PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

Size Price Stock Quantity  
In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock

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2 Customer Reviews

  • Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDWPIFKSzVyPUCuPFIxOjRizszN NUD5ZpZUW0GQR1XS
UACC-893 MnvFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3W1XmlEPTB;NT6xPVg5PiEQvF2= Mn;KV2FPT0WU
A427 NGrVN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnW0TWM2OD13LkeyOVY4KM7:TR?= MmHIV2FPT0WU
OCUB-M MkmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn1[GRiUUN3ME22MlY3OTB{IN88US=> Mn\3V2FPT0WU
SW684 NUDlenY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTdwNUKyOlgh|ryP NVG0cWt1W0GQR1XS
SK-LMS-1 NHz0O4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jLS2lEPTB;OT6wNVMxOiEQvF2= NWD1ZopWW0GQR1XS
CP50-MEL-B NGrFOlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTlwM{C0NVkh|ryP Mkf2V2FPT0WU
NCI-H1651 M2rU[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPSTWM2OD1zMD6wNlc3KM7:TR?= NWG1eYc5W0GQR1XS
ABC-1 M2PCW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlG5TWM2OD1zMD6xNFM4KM7:TR?= NESwSpBUSU6JRWK=
OE19 NWjYWpNNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTFyLkG3N|Mh|ryP NHv4T4lUSU6JRWK=
DSH1 M3q2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrwTnNKSzVyPUGwMlg5PzlizszN NXnDT3d7W0GQR1XS
SW13 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1T3V2lEPTB;MUGuPVMyQSEQvF2= MXXTRW5ITVJ?
MDA-MB-453 M2HFOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTlTWM2OD1zMj6xOlA{KM7:TR?= NIC3cldUSU6JRWK=
647-V MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC5VVJTUUN3ME2xNk4{PTh{IN88US=> NFKxd5ZUSU6JRWK=
NCI-H2342 NUDRfVNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTkTWM2OD1zMj6zPVk2KM7:TR?= M4TYN3NCVkeHUh?=
LB2241-RCC NUmxRnFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjuTWM2OD1zMj61O|c6KM7:TR?= MnqzV2FPT0WU
UACC-257 NIfpNZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHmd4JKSzVyPUGzMlQ1PTNizszN NWL0TFRlW0GQR1XS
NCI-H661 NXXsVpVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnrNoFKSzVyPUGzMlY1PDlizszN NGLyfVVUSU6JRWK=
FADU MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rHNmlEPTB;MUOuOlk6OiEQvF2= MmjwV2FPT0WU
A2780 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\rSHRKSzVyPUGzMlgxPDFizszN NHPhdolUSU6JRWK=
NCI-H1793 NH2ydY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7Ce|dRUUN3ME2xOE41ODh3IN88US=> MUDTRW5ITVJ?
TE-8 M1\GV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGwTWM2OD1zNT6zOFY2KM7:TR?= MXjTRW5ITVJ?
HGC-27 MnT1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF4LkG2OFQh|ryP MU\TRW5ITVJ?
MMAC-SF NWfkVZdNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXaUWQzUUN3ME2xO{4{PzJ5IN88US=> NXL3Z3d{W0GQR1XS
Calu-6 MmnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PiR2lEPTB;MUiuNVUyOyEQvF2= NWHnc2tCW0GQR1XS
HUTU-80 M{TrcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF6LkO5OVkh|ryP MUjTRW5ITVJ?
SAS NVXnZm1CT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPRTWM2OD1zOD62OFU2KM7:TR?= M1SwXnNCVkeHUh?=
IST-MES1 MnnmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTF6Lk[1NFgh|ryP NHGySGVUSU6JRWK=
C3A NHPxT3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF6Lke5NVkh|ryP NV\KRpkxW0GQR1XS
ES3 M1fTN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTF6LkizOlQh|ryP M1vWZnNCVkeHUh?=
HSC-2 M4TteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTF7Lk[1OFEh|ryP NHrsPYhUSU6JRWK=
T47D MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\SeWV1UUN3ME2yNE4yPDh3IN88US=> MVfTRW5ITVJ?
EW-7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTJyLki1PFgh|ryP NXrQWYFKW0GQR1XS
LN-405 MmfMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHQbnVKSzVyPUKwMlg6PjVizszN NUP5[3IxW0GQR1XS
U031 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnTTTWM2OD1{MT60PFAzKM7:TR?= MXnTRW5ITVJ?
A549 M37oZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\qe5BsUUN3ME2yNU45PDlzIN88US=> NFKzZYNUSU6JRWK=
RMG-I MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCwb2REUUN3ME2yNk4zPjZ6IN88US=> Mn3OV2FPT0WU
BT-474 M4SzXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmfZTWM2OD1{Mj62OVUyKM7:TR?= MVzTRW5ITVJ?
NB69 MlLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DKTWlEPTB;MkOuNVUzKM7:TR?= M1LpcXNCVkeHUh?=
NB7 NIP0VJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\CTWM2OD1{ND6xPFgh|ryP M3\GZ3NCVkeHUh?=
HCC1569 M1XCOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPTTWM2OD1{ND62NVI2KM7:TR?= NH3PenNUSU6JRWK=
MEL-JUSO NXXrdYZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XBO2lEPTB;MkSuOlkxQCEQvF2= NXO3UZUxW0GQR1XS
MDA-MB-175-VII MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXziZmNQUUN3ME2yOU4zPTF5IN88US=> MWnTRW5ITVJ?
HCC1419 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13DV2lEPTB;MkWuOlAxOyEQvF2= MVnTRW5ITVJ?
Ca9-22 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO5TWM2OD1{NT62OFMzKM7:TR?= M2\wZ3NCVkeHUh?=
KGN NVT4OmpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjuVoFxUUN3ME2yOU44PTR5IN88US=> M4DlTnNCVkeHUh?=
LB373-MEL-D NF;YXGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXyb25KSzVyPUK2MlE6OzhizszN MoqwV2FPT0WU
NCI-H1755 M{S2[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\JO|V7UUN3ME2yOk45QDRzIN88US=> NYrJbnA4W0GQR1XS
D-423MG MmG3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HoTmlEPTB;MkeuNFcyPSEQvF2= M{e2RnNCVkeHUh?=
DK-MG MoK2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nQcGlEPTB;MkiuO|g1PiEQvF2= M4rpbnNCVkeHUh?=
NCI-H1623 NGPE[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTYTWM2OD1{OD64N|QzKM7:TR?= M2jkTnNCVkeHUh?=
KU-19-19 MkfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfSR|dKSzVyPUK4Mlk6PSEQvF2= MkHpV2FPT0WU
C-33-A MmexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTJ7LkKxPVgh|ryP Mnv5V2FPT0WU
SCC-4 NXfMZmxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXJTWM2OD1|MD6zN|U1KM7:TR?= MYjTRW5ITVJ?
MG-63 M1TqTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj6WYVKSzVyPUOwMlU6QTRizszN M2nmenNCVkeHUh?=
LNCaP-Clone-FGC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTNzLkS5NlEh|ryP MUPTRW5ITVJ?
CAPAN-1 NHjCZnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTYdphXUUN3ME2zNU42Ojh4IN88US=> NHiwcHBUSU6JRWK=
GI-ME-N NWTHUW9TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTNzLkWzOVMh|ryP NGrEOo9USU6JRWK=
RERF-LC-MS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2n3c2lEPTB;M{KuOlc1PyEQvF2= MXXTRW5ITVJ?
KLE M3u1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN|LkSzN|Qh|ryP NHLEeXRUSU6JRWK=
KNS-81-FD NF;RTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\5VGFGUUN3ME2zN{42ODB6IN88US=> NYDNc3o3W0GQR1XS
DOK NV7mRWRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfURVBpUUN3ME2zOE43PjF{IN88US=> M2q0XnNCVkeHUh?=
ACHN M2HjdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTN3LkG1PFgh|ryP MUPTRW5ITVJ?
KYSE-520 MknIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTN3LkKzOlEh|ryP NHXTXJZUSU6JRWK=
SBC-5 MnPpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfoc4hpUUN3ME2zOU42OTF4IN88US=> NXrSWJo1W0GQR1XS
NCI-H28 MkCyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\MWmlEPTB;M{WuOlY6PSEQvF2= MVvTRW5ITVJ?
ES7 NUi5NllLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTN4LkKyOFkh|ryP NH20cFZUSU6JRWK=
A172 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HHbGlEPTB;M{[uOFE5PyEQvF2= NFLDSZNUSU6JRWK=
UM-UC-3 NVm3bWpFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGwfWNKSzVyPUO3Mlg4PDZizszN MUXTRW5ITVJ?
LXF-289 NFPjeFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\xbndqUUN3ME2zPE4xODR5IN88US=> Mmn2V2FPT0WU
KP-4 NV\se2FWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zzcWlEPTB;M{iuOFc{QSEQvF2= NXrtZWNWW0GQR1XS
TE-1 M2Pkd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTN7Lk[1PFkh|ryP NYPQWmc5W0GQR1XS
G-402 NIrmNVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTOdFhZUUN3ME20NE4xPjFizszN NWPzU2ZRW0GQR1XS
786-0 NEXjW2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrBeIxtUUN3ME20NE46ODl4IN88US=> NWrBenlTW0GQR1XS
K5 MkLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTRzLkO2PFYh|ryP M2Dx[HNCVkeHUh?=
SK-N-DZ NFvL[HlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTRzLkO4NlMh|ryP NUnSOlBGW0GQR1XS
OVCAR-4 NVTTVnY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHCVWNKSzVyPUSxMlc2PjhizszN MVLTRW5ITVJ?
T84 M4Hv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjsTWM2OD12Mj6xNlY{KM7:TR?= NHjjVm9USU6JRWK=
GCIY NXS3fms5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTR|LkC4NFMh|ryP NEPibVRUSU6JRWK=
BB49-HNC NHLJSGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIiweVlKSzVyPUSzMlM{PDhizszN NUP3bGxvW0GQR1XS
SNU-C2B NXG1[WVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHuS2hVUUN3ME20N{43PDN4IN88US=> M2fsdHNCVkeHUh?=
TE-6 M1LXR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXmy[ZV1UUN3ME20N{45QDl2IN88US=> M3WwZ3NCVkeHUh?=
23132-87 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHHTWM2OD12ND6yPVc5KM7:TR?= NV6zO4d[W0GQR1XS
DMS-53 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTR2LkOzPFQh|ryP NIj1SJdUSU6JRWK=
ONS-76 NF[5VXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTR2Lke2OlEh|ryP NF[3fppUSU6JRWK=
DMS-273 NUjZUlh5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTR2Lkm0N{DPxE1? MVvTRW5ITVJ?
COLO-824 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHHb3ZMUUN3ME20OU45Pzd3IN88US=> MXHTRW5ITVJ?
DMS-114 M1W2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITsTmxKSzVyPUS1Mlg6OjdizszN NYX6Tnp{W0GQR1XS
YKG-1 M1PlXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LSTWlEPTB;NE[uNFM2PSEQvF2= MYTTRW5ITVJ?
RH-18 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPkTWM2OD12Nj6zO|M{KM7:TR?= MkXGV2FPT0WU
NCI-H1355 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrhZ45KSzVyPUS2MlYyQCEQvF2= MX3TRW5ITVJ?
NCI-H2170 NEj5cmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3NWJo4UUN3ME20O{44PTh2IN88US=> M2\oWHNCVkeHUh?=
OC-314 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13WZ2lEPTB;NEeuPFQ4QCEQvF2= NVH3WFA4W0GQR1XS
NCI-H2030 NE\nZVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fpRWlEPTB;NEeuPFkxPiEQvF2= MVrTRW5ITVJ?
22RV1 Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTR5LkmwNVUh|ryP M1[2OXNCVkeHUh?=
G-401 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTR6LkS0NVUh|ryP MkjSV2FPT0WU
YAPC NXHURnZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD3T4hKSzVyPUS5MlgxPzNizszN M2PhfHNCVkeHUh?=
SW1573 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmP5TWM2OD13MD6yOFM2KM7:TR?= NF7DblFUSU6JRWK=
COLO-792 NF7SR3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV:2TYZJUUN3ME21NE43OjN5IN88US=> MkCzV2FPT0WU
KNS-62 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPmVoNrUUN3ME21NE44PTB6IN88US=> NVnZ[YpDW0GQR1XS
NB5 MkT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYi0VpR[UUN3ME21NU41PTB7IN88US=> NYLtRmRsW0GQR1XS
CP66-MEL NF7TUVRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi0SmhuUUN3ME21NU43PDB6IN88US=> NXm1R5JGW0GQR1XS
CaR-1 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrLeJBHUUN3ME21Nk4xPjB4IN88US=> MWPTRW5ITVJ?
CAL-54 NH;qWYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLCTWM2OD13Mj6xNVAzKM7:TR?= MUDTRW5ITVJ?
8305C MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHBOog1UUN3ME21Nk4{OTVizszN MkPEV2FPT0WU
Calu-3 MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnJTWM2OD13Mj6zO|M{KM7:TR?= NY\nb4NOW0GQR1XS
AU565 NYXO[Y1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1O5O2lEPTB;NUKuOVUxQSEQvF2= M3[wZnNCVkeHUh?=
CW-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\xb2lEPTB;NUKuPFY2PCEQvF2= NVLSTWQ5W0GQR1XS
BEN NVnRSmVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M171eGlEPTB;NUOuO|g3OiEQvF2= NELCT|VUSU6JRWK=
NCI-H1975 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTV|Lki5OlYh|ryP M{DjNnNCVkeHUh?=
HCT-116 M1fGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\0TWM2OD13ND6wN|I4KM7:TR?= NYXvZZd[W0GQR1XS
SH-4 M4G4XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjyTWM2OD13ND6xN|gh|ryP MnfJV2FPT0WU
NCI-H1693 M4P4WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofVTWM2OD13ND6yNVA{KM7:TR?= NGr5N2JUSU6JRWK=
BPH-1 MmSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTwR3pKSzVyPUW1MlI5QTJizszN NU\GSJE4W0GQR1XS
CAMA-1 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrtNFZpUUN3ME21OU45OTF4IN88US=> Mli4V2FPT0WU
A388 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj1OYNKSzVyPUW2MlA6QDVizszN MVjTRW5ITVJ?
C2BBe1 NIjHPYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTV4LkK2N|Qh|ryP MorLV2FPT0WU
GAMG M2HRVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF65elhKSzVyPUW2MlU6PTVizszN MkPoV2FPT0WU
MKN28 NXvIPZZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEizeZZKSzVyPUW2MlgxOTNizszN MULTRW5ITVJ?
VA-ES-BJ NVj2bItKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfPXmNKSzVyPUW2Mlg4PDVizszN NEHLdoZUSU6JRWK=
HuCCT1 MlHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTEV|FJUUN3ME21O{4xPDl{IN88US=> MkiyV2FPT0WU
BFTC-905 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIWzUXBKSzVyPUW3MlI5QThizszN NXewfFZlW0GQR1XS
LS-123 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTKU|RPUUN3ME21O{42PjZ6IN88US=> Mn3wV2FPT0WU
LB996-RCC M4HsTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;GZmZLUUN3ME21PE4xOjh5IN88US=> M3zsTHNCVkeHUh?=
NCI-H1048 Ml\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHU[YdIUUN3ME21PE4zOTh6IN88US=> MkfXV2FPT0WU
COR-L105 MlnIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjUVHZlUUN3ME21PE44OzN5IN88US=> Mn3KV2FPT0WU
OVCAR-8 M2L2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfkV2FyUUN3ME21PU4yPzF4IN88US=> NH:3Z|JUSU6JRWK=
SK-N-FI M4D4Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrh[4VKSzVyPUW5MlMzODdizszN NUTVU2M6W0GQR1XS
MES-SA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWHJR|UxRTV7LkS1NFkh|ryP MljMV2FPT0WU
SCC-9 NYH5[2xUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjCV3JKSzVyPUW5MlQ4PTNizszN M33Zd3NCVkeHUh?=
EFO-27 MnTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT4[WhKSzVyPUW5Mlk1OyEQvF2= MnXOV2FPT0WU
GT3TKB NWjsdnpUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkn4TWM2OD14MD62NFQ5KM7:TR?= MVzTRW5ITVJ?
HCC38 NYfZOGR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnHT2VKSzVyPU[xMlQ{PzlizszN M1jyVHNCVkeHUh?=
MLMA MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTZzLk[xOlMh|ryP NFm2O4lUSU6JRWK=
D-566MG NGizOZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjnTWM2OD14Mz61NlI1KM7:TR?= NWDCUJREW0GQR1XS
SF295 MmLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPETWM2OD14Mz62OlU2KM7:TR?= NYTw[WUzW0GQR1XS
ES4 NH;iO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLMTWM2OD14ND60O|E6KM7:TR?= MkfVV2FPT0WU
CAKI-1 NX3ydlhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXmOmd1UUN3ME22OE42PzJzIN88US=> MWPTRW5ITVJ?
OAW-28 NG\3[XVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDD[5RKSzVyPU[0Mlk3PDdizszN MnLTV2FPT0WU
NCI-H460 M1zVbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXYTWM2OD14NT6wPFk4KM7:TR?= MV7TRW5ITVJ?
JAR M{\OPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzIOYJsUUN3ME22OU42PTF4IN88US=> NHvTdXVUSU6JRWK=
SNU-449 NWDndXRpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFSxXIdKSzVyPU[1Mlc3OTZizszN MknvV2FPT0WU
D-392MG M37KTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;zZ2lEPTB;NkWuPVQ{PCEQvF2= NHTqVXVUSU6JRWK=
EW-22 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTZ4LkO5OUDPxE1? M3P3UXNCVkeHUh?=
GCT NFnCe4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVG2dIYxUUN3ME22O{4xPDR|IN88US=> Ml;WV2FPT0WU
NOS-1 NFfUfYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jIPWlEPTB;NkeuOlg3PyEQvF2= NFvodWFUSU6JRWK=
RH-1 NEG0W5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfNdmNHUUN3ME22PE42PTV7IN88US=> NXLI[I0yW0GQR1XS
HuH-7 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTPTWM2OD14OT6xNFAzKM7:TR?= NITFfXFUSU6JRWK=
NUGC-3 NH7MUYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPB[XBKSzVyPUewMlk3PDRizszN MV3TRW5ITVJ?
IST-SL1 M3Ox[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7CTWM2OD15MT6yN|I1KM7:TR?= NXfOUVhWW0GQR1XS
SHP-77 NGfMNZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnKxTWM2OD15Mj6xNVkh|ryP MojqV2FPT0WU
SW1116 NEXROZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrWPGVKSzVyPUeyMlE1ODdizszN MU\TRW5ITVJ?
LK-2 NHvEOWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHmTWM2OD15Mj64OlEzKM7:TR?= M1;CcXNCVkeHUh?=
U-2-OS NVPK[Fh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7lOWZKUUN3ME23N{4yQDJ6IN88US=> NHXBXGZUSU6JRWK=
KYSE-150 MnzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;k[|RKSzVyPUezMlYyOThizszN NETQcIlUSU6JRWK=
U251 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvhZZNlUUN3ME23N{45OTZ6IN88US=> M2\2[nNCVkeHUh?=
HT-1080 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrMe3dKSzVyPUe0MlI2PzRizszN NHWyO3dUSU6JRWK=
NCI-H1437 NHr6e4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTd2Lk[zNlYh|ryP NIjuPXBUSU6JRWK=
HPAF-II MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRTd2Lk[0NVUh|ryP NHrmW2hUSU6JRWK=
Becker MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTd3LkGxNFUh|ryP M2\vPHNCVkeHUh?=
PANC-10-05 M3u1Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33VZ2lEPTB;N{WuNlg3PSEQvF2= MkX1V2FPT0WU
TYK-nu NHnZboJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPmZoxKSzVyPUe1MlMyODJizszN M3jSV3NCVkeHUh?=
SKG-IIIa M3HlUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlW4TWM2OD15NT6zN|QyKM7:TR?= MnztV2FPT0WU
NCI-H1993 M1PUbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPSUZJKSzVyPUe1Mlc{QTdizszN MW\TRW5ITVJ?
S-117 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2DuOWlEPTB;N{WuO|U2KM7:TR?= MVTTRW5ITVJ?
HuO9 M4XhVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LDOmlEPTB;N{[uNFA1QCEQvF2= MkXvV2FPT0WU
CAL-51 NGrs[mpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1Pid2lEPTB;N{[uNVAxPiEQvF2= NFrM[m9USU6JRWK=
BT-20 M3r6Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLVWWFIUUN3ME23Ok4zOTZ6IN88US=> M2niUHNCVkeHUh?=
LB831-BLC NHzKRXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTd4LkOyNVch|ryP Mn7yV2FPT0WU
LB1047-RCC MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fTcmlEPTB;N{[uO|YyQSEQvF2= M4TkWHNCVkeHUh?=
ES8 Mn\2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PXemlEPTB;N{iuNFA4OyEQvF2= NUjQeZFSW0GQR1XS
UMC-11 M1\Pcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7lW5N4UUN3ME23PE4xQDh2IN88US=> MmTJV2FPT0WU
NCI-H226 M33hXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\6U2lEPTB;N{iuNVMyPSEQvF2= Mom0V2FPT0WU
IGROV-1 NFTaU4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjpTYpKSzVyPUe4MlU2PSEQvF2= M1v3fXNCVkeHUh?=
BHY MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\NO3FxUUN3ME23PU42QTZizszN MlzaV2FPT0WU
MKN45 M{Hh[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHntc45KSzVyPUiwMlMyPzRizszN NHXJepFUSU6JRWK=
IA-LM NGDvcG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nIZWlEPTB;OECuN|UyOSEQvF2= MXTTRW5ITVJ?
WM-115 M4LrOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e2RWlEPTB;OEGuOFEyPCEQvF2= NEXFO41USU6JRWK=
VMRC-RCZ NYfpOXVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX3hTlBWUUN3ME24NU41PDJ3IN88US=> NFLr[G1USU6JRWK=
NCI-H2291 M{Ppbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRThzLk[4OFIh|ryP NETsUGtUSU6JRWK=
MCF7 NVnCdZl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTh|LkK4PVch|ryP M1PyWHNCVkeHUh?=
639-V NHHRRpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTh2Lk[xNlkh|ryP NV74R5VSW0GQR1XS
RT4 Mm[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTh3LkK0NFMh|ryP NXf4cYxSW0GQR1XS
NCI-H2405 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\GXXdKSzVyPUi1MlI6QTdizszN Mn3jV2FPT0WU
CAL-33 NX:1XIxyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnIR4xKSzVyPUi1MlY{OTVizszN NVW5VYM2W0GQR1XS
BT-549 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rTSmlEPTB;OEWuPVM5OiEQvF2= MnnXV2FPT0WU
HT-1197 Mn\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnafFhKSzVyPUi4MlExPzdizszN M4fTfXNCVkeHUh?=
G-361 MoTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTh6LkG0O|Qh|ryP MofIV2FPT0WU
LS-411N M1nUbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mly3TWM2OD16OT6zN|g5KM7:TR?= MVXTRW5ITVJ?
HT-144 MoG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nod2lEPTB;OEmuOVk6OiEQvF2= MWTTRW5ITVJ?
DJM-1 NFzXb3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTRTWM2OD16OT64PFQ2KM7:TR?= MnP4V2FPT0WU
CAL-12T MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTlyLke4PVUh|ryP MXnTRW5ITVJ?
MKN7 NHrENXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULxbZo4UUN3ME25NU4{PTVzIN88US=> NX7kTXpyW0GQR1XS
HuP-T3 MnjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjlcJFKSzVyPUm2MlExODRizszN NETZb|lUSU6JRWK=
SK-MG-1 Ml21S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTSTWM2OD17Nj6xN|Q5KM7:TR?= NEfPcnVUSU6JRWK=
NCI-H2347 NF\ER4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTl6LkGwOFIh|ryP MUHTRW5ITVJ?
SW872 MlzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXiTWM2OD1zMECuOFU3KM7:TR?= NWHQNI9MW0GQR1XS
COLO-829 NF;sSYVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3WzW2lEPTB;MUCwMlU2OyEQvF2= Mo\iV2FPT0WU
MC-IXC MljlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDCV4xKSzVyPUGwNE43OTVizszN NI\KZW1USU6JRWK=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID