Research Area
Product Type
United States ( Change Country )
Tipifarnib (Zarnestra) Chemical Structure
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Biological Activity
Tipifarnib (Zarnestra) is a farnesyltransferase inhibitor with an IC50 of 0.6 nM. It is a nonpeptidomimetic quinolinone with potential antineoplastic activity. It binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, it prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. [1][2][3]
References on Tipifarnib (Zarnestra)
- [1] http://en.wikipedia.org/wiki/Tipifarnib ;
- [2] http://www.cancer.gov/drugdictionary/?CdrID=42626 ;
- [3] Acta Haematol. 2008;120(1):51-6.
Chemical Information
| Molecular Weight (WM): | 489.4 |
|---|---|
| Formula: | C27H22Cl2N4O |
| CAS No.: | 192185-72-1 |
| Synonyms: |
R115777
|
| Dissolve in (25°C): | DMSO ≥14mg/mL |
| Water <1mg/mL | |
| Ethanol ≥6mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Others >> Others >> Other Inhibitors
Apoptosis >> Ras / p21 >> Ras / p21 Inhibitors
MAPK >> Ras / p21 >> Ras / p21 Inhibitors
Apoptosis >> Ras / p21 >> Ras / p21 Inhibitors
MAPK >> Ras / p21 >> Ras / p21 Inhibitors
Notes:
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