Home Metabolism Transferase inhibitor - Acyltransferase inhibitor Cyclandelate

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Cyclandelate Transferase inhibitor

Cat.No.S4189

Cyclandelate (BS 572,3,5,5-Trimethylcyclohexyl mandelate) is an effective inhibitor of rat hepatic acycloenzyme A: cholesterol acyltransferase (ACAT) with IC50 of 80 μM.
Cyclandelate Transferase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 276.37

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S418901 DMSO]55 mg/mL]false]Ethanol]55 mg/mL]false]Water]Insoluble]false Purity: 99.51%
99.51

Chemical Information, Storage & Stability

Molecular Weight 276.37 Formula

C17H24O3

 Storage (From the date of receipt)
CAS No. 456-59-7 Download SDF Storage of Stock Solutions

Synonyms BS 572,3,5,5-Trimethylcyclohexyl mandelate Smiles CC1CC(CC(C1)(C)C)OC(=O)C(C2=CC=CC=C2)O

Solubility

In vitro
Batch:

DMSO : 55 mg/mL (199.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 55 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
ACAT [1]
(Cell-free assay)
80 μM
In vitro

Cyclandelate is a direct-acting smooth muscle relaxant used to dilate blood vessels. It may cause gastrointestinal distress and tachycardia. This compound is in a class of drugs called vasodilators. It relaxes veins and arteries, which makes them wider and allows blood to pass through them more easily. This chemical produces peripheral vasodilation by a direct effect on vascular smooth muscle. Its pharmacological action may be due to calcium-channel antagonism. [1] It is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. This agent hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl CoA ester. [2]
References

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