Transferase

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1453 Tipifarnib <1 mg/mL 14 mg/mL <1 mg/mL
S2797 Lonafarnib <1 mg/mL 127 mg/mL 127 mg/mL
S2799 Daporinad (FK866, APO866) <1 mg/mL <1 mg/mL 78 mg/mL
S2674 A922500 <1 mg/mL 86 mg/mL <1 mg/mL
S8056 Lomeguatrib <1 mg/mL 65 mg/mL <1 mg/mL
S3945 L-Cycloserine 20 mg/mL 8 mg/mL -1 mg/mL
S8608 Adenosine Dialdehyde (ADOX) 3 mg/mL 19 mg/mL <1 mg/mL
S3658 O6-Benzylguanine <1 mg/mL 48 mg/mL 12 mg/mL
S4743 Wogonin <1 mg/mL 56 mg/mL 3 mg/mL
S7466 GGTI 298 TFA salt <1 mg/mL 100 mg/mL 100 mg/mL
S8244 Etomoxir (Na salt) 64 mg/mL 64 mg/mL 13 mg/mL
S4021 Tolcapone <1 mg/mL 55 mg/mL 55 mg/mL
S4589 Amodiaquine dihydrochloride dihydrate 29 mg/mL 92 mg/mL <1 mg/mL
S7467 LB42708 <1 mg/mL 100 mg/mL 86 mg/mL
S4280 Meclofenoxate (Centrophenoxine) HCl 58 mg/mL 58 mg/mL 58 mg/mL
S7192 PF-04620110 <1 mg/mL 49 mg/mL <1 mg/mL
S7465 FTI 277 HCl 17 mg/mL 96 mg/mL 14 mg/mL
Catalog No. Information Product Use Citations Product Validations
S1453

Tipifarnib

Tipifarnib (R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.

S2797

Lonafarnib

Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.

S2799

Daporinad (FK866, APO866)

Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM in a cell-free assay. Phase 1/2.

S2674

A922500

A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.

S8056

Lomeguatrib

Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

S3945New

L-Cycloserine

L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.

S8608New

Adenosine Dialdehyde (ADOX)

Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.

S3658New

O6-Benzylguanine

O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

S4743New

Wogonin

Wogonin, a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.

S7466

GGTI 298 TFA salt

GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.

S8244

Etomoxir (Na salt)

Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.

S4021

Tolcapone

Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.

S4589

Amodiaquine dihydrochloride dihydrate

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase in human erythrocytes, also used as an antimalarial and anti-inflammatory agent.

S7467

LB42708

LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.

S4280

Meclofenoxate (Centrophenoxine) HCl

Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.

S7192

PF-04620110

PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.

S7465

FTI 277 HCl

FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I.

Tags: Transferase activity | Transferase inhibition | Transferase activity | protein transferase | farnesyltransferase | DNA methyltransferase cancer | DNA methyltransferase activity | DNA methyltransferase assay | DNA methyltransferase mechanism | farnesyl transferase assay | Transferase inhibitor review