AhR Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S6926	GNF351	GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR). This compound interacts directly with the AHR ligand binding pocket and competes with a well-characterized photoaffinity AHR ligand for binding to the AHR with IC50 of 62 nM.	Front Pharmacol, 2021, 12:655281
S0154	CAY10465	CAY 10465 is a selective and high-affinity agonist on aryl hydrocarbon receptor (AhR) with Ki of 0.2 nM.	Chem Biol Interact, 2025, 412:111478
S5839	L-Kynurenine	L-Kynurenine ((S)-Kynurenine) is a aryl hydrocarbon receptor agonist. This compound is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway.	Theranostics, 2021, 11(19):9623-9651
S3205	Perillaldehyde	Perillaldehyde (Perilladehyde, Perillal, PAE, PA), the main component of Perilla frutescens (a traditional medicinal antioxidant herb), inhibits BaP-induced AHR activation and ROS production, inhibits BaP/AHR-mediated release of the CCL2 chemokine, and activats the NRF2/HO1 antioxidant pathway.	Front Cell Dev Biol, 2025, 13:1598520
S6607	YL-109	YL-109 is a novel antitumor agent that has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo.
S0155	PDM-11	PDM-11 is a derivative of resveratrol that exhibits stronger antagonist affinity for arylhydrocarbon receptors (AhR) than resveratrol, without any affinity for the estrogen receptor.
E5768	Indolelactic acid	Indolelactic acid (Indole-3-lactic acid), a metabolite of tryptophan (Trp), plays a role in immune cell differentiation and cytokine production by activating aryl hydrocarbon receptors (AhR). This regulation supports immune responses and aids in anti-inflammatory and anti-allergic activities. It also plays an important role in the balance of Th17/Treg cells by reprogramming CD4+ Th cells into CD4+CD8+ Treg cells and inhibiting the polarization of Th17 cells.
E0143	ITE	ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM.
S1177	PD 98059	PD98059 is a non-ATP competitive MEK inhibitor with IC50 of 2 μM in a cell-free assay, specifically inhibits MEK-1-mediated activation of MAPK; does not directly inhibit ERK1 or ERK2. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR) and functions as an AHR antagonist.	Nat Commun, 2025, 16(1):212 Adv Sci (Weinh), 2025, 12(28):e2502634 Theranostics, 2025, 15(6):2624-2648
S1247	Leflunomide	Leflunomide is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of this compound is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). This chemical is also an agonist of the AhR.	Cancer Cell, 2025, 43(4):776-796.e14 J Transl Med, 2025, 23(1):917 J Virol, 2025, 99(2):e0211024
S1891	Carbidopa	Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor with an IC50 of 29 ± 2 μM.	Signal Transduct Target Ther, 2021, 6(1):77 J Cell Physiol, 2021, 10.1002/jcp.30587 PLoS One, 2017, 12(3):e0173240
S2313	Indole-3-carbinol	Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, and it is also an inhibitor of WWP1 (E3 ubiquitin ligase with WW domain).	J Med Virol, 2023, 95(2):e28478 Am J Cancer Res, 2021, 11(10):4994-5005 J Med Virol, 2019, 91(8):1440-1447
S4959	Skatole	Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.	Nutrients, 2023, 15(6)1490 Exp Cell Res, 2022, 421(1):113373