PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 NUTB[FQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLSOYlLUUN3ME2wMlgzODJ2IN88US=> MUXTRW5ITVJ?
UACC-893 NHfpOplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkS2TWM2OD13LkG5PFg3KM7:TR?= MWHTRW5ITVJ?
A427 MmW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvZeFdPUUN3ME21MlczPTZ5IN88US=> NEDYUIxUSU6JRWK=
OCUB-M NWjTSnZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfpTWM2OD14Lk[2NVAzKM7:TR?= NXnWNnU4W0GQR1XS
SW684 MmfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXPTWM2OD15LkWyNlY5KM7:TR?= NVfyc21QW0GQR1XS
SK-LMS-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjuPVdrUUN3ME25MlAyOzB{IN88US=> MkLuV2FPT0WU
CP50-MEL-B NELRTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTsTIV4UUN3ME25MlMxPDF7IN88US=> NHrIUIxUSU6JRWK=
NCI-H1651 NUTCeVd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlG0TWM2OD1zMD6wNlc3KM7:TR?= M4XrNXNCVkeHUh?=
ABC-1 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTHeYE2UUN3ME2xNE4yODN5IN88US=> MWTTRW5ITVJ?
OE19 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\5TWM2OD1zMD6xO|M{KM7:TR?= NXKzZ5N[W0GQR1XS
DSH1 M4rmZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17QSWlEPTB;MUCuPFg4QSEQvF2= NV;hZpBMW0GQR1XS
SW13 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXryXnZEUUN3ME2xNU46OzF7IN88US=> MU\TRW5ITVJ?
MDA-MB-453 M2\kN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1uwXGlEPTB;MUKuNVYxOyEQvF2= MmGzV2FPT0WU
647-V MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPLTWM2OD1zMj6zOVgzKM7:TR?= M{TxenNCVkeHUh?=
NCI-H2342 NHKy[4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTEeGszUUN3ME2xNk4{QTl3IN88US=> NHTr[JZUSU6JRWK=
LB2241-RCC NE[4d3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr0OZRmUUN3ME2xNk42Pzd7IN88US=> NWrURoo2W0GQR1XS
UACC-257 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXVRWRKSzVyPUGzMlQ1PTNizszN NGPRRXdUSU6JRWK=
NCI-H661 M1rxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTF|Lk[0OFkh|ryP MXTTRW5ITVJ?
FADU M{LhW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{i3SmlEPTB;MUOuOlk6OiEQvF2= MUPTRW5ITVJ?
A2780 MlrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvNV5JKSzVyPUGzMlgxPDFizszN NX\QR2tMW0GQR1XS
NCI-H1793 MmDaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nm[2lEPTB;MUSuOFA5PSEQvF2= MmrLV2FPT0WU
TE-8 M3ThfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTF3LkO0OlUh|ryP MVLTRW5ITVJ?
HGC-27 M{Hmfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LMSmlEPTB;MU[uNVY1PCEQvF2= NWj4OpdNW0GQR1XS
MMAC-SF MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlroTWM2OD1zNz6zO|I4KM7:TR?= NIjjT41USU6JRWK=
Calu-6 NUDmTnBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1fXVWlEPTB;MUiuNVUyOyEQvF2= NFqyXXhUSU6JRWK=
HUTU-80 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTF6LkO5OVkh|ryP MnXmV2FPT0WU
SAS MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjFN|hZUUN3ME2xPE43PDV3IN88US=> MUjTRW5ITVJ?
IST-MES1 MoDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF6Lk[1NFgh|ryP MlTTV2FPT0WU
C3A MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fVcWlEPTB;MUiuO|kyQSEQvF2= M4fMXnNCVkeHUh?=
ES3 MmjqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF6LkizOlQh|ryP NIPMZ3dUSU6JRWK=
HSC-2 NGD6SIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSwVXY{UUN3ME2xPU43PTRzIN88US=> NYSyV5lsW0GQR1XS
T47D MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPSPXRZUUN3ME2yNE4yPDh3IN88US=> NYDCXVRvW0GQR1XS
EW-7 NGDYUpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TOdmlEPTB;MkCuPFU5QCEQvF2= M32yTHNCVkeHUh?=
LN-405 NI\mTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml64TWM2OD1{MD64PVY2KM7:TR?= MUTTRW5ITVJ?
U031 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnHTWM2OD1{MT60PFAzKM7:TR?= NHGxOlBUSU6JRWK=
A549 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJzLki0PVEh|ryP NUDRNnE6W0GQR1XS
RMG-I Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PPZ2lEPTB;MkKuNlY3QCEQvF2= MWPTRW5ITVJ?
BT-474 NV3SbZBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\VWYV{UUN3ME2yNk43PTVzIN88US=> NF3Q[ZhUSU6JRWK=
NB69 NIPicHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO4TWM2OD1{Mz6xOVIh|ryP MlLvV2FPT0WU
NB7 NWPETJJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVv6d5NLUUN3ME2yOE4yQDhizszN M{nnZXNCVkeHUh?=
HCC1569 M2XnZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vac2lEPTB;MkSuOlEzPSEQvF2= M1nyNHNCVkeHUh?=
MEL-JUSO NVLKbY4{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLFTWM2OD1{ND62PVA5KM7:TR?= NVvENJNjW0GQR1XS
MDA-MB-175-VII MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkD5TWM2OD1{NT6yOVE4KM7:TR?= M4fXNXNCVkeHUh?=
HCC1419 Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrYOmx6UUN3ME2yOU43ODB|IN88US=> M2LvXHNCVkeHUh?=
Ca9-22 NE\lOIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTJ3Lk[0N|Ih|ryP NUG3XIZkW0GQR1XS
KGN NYDCVWxtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfseJdoUUN3ME2yOU44PTR5IN88US=> M1rBdXNCVkeHUh?=
LB373-MEL-D MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTYTWM2OD1{Nj6xPVM5KM7:TR?= NV7qS2NoW0GQR1XS
NCI-H1755 MlG0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnzlTWM2OD1{Nj64PFQyKM7:TR?= NIWxXYxUSU6JRWK=
D-423MG Moq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTJ5LkC3NVUh|ryP NUnONm9uW0GQR1XS
DK-MG M3nYRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTzUphGUUN3ME2yPE44QDR4IN88US=> MlqxV2FPT0WU
NCI-H1623 M361c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\UcGlEPTB;MkiuPFM1OiEQvF2= MlTSV2FPT0WU
KU-19-19 NFjkNGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYS3R3R[UUN3ME2yPE46QTVizszN NUjFR4cxW0GQR1XS
C-33-A MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWfxVIVSUUN3ME2yPU4zOTl6IN88US=> M1qxSXNCVkeHUh?=
SCC-4 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvHTnNHUUN3ME2zNE4{OzV2IN88US=> MUXTRW5ITVJ?
MG-63 MlrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmSwTWM2OD1|MD61PVk1KM7:TR?= MnvBV2FPT0WU
LNCaP-Clone-FGC MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7YSoRKSzVyPUOxMlQ6OjFizszN NX;2ZmNSW0GQR1XS
CAPAN-1 M1vUT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17VTmlEPTB;M{GuOVI5PiEQvF2= NHfnNYlUSU6JRWK=
GI-ME-N MnvmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rlXmlEPTB;M{GuOVM2OyEQvF2= M2exV3NCVkeHUh?=
RERF-LC-MS NWXSfmY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DMOmlEPTB;M{KuOlc1PyEQvF2= MVHTRW5ITVJ?
KLE NYXuTYFWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLWTWM2OD1|Mz60N|M1KM7:TR?= M1XOV3NCVkeHUh?=
KNS-81-FD NHnkV5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXLJR|UxRTN|LkWwNFgh|ryP M2ixUnNCVkeHUh?=
DOK MoTaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTN2Lk[2NVIh|ryP MV\TRW5ITVJ?
ACHN M16zPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4e0VmlEPTB;M{WuNVU5QCEQvF2= Moe3V2FPT0WU
KYSE-520 NWfJbJVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjXS|NKSzVyPUO1MlI{PjFizszN MnvtV2FPT0WU
SBC-5 M{OxfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3yyd2lEPTB;M{WuOVEyPiEQvF2= MoXFV2FPT0WU
NCI-H28 NEnoTJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\ld2xKSzVyPUO1MlY3QTVizszN NXzSSYc2W0GQR1XS
ES7 NGHROVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkflTWM2OD1|Nj6yNlQ6KM7:TR?= MYjTRW5ITVJ?
A172 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrtTWM2OD1|Nj60NVg4KM7:TR?= M2O3UnNCVkeHUh?=
UM-UC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;Bbo9KSzVyPUO3Mlg4PDZizszN NHvzRpRUSU6JRWK=
LXF-289 NHLIPXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3m3WGlEPTB;M{iuNFA1PyEQvF2= MlnRV2FPT0WU
KP-4 NHPReZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXCTWM2OD1|OD60O|M6KM7:TR?= M2LsOHNCVkeHUh?=
TE-1 MoPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTN7Lk[1PFkh|ryP NEjuXZRUSU6JRWK=
G-402 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHi2[pdKSzVyPUSwMlA3OSEQvF2= M1\YRXNCVkeHUh?=
786-0 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1z3UGlEPTB;NECuPVA6PiEQvF2= NY\ZTG5DW0GQR1XS
K5 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFToOFFKSzVyPUSxMlM3QDZizszN M4X1VHNCVkeHUh?=
SK-N-DZ NFPRN5hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLnWmZWUUN3ME20NU4{QDJ|IN88US=> MoLRV2FPT0WU
OVCAR-4 NYTBRlBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\QTWM2OD12MT63OVY5KM7:TR?= NHv6SmZUSU6JRWK=
T84 M1;YOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTNTWM2OD12Mj6xNlY{KM7:TR?= M{nTPXNCVkeHUh?=
GCIY MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7STWM2OD12Mz6wPFA{KM7:TR?= MnSxV2FPT0WU
BB49-HNC M{\vTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfQTWM2OD12Mz6zN|Q5KM7:TR?= MlW5V2FPT0WU
SNU-C2B MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR|Lk[0N|Yh|ryP MWnTRW5ITVJ?
TE-6 MlfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vofGlEPTB;NEOuPFg6PCEQvF2= MX\TRW5ITVJ?
23132-87 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTR2LkK5O|gh|ryP NWHuRnJUW0GQR1XS
DMS-53 NWi5dWs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nseGlEPTB;NESuN|M5PCEQvF2= Ml73V2FPT0WU
ONS-76 NFjadoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTR2Lke2OlEh|ryP NFy2VXdUSU6JRWK=
DMS-273 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTrWlhKSzVyPUS0Mlk1OyEQvF2= NWribJpuW0GQR1XS
COLO-824 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPjTZpKSzVyPUS1Mlg4PzVizszN NHq1bZNUSU6JRWK=
DMS-114 NYnBVGFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PBeWlEPTB;NEWuPFkzPyEQvF2= MWDTRW5ITVJ?
YKG-1 NGDqfGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTR4LkCzOVUh|ryP Mny2V2FPT0WU
RH-18 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTR4LkO3N|Mh|ryP M1jBe3NCVkeHUh?=
NCI-H1355 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfqTWM2OD12Nj62NVgh|ryP MkfQV2FPT0WU
NCI-H2170 Mn;kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTR5Lke1PFQh|ryP NXnWZY15W0GQR1XS
OC-314 NXXG[|FDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTR5Lki0O|gh|ryP MX;TRW5ITVJ?
NCI-H2030 MorYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXr4c5Z4UUN3ME20O{45QTB4IN88US=> NUPJ[YFFW0GQR1XS
22RV1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3nepVNUUN3ME20O{46ODF3IN88US=> MYXTRW5ITVJ?
G-401 M1Kyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknsTWM2OD12OD60OFE2KM7:TR?= MWTTRW5ITVJ?
YAPC NF\MZlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDwNnVKSzVyPUS5MlgxPzNizszN MV;TRW5ITVJ?
SW1573 NXrFWHdQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTVyLkK0N|Uh|ryP MX7TRW5ITVJ?
COLO-792 M1;sXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\wOWhKSzVyPUWwMlYzOzdizszN NFv4WIJUSU6JRWK=
KNS-62 MkjZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnXcJVWUUN3ME21NE44PTB6IN88US=> NF3BXXhUSU6JRWK=
NB5 Mlj1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TyWmlEPTB;NUGuOFUxQSEQvF2= Mn7xV2FPT0WU
CP66-MEL NEnkSWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zBOGlEPTB;NUGuOlQxQCEQvF2= M2jzTXNCVkeHUh?=
CaR-1 M1P1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3[zeGlEPTB;NUKuNFYxPiEQvF2= NW\QOW15W0GQR1XS
CAL-54 Ml;xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTV{LkGxNFIh|ryP NVeyUpJGW0GQR1XS
8305C MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTV{LkOxOUDPxE1? MmT6V2FPT0WU
Calu-3 MmrrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn[wTWM2OD13Mj6zO|M{KM7:TR?= NHnZXFVUSU6JRWK=
AU565 M{\OT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfWPItKSzVyPUWyMlU2ODlizszN MoOxV2FPT0WU
CW-2 NG\3d5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXfJR|UxRTV{Lki2OVQh|ryP MoDXV2FPT0WU
BEN M1;NZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnSRpNKSzVyPUWzMlc5PjJizszN NUi3dHFIW0GQR1XS
NCI-H1975 NHfueGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjZW5RKSzVyPUWzMlg6PjZizszN NVy0VolmW0GQR1XS
HCT-116 NYK5XWZNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkewTWM2OD13ND6wN|I4KM7:TR?= M325XHNCVkeHUh?=
SH-4 NVTZUm5XT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGrwXVRKSzVyPUW0MlE{QCEQvF2= NWfGPXlZW0GQR1XS
NCI-H1693 NFXYd|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTV2LkKxNFMh|ryP MnHkV2FPT0WU
BPH-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HXTmlEPTB;NUWuNlg6OiEQvF2= NHzDZlNUSU6JRWK=
CAMA-1 NX\FeppwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkf2TWM2OD13NT64NVE3KM7:TR?= MkPsV2FPT0WU
A388 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTV4LkC5PFUh|ryP NGjtWJFUSU6JRWK=
C2BBe1 Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPIZmc3UUN3ME21Ok4zPjN2IN88US=> NEm3TplUSU6JRWK=
GAMG MoXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7BTWM2OD13Nj61PVU2KM7:TR?= MVLTRW5ITVJ?
MKN28 M{TWU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTDOphXUUN3ME21Ok45ODF|IN88US=> M1fWfnNCVkeHUh?=
VA-ES-BJ MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYK2bpZjUUN3ME21Ok45PzR3IN88US=> M4e4d3NCVkeHUh?=
HuCCT1 NITzXWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfqdWtKSzVyPUW3MlA1QTJizszN NXHMUmx[W0GQR1XS
BFTC-905 Ml3xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTV5LkK4PVgh|ryP MlfLV2FPT0WU
LS-123 NWX1OWIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X6cGlEPTB;NUeuOVY3QCEQvF2= MnnDV2FPT0WU
LB996-RCC M3zCWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTV6LkCyPFch|ryP NHWxTGhUSU6JRWK=
NCI-H1048 NEnQeIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPGT4NXUUN3ME21PE4zOTh6IN88US=> NYPTRlUyW0GQR1XS
COR-L105 M2DhS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLYTYh4UUN3ME21PE44OzN5IN88US=> MV\TRW5ITVJ?
OVCAR-8 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTV7LkG3NVYh|ryP MlX6V2FPT0WU
SK-N-FI MoPwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTV7LkOyNFch|ryP NVSxO4poW0GQR1XS
MES-SA NUnOWFhOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1u1RmlEPTB;NUmuOFUxQSEQvF2= NEXlc5pUSU6JRWK=
SCC-9 M2\mUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3X4RmlEPTB;NUmuOFc2OyEQvF2= MWfTRW5ITVJ?
EFO-27 M1P3Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3n4ZmlEPTB;NUmuPVQ{KM7:TR?= NWrUUIFtW0GQR1XS
GT3TKB NEPJepdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTZyLk[wOFgh|ryP Mn\tV2FPT0WU
HCC38 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTZzLkSzO|kh|ryP NGXYbZhUSU6JRWK=
MLMA Mn7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPB[pRKSzVyPU[xMlYyPjNizszN NVHnTIN7W0GQR1XS
D-566MG M4L5Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonHTWM2OD14Mz61NlI1KM7:TR?= Mn\XV2FPT0WU
SF295 NYntc2xXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Ps[WlEPTB;NkOuOlY2PSEQvF2= NFPRW3hUSU6JRWK=
ES4 NFjaZ29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13BTGlEPTB;NkSuOFcyQSEQvF2= M3WwZnNCVkeHUh?=
CAKI-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjhNGpKUUN3ME22OE42PzJzIN88US=> NHLCWpZUSU6JRWK=
OAW-28 NYjU[Zp2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTZ2Lkm2OFch|ryP MYXTRW5ITVJ?
NCI-H460 Mn2yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ETWM2OD14NT6wPFk4KM7:TR?= MnjKV2FPT0WU
JAR MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmroTWM2OD14NT61OVE3KM7:TR?= MoHUV2FPT0WU
SNU-449 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPVfZlUUUN3ME22OU44PjF4IN88US=> M1GxOHNCVkeHUh?=
D-392MG NIDlPYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;GTWM2OD14NT65OFM1KM7:TR?= MXPTRW5ITVJ?
EW-22 NVfjToJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTZ4LkO5OUDPxE1? MlXEV2FPT0WU
GCT MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzOcmhKSzVyPU[3MlA1PDNizszN NX;FNFZuW0GQR1XS
NOS-1 NVLUVZh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnFVmcyUUN3ME22O{43QDZ5IN88US=> M4n1WXNCVkeHUh?=
RH-1 MorRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLnWoNEUUN3ME22PE42PTV7IN88US=> NYHLOYx6W0GQR1XS
HuH-7 NIj1Z4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3UVY9KSzVyPU[5MlExODJizszN M3jxOnNCVkeHUh?=
NUGC-3 M{\RSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDrRVBKSzVyPUewMlk3PDRizszN NWC5OW9qW0GQR1XS
IST-SL1 MlXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTdzLkKzNlQh|ryP NFKzV5RUSU6JRWK=
SHP-77 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTd{LkGxPUDPxE1? MVTTRW5ITVJ?
SW1116 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHJe5R2UUN3ME23Nk4yPDB5IN88US=> M1vJUnNCVkeHUh?=
LK-2 Ml7HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj6TWM2OD15Mj64OlEzKM7:TR?= MkXWV2FPT0WU
U-2-OS M2j0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mne4TWM2OD15Mz6xPFI5KM7:TR?= NUT1[4ZxW0GQR1XS
KYSE-150 M4\kbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTNTWM2OD15Mz62NVE5KM7:TR?= MUfTRW5ITVJ?
U251 M3;oNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGPYWnZKSzVyPUezMlgyPjhizszN NXXwcIxjW0GQR1XS
HT-1080 NHjDN2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTxUGU1UUN3ME23OE4zPTd2IN88US=> M3jC[nNCVkeHUh?=
NCI-H1437 MlLlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTd2Lk[zNlYh|ryP NFX5NWhUSU6JRWK=
HPAF-II NV3hRVh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[4OWlEPTB;N{SuOlQyPSEQvF2= MYjTRW5ITVJ?
Becker NYXicGRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTd3LkGxNFUh|ryP MknwV2FPT0WU
PANC-10-05 M3HE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTYTWM2OD15NT6yPFY2KM7:TR?= MkXGV2FPT0WU
TYK-nu MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGP2fmNKSzVyPUe1MlMyODJizszN MWfTRW5ITVJ?
SKG-IIIa MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTd3LkOzOFEh|ryP MWrTRW5ITVJ?
NCI-H1993 MoDxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn65TWM2OD15NT63N|k4KM7:TR?= MWfTRW5ITVJ?
S-117 MlTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWD2c3o6UUN3ME23OU44PTVizszN MoXzV2FPT0WU
HuO9 M2fJd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnvTWM2OD15Nj6wNFQ5KM7:TR?= MVnTRW5ITVJ?
CAL-51 M4e2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3i5cmlEPTB;N{[uNVAxPiEQvF2= M1nhUHNCVkeHUh?=
BT-20 NVXZbZROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;aTWM2OD15Nj6yNVY5KM7:TR?= NWnHPWp1W0GQR1XS
LB831-BLC M{\qeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTd4LkOyNVch|ryP NFuycldUSU6JRWK=
LB1047-RCC M2fB[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTd4Lke2NVkh|ryP NUTGPYdTW0GQR1XS
ES8 NEjIWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfqO3dwUUN3ME23PE4xODd|IN88US=> MnyzV2FPT0WU
UMC-11 MlvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTd6LkC4PFQh|ryP MnP2V2FPT0WU
NCI-H226 M2nV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn3TWM2OD15OD6xN|E2KM7:TR?= MkW4V2FPT0WU
IGROV-1 M13rXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:4Wm9KSzVyPUe4MlU2PSEQvF2= NYXpSGZnW0GQR1XS
BHY Ml22S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFuxN29KSzVyPUe5MlU6PiEQvF2= NYjCbYhoW0GQR1XS
MKN45 M1;WW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzRXmdvUUN3ME24NE4{OTd2IN88US=> Mn\mV2FPT0WU
IA-LM M{nseWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRThyLkO1NVEh|ryP MYXTRW5ITVJ?
WM-115 M2TzTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPzU2FKSzVyPUixMlQyOTRizszN NHT3[5ZUSU6JRWK=
VMRC-RCZ NIrlfGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\aZWlEPTB;OEGuOFQzPSEQvF2= MVXTRW5ITVJ?
NCI-H2291 Ml7MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTWTnNtUUN3ME24NU43QDR{IN88US=> Mkn0V2FPT0WU
MCF7 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorYTWM2OD16Mz6yPFk4KM7:TR?= M2HsSXNCVkeHUh?=
639-V M4\RSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPZTWM2OD16ND62NVI6KM7:TR?= NUf1emlbW0GQR1XS
RT4 M1XZWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LSSGlEPTB;OEWuNlQxOyEQvF2= MWfTRW5ITVJ?
NCI-H2405 MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTh3LkK5PVch|ryP MnS1V2FPT0WU
CAL-33 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTh3Lk[zNVUh|ryP MYLTRW5ITVJ?
BT-549 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HrXWlEPTB;OEWuPVM5OiEQvF2= MoDSV2FPT0WU
HT-1197 Mm[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGP2ToJKSzVyPUi4MlExPzdizszN M3jsc3NCVkeHUh?=
G-361 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXwdFhwUUN3ME24PE4yPDd2IN88US=> NYf3eWpRW0GQR1XS
LS-411N M3jQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf6TWM2OD16OT6zN|g5KM7:TR?= NEXnTXpUSU6JRWK=
HT-144 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvmTWM2OD16OT61PVkzKM7:TR?= NGSzTJVUSU6JRWK=
DJM-1 M2HiTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLKTVlKSzVyPUi5Mlg5PDVizszN NYjQe2p5W0GQR1XS
CAL-12T NHvuUolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjQbpNmUUN3ME25NE44QDl3IN88US=> NF7hXmdUSU6JRWK=
MKN7 NXixc4ZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XaWGlEPTB;OUGuN|U2OSEQvF2= NYO4eppZW0GQR1XS
HuP-T3 M2f6dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTl4LkGwNFQh|ryP MWLTRW5ITVJ?
SK-MG-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHxTWM2OD17Nj6xN|Q5KM7:TR?= MnPGV2FPT0WU
NCI-H2347 NFHJfJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGOxRWNKSzVyPUm4MlExPDJizszN MnvGV2FPT0WU
SW872 MonHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\aTWM2OD1zMECuOFU3KM7:TR?= NV[3U5dGW0GQR1XS
COLO-829 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjlbo9iUUN3ME2xNFAvPTV|IN88US=> M3fOTHNCVkeHUh?=
MC-IXC MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTFyMD62NVUh|ryP Ml;OV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID