PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

Size Price Stock Quantity  
In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock

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2 Customer Reviews

  • Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 NXf6eGZ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;TVYVKSzVyPUCuPFIxOjRizszN MkPwV2FPT0WU
UACC-893 NIW0RYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjJRZFuUUN3ME21MlE6QDh4IN88US=> MkjxV2FPT0WU
A427 NISzZmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLlV|RJUUN3ME21MlczPTZ5IN88US=> NFvQ[pJUSU6JRWK=
OCUB-M NEnpXW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTZwNk[xNFIh|ryP NFvxVopUSU6JRWK=
SW684 NWDIb2tkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\vUVBKSzVyPUeuOVIzPjhizszN M2\uRXNCVkeHUh?=
SK-LMS-1 NYPJcnFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTlwMEGzNFIh|ryP Mn7vV2FPT0WU
CP50-MEL-B NIXHXnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjqTWM2OD17LkOwOFE6KM7:TR?= M{PSSnNCVkeHUh?=
NCI-H1651 M3npUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2T2dmlEPTB;MUCuNFI4PiEQvF2= M4juWXNCVkeHUh?=
ABC-1 M{HXV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTFyLkGwN|ch|ryP MmOzV2FPT0WU
OE19 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTFyLkG3N|Mh|ryP NF7obZlUSU6JRWK=
DSH1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf1NZNKSzVyPUGwMlg5PzlizszN M2fQUHNCVkeHUh?=
SW13 NFLtfItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\kTWM2OD1zMT65N|E6KM7:TR?= MVPTRW5ITVJ?
MDA-MB-453 NIPBeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPRXoo3UUN3ME2xNk4yPjB|IN88US=> Ml\4V2FPT0WU
647-V NULld5Z2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XJUWlEPTB;MUKuN|U5OiEQvF2= NETaPYxUSU6JRWK=
NCI-H2342 Ml3jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj0Z4JKSzVyPUGyMlM6QTVizszN NF3jS4lUSU6JRWK=
LB2241-RCC MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zXZmlEPTB;MUKuOVc4QSEQvF2= NInLdGdUSU6JRWK=
UACC-257 NHu4fZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorITWM2OD1zMz60OFU{KM7:TR?= M{XpRnNCVkeHUh?=
NCI-H661 M1PzUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWe1UploUUN3ME2xN{43PDR7IN88US=> NIPsW2RUSU6JRWK=
FADU NID4fohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTzVHNKSzVyPUGzMlY6QTJizszN NHPUOnpUSU6JRWK=
A2780 NWXXbII3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTF|LkiwOFEh|ryP MVXTRW5ITVJ?
NCI-H1793 NIDIfGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmqwTWM2OD1zND60NFg2KM7:TR?= MomxV2FPT0WU
TE-8 NIHWUHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnk[2tbUUN3ME2xOU4{PDZ3IN88US=> NUjDXI85W0GQR1XS
HGC-27 M2TPOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTF4LkG2OFQh|ryP M3mwNHNCVkeHUh?=
MMAC-SF MkPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTF5LkO3Nlch|ryP NWDVdWx7W0GQR1XS
Calu-6 NYjDU4I1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCyXnB{UUN3ME2xPE4yPTF|IN88US=> MXLTRW5ITVJ?
HUTU-80 NV7abGxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXVTWM2OD1zOD6zPVU6KM7:TR?= MU\TRW5ITVJ?
SAS M2DWRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TUZmlEPTB;MUiuOlQ2PSEQvF2= MYjTRW5ITVJ?
IST-MES1 NIPD[HJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LZRWlEPTB;MUiuOlUxQCEQvF2= NH\pdHRUSU6JRWK=
C3A MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[1TWM2OD1zOD63PVE6KM7:TR?= M3rGVHNCVkeHUh?=
ES3 NFfpN|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LPTWlEPTB;MUiuPFM3PCEQvF2= Mn7NV2FPT0WU
HSC-2 Mlm1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml\vTWM2OD1zOT62OVQyKM7:TR?= M4nq[3NCVkeHUh?=
T47D NUX3[pZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLJTWM2OD1{MD6xOFg2KM7:TR?= MUnTRW5ITVJ?
EW-7 M3\DPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XDZ2lEPTB;MkCuPFU5QCEQvF2= NVvvSZJEW0GQR1XS
LN-405 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV2yUmhsUUN3ME2yNE45QTZ3IN88US=> M3S5bXNCVkeHUh?=
U031 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEe5fWJKSzVyPUKxMlQ5ODJizszN MkHkV2FPT0WU
A549 M{TMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPsWJFsUUN3ME2yNU45PDlzIN88US=> MY\TRW5ITVJ?
RMG-I NEi1dY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvnVmpoUUN3ME2yNk4zPjZ6IN88US=> MVfTRW5ITVJ?
BT-474 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH4TWM2OD1{Mj62OVUyKM7:TR?= NIWwfopUSU6JRWK=
NB69 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\DTWM2OD1{Mz6xOVIh|ryP NWWwSplGW0GQR1XS
NB7 MnvBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnVeGNpUUN3ME2yOE4yQDhizszN NXz3OYtsW0GQR1XS
HCC1569 M3rM[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn72TWM2OD1{ND62NVI2KM7:TR?= MWLTRW5ITVJ?
MEL-JUSO MofSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTJ2Lk[5NFgh|ryP MnXxV2FPT0WU
MDA-MB-175-VII NHzK[ZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJ3LkK1NVch|ryP NF[yR4RUSU6JRWK=
HCC1419 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvZS4ZKSzVyPUK1MlYxODNizszN MU\TRW5ITVJ?
Ca9-22 NUTNdpR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\FTWM2OD1{NT62OFMzKM7:TR?= MWjTRW5ITVJ?
KGN NIfWdFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XvUGlEPTB;MkWuO|U1PyEQvF2= NXW0SldpW0GQR1XS
LB373-MEL-D M3;OOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnBTWM2OD1{Nj6xPVM5KM7:TR?= NWrub3oyW0GQR1XS
NCI-H1755 MmX1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M333ZWlEPTB;Mk[uPFg1OSEQvF2= M4LVV3NCVkeHUh?=
D-423MG Mo[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\GNWlEPTB;MkeuNFcyPSEQvF2= NUOzUnBIW0GQR1XS
DK-MG NUPQSGQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LFdWlEPTB;MkiuO|g1PiEQvF2= MlLoV2FPT0WU
NCI-H1623 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTJ6LkizOFIh|ryP MYLTRW5ITVJ?
KU-19-19 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInqZ3JKSzVyPUK4Mlk6PSEQvF2= NHT0fYNUSU6JRWK=
C-33-A MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\FNldKSzVyPUK5MlIyQThizszN NH7vNGtUSU6JRWK=
SCC-4 NW[1RWV4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrNVJNoUUN3ME2zNE4{OzV2IN88US=> NGrJ[WRUSU6JRWK=
MG-63 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XLcmlEPTB;M{CuOVk6PCEQvF2= M{DwW3NCVkeHUh?=
LNCaP-Clone-FGC MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT6TWM2OD1|MT60PVIyKM7:TR?= MkfkV2FPT0WU
CAPAN-1 NVX6SJFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTNzLkWyPFYh|ryP NF7OVlJUSU6JRWK=
GI-ME-N MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTNzLkWzOVMh|ryP NWn1bVB2W0GQR1XS
RERF-LC-MS NF7NPJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTN{Lk[3OFch|ryP MVPTRW5ITVJ?
KLE M1HqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvne|VKSzVyPUOzMlQ{OzRizszN NIXVe4xUSU6JRWK=
KNS-81-FD MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTqWZlWUUN3ME2zN{42ODB6IN88US=> MmPBV2FPT0WU
DOK MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTN2Lk[2NVIh|ryP NUDLcIdSW0GQR1XS
ACHN M4W3VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrNV|FKSzVyPUO1MlE2QDhizszN MorPV2FPT0WU
KYSE-520 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXGVplqUUN3ME2zOU4zOzZzIN88US=> NUntWVJQW0GQR1XS
SBC-5 MlTES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\YRnVOUUN3ME2zOU42OTF4IN88US=> NUDTUXhtW0GQR1XS
NCI-H28 NX;WZ|hJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTN3Lk[2PVUh|ryP MoHlV2FPT0WU
ES7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH1TWM2OD1|Nj6yNlQ6KM7:TR?= MV3TRW5ITVJ?
A172 M2e3e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLsW4tKSzVyPUO2MlQyQDdizszN MY\TRW5ITVJ?
UM-UC-3 M3L2eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHlTWM2OD1|Nz64O|Q3KM7:TR?= M3HRcHNCVkeHUh?=
LXF-289 M2fQRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG4TWM2OD1|OD6wNFQ4KM7:TR?= NGDBWWNUSU6JRWK=
KP-4 NEnwOoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\WWVVKSzVyPUO4MlQ4OzlizszN NFj2eGpUSU6JRWK=
TE-1 MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTN7Lk[1PFkh|ryP NHzyO25USU6JRWK=
G-402 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknrTWM2OD12MD6wOlEh|ryP Mk[yV2FPT0WU
786-0 M1LmUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X6dGlEPTB;NECuPVA6PiEQvF2= NIi3bIhUSU6JRWK=
K5 NHnON4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnme2pKSzVyPUSxMlM3QDZizszN NF7RbXZUSU6JRWK=
SK-N-DZ NFHpNnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnsTWM2OD12MT6zPFI{KM7:TR?= NYrJbI1[W0GQR1XS
OVCAR-4 NGf6UlRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Hn[2lEPTB;NEGuO|U3QCEQvF2= NX\z[FliW0GQR1XS
T84 NVjGWJhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jiVmlEPTB;NEKuNVI3OyEQvF2= NHnKNGRUSU6JRWK=
GCIY M17qPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu3S4xKSzVyPUSzMlA5ODNizszN MYPTRW5ITVJ?
BB49-HNC NEHmcFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLuTWM2OD12Mz6zN|Q5KM7:TR?= MXPTRW5ITVJ?
SNU-C2B NEnrb3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTR|Lk[0N|Yh|ryP M1GyXXNCVkeHUh?=
TE-6 NUfxRXIyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTR|Lki4PVQh|ryP MY\TRW5ITVJ?
23132-87 M4\VOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTR2LkK5O|gh|ryP MlnsV2FPT0WU
DMS-53 NIW5OnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPjTWM2OD12ND6zN|g1KM7:TR?= M{XvRnNCVkeHUh?=
ONS-76 NUC1Xo1iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nDXWlEPTB;NESuO|Y3OSEQvF2= MULTRW5ITVJ?
DMS-273 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPlc2VFUUN3ME20OE46PDNizszN MkPEV2FPT0WU
COLO-824 NVuxPYhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTR3Lki3O|Uh|ryP Mm\tV2FPT0WU
DMS-114 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3uyT2lEPTB;NEWuPFkzPyEQvF2= NXS5SnByW0GQR1XS
YKG-1 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmCwTWM2OD12Nj6wN|U2KM7:TR?= NXXi[ngxW0GQR1XS
RH-18 Mn;LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfjdXVFUUN3ME20Ok4{PzN|IN88US=> NF3CbFRUSU6JRWK=
NCI-H1355 NHLhT2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XvWWlEPTB;NE[uOlE5KM7:TR?= NWjoU3dXW0GQR1XS
NCI-H2170 M1e4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DmSmlEPTB;NEeuO|U5PCEQvF2= NYfM[mYxW0GQR1XS
OC-314 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnQcYVDUUN3ME20O{45PDd6IN88US=> M4DJWnNCVkeHUh?=
NCI-H2030 NH\YOG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVe4WWRbUUN3ME20O{45QTB4IN88US=> MlTNV2FPT0WU
22RV1 NY[5TItIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1POUWlEPTB;NEeuPVAyPSEQvF2= NWjTWmkyW0GQR1XS
G-401 NYLqPWxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXHTZliUUN3ME20PE41PDF3IN88US=> M1fCWnNCVkeHUh?=
YAPC NXf5SGpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXOcGxKSzVyPUS5MlgxPzNizszN NVTTOY5jW0GQR1XS
SW1573 NFLyV4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rBeWlEPTB;NUCuNlQ{PSEQvF2= MmHVV2FPT0WU
COLO-792 MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfuU3N4UUN3ME21NE43OjN5IN88US=> Mo\4V2FPT0WU
KNS-62 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoG2TWM2OD13MD63OVA5KM7:TR?= MXXTRW5ITVJ?
NB5 M2\vdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjsTWM2OD13MT60OVA6KM7:TR?= MVnTRW5ITVJ?
CP66-MEL MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLPOm1sUUN3ME21NU43PDB6IN88US=> NU[wW2N6W0GQR1XS
CaR-1 M36xO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3FOHdKSzVyPUWyMlA3ODZizszN M3zkUHNCVkeHUh?=
CAL-54 NIT2W25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XjOGlEPTB;NUKuNVExOiEQvF2= MmfhV2FPT0WU
8305C NHfIcpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC4TWM2OD13Mj6zNVUh|ryP M2r4fXNCVkeHUh?=
Calu-3 NI\id3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfQZXNKSzVyPUWyMlM4OzNizszN MXTTRW5ITVJ?
AU565 M1fy[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkH4TWM2OD13Mj61OVA6KM7:TR?= M3z0[HNCVkeHUh?=
CW-2 NYPw[JZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NES2TZFKSzVyPUWyMlg3PTRizszN NEHuc|hUSU6JRWK=
BEN M1Lqcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHoTWM2OD13Mz63PFYzKM7:TR?= M1jMPXNCVkeHUh?=
NCI-H1975 NWDYcotiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHhTWM2OD13Mz64PVY3KM7:TR?= NXfsTpA6W0GQR1XS
HCT-116 NGTHe4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HlSWlEPTB;NUSuNFMzPyEQvF2= MV\TRW5ITVJ?
SH-4 NXn2RYV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUjOOnZEUUN3ME21OE4yOzhizszN MX3TRW5ITVJ?
NCI-H1693 MljWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX2OWVKSzVyPUW0MlIyODNizszN NX20VmpjW0GQR1XS
BPH-1 M2PPdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTV3LkK4PVIh|ryP NIX6T3pUSU6JRWK=
CAMA-1 NIrZXmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\R[GlEPTB;NUWuPFEyPiEQvF2= MnvtV2FPT0WU
A388 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTV4LkC5PFUh|ryP Ml3wV2FPT0WU
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GAMG NWTOXodCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWrJZ5BUUUN3ME21Ok42QTV3IN88US=> MoL5V2FPT0WU
MKN28 NGniR5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\YTWM2OD13Nj64NFE{KM7:TR?= M4jxO3NCVkeHUh?=
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HuCCT1 NYTSXZFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoOwTWM2OD13Nz6wOFkzKM7:TR?= M2PaOXNCVkeHUh?=
BFTC-905 M3fmW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTV5LkK4PVgh|ryP NUHUfXpUW0GQR1XS
LS-123 M3eyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTV5LkW2Olgh|ryP M3PCRXNCVkeHUh?=
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NCI-H1048 NGK5[mlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTV6LkKxPFgh|ryP NHGxXlNUSU6JRWK=
COR-L105 NWezfnhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjQN|Y4UUN3ME21PE44OzN5IN88US=> NIHrSXNUSU6JRWK=
OVCAR-8 NInEbGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLrNlZKSzVyPUW5MlE4OTZizszN NGC1UolUSU6JRWK=
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MES-SA MkW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTV7LkS1NFkh|ryP M1fsbnNCVkeHUh?=
SCC-9 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrRV2p3UUN3ME21PU41PzV|IN88US=> MYTTRW5ITVJ?
EFO-27 M1jhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O0V2lEPTB;NUmuPVQ{KM7:TR?= MnPiV2FPT0WU
GT3TKB NFXiTmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfGSY5LUUN3ME22NE43ODR6IN88US=> MmHpV2FPT0WU
HCC38 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfUfGVKSzVyPU[xMlQ{PzlizszN NEHW[4FUSU6JRWK=
MLMA MmPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TyZ2lEPTB;NkGuOlE3OyEQvF2= MX\TRW5ITVJ?
D-566MG MlvTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIqzNpJKSzVyPU[zMlUzOjRizszN Mn7zV2FPT0WU
SF295 NFzo[o5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvZ[XhKSzVyPU[zMlY3PTVizszN MV\TRW5ITVJ?
ES4 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Xj[GlEPTB;NkSuOFcyQSEQvF2= MknnV2FPT0WU
CAKI-1 NHf5eJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTZ2LkW3NlEh|ryP NXjyT5o3W0GQR1XS
OAW-28 M{jQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmq1TWM2OD14ND65OlQ4KM7:TR?= NEj5NVdUSU6JRWK=
NCI-H460 NV2z[5lqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTZ3LkC4PVch|ryP NGHpZZpUSU6JRWK=
JAR MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\pcGJZUUN3ME22OU42PTF4IN88US=> MVjTRW5ITVJ?
SNU-449 NYXReXl4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfZ[pNKSzVyPU[1Mlc3OTZizszN NI\PZ4dUSU6JRWK=
D-392MG MnrvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPtTWM2OD14NT65OFM1KM7:TR?= NILVVWRUSU6JRWK=
EW-22 NWDWeGlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH25RXJKSzVyPU[2MlM6PSEQvF2= M{\KOHNCVkeHUh?=
GCT NY\reWR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTZ5LkC0OFMh|ryP NIXQSIZUSU6JRWK=
NOS-1 M3Xm[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvqb3J7UUN3ME22O{43QDZ5IN88US=> Mn7kV2FPT0WU
RH-1 NHfCXXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTZ6LkW1OVkh|ryP NGj4b|RUSU6JRWK=
HuH-7 NXuwSGc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Fc|VKSzVyPU[5MlExODJizszN MXfTRW5ITVJ?
NUGC-3 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTdyLkm2OFQh|ryP MVPTRW5ITVJ?
IST-SL1 NVziWYxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDuXmZKSzVyPUexMlI{OjRizszN M1jUc3NCVkeHUh?=
SHP-77 NF7Wc2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTd{LkGxPUDPxE1? M2jmdnNCVkeHUh?=
SW1116 NHzaO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HS[mlEPTB;N{KuNVQxPyEQvF2= MX3TRW5ITVJ?
LK-2 MnXCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLwTWM2OD15Mj64OlEzKM7:TR?= M3iyOXNCVkeHUh?=
U-2-OS NF6wXYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\3fllWUUN3ME23N{4yQDJ6IN88US=> M33qV3NCVkeHUh?=
KYSE-150 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIPEN|JKSzVyPUezMlYyOThizszN M3vUVXNCVkeHUh?=
U251 NXH5VZZrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTWTWM2OD15Mz64NVY5KM7:TR?= MV3TRW5ITVJ?
HT-1080 M1\pbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTd2LkK1O|Qh|ryP M1HQeXNCVkeHUh?=
NCI-H1437 M2jvO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTd2Lk[zNlYh|ryP MXfTRW5ITVJ?
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Becker MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnFTWM2OD15NT6xNVA2KM7:TR?= NYXsZ3pJW0GQR1XS
PANC-10-05 NVzPZ5JGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7HTWM2OD15NT6yPFY2KM7:TR?= MnPTV2FPT0WU
TYK-nu MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTadYE4UUN3ME23OU4{OTB{IN88US=> MVXTRW5ITVJ?
SKG-IIIa NH71cm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XRdmlEPTB;N{WuN|M1OSEQvF2= MkjtV2FPT0WU
NCI-H1993 MkHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTd3LkezPVch|ryP MlrVV2FPT0WU
S-117 NF3GbI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTd3Lke1OUDPxE1? MmDMV2FPT0WU
HuO9 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrnTWM2OD15Nj6wNFQ5KM7:TR?= MXPTRW5ITVJ?
CAL-51 NEnSTpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjMfXY6UUN3ME23Ok4yODB4IN88US=> M3\IeXNCVkeHUh?=
BT-20 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\NS2dKSzVyPUe2MlIyPjhizszN NIi0UFBUSU6JRWK=
LB831-BLC M3HGZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTd4LkOyNVch|ryP MoTZV2FPT0WU
LB1047-RCC NUCxOWVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i0cWlEPTB;N{[uO|YyQSEQvF2= NGDyN2pUSU6JRWK=
ES8 M2DrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrnbZFKSzVyPUe4MlAxPzNizszN M3z5UnNCVkeHUh?=
UMC-11 NH3vVZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zibmlEPTB;N{iuNFg5PCEQvF2= MULTRW5ITVJ?
NCI-H226 M3e0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzBPGxKSzVyPUe4MlE{OTVizszN MV\TRW5ITVJ?
IGROV-1 M{CzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXHJR|UxRTd6LkW1OUDPxE1? MlfsV2FPT0WU
BHY MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXuW3pZUUN3ME23PU42QTZizszN MWTTRW5ITVJ?
MKN45 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\wTWM2OD16MD6zNVc1KM7:TR?= NFL0VY1USU6JRWK=
IA-LM M1vpNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRThyLkO1NVEh|ryP M4jTPHNCVkeHUh?=
WM-115 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTO2lEPTB;OEGuOFEyPCEQvF2= Mm\CV2FPT0WU
VMRC-RCZ NGjHNmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRThzLkS0NlUh|ryP NGDoclJUSU6JRWK=
NCI-H2291 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRThzLk[4OFIh|ryP NFnEUIRUSU6JRWK=
MCF7 NIeyZ21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTh|LkK4PVch|ryP NFjxOXdUSU6JRWK=
639-V Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEH1N25KSzVyPUi0MlYyOjlizszN Ml7oV2FPT0WU
RT4 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfadXdKSzVyPUi1MlI1ODNizszN MWPTRW5ITVJ?
NCI-H2405 MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LR[GlEPTB;OEWuNlk6PyEQvF2= M4PZeHNCVkeHUh?=
CAL-33 MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW5TWM2OD16NT62N|E2KM7:TR?= NF3OW3NUSU6JRWK=
BT-549 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jJbWlEPTB;OEWuPVM5OiEQvF2= NXPpcZFrW0GQR1XS
HT-1197 M4PUXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTh6LkGwO|ch|ryP NGnyNmhUSU6JRWK=
G-361 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTh6LkG0O|Qh|ryP MYLTRW5ITVJ?
LS-411N MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmDCTWM2OD16OT6zN|g5KM7:TR?= MWLTRW5ITVJ?
HT-144 NWfFSGdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfpUWZKSzVyPUi5MlU6QTJizszN NVP3Ro9DW0GQR1XS
DJM-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTh7Lki4OFUh|ryP MVTTRW5ITVJ?
CAL-12T MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHvTWM2OD17MD63PFk2KM7:TR?= NYTocINpW0GQR1XS
MKN7 MlPiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXpe3hEUUN3ME25NU4{PTVzIN88US=> NUXs[5MxW0GQR1XS
HuP-T3 M{fVSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7vTWM2OD17Nj6xNFA1KM7:TR?= MUnTRW5ITVJ?
SK-MG-1 NWT2WYFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnR[JRKSzVyPUm2MlE{PDhizszN NGLROZFUSU6JRWK=
NCI-H2347 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTl6LkGwOFIh|ryP MYjTRW5ITVJ?
SW872 NUnJdpZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTFyMD60OVYh|ryP M2TTb3NCVkeHUh?=
COLO-829 MnLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI[0SHZKSzVyPUGwNE42PTNizszN Mkn2V2FPT0WU
MC-IXC NWr4[JlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTFyMD62NVUh|ryP Mmj4V2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID