AhR Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S8842	BAY-218	BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands.	Sci Rep, 2025, 15(1):8826 Scientific Reports, 2025, 8826 Cancer Commun (Lond), 2024, 10.1002/cac2.12545
S3205	Perillaldehyde	Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.	Front Cell Dev Biol, 2025, 13:1598520
S1891	Carbidopa	Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.	Drug Design, Development and Therapy, 2026, 1-23 Signal Transduct Target Ther, 2021, 6(1):77 Signal Transduction and Targeted Therapy, 2021, 77
S2313	Indole-3-carbinol	Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, and it is also an inhibitor of WWP1 (E3 ubiquitin ligase with WW domain).	J Med Virol, 2023, 95(2):e28478 Am J Cancer Res, 2021, 11(10):4994-5005 American Journal of Cancer Research, 2021, 4994-5005