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Apoptosis related Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
E3848 Hypericum Sampsonii Extract Hypericum Sampsonii Extract is extracted from Hypericum sampsonii, which induces apoptosis of cancer cells by modulating the subcellular localization of RXRalpha.
P1261New Cytochrome C Cytochrome c is a mitochondrial protein essential for electron transport and energy production. Upon apoptotic signals, it binds cardiolipin, gains peroxidase activity, and triggers cell death via caspase activation. Its function is tightly regulated by tissue-specific phosphorylation and ATP binding, which control respiration, ROS production, and apoptosis sensitivity.
E7174 D-α-Tocopherol Succinate D-α-tocopherol succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E that significantly reduces the cisplatin-induced increase of ROS and decreases cellular necrosis and late apoptosis, thereby inhibiting cisplatin-induced cytotoxicity in HEIOC1 cells. It also exhibits an anti-apoptotic effect.
E3796 Flaxseed Extract Flaxseed Extract is drawed from Linum usitatissimum, which can regulate the growth of MCF-7 cells and induce apoptosis.
S7307 GSK2606414 GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. This compound impairs GANT-61 induced autophagy in NB cells with MYCN amplification. It exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.
Immunity, 2025, 58(10):2489-2504.e8
J Transl Med, 2025, 23(1):860
Biomolecules, 2025, 15(1)76
Verified customer review of GSK2606414
S1204 Melatonin Melatonin is a MT receptor agonist, used as a dietary supplement. This compound is a selective ATF-6 inhibitor and downregulates COX-2. It enhances mitophagy and regulates the homeostasis of apoptosis and autophagy.
Antioxidants (Basel), 2025, 14(5)528
Sci Rep, 2025, 15(1):8451
Biochem Biophys Res Commun, 2025, 760:151706
Verified customer review of Melatonin
S6889 Monomethyl Fumarate Monomethyl Fumarate (MMF, Monomethylfumarate, Fumaric acid monomethyl ester, Methyl hydrogen fumarate), the active metabolite of the psoriasis drug Fumaderm, is a potent GPR109A agonist. This compound prevents major dysfunctions associated with neurodegenerative diseases: oxidative stress, mitochondrial dysfunction, apoptosis and autophagy.
Cell Cycle, 2023, 818-828
Cell Cycle, 2022, 1-11.
Aging (Albany NY), 2021, 17097-17117