AhR Agonists

Cat.No.	Product Name	Information	Product Use Citations
S9700	Tapinarof (Benvitimod, WBI-1001)	Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Tapinarof induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM.	Pharmaceutics, 2025, 17(6)731 Molecular Cancer Therapeutics, 2024, MCT-24-0211 Mol Cancer Res, 2024, 10.1158/1541-7786.MCR-24-0151
S9682	FICZ (6-Formylindolo[3,2-b]carbazole)	FICZ (6-Formylindolo[3,2-b]carbazole) is a potent agonist of aryl hydrocarbon receptor (AhR) that is efficiently metabolized by AHR-regulated cytochrome P4501 enzymes.	Biochem Pharmacol, 2025, 236:116872 Front Immunol, 2024, 15:1513595 Cell Death Dis, 2023, 14(1):18
S2292	Diosmin	Diosmin is an agonist of the aryl hydrocarbon receptor (AhR). This compound is a semisynthetic phlebotropic agent and a flavonoid found in a variety of citrus fruits.	Int J Mol Sci, 2020, 21(14):5025 Mol Biol Rep, 2020, 47(3):2217-2230
S9092	Norisoboldine	Norisoboldine (Laurelliptine), a natural aryl hydrocarbon receptor (AhR) agonist, attenuates ulcerative colitis (UC) and induces the generation of Treg cells.	iScience, 2024, 27(5):109682 bioRxiv, 2024, 2023.11.04.565649
S5839	L-Kynurenine	L-Kynurenine ((S)-Kynurenine) is a aryl hydrocarbon receptor agonist. This compound is a metabolite of the amino acid L-tryptophan used in the production of niacin and a central compound of the tryptophan metabolism pathway.	Journal of Virology, 2024, e00458-24 Theranostics, 2021, 11(19):9623-9651
S0154	CAY10465	CAY 10465 is a selective and high-affinity agonist on aryl hydrocarbon receptor (AhR) with Ki of 0.2 nM.	Chem Biol Interact, 2025, 412:111478
E0143	ITE	ITE (2-(1′H-indole-3′-carbonyl)-thiazole-4-carboxylic acid methyl ester) is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) that directly binds to AHR with a Ki of 3 nM.
S2929	Pifithrin-α (PFTα) Hhydrobromide	Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).	J Adv Res, 2025, S2090-1232(25)00192-4 Front Pharmacol, 2025, 16:1608156 J Cell Mol Med, 2025, 29(11):e70641
S1247	Leflunomide	Leflunomide is a pyrimidine synthesis and protein tyrosine kinase inhibitor belonging to the DMARD, used as an immunosuppressant agent. The active metabolite of this compound is A77 1726, which inhibits dihydroorotate dehydrogenase (DHODH). This chemical is also an agonist of the AhR.	Cancer Cell, 2025, 43(4):776-796.e14 J Transl Med, 2025, 23(1):917 J Virol, 2025, 99(2):e0211024