PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 M4DmS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HsU2lEPTB;MD64NlAzPCEQvF2= MWXTRW5ITVJ?
UACC-893 M3rUXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjFTWM2OD13LkG5PFg3KM7:TR?= M4PtPXNCVkeHUh?=
A427 MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF72V49KSzVyPUWuO|I2PjdizszN Ml\nV2FPT0WU
OCUB-M NGLERoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnJNnVFUUN3ME22MlY3OTB{IN88US=> MV\TRW5ITVJ?
SW684 M1nuW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;l[ok6UUN3ME23MlUzOjZ6IN88US=> NF\3eppUSU6JRWK=
SK-LMS-1 NYnNOWZOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnlW|VjUUN3ME25MlAyOzB{IN88US=> M3\J[HNCVkeHUh?=
CP50-MEL-B MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP5TWM2OD17LkOwOFE6KM7:TR?= NHS0bZlUSU6JRWK=
NCI-H1651 NFjyXYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlS0TWM2OD1zMD6wNlc3KM7:TR?= MkPEV2FPT0WU
ABC-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlztTWM2OD1zMD6xNFM4KM7:TR?= NGLOW|lUSU6JRWK=
OE19 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWS5RoZJUUN3ME2xNE4yPzN|IN88US=> NYr2d21HW0GQR1XS
DSH1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTFyLki4O|kh|ryP MnztV2FPT0WU
SW13 NHnGb2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK2TWM2OD1zMT65N|E6KM7:TR?= NG\rNFJUSU6JRWK=
MDA-MB-453 M2XlVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LmUGlEPTB;MUKuNVYxOyEQvF2= MnTZV2FPT0WU
647-V MlTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVrJR|UxRTF{LkO1PFIh|ryP NFLlVG9USU6JRWK=
NCI-H2342 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nzVGlEPTB;MUKuN|k6PSEQvF2= M{ezdnNCVkeHUh?=
LB2241-RCC Mme0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj5TWM2OD1zMj61O|c6KM7:TR?= NUjKeFVCW0GQR1XS
UACC-257 M33Ie2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXuT5NpUUN3ME2xN{41PDV|IN88US=> MVfTRW5ITVJ?
NCI-H661 NGqxVHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTF|Lk[0OFkh|ryP MULTRW5ITVJ?
FADU MmnkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUX4cJNFUUN3ME2xN{43QTl{IN88US=> NY\yWFlwW0GQR1XS
A2780 NUK2eXppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzMWGRpUUN3ME2xN{45ODRzIN88US=> MYPTRW5ITVJ?
NCI-H1793 M2\lUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTF2LkSwPFUh|ryP NH2wZotUSU6JRWK=
TE-8 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn:1TWM2OD1zNT6zOFY2KM7:TR?= MWrTRW5ITVJ?
HGC-27 MkL0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG[wWm9KSzVyPUG2MlE3PDRizszN NFXDPHhUSU6JRWK=
MMAC-SF M2\Wfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jBRmlEPTB;MUeuN|czPyEQvF2= MYnTRW5ITVJ?
Calu-6 NYjpeFA2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LTemlEPTB;MUiuNVUyOyEQvF2= MmjNV2FPT0WU
HUTU-80 M1S1NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITJXGtKSzVyPUG4MlM6PTlizszN Mm\hV2FPT0WU
SAS NWfTPIJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzTXplKSzVyPUG4MlY1PTVizszN NFPKVFJUSU6JRWK=
IST-MES1 Mmf5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVWxOokxUUN3ME2xPE43PTB6IN88US=> Mmj1V2FPT0WU
C3A M{D1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUn0TGdsUUN3ME2xPE44QTF7IN88US=> MVXTRW5ITVJ?
ES3 NH3sW3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHze3VKUUN3ME2xPE45OzZ2IN88US=> M2nXV3NCVkeHUh?=
HSC-2 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzQOlJRUUN3ME2xPU43PTRzIN88US=> NFfJW|dUSU6JRWK=
T47D Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7FTWM2OD1{MD6xOFg2KM7:TR?= NFPKPJpUSU6JRWK=
EW-7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTJyLki1PFgh|ryP NFPJdY9USU6JRWK=
LN-405 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\WTWM2OD1{MD64PVY2KM7:TR?= NUnIblVmW0GQR1XS
U031 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTLbpRKSzVyPUKxMlQ5ODJizszN M17o[nNCVkeHUh?=
A549 NHrEXIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYD4c2lHUUN3ME2yNU45PDlzIN88US=> MV7TRW5ITVJ?
RMG-I NI\3SFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTJ{LkK2Olgh|ryP MWHTRW5ITVJ?
BT-474 NGPzNG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLZTWM2OD1{Mj62OVUyKM7:TR?= MmfyV2FPT0WU
NB69 NILtTIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XLSGlEPTB;MkOuNVUzKM7:TR?= MU\TRW5ITVJ?
NB7 M{D3Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4X6c2lEPTB;MkSuNVg5KM7:TR?= Mon1V2FPT0WU
HCC1569 NGfSbZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJ2Lk[xNlUh|ryP NV7ob5pXW0GQR1XS
MEL-JUSO NGra[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnTTTWM2OD1{ND62PVA5KM7:TR?= NXvKbos1W0GQR1XS
MDA-MB-175-VII MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXn4NHBKUUN3ME2yOU4zPTF5IN88US=> MWLTRW5ITVJ?
HCC1419 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWP4Opc5UUN3ME2yOU43ODB|IN88US=> MlW3V2FPT0WU
Ca9-22 NEO3NGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLyTWM2OD1{NT62OFMzKM7:TR?= MX\TRW5ITVJ?
KGN NHzCZ4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrXUJBKSzVyPUK1Mlc2PDdizszN NYXTZY8{W0GQR1XS
LB373-MEL-D M3vYfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTTeWFKSzVyPUK2MlE6OzhizszN MXHTRW5ITVJ?
NCI-H1755 M4LDTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nteGlEPTB;Mk[uPFg1OSEQvF2= MljGV2FPT0WU
D-423MG NVLLWodmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTJ5LkC3NVUh|ryP MY\TRW5ITVJ?
DK-MG MojMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{C4U2lEPTB;MkiuO|g1PiEQvF2= MYnTRW5ITVJ?
NCI-H1623 MonxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3FTWM2OD1{OD64N|QzKM7:TR?= NF\6[mhUSU6JRWK=
KU-19-19 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnDSmdNUUN3ME2yPE46QTVizszN NYnHb5BlW0GQR1XS
C-33-A M2PkU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M160R2lEPTB;MkmuNlE6QCEQvF2= NEnhW4RUSU6JRWK=
SCC-4 NXP4bW9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLqdnVKSzVyPUOwMlM{PTRizszN MmS0V2FPT0WU
MG-63 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnHETWM2OD1|MD61PVk1KM7:TR?= MUXTRW5ITVJ?
LNCaP-Clone-FGC NHmwWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnxTWM2OD1|MT60PVIyKM7:TR?= M4\2cXNCVkeHUh?=
CAPAN-1 M1HhSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTNzLkWyPFYh|ryP MX;TRW5ITVJ?
GI-ME-N NHPz[I9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHxTWM2OD1|MT61N|U{KM7:TR?= NWTNVFRPW0GQR1XS
RERF-LC-MS NGXLd2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvvTWM2OD1|Mj62O|Q4KM7:TR?= NFnWdWpUSU6JRWK=
KLE NWrzU3JxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTsTWM2OD1|Mz60N|M1KM7:TR?= NGLod4NUSU6JRWK=
KNS-81-FD MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHVb3VKSzVyPUOzMlUxODhizszN M3HRT3NCVkeHUh?=
DOK MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{SwPGlEPTB;M{SuOlYyOiEQvF2= NGjVZoJUSU6JRWK=
ACHN MmfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXIOZlKSzVyPUO1MlE2QDhizszN MX\TRW5ITVJ?
KYSE-520 NXrNOYFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnrfVRKSzVyPUO1MlI{PjFizszN MmDIV2FPT0WU
SBC-5 NFf4[WdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGrqbYxKSzVyPUO1MlUyOTZizszN MVTTRW5ITVJ?
NCI-H28 NVLa[Hc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\GcWlEPTB;M{WuOlY6PSEQvF2= M4DBc3NCVkeHUh?=
ES7 M1W3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\qcpA1UUN3ME2zOk4zOjR7IN88US=> M1q3W3NCVkeHUh?=
A172 MmrHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnaTWM2OD1|Nj60NVg4KM7:TR?= MkPZV2FPT0WU
UM-UC-3 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2W4TWlEPTB;M{euPFc1PiEQvF2= NXXKZ3VnW0GQR1XS
LXF-289 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHXRmRKSzVyPUO4MlAxPDdizszN NXXVNJI3W0GQR1XS
KP-4 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPnUHdKSzVyPUO4MlQ4OzlizszN Mn:wV2FPT0WU
TE-1 NXP2NGR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHqTWM2OD1|OT62OVg6KM7:TR?= NH:3b5NUSU6JRWK=
G-402 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTRyLkC2NUDPxE1? MkDlV2FPT0WU
786-0 NEDNcFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XaemlEPTB;NECuPVA6PiEQvF2= NVfmWXg3W0GQR1XS
K5 NFTLSnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXJTWM2OD12MT6zOlg3KM7:TR?= MWPTRW5ITVJ?
SK-N-DZ MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTRzLkO4NlMh|ryP NIS3cmJUSU6JRWK=
OVCAR-4 MoLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTRzLke1Olgh|ryP NFvPVI1USU6JRWK=
T84 MmjJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7WdWU2UUN3ME20Nk4yOjZ|IN88US=> NHnkRVNUSU6JRWK=
GCIY MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrGTWM2OD12Mz6wPFA{KM7:TR?= NV60fWZVW0GQR1XS
BB49-HNC NH\RR4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX5TWM2OD12Mz6zN|Q5KM7:TR?= MoD4V2FPT0WU
SNU-C2B NFHyV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3RTWM2OD12Mz62OFM3KM7:TR?= NGntRo9USU6JRWK=
TE-6 NH;YVXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr4TWM2OD12Mz64PFk1KM7:TR?= Mn;BV2FPT0WU
23132-87 MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DrOmlEPTB;NESuNlk4QCEQvF2= NYe5Zo02W0GQR1XS
DMS-53 M1\ae2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MojyTWM2OD12ND6zN|g1KM7:TR?= NWKwTlk2W0GQR1XS
ONS-76 MoPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPlTWM2OD12ND63OlYyKM7:TR?= MYfTRW5ITVJ?
DMS-273 MkjsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTufYFKSzVyPUS0Mlk1OyEQvF2= M17zZ3NCVkeHUh?=
COLO-824 M{O0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\IZmpKSzVyPUS1Mlg4PzVizszN MXHTRW5ITVJ?
DMS-114 NFLqSnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTR3Lki5Nlch|ryP NITwPVlUSU6JRWK=
YKG-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPydJBUUUN3ME20Ok4xOzV3IN88US=> M4fuZ3NCVkeHUh?=
RH-18 M3nnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTR4LkO3N|Mh|ryP MnzlV2FPT0WU
NCI-H1355 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17BSWlEPTB;NE[uOlE5KM7:TR?= M2S0XnNCVkeHUh?=
NCI-H2170 M370e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD6fVRKSzVyPUS3Mlc2QDRizszN MmXuV2FPT0WU
OC-314 MmP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETIPWRKSzVyPUS3Mlg1PzhizszN NXfJfIFmW0GQR1XS
NCI-H2030 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfCdFM2UUN3ME20O{45QTB4IN88US=> NEGxd5JUSU6JRWK=
22RV1 MoGyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvEOZVKSzVyPUS3MlkxOTVizszN NV\Ub5lNW0GQR1XS
G-401 Mkn1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7MTWM2OD12OD60OFE2KM7:TR?= MWPTRW5ITVJ?
YAPC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHwcHRyUUN3ME20PU45ODd|IN88US=> MkS0V2FPT0WU
SW1573 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkH3TWM2OD13MD6yOFM2KM7:TR?= NHTLZ|BUSU6JRWK=
COLO-792 NFPmbVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\UTWM2OD13MD62NlM4KM7:TR?= NWH0RnhzW0GQR1XS
KNS-62 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkCxTWM2OD13MD63OVA5KM7:TR?= MW\TRW5ITVJ?
NB5 MmW1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TMcmlEPTB;NUGuOFUxQSEQvF2= NIPFTFRUSU6JRWK=
CP66-MEL MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LmR2lEPTB;NUGuOlQxQCEQvF2= NWjiVFM1W0GQR1XS
CaR-1 MkS0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTV{LkC2NFYh|ryP NWP0RY1YW0GQR1XS
CAL-54 M2L4Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXrTWM2OD13Mj6xNVAzKM7:TR?= MonjV2FPT0WU
8305C MlXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXETWM2OD13Mj6zNVUh|ryP NFL6NIhUSU6JRWK=
Calu-3 MmezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1G2RWlEPTB;NUKuN|c{OyEQvF2= MlGxV2FPT0WU
AU565 MoTHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkDnTWM2OD13Mj61OVA6KM7:TR?= NH\DeGlUSU6JRWK=
CW-2 M2TBcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\sXoxKSzVyPUWyMlg3PTRizszN NETFbIZUSU6JRWK=
BEN NWKycI9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;vVXZKSzVyPUWzMlc5PjJizszN MWjTRW5ITVJ?
NCI-H1975 NYCycYJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1WwcGlEPTB;NUOuPFk3PiEQvF2= MWLTRW5ITVJ?
HCT-116 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjaXHFKSzVyPUW0MlA{OjdizszN NIjWUpVUSU6JRWK=
SH-4 NYLPdWFyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;JSmlEPTB;NUSuNVM5KM7:TR?= M1vNcnNCVkeHUh?=
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MKN7 NH;hR3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzFcJZGUUN3ME25NU4{PTVzIN88US=> MYTTRW5ITVJ?
HuP-T3 NW\oS3NqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvaTWM2OD17Nj6xNFA1KM7:TR?= MYnTRW5ITVJ?
SK-MG-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTl4LkGzOFgh|ryP NVjIXGRDW0GQR1XS
NCI-H2347 NYTRb4xHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn33TWM2OD17OD6xNFQzKM7:TR?= M4Lhe3NCVkeHUh?=
SW872 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrlTIhZUUN3ME2xNFAvPDV4IN88US=> MUTTRW5ITVJ?
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... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID