, is a white crystalline salt derived from propionic acid with anti-inflammatory properties. This compound is used as a supplement in transgalactic-oligosaccharides (TOS) medium for the isolation of bifidobacteria and as a supplement in the SCFA (short-chain fatty acid) diet prepared for mice.
Cell Reports Medicine, 2025, 102410
Cell Rep Med, 2025, 6(10):102410
Cancer Research, 2025, 2468-2484
S9279 Euphorbia factor L3 Euphorbia factor L3 (5,15-Diacetyl-3-benzoyllathyrol), belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed, shows potent cytotoxicity and induces apoptosis via the mitochondrial pathway in A549 cells.
Bioengineered, 2022, 13(4):10984-10997
Bioengineered, 2022, 10984-10997
S4758 Crocin Crocin (Alpha-Crocin, Gardenia Yellow) is a water-soluble carotenoid pigment of saffron (Crocus sativus L.). It has been used as a spice for flavoring and coloring food preparations, and in Chinese traditional medicine as an anodyne or tranquilizer.
Toxicol Appl Pharmacol, 2022, 437:115892
ACS Chem Neurosci, 2020, 15;11(8):1159-1170
S3975 Protocatechuic acid Protocatechuic acid (PCA, 3,4-Dihydroxybenzoic acid, Protocatechuate), a dihydroxybenzoic acid, is a type of widely distributed naturally occurring phenolic acid.
Biosci Rep, 2021, BSR20211828
Bioscience Reports, 2021, BSR20211828
S3938 Bisdemethoxycurcumin (BDMC) Bisdemethoxycurcumin (BDMC), a natural demethoxy derivative of curcumin, possesses several biological activities, such as anti-inflammation and anti-cancer activities.
Drug Des Devel Ther, 2020, 14:993-1001
Drug Design, Development and Therapy, 2020, 993-1001
S3895 Sophoridine Sophoridine (5-Epidihydrosophocarpine, Dihydro-5-episophocarpine), a natural product obtained from medicinal plants, has a variety of pharmacological effects, including anti-cancer and anti-arrhythmia, and affects the immune and central nervous systems.
J Cell Mol Med, 2020, 10.1111/jcmm.16108
S3967 Flavone Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.
Nat Commun, 2019, 11;10(1):4621
E0213 Bruceine D

Bruceine D, isolated from Brucea javanica (L.) Merr. (Simaroubaceae), shows antineoplastic properties in various human cancers including pancreas, breast, lung, blood, bone, and liver. This compound induces apoptosis in human chronic myeloid leukemia K562 cells via mitochondrial pathway.
S3814 Tubeimoside I Tubeimoside I (Lobatoside H, TBMS1), a triterpenoid saponin, isolated from the tubers of Bolbostemma paniculatum, shows potent antitumor and antitumor-promoting effects.
E4831 L-Arginine (L-glutamate) L-Arginine (L-glutamate), also known as arginine glutamate, is a mixture of amino acids that induces apoptosis via hypertonic stress. It also promotes gastric relaxation by providing L-arginine for nitric oxide production, thereby benefiting gastrointestinal motility and conditions associated with vagus nerve dysfunction.
S0307 BTR-1 BTR-1 induces cytotoxicity in a time- and concentration-dependent manner on leukemia cell line CEM. This compound affects DNA replication by inducing a block at S phase and leads to activation of apoptosis to induce cell death.
E3685 Ampelopsis grossedentata Extract Ampelopsis Grossedentata Extract is extracted from Ampelopsis Grossedentata, which can induce apoptosis in cancer cells.
E7084 C6 Ceramide C6 Ceramide (C6-Cer, N-Hexanoylsphingosine) is a short-chain, cell-permeable ceramide with anticancer properties, including cell cycle arrest, apoptosis, and tumor growth inhibition. It enhances chemotherapy efficacy in drug-resistant cancers by promoting miR-29b expression, which suppresses endothelial cell proliferation, migration, and angiogenesis through the Akt signaling pathway. In combination with Trichostatin A, this compound disrupts the HDAC6/PP1/tubulin complex, leading to AKT dephosphorylation.
E1560 Raptinal Raptinal is a pro-apoptotic compound that induces apoptosis by promoting the release of cytochrome c from the mitochondria, thereby activating the intrinsic apoptotic pathway. It also inhibits the activity of caspase-activated Pannexin 1 (PANX1), a ubiquitously expressed transmembrane channel involved in regulating various cell death-associated processes.
E7116 Deoxynivalenol Deoxynivalenol (Vomitoxin) is an orally active trichothecene mycotoxin produced by Fusarium fungi, commonly contaminating cereal grains such as wheat, barley, and corn. It disrupts protein synthesis, impairs gut integrity, and triggers immune dysregulation, leading to vomiting, growth suppression, and inflammation in humans and animals. It also induces p38-mediated gene expression and apoptosis in leukocytes, promoting systemic release of interleukin-6 (IL-6) and other proinflammatory cytokines.
S9410 Euphorbia factor L1 Euphorbia factor L1, a diterpenoid isolated from Euphorbia lathyris, inhibits osteoclastogenesis and induces osteoclast apoptosis.
S3857 4-Hydroxybenzyl alcohol 4-hydroxybenzyl alcohol (P-Methylolphenol, 4-Methylolphenol), an important phenolic constituent of Gastrodia elata Blume (GEB), has been shown to have many beneficial effects in different animal models of neurological disorders, such as, headaches, convulsive behavior, dizziness, and vertigo.
E0222 Glaucocalyxin A

Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. This compound induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
E0225 Licochalcone B

Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces the cell cycle arrest and apoptosis in human hepatoma cell HepG2. This compound specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction.
E7199 Transferrins Transferrin is a glycoprotein that plays a crucial role in iron transport in the bloodstream. It binds ferric ions (Fe³⁺), forming a stable complex that is transported to cells through transferrin receptors (CD71) on the cell membrane. By maintaining cellular iron balance, transferrin helps protect against apoptosis, especially during iron deficiency. Transferrin levels and receptor expression serves as a key biomarkers for evaluating iron status, diagnosing anemia, and assessing cancer prognosis.
S9182 Crebanine Crebanine, an aporphine alkaloid isolated from the crude hexane extract of the dried tuber of Stephania venosa, exhibits anti-cancer effects.
E0212 Cornuside

Cornuside is a bisiridoid glucoside compound isolated from the fruit of Cornus officinalis SIEB. et ZUCC. This compound suppresses lipopolysaccharide-induced inflammatory mediators by inhibiting NF-κB activation in RAW 264.7 macrophages. It attenuates apoptosis in rat cortical neurons.
E0216 Hinokiflavone

Hinokiflavone, isolated from Selaginella P. Beauv, Juniperus phoenicea and Rhus succedanea, possesses excellent pharmacological activities, including anti-inflammatory, antioxidant and antitumor activity. This compound induces apoptosis and inhibits migration of breast cancer cells via EMT signalling pathway.
E7840 EF24 EF24, a synthetic analog of curcumin, is a potent antitumor agent that inhibits tumor growth and metastasis by blocking NF-κB-dependent signaling pathways. It also induces cell cycle arrest and apoptosis through a redox-dependent mechanism in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells.
E3091 Citri Reticulatae Pericarpium Extract Citri Reticulatae Pericarpium Extract is obtained from Citri Reticulatae Pericarpium, which enriches with polymethoxy flavonoids, has been identified as a prospective therapeutic treatment for metabolic disorders and circulatory system diseases due to the remarkable anti-inflammatory, antioxidant, and anti-apoptotic activity.
E7797 Mitoguazone Mitoguazone (MGBG, Methyl-GAG) is a polyamine analog that disrupts polyamine biosynthesis by inhibiting S-adenosylmethionine decarboxylase (SAMDC). It induces apoptosis and triggers p53-independent programmed cell death in the MCF7 cell line. It also inhibits the integration of HIV DNA into cellular DNA in both monocytes and macrophages.
E2374 PI-273 PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.