PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

Size Price Stock Quantity  
In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jIWWlEPTB;MD64NlAzPCEQvF2= M1XXNHNCVkeHUh?=
UACC-893 NFK2fIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7DTWM2OD13LkG5PFg3KM7:TR?= MYXTRW5ITVJ?
A427 NHLiWohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn20TWM2OD13LkeyOVY4KM7:TR?= M4HxNXNCVkeHUh?=
OCUB-M MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTZwNk[xNFIh|ryP Mn;TV2FPT0WU
SW684 M1XZVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYX2NFZQUUN3ME23MlUzOjZ6IN88US=> M1HCWHNCVkeHUh?=
SK-LMS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjp[YJpUUN3ME25MlAyOzB{IN88US=> MVPTRW5ITVJ?
CP50-MEL-B MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r0UWlEPTB;OT6zNFQyQSEQvF2= M1e2Z3NCVkeHUh?=
NCI-H1651 M3zNOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHniV2VKSzVyPUGwMlAzPzZizszN MUfTRW5ITVJ?
ABC-1 MnzvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTFyLkGwN|ch|ryP MVzTRW5ITVJ?
OE19 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fUXmlEPTB;MUCuNVc{OyEQvF2= MlvxV2FPT0WU
DSH1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[yO2hKSzVyPUGwMlg5PzlizszN MWrTRW5ITVJ?
SW13 M2HHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4r2emlEPTB;MUGuPVMyQSEQvF2= NELiUnJUSU6JRWK=
MDA-MB-453 NEnDWZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLERZVKSzVyPUGyMlE3ODNizszN NGTOd4hUSU6JRWK=
647-V Mln4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\i[WlEPTB;MUKuN|U5OiEQvF2= MnW1V2FPT0WU
NCI-H2342 NHHpNmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF{LkO5PVUh|ryP M4LDWXNCVkeHUh?=
LB2241-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHOZ|VKSzVyPUGyMlU4PzlizszN MkHTV2FPT0WU
UACC-257 M1rGRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVWzNJB{UUN3ME2xN{41PDV|IN88US=> NWLDW|U{W0GQR1XS
NCI-H661 NV\oclFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfaTWM2OD1zMz62OFQ6KM7:TR?= NUnq[JdkW0GQR1XS
FADU M2TreGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4GxTWlEPTB;MUOuOlk6OiEQvF2= MYTTRW5ITVJ?
A2780 NV3KRlRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTF|LkiwOFEh|ryP M37VSnNCVkeHUh?=
NCI-H1793 M1zKVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrKTWM2OD1zND60NFg2KM7:TR?= NW\jR5I1W0GQR1XS
TE-8 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfPbopPUUN3ME2xOU4{PDZ3IN88US=> NIjxW4ZUSU6JRWK=
HGC-27 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXCfo9GUUN3ME2xOk4yPjR2IN88US=> NVnoVnFXW0GQR1XS
MMAC-SF NH:5b41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof5TWM2OD1zNz6zO|I4KM7:TR?= NYL5XZBXW0GQR1XS
Calu-6 NYL1TnNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zzPWlEPTB;MUiuNVUyOyEQvF2= NVLIUWxDW0GQR1XS
HUTU-80 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml3jTWM2OD1zOD6zPVU6KM7:TR?= MUDTRW5ITVJ?
SAS NGn3[nZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTF6Lk[0OVUh|ryP NWXKeXRFW0GQR1XS
IST-MES1 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rUUmlEPTB;MUiuOlUxQCEQvF2= MY\TRW5ITVJ?
C3A MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe2fYFKSzVyPUG4Mlc6OTlizszN NEnER4dUSU6JRWK=
ES3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLueYxCUUN3ME2xPE45OzZ2IN88US=> M3;UfXNCVkeHUh?=
HSC-2 NID2UmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnYXI45UUN3ME2xPU43PTRzIN88US=> M4HHWHNCVkeHUh?=
T47D M3qxUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHle4hKSzVyPUKwMlE1QDVizszN MYTTRW5ITVJ?
EW-7 M13QWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjpdWlKSzVyPUKwMlg2QDhizszN NWLo[4Z7W0GQR1XS
LN-405 M3v1UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJyLki5OlUh|ryP MY\TRW5ITVJ?
U031 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fCSWlEPTB;MkGuOFgxOiEQvF2= NXHOd29IW0GQR1XS
A549 Mnr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe4dG9GUUN3ME2yNU45PDlzIN88US=> NVL4TYdJW0GQR1XS
RMG-I NXniR3BuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTJ{LkK2Olgh|ryP NWjIbYo2W0GQR1XS
BT-474 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DEZWlEPTB;MkKuOlU2OSEQvF2= Mnr2V2FPT0WU
NB69 MkTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTJ|LkG1NkDPxE1? MUTTRW5ITVJ?
NB7 NXGyN3Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLLOlM5UUN3ME2yOE4yQDhizszN NIPjPVRUSU6JRWK=
HCC1569 M{H4[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXPCPIdEUUN3ME2yOE43OTJ3IN88US=> M{fUZnNCVkeHUh?=
MEL-JUSO MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoK0TWM2OD1{ND62PVA5KM7:TR?= MoDVV2FPT0WU
MDA-MB-175-VII MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX4d3lKSzVyPUK1MlI2OTdizszN NHPsZVlUSU6JRWK=
HCC1419 M2\2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnGcXpKUUN3ME2yOU43ODB|IN88US=> M4rae3NCVkeHUh?=
Ca9-22 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLuTWM2OD1{NT62OFMzKM7:TR?= NUDKUGo4W0GQR1XS
KGN MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJ3Lke1OFch|ryP NHSyVlhUSU6JRWK=
LB373-MEL-D Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PiXWlEPTB;Mk[uNVk{QCEQvF2= M2LVbnNCVkeHUh?=
NCI-H1755 NFvhVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzUZo8{UUN3ME2yOk45QDRzIN88US=> NW\wNIV4W0GQR1XS
D-423MG MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn[5TWM2OD1{Nz6wO|E2KM7:TR?= NFPaXWJUSU6JRWK=
DK-MG M4[xeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJ6Lke4OFYh|ryP M1\IPXNCVkeHUh?=
NCI-H1623 NILmdVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF:w[3JKSzVyPUK4Mlg{PDJizszN MmPtV2FPT0WU
KU-19-19 NV\4Z4Y{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvUTWM2OD1{OD65PVUh|ryP MUjTRW5ITVJ?
C-33-A M3\2Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnEdoE3UUN3ME2yPU4zOTl6IN88US=> NH3L[2JUSU6JRWK=
SCC-4 M2\mZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDtT|R5UUN3ME2zNE4{OzV2IN88US=> NGOwVVhUSU6JRWK=
MG-63 M{LMbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\CNXZKSzVyPUOwMlU6QTRizszN NELLOWZUSU6JRWK=
LNCaP-Clone-FGC NHvrdldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrQ[ZRKSzVyPUOxMlQ6OjFizszN MkjYV2FPT0WU
CAPAN-1 Mk\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqzTWM2OD1|MT61Nlg3KM7:TR?= MV\TRW5ITVJ?
GI-ME-N M{PBUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoDuTWM2OD1|MT61N|U{KM7:TR?= M{\CVXNCVkeHUh?=
RERF-LC-MS MnfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFS1bpNKSzVyPUOyMlY4PDdizszN MonKV2FPT0WU
KLE Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPnTWM2OD1|Mz60N|M1KM7:TR?= NXGwe4JUW0GQR1XS
KNS-81-FD M4m1emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\BcI1tUUN3ME2zN{42ODB6IN88US=> M32yPHNCVkeHUh?=
DOK NGDTOYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlT4TWM2OD1|ND62OlEzKM7:TR?= NInsPG5USU6JRWK=
ACHN NFvMdFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPaO4hbUUN3ME2zOU4yPTh6IN88US=> NH\OdZZUSU6JRWK=
KYSE-520 NE\GU45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrZboxiUUN3ME2zOU4zOzZzIN88US=> NHG1XYJUSU6JRWK=
SBC-5 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzPVXFKSzVyPUO1MlUyOTZizszN NInTNIxUSU6JRWK=
NCI-H28 NV7pbHdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRTN3Lk[2PVUh|ryP M4\Qd3NCVkeHUh?=
ES7 Ml\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvDTWM2OD1|Nj6yNlQ6KM7:TR?= NXzkT4kzW0GQR1XS
A172 M4j4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDLfmFLUUN3ME2zOk41OTh5IN88US=> NX63e|NWW0GQR1XS
UM-UC-3 NIDMPHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jOd2lEPTB;M{euPFc1PiEQvF2= NVPnTW15W0GQR1XS
LXF-289 NWjVb|VrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGwN|dKSzVyPUO4MlAxPDdizszN MlX2V2FPT0WU
KP-4 NWPzSndGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXfrXINNUUN3ME2zPE41PzN7IN88US=> M4HodHNCVkeHUh?=
TE-1 NHfDclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYntTnZKUUN3ME2zPU43PTh7IN88US=> M4jpdnNCVkeHUh?=
G-402 M4Xwb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LtRWlEPTB;NECuNFYyKM7:TR?= NXfJelRVW0GQR1XS
786-0 M{L0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1;pS2lEPTB;NECuPVA6PiEQvF2= NV62VYZmW0GQR1XS
K5 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPMdIRSUUN3ME20NU4{Pjh4IN88US=> MXvTRW5ITVJ?
SK-N-DZ NUXQcnFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;tWHN2UUN3ME20NU4{QDJ|IN88US=> MWXTRW5ITVJ?
OVCAR-4 NVLU[pBST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTMTWM2OD12MT63OVY5KM7:TR?= NIX2Z49USU6JRWK=
T84 Ml7pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTR{LkGyOlMh|ryP MoLnV2FPT0WU
GCIY NHvCN4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn\zTWM2OD12Mz6wPFA{KM7:TR?= NFPRTmhUSU6JRWK=
BB49-HNC NF\WcW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4q0TmlEPTB;NEOuN|M1QCEQvF2= NHjqTVZUSU6JRWK=
SNU-C2B MnzVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfFc3FKSzVyPUSzMlY1OzZizszN NUnUR4JvW0GQR1XS
TE-6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTR|Lki4PVQh|ryP NY\xXY81W0GQR1XS
23132-87 MojtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYL0NpYyUUN3ME20OE4zQTd6IN88US=> NFfk[|ZUSU6JRWK=
DMS-53 NEDUXGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1;vUWlEPTB;NESuN|M5PCEQvF2= MXHTRW5ITVJ?
ONS-76 NIDPVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTR2Lke2OlEh|ryP NV\CN4NvW0GQR1XS
DMS-273 NG\rTohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;aVIZKSzVyPUS0Mlk1OyEQvF2= NV\l[ItuW0GQR1XS
COLO-824 NFLPenVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PNTmlEPTB;NEWuPFc4PSEQvF2= MmTZV2FPT0WU
DMS-114 MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4L5eGlEPTB;NEWuPFkzPyEQvF2= NV7OeI4yW0GQR1XS
YKG-1 MmDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvvTWM2OD12Nj6wN|U2KM7:TR?= MUnTRW5ITVJ?
RH-18 M1[zN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHMTWM2OD12Nj6zO|M{KM7:TR?= MmK3V2FPT0WU
NCI-H1355 NYDDOI5kT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jwdmlEPTB;NE[uOlE5KM7:TR?= NEDEc5VUSU6JRWK=
NCI-H2170 NGHTO4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzSeoxKSzVyPUS3Mlc2QDRizszN NULGeoFRW0GQR1XS
OC-314 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e3RmlEPTB;NEeuPFQ4QCEQvF2= NFK5NphUSU6JRWK=
NCI-H2030 M173PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3SzbGlEPTB;NEeuPFkxPiEQvF2= M{PNc3NCVkeHUh?=
22RV1 NWrxRZRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR5LkmwNVUh|ryP NV7mXYhFW0GQR1XS
G-401 MmexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13l[mlEPTB;NEiuOFQyPSEQvF2= NWPGNJNOW0GQR1XS
YAPC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXJVXZKSzVyPUS5MlgxPzNizszN MXTTRW5ITVJ?
SW1573 NV\CZ4U2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlyzTWM2OD13MD6yOFM2KM7:TR?= MVXTRW5ITVJ?
COLO-792 Mn;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFrLN3NKSzVyPUWwMlYzOzdizszN MXfTRW5ITVJ?
KNS-62 NIm1VHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[ySmlEPTB;NUCuO|UxQCEQvF2= M2\vfnNCVkeHUh?=
NB5 MkfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK2VpdKSzVyPUWxMlQ2ODlizszN NWrEbWNrW0GQR1XS
CP66-MEL M2LxdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz4R|JKSzVyPUWxMlY1ODhizszN NFrVToZUSU6JRWK=
CaR-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NISzRpJKSzVyPUWyMlA3ODZizszN M17LcnNCVkeHUh?=
CAL-54 NGPCRVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTs[HNbUUN3ME21Nk4yOTB{IN88US=> MXjTRW5ITVJ?
8305C NGLVWpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHaNXo6UUN3ME21Nk4{OTVizszN MYLTRW5ITVJ?
Calu-3 Mn\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Tpb2lEPTB;NUKuN|c{OyEQvF2= MVTTRW5ITVJ?
AU565 M{DRNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGm3UXRKSzVyPUWyMlU2ODlizszN MojFV2FPT0WU
CW-2 NEi0fFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDxO2pxUUN3ME21Nk45PjV2IN88US=> M4jrNHNCVkeHUh?=
BEN M1LUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFWzXWdKSzVyPUWzMlc5PjJizszN MkjFV2FPT0WU
NCI-H1975 NYW5W4lKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vFZmlEPTB;NUOuPFk3PiEQvF2= MlXoV2FPT0WU
HCT-116 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rQe2lEPTB;NUSuNFMzPyEQvF2= MWTTRW5ITVJ?
SH-4 MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfNTWM2OD13ND6xN|gh|ryP M2\lTnNCVkeHUh?=
NCI-H1693 NEfWUm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlPxTWM2OD13ND6yNVA{KM7:TR?= Ml7xV2FPT0WU
BPH-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzTTWM2OD13NT6yPFkzKM7:TR?= NIS1S41USU6JRWK=
CAMA-1 MnHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PPZmlEPTB;NUWuPFEyPiEQvF2= NWX2dm5SW0GQR1XS
A388 NFTsZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPOW2lwUUN3ME21Ok4xQTh3IN88US=> MnOwV2FPT0WU
C2BBe1 MnfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPJTWM2OD13Nj6yOlM1KM7:TR?= NYOzSmVDW0GQR1XS
GAMG MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYDJR|UxRTV4LkW5OVUh|ryP NEPtT4tUSU6JRWK=
MKN28 M4D5NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXfQdGVFUUN3ME21Ok45ODF|IN88US=> M2HaW3NCVkeHUh?=
VA-ES-BJ NH23SoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTV4Lki3OFUh|ryP MlHnV2FPT0WU
HuCCT1 M3rlZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTV5LkC0PVIh|ryP NVS0SVAxW0GQR1XS
BFTC-905 NEHqNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvKOpRKSzVyPUW3MlI5QThizszN M2Hm[HNCVkeHUh?=
LS-123 NHnzTlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUizOHBoUUN3ME21O{42PjZ6IN88US=> NFrubHBUSU6JRWK=
LB996-RCC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjURopKSzVyPUW4MlAzQDdizszN M1HMXnNCVkeHUh?=
NCI-H1048 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTV6LkKxPFgh|ryP NUSxOI1YW0GQR1XS
COR-L105 MkXvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYTkeIZMUUN3ME21PE44OzN5IN88US=> MkXiV2FPT0WU
OVCAR-8 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkXCTWM2OD13OT6xO|E3KM7:TR?= M2TSPHNCVkeHUh?=
SK-N-FI MlnoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTV7LkOyNFch|ryP NGiwVJhUSU6JRWK=
MES-SA NHrKW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HZfGlEPTB;NUmuOFUxQSEQvF2= NVPNeZBEW0GQR1XS
SCC-9 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln4TWM2OD13OT60O|U{KM7:TR?= NY\ve5BTW0GQR1XS
EFO-27 NInNU5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPkWlhXUUN3ME21PU46PDNizszN NX;5c29FW0GQR1XS
GT3TKB M13h[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i2[WlEPTB;NkCuOlA1QCEQvF2= Ml3UV2FPT0WU
HCC38 M4nRVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\jVlBKSzVyPU[xMlQ{PzlizszN Mnm2V2FPT0WU
MLMA M3u0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLBTWM2OD14MT62NVY{KM7:TR?= NWHVSXI{W0GQR1XS
D-566MG MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PEbGlEPTB;NkOuOVIzPCEQvF2= NHTQTYtUSU6JRWK=
SF295 M2jh[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTZ|Lk[2OVUh|ryP MmmxV2FPT0WU
ES4 MmrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjXPGFkUUN3ME22OE41PzF7IN88US=> NXzCSFJHW0GQR1XS
CAKI-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmGyTWM2OD14ND61O|IyKM7:TR?= NEnwbnpUSU6JRWK=
OAW-28 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLqTWM2OD14ND65OlQ4KM7:TR?= NV;D[WN[W0GQR1XS
NCI-H460 NXfYUlVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKyTWM2OD14NT6wPFk4KM7:TR?= NUTOO|ZqW0GQR1XS
JAR NE\PNplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTZ3LkW1NVYh|ryP MojQV2FPT0WU
SNU-449 NIH6NXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHneoJQUUN3ME22OU44PjF4IN88US=> M37ZV3NCVkeHUh?=
D-392MG M2fBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmP5TWM2OD14NT65OFM1KM7:TR?= NVPhdZJWW0GQR1XS
EW-22 M37pZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nKbWlEPTB;Nk[uN|k2KM7:TR?= M2rjWnNCVkeHUh?=
GCT M{Tkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7nTWM2OD14Nz6wOFQ{KM7:TR?= MlrlV2FPT0WU
NOS-1 MlS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTZ5Lk[4Olch|ryP NIKxPHlUSU6JRWK=
RH-1 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT1TWM2OD14OD61OVU6KM7:TR?= MYXTRW5ITVJ?
HuH-7 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DNUWlEPTB;NkmuNVAxOiEQvF2= MV\TRW5ITVJ?
NUGC-3 NFrKWoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnz0TWM2OD15MD65OlQ1KM7:TR?= NV7aSWVvW0GQR1XS
IST-SL1 M3z4SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmXLTWM2OD15MT6yN|I1KM7:TR?= NEC2blZUSU6JRWK=
SHP-77 NE[4SopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH;GXnZKSzVyPUeyMlEyQSEQvF2= M1ztUnNCVkeHUh?=
SW1116 NFX5Ro1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTd{LkG0NFch|ryP MWjTRW5ITVJ?
LK-2 M37Sfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[xZnpRUUN3ME23Nk45PjF{IN88US=> M2rFdHNCVkeHUh?=
U-2-OS M2\xW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTd|LkG4Nlgh|ryP MlrIV2FPT0WU
KYSE-150 M4r6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTd|Lk[xNVgh|ryP M1\wcXNCVkeHUh?=
U251 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XmO2lEPTB;N{OuPFE3QCEQvF2= MUfTRW5ITVJ?
HT-1080 M2PYWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnLUHJuUUN3ME23OE4zPTd2IN88US=> M3XxN3NCVkeHUh?=
NCI-H1437 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPkOo1LUUN3ME23OE43OzJ4IN88US=> M1LrRXNCVkeHUh?=
HPAF-II MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn2Z4hKSzVyPUe0MlY1OTVizszN MVrTRW5ITVJ?
Becker M17ieGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTd3LkGxNFUh|ryP NV3kUlRsW0GQR1XS
PANC-10-05 NHPNRm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLPXmJWUUN3ME23OU4zQDZ3IN88US=> MkTpV2FPT0WU
TYK-nu M2DTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{C3T2lEPTB;N{WuN|ExOiEQvF2= NGH5ZWVUSU6JRWK=
SKG-IIIa NXfsWIpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTd3LkOzOFEh|ryP MVPTRW5ITVJ?
NCI-H1993 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTd3LkezPVch|ryP M3fQUHNCVkeHUh?=
S-117 M2nBWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTd3Lke1OUDPxE1? Mon4V2FPT0WU
HuO9 M13ncWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnz5TWM2OD15Nj6wNFQ5KM7:TR?= MVrTRW5ITVJ?
CAL-51 M2i1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTd4LkGwNFYh|ryP MULTRW5ITVJ?
BT-20 NX2wS3V3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XHS2lEPTB;N{[uNlE3QCEQvF2= MYXTRW5ITVJ?
LB831-BLC NULnXZlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XrNGlEPTB;N{[uN|IyPyEQvF2= NUnZUndkW0GQR1XS
LB1047-RCC NFjhWXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE[5UmtKSzVyPUe2Mlc3OTlizszN NHX5NItUSU6JRWK=
ES8 NYDiSm5nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWX3cGNOUUN3ME23PE4xODd|IN88US=> M3\4[XNCVkeHUh?=
UMC-11 M3vmbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoPVTWM2OD15OD6wPFg1KM7:TR?= MoC4V2FPT0WU
NCI-H226 NFXYUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTd6LkGzNVUh|ryP M2XzdXNCVkeHUh?=
IGROV-1 M17aVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjYTWM2OD15OD61OVUh|ryP MUTTRW5ITVJ?
BHY NGT6cZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHUemJKSzVyPUe5MlU6PiEQvF2= MkHiV2FPT0WU
MKN45 M2HVfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rHS2lEPTB;OECuN|E4PCEQvF2= M4T4cHNCVkeHUh?=
IA-LM NGjJZ5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX0TWM2OD16MD6zOVEyKM7:TR?= NIK3PVlUSU6JRWK=
WM-115 M3vze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWKz[4s3UUN3ME24NU41OTF2IN88US=> MnXoV2FPT0WU
VMRC-RCZ M2PsUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIr2fHdKSzVyPUixMlQ1OjVizszN MXTTRW5ITVJ?
NCI-H2291 NHi4V|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XK[mlEPTB;OEGuOlg1OiEQvF2= Mo\2V2FPT0WU
MCF7 MoPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuybFFKSzVyPUizMlI5QTdizszN Mnm4V2FPT0WU
639-V M2Xi[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XCfmlEPTB;OESuOlEzQSEQvF2= Mkf5V2FPT0WU
RT4 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlj3TWM2OD16NT6yOFA{KM7:TR?= MlTQV2FPT0WU
NCI-H2405 NEf1OJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml76TWM2OD16NT6yPVk4KM7:TR?= MlXDV2FPT0WU
CAL-33 NI\WeIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfONoJKSzVyPUi1MlY{OTVizszN Mki2V2FPT0WU
BT-549 NGHNemlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrOVpZiUUN3ME24OU46Ozh{IN88US=> MnPZV2FPT0WU
HT-1197 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTh6LkGwO|ch|ryP M4HJeHNCVkeHUh?=
G-361 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\JeWlEPTB;OEiuNVQ4PCEQvF2= NV[5O4FKW0GQR1XS
LS-411N M33FXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDGTWM2OD16OT6zN|g5KM7:TR?= NYPkXFZuW0GQR1XS
HT-144 Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvzdG5KSzVyPUi5MlU6QTJizszN M3vuZnNCVkeHUh?=
DJM-1 M1Lj[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\5WVV[UUN3ME24PU45QDR3IN88US=> M3fYPHNCVkeHUh?=
CAL-12T MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zUcmlEPTB;OUCuO|g6PSEQvF2= NFu3UZdUSU6JRWK=
MKN7 NWTpT4l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[5eFg3UUN3ME25NU4{PTVzIN88US=> MkKxV2FPT0WU
HuP-T3 NYezUG1nT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHuT3VFUUN3ME25Ok4yODB2IN88US=> M{m1VXNCVkeHUh?=
SK-MG-1 MmTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{OyXmlEPTB;OU[uNVM1QCEQvF2= MXnTRW5ITVJ?
NCI-H2347 M{GwVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTl6LkGwOFIh|ryP MmHaV2FPT0WU
SW872 NWXhPJJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjlfnlKSzVyPUGwNE41PTZizszN M1\COnNCVkeHUh?=
COLO-829 NHnoS4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjRfII4UUN3ME2xNFAvPTV|IN88US=> NVXyTHU1W0GQR1XS
MC-IXC NITFc|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHJd|RKSzVyPUGwNE43OTVizszN MkXWV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products

Tags: buy PF-4708671 | PF-4708671 supplier | purchase PF-4708671 | PF-4708671 cost | PF-4708671 manufacturer | order PF-4708671 | PF-4708671 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID