PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 MlvaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjRTWM2OD1yLkiyNFI1KM7:TR?= NGLVbmJUSU6JRWK=
UACC-893 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITiSYlKSzVyPUWuNVk5QDZizszN MVzTRW5ITVJ?
A427 NGH5RnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTSc4RKSzVyPUWuO|I2PjdizszN MXXTRW5ITVJ?
OCUB-M MnPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTBTWM2OD14Lk[2NVAzKM7:TR?= MoLuV2FPT0WU
SW684 M2fGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTdwNUKyOlgh|ryP MkT2V2FPT0WU
SK-LMS-1 MomyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTlwMEGzNFIh|ryP M{O0VXNCVkeHUh?=
CP50-MEL-B NYH4O486T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTzd3RCUUN3ME25MlMxPDF7IN88US=> M1jHS3NCVkeHUh?=
NCI-H1651 M4HEOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoS0TWM2OD1zMD6wNlc3KM7:TR?= MmnVV2FPT0WU
ABC-1 MmDiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYC1bWhJUUN3ME2xNE4yODN5IN88US=> M4\SWnNCVkeHUh?=
OE19 NXTtWnQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVi0N3o6UUN3ME2xNE4yPzN|IN88US=> M2r4ZXNCVkeHUh?=
DSH1 Ml\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3q4eWlEPTB;MUCuPFg4QSEQvF2= MVfTRW5ITVJ?
SW13 NFz3dWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTFzLkmzNVkh|ryP MVjTRW5ITVJ?
MDA-MB-453 M3TSZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTF{LkG2NFMh|ryP NXrEdldZW0GQR1XS
647-V NHWxVoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELqT|FKSzVyPUGyMlM2QDJizszN M2LS[3NCVkeHUh?=
NCI-H2342 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfsTWM2OD1zMj6zPVk2KM7:TR?= MnLGV2FPT0WU
LB2241-RCC MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjOPVRKSzVyPUGyMlU4PzlizszN NVL1Rox2W0GQR1XS
UACC-257 M2exS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXJXpRKSzVyPUGzMlQ1PTNizszN Ml[3V2FPT0WU
NCI-H661 MlPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf6fW1KSzVyPUGzMlY1PDlizszN NHP6T41USU6JRWK=
FADU M{DJRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK0c3A{UUN3ME2xN{43QTl{IN88US=> MVfTRW5ITVJ?
A2780 M1rnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrsNnVKSzVyPUGzMlgxPDFizszN MXrTRW5ITVJ?
NCI-H1793 M1:5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTF2LkSwPFUh|ryP MUTTRW5ITVJ?
TE-8 NIPxeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nMbGlEPTB;MUWuN|Q3PSEQvF2= NV\Yfo9pW0GQR1XS
HGC-27 NFLzSlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXxepFKSzVyPUG2MlE3PDRizszN NI\kbVRUSU6JRWK=
MMAC-SF M{LTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk[xTWM2OD1zNz6zO|I4KM7:TR?= MUHTRW5ITVJ?
Calu-6 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LIc2lEPTB;MUiuNVUyOyEQvF2= M1HFWXNCVkeHUh?=
HUTU-80 NF\KVFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTF6LkO5OVkh|ryP NX3YS4JEW0GQR1XS
SAS NXWyVGI3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTF6Lk[0OVUh|ryP MYPTRW5ITVJ?
IST-MES1 MlzZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\6TWM2OD1zOD62OVA5KM7:TR?= MoPiV2FPT0WU
C3A NH[4NWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MluyTWM2OD1zOD63PVE6KM7:TR?= M2KwWHNCVkeHUh?=
ES3 M2PPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HQN2lEPTB;MUiuPFM3PCEQvF2= NX35cXFxW0GQR1XS
HSC-2 NUjNNJBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\BdGlEPTB;MUmuOlU1OSEQvF2= MVLTRW5ITVJ?
T47D MnrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjkXGNiUUN3ME2yNE4yPDh3IN88US=> MVTTRW5ITVJ?
EW-7 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvGTWM2OD1{MD64OVg5KM7:TR?= NFqyTGFUSU6JRWK=
LN-405 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPTR3NKSzVyPUKwMlg6PjVizszN M{nZeHNCVkeHUh?=
U031 NHXlUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jifmlEPTB;MkGuOFgxOiEQvF2= MV\TRW5ITVJ?
A549 NXHvSmVHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVqxbpBHUUN3ME2yNU45PDlzIN88US=> MYDTRW5ITVJ?
RMG-I NUXpV5NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7ENlVKSzVyPUKyMlI3PjhizszN NUTZSXBXW0GQR1XS
BT-474 M{jpWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\nN2lEPTB;MkKuOlU2OSEQvF2= NYCzdmVNW0GQR1XS
NB69 M2G4emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\VTWM2OD1{Mz6xOVIh|ryP NIrX[|FUSU6JRWK=
NB7 NHzDeJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrjUFVMUUN3ME2yOE4yQDhizszN NU\Cb4tqW0GQR1XS
HCC1569 M3G2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJ2Lk[xNlUh|ryP NH\NPJNUSU6JRWK=
MEL-JUSO MnrlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHGUYRKSzVyPUK0MlY6ODhizszN M3zZOHNCVkeHUh?=
MDA-MB-175-VII M3q5Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4L5VWlEPTB;MkWuNlUyPyEQvF2= NEnDUYtUSU6JRWK=
HCC1419 M2S5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTJ3Lk[wNFMh|ryP MlHEV2FPT0WU
Ca9-22 Mor0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTYTWM2OD1{NT62OFMzKM7:TR?= MoHmV2FPT0WU
KGN NYLrVmpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDLUWpKSzVyPUK1Mlc2PDdizszN NH\oXpNUSU6JRWK=
LB373-MEL-D MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWD1eWU3UUN3ME2yOk4yQTN6IN88US=> MlnhV2FPT0WU
NCI-H1755 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrpTWM2OD1{Nj64PFQyKM7:TR?= M3P1b3NCVkeHUh?=
D-423MG MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfQWFRoUUN3ME2yO{4xPzF3IN88US=> MkHvV2FPT0WU
DK-MG NH3X[|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3:3UWlEPTB;MkiuO|g1PiEQvF2= MnfVV2FPT0WU
NCI-H1623 MoLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nLUmlEPTB;MkiuPFM1OiEQvF2= NIrnb3dUSU6JRWK=
KU-19-19 M1vm[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XPemlEPTB;MkiuPVk2KM7:TR?= MWrTRW5ITVJ?
C-33-A MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJ7LkKxPVgh|ryP M122UXNCVkeHUh?=
SCC-4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HBXWlEPTB;M{CuN|M2PCEQvF2= MnPXV2FPT0WU
MG-63 NGDJPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fWdGlEPTB;M{CuOVk6PCEQvF2= M1\Ob3NCVkeHUh?=
LNCaP-Clone-FGC NUPJTJZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fOUGlEPTB;M{GuOFkzOSEQvF2= NYX3PYlKW0GQR1XS
CAPAN-1 NX7QTFFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTNzLkWyPFYh|ryP Mk\LV2FPT0WU
GI-ME-N MmrGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPjTWM2OD1|MT61N|U{KM7:TR?= NXz1emFKW0GQR1XS
RERF-LC-MS Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7aSGFKSzVyPUOyMlY4PDdizszN NFSzTGZUSU6JRWK=
KLE Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTN|LkSzN|Qh|ryP NFnFfmVUSU6JRWK=
KNS-81-FD NV61e2hvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HKfmlEPTB;M{OuOVAxQCEQvF2= NVrrd2FxW0GQR1XS
DOK NGr1N2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN2Lk[2NVIh|ryP MVzTRW5ITVJ?
ACHN NX21d25pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjsc4VKSzVyPUO1MlE2QDhizszN NGj0UGpUSU6JRWK=
KYSE-520 MnzjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGf4V4dKSzVyPUO1MlI{PjFizszN NVr4[GJGW0GQR1XS
SBC-5 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN3LkWxNVYh|ryP NUX4fYtWW0GQR1XS
NCI-H28 NHfGRY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLvO3ZGUUN3ME2zOU43Pjl3IN88US=> MWHTRW5ITVJ?
ES7 MlWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFK1dHpKSzVyPUO2MlIzPDlizszN NXj1fHJpW0GQR1XS
A172 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTzWlNKSzVyPUO2MlQyQDdizszN NG\iN3NUSU6JRWK=
UM-UC-3 M3O1V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nLSmlEPTB;M{euPFc1PiEQvF2= M{O2ZnNCVkeHUh?=
LXF-289 NGfYU4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTN6LkCwOFch|ryP NILEco5USU6JRWK=
KP-4 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mli2TWM2OD1|OD60O|M6KM7:TR?= M3PEXXNCVkeHUh?=
TE-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnOblVVUUN3ME2zPU43PTh7IN88US=> M4q3XHNCVkeHUh?=
G-402 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTRyLkC2NUDPxE1? NXjRfndCW0GQR1XS
786-0 NYrEblhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[xUmlEPTB;NECuPVA6PiEQvF2= M{\lXHNCVkeHUh?=
K5 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PtT2lEPTB;NEGuN|Y5PiEQvF2= NFnmZpNUSU6JRWK=
SK-N-DZ NVmyTolPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n1cGlEPTB;NEGuN|gzOyEQvF2= MnXBV2FPT0WU
OVCAR-4 NHHnZ5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DkOGlEPTB;NEGuO|U3QCEQvF2= NES1eItUSU6JRWK=
T84 M{LrPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rGdmlEPTB;NEKuNVI3OyEQvF2= NHTCcndUSU6JRWK=
GCIY MkXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULmSXhUUUN3ME20N{4xQDB|IN88US=> NYPZ[nR7W0GQR1XS
BB49-HNC NGTuW2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4qwR2lEPTB;NEOuN|M1QCEQvF2= MWnTRW5ITVJ?
SNU-C2B MmPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfsOoQ1UUN3ME20N{43PDN4IN88US=> NUHjd2o1W0GQR1XS
TE-6 M{LOb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjTc5JLUUN3ME20N{45QDl2IN88US=> MUDTRW5ITVJ?
23132-87 NU\V[4Z4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTR2LkK5O|gh|ryP NEjSbYxUSU6JRWK=
DMS-53 M1nDU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHjxUmhKSzVyPUS0MlM{QDRizszN MlTsV2FPT0WU
ONS-76 Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTR2Lke2OlEh|ryP M1[zcHNCVkeHUh?=
DMS-273 Mm[2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTR2Lkm0N{DPxE1? MW\TRW5ITVJ?
COLO-824 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HQSGlEPTB;NEWuPFc4PSEQvF2= MkH5V2FPT0WU
DMS-114 M4PZUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nOfGlEPTB;NEWuPFkzPyEQvF2= Ml;XV2FPT0WU
YKG-1 MkTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;hb4NiUUN3ME20Ok4xOzV3IN88US=> MVnTRW5ITVJ?
RH-18 NHXWToJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXxdYZKSzVyPUS2MlM4OzNizszN NIX5e4hUSU6JRWK=
NCI-H1355 Mo\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTR4Lk[xPEDPxE1? NUm3fll7W0GQR1XS
NCI-H2170 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDVc5FKSzVyPUS3Mlc2QDRizszN NV[wNWhLW0GQR1XS
OC-314 NI[0Z5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknrTWM2OD12Nz64OFc5KM7:TR?= Mom4V2FPT0WU
NCI-H2030 NFrhXGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkK3TWM2OD12Nz64PVA3KM7:TR?= NWDQeXJYW0GQR1XS
22RV1 MnXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTR5LkmwNVUh|ryP MknCV2FPT0WU
G-401 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTR6LkS0NVUh|ryP MUTTRW5ITVJ?
YAPC MkfVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;6S2lEPTB;NEmuPFA4OyEQvF2= M3Lr[XNCVkeHUh?=
SW1573 NUe2c5B7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTVyLkK0N|Uh|ryP NWHUZ4JkW0GQR1XS
COLO-792 NWrUfFlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M16xeWlEPTB;NUCuOlI{PyEQvF2= NU\wdFNDW0GQR1XS
KNS-62 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF[yTpBKSzVyPUWwMlc2ODhizszN NX\RV5ZJW0GQR1XS
NB5 Mnu2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknWTWM2OD13MT60OVA6KM7:TR?= MoTiV2FPT0WU
CP66-MEL M{LPcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33MSGlEPTB;NUGuOlQxQCEQvF2= NXHXNWtSW0GQR1XS
CaR-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPpTWM2OD13Mj6wOlA3KM7:TR?= M2PIW3NCVkeHUh?=
CAL-54 NILKeI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\6TWM2OD13Mj6xNVAzKM7:TR?= M{XKSnNCVkeHUh?=
8305C NYXsSm17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;R[WlEPTB;NUKuN|E2KM7:TR?= M1HrVnNCVkeHUh?=
Calu-3 NHnMdmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HTe2lEPTB;NUKuN|c{OyEQvF2= MnezV2FPT0WU
AU565 NHvJW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTvTWM2OD13Mj61OVA6KM7:TR?= MoniV2FPT0WU
CW-2 M1jUeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37vNWlEPTB;NUKuPFY2PCEQvF2= MmfnV2FPT0WU
BEN MoTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\pd2FKSzVyPUWzMlc5PjJizszN NXOzWnplW0GQR1XS
NCI-H1975 MlG2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTV|Lki5OlYh|ryP NH7tW2RUSU6JRWK=
HCT-116 M3\1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnuTWM2OD13ND6wN|I4KM7:TR?= MonrV2FPT0WU
SH-4 NH\kS|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnVRlhWUUN3ME21OE4yOzhizszN NX;kPI1VW0GQR1XS
NCI-H1693 NFHpSFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTV2LkKxNFMh|ryP NVXtUJdmW0GQR1XS
BPH-1 NX;XcoM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTV3LkK4PVIh|ryP MmXuV2FPT0WU
CAMA-1 NFfnXVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;1TWM2OD13NT64NVE3KM7:TR?= MoL6V2FPT0WU
A388 NHXDT2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTV4LkC5PFUh|ryP MUDTRW5ITVJ?
C2BBe1 M3TtR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTpRld6UUN3ME21Ok4zPjN2IN88US=> MV;TRW5ITVJ?
GAMG MnHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3aNFVKSzVyPUW2MlU6PTVizszN M{XKR3NCVkeHUh?=
MKN28 NXL2T414T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXhUodDUUN3ME21Ok45ODF|IN88US=> MofBV2FPT0WU
VA-ES-BJ Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PqZWlEPTB;NU[uPFc1PSEQvF2= NH:2S25USU6JRWK=
HuCCT1 NXPwfYZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\5bWlEPTB;NUeuNFQ6OiEQvF2= NXHiSodTW0GQR1XS
BFTC-905 NHHXPYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HGfmlEPTB;NUeuNlg6QCEQvF2= MWDTRW5ITVJ?
LS-123 NX\MT3pnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPFbodKSzVyPUW3MlU3PjhizszN MoD3V2FPT0WU
LB996-RCC MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDnTWM2OD13OD6wNlg4KM7:TR?= NVjnU4U1W0GQR1XS
NCI-H1048 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{faTmlEPTB;NUiuNlE5QCEQvF2= NXLROnBnW0GQR1XS
COR-L105 NWfFenBTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPMTWM2OD13OD63N|M4KM7:TR?= M17CcnNCVkeHUh?=
OVCAR-8 NYDmcIdST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\XTWM2OD13OT6xO|E3KM7:TR?= NH7mNpRUSU6JRWK=
SK-N-FI Mke4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTV7LkOyNFch|ryP NV6xXG1CW0GQR1XS
MES-SA NHTM[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfGTZNmUUN3ME21PU41PTB7IN88US=> NVvoPVBFW0GQR1XS
SCC-9 NUjhOI97T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1f0bGlEPTB;NUmuOFc2OyEQvF2= Mki0V2FPT0WU
EFO-27 MnPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTV7Lkm0N{DPxE1? MVXTRW5ITVJ?
GT3TKB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1:yd2lEPTB;NkCuOlA1QCEQvF2= MXnTRW5ITVJ?
HCC38 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37PNGlEPTB;NkGuOFM4QSEQvF2= NXrYT|JYW0GQR1XS
MLMA MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTZzLk[xOlMh|ryP MWLTRW5ITVJ?
D-566MG M2fqbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPHV4dKSzVyPU[zMlUzOjRizszN M3;SOnNCVkeHUh?=
SF295 NHjXTFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIDyXZVKSzVyPU[zMlY3PTVizszN NEPNXoRUSU6JRWK=
ES4 NG\r[pVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTDTWM2OD14ND60O|E6KM7:TR?= NGDyTFhUSU6JRWK=
CAKI-1 MnT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITMUXdKSzVyPU[0MlU4OjFizszN NFjJNWVUSU6JRWK=
OAW-28 M{TPfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[1TWM2OD14ND65OlQ4KM7:TR?= NVnhNlhEW0GQR1XS
NCI-H460 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jubWlEPTB;NkWuNFg6PyEQvF2= NHXBUXdUSU6JRWK=
JAR MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fqW2lEPTB;NkWuOVUyPiEQvF2= Ml65V2FPT0WU
SNU-449 NXjTS4ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLMTWM2OD14NT63OlE3KM7:TR?= NFrTSVlUSU6JRWK=
D-392MG NXXWPYtYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUOyVmJ2UUN3ME22OU46PDN2IN88US=> NY\rWFV{W0GQR1XS
EW-22 MnT6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjDbZBXUUN3ME22Ok4{QTVizszN NVu2S2J2W0GQR1XS
GCT NEPicZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fIOmlEPTB;NkeuNFQ1OyEQvF2= MlHIV2FPT0WU
NOS-1 NEL5N29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TvdmlEPTB;NkeuOlg3PyEQvF2= NV76do92W0GQR1XS
RH-1 M4nvU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoL0TWM2OD14OD61OVU6KM7:TR?= NUPGPWF[W0GQR1XS
HuH-7 M4LBPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO4NYtZUUN3ME22PU4yODB{IN88US=> M3nKNnNCVkeHUh?=
NUGC-3 NVPzbIFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTdyLkm2OFQh|ryP MXnTRW5ITVJ?
IST-SL1 M4LrTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\NTWM2OD15MT6yN|I1KM7:TR?= M2G1eXNCVkeHUh?=
SHP-77 M2Hs[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zBNmlEPTB;N{KuNVE6KM7:TR?= Mn74V2FPT0WU
SW1116 NWToNpNlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWHpWmpjUUN3ME23Nk4yPDB5IN88US=> MXLTRW5ITVJ?
LK-2 M4DmT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTd{Lki2NVIh|ryP NH3uUm1USU6JRWK=
U-2-OS M134UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfuVFRKSzVyPUezMlE5OjhizszN MmTnV2FPT0WU
KYSE-150 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT2OpI2UUN3ME23N{43OTF6IN88US=> MVfTRW5ITVJ?
U251 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M16yc2lEPTB;N{OuPFE3QCEQvF2= MmDtV2FPT0WU
HT-1080 NX6zXlF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHzVdGdKSzVyPUe0MlI2PzRizszN NWTvXI5[W0GQR1XS
NCI-H1437 NF7Db5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTd2Lk[zNlYh|ryP Ml\GV2FPT0WU
HPAF-II NWCxXFVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jkVWlEPTB;N{SuOlQyPSEQvF2= M4nVZXNCVkeHUh?=
Becker NHfRU2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjSTWM2OD15NT6xNVA2KM7:TR?= M{\3fHNCVkeHUh?=
PANC-10-05 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\zWYNmUUN3ME23OU4zQDZ3IN88US=> MUXTRW5ITVJ?
TYK-nu M{KwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDFTWM2OD15NT6zNVAzKM7:TR?= NFO3SGxUSU6JRWK=
SKG-IIIa NInjW4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofrTWM2OD15NT6zN|QyKM7:TR?= NG\yU3BUSU6JRWK=
NCI-H1993 Ml;YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17tWWlEPTB;N{WuO|M6PyEQvF2= MlnpV2FPT0WU
S-117 NHzXOFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfk[JdKSzVyPUe1Mlc2PSEQvF2= M2fhRXNCVkeHUh?=
HuO9 NGD2cYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7jfoJKSzVyPUe2MlAxPDhizszN MVrTRW5ITVJ?
CAL-51 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTd4LkGwNFYh|ryP M2XucnNCVkeHUh?=
BT-20 NGrxSmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e3WWlEPTB;N{[uNlE3QCEQvF2= M{LaPXNCVkeHUh?=
LB831-BLC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILY[5ZKSzVyPUe2MlMzOTdizszN NFjTdFdUSU6JRWK=
LB1047-RCC NUTFUW81T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlT5TWM2OD15Nj63OlE6KM7:TR?= M2jPUHNCVkeHUh?=
ES8 MnmwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M165SWlEPTB;N{iuNFA4OyEQvF2= MnHXV2FPT0WU
UMC-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\QfpBuUUN3ME23PE4xQDh2IN88US=> MVHTRW5ITVJ?
NCI-H226 NIjHV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojVTWM2OD15OD6xN|E2KM7:TR?= NIrFO|NUSU6JRWK=
IGROV-1 M2DQdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknsTWM2OD15OD61OVUh|ryP MYPTRW5ITVJ?
BHY MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEm2TIlKSzVyPUe5MlU6PiEQvF2= NVLPU4dOW0GQR1XS
MKN45 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRThyLkOxO|Qh|ryP NWLLXlZjW0GQR1XS
IA-LM NHfDVWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRThyLkO1NVEh|ryP MUHTRW5ITVJ?
WM-115 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NULZd|RpUUN3ME24NU41OTF2IN88US=> MorRV2FPT0WU
VMRC-RCZ M2fq[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nhdGlEPTB;OEGuOFQzPSEQvF2= NUDBe2NEW0GQR1XS
NCI-H2291 MoPTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRThzLk[4OFIh|ryP NXLDWpJQW0GQR1XS
MCF7 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vnOWlEPTB;OEOuNlg6PyEQvF2= MofXV2FPT0WU
639-V MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjRVGJKSzVyPUi0MlYyOjlizszN NXrzRVY3W0GQR1XS
RT4 M2Sx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTh3LkK0NFMh|ryP NIjDPFVUSU6JRWK=
NCI-H2405 MonpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTh3LkK5PVch|ryP NV6xOXZUW0GQR1XS
CAL-33 M1z0Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpfolKSzVyPUi1MlY{OTVizszN NWPZfIRLW0GQR1XS
BT-549 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTh3LkmzPFIh|ryP NGDZOpdUSU6JRWK=
HT-1197 MkDhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHy5TZJKSzVyPUi4MlExPzdizszN NInaSnpUSU6JRWK=
G-361 NXLMboRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHuS4tFUUN3ME24PE4yPDd2IN88US=> MljvV2FPT0WU
LS-411N MkP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPEcWJyUUN3ME24PU4{Ozh6IN88US=> M3izOXNCVkeHUh?=
HT-144 M{HV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnsfW85UUN3ME24PU42QTl{IN88US=> NFXCTmhUSU6JRWK=
DJM-1 MkX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTh7Lki4OFUh|ryP M1PWNnNCVkeHUh?=
CAL-12T M3HMSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq2TVVKSzVyPUmwMlc5QTVizszN NIfwWXRUSU6JRWK=
MKN7 MlfjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PIVmlEPTB;OUGuN|U2OSEQvF2= NX7CfYVlW0GQR1XS
HuP-T3 MlT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;mUJFIUUN3ME25Ok4yODB2IN88US=> MXzTRW5ITVJ?
SK-MG-1 M{HGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\3TWM2OD17Nj6xN|Q5KM7:TR?= NXmwU|V1W0GQR1XS
NCI-H2347 Mmj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXOTWM2OD17OD6xNFQzKM7:TR?= NWTJWZNOW0GQR1XS
SW872 M3\aS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HCRWlEPTB;MUCwMlQ2PiEQvF2= MXnTRW5ITVJ?
COLO-829 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DxR2lEPTB;MUCwMlU2OyEQvF2= NVjOeYVIW0GQR1XS
MC-IXC M{HhPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfRTWM2OD1zMECuOlE2KM7:TR?= NVvaRmJzW0GQR1XS

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID