PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 NXfR[pN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHsU|hKSzVyPUCuPFIxOjRizszN NH\TTY1USU6JRWK=
UACC-893 NIj0NG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXETpNKSzVyPUWuNVk5QDZizszN MmrZV2FPT0WU
A427 MnTFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTVwN{K1Olch|ryP NGe2U2ZUSU6JRWK=
OCUB-M MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXvb2o1UUN3ME22MlY3OTB{IN88US=> NUjEOmNQW0GQR1XS
SW684 M2\Hbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTdwNUKyOlgh|ryP MlH6V2FPT0WU
SK-LMS-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NInoOVRKSzVyPUmuNFE{ODJizszN MWHTRW5ITVJ?
CP50-MEL-B M{LlWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTlwM{C0NVkh|ryP NUHHT|JnW0GQR1XS
NCI-H1651 M4HPR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHDbFhKSzVyPUGwMlAzPzZizszN NYnvUlhQW0GQR1XS
ABC-1 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFyLkGwN|ch|ryP M3ToPHNCVkeHUh?=
OE19 NFfIWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvFbItGUUN3ME2xNE4yPzN|IN88US=> NH\GZlBUSU6JRWK=
DSH1 NF\DNFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDrTWM2OD1zMD64PFc6KM7:TR?= NYjkOXR5W0GQR1XS
SW13 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoH0TWM2OD1zMT65N|E6KM7:TR?= NFzje4FUSU6JRWK=
MDA-MB-453 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlH5TWM2OD1zMj6xOlA{KM7:TR?= MX7TRW5ITVJ?
647-V MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmT2TWM2OD1zMj6zOVgzKM7:TR?= M4q4UHNCVkeHUh?=
NCI-H2342 NGOzNXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor4TWM2OD1zMj6zPVk2KM7:TR?= MWDTRW5ITVJ?
LB2241-RCC Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDjTmh4UUN3ME2xNk42Pzd7IN88US=> M3rTVXNCVkeHUh?=
UACC-257 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHWTWM2OD1zMz60OFU{KM7:TR?= NHv6[ZZUSU6JRWK=
NCI-H661 M3XUbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjmTWM2OD1zMz62OFQ6KM7:TR?= MVXTRW5ITVJ?
FADU M{HoWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfhdVZbUUN3ME2xN{43QTl{IN88US=> MljFV2FPT0WU
A2780 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTF|LkiwOFEh|ryP NEPvZ|VUSU6JRWK=
NCI-H1793 M4HsN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXjenVKSzVyPUG0MlQxQDVizszN NGeyfIxUSU6JRWK=
TE-8 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\h[IhKSzVyPUG1MlM1PjVizszN MXrTRW5ITVJ?
HGC-27 M3;5cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIO5R4JKSzVyPUG2MlE3PDRizszN NGL5c2RUSU6JRWK=
MMAC-SF NVG1VHRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4W1[mlEPTB;MUeuN|czPyEQvF2= MXTTRW5ITVJ?
Calu-6 Mn;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnX4TWM2OD1zOD6xOVE{KM7:TR?= MV3TRW5ITVJ?
HUTU-80 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7JcFJQUUN3ME2xPE4{QTV7IN88US=> M3TzZ3NCVkeHUh?=
SAS NEfiRmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Ht[GlEPTB;MUiuOlQ2PSEQvF2= MXHTRW5ITVJ?
IST-MES1 NEPpSphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIizbI5KSzVyPUG4MlY2ODhizszN NEfVS5ZUSU6JRWK=
C3A NVTTWlFvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjuTWM2OD1zOD63PVE6KM7:TR?= M{jBe3NCVkeHUh?=
ES3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHCV4Z3UUN3ME2xPE45OzZ2IN88US=> NEPYeIVUSU6JRWK=
HSC-2 MmHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7OTWM2OD1zOT62OVQyKM7:TR?= NV\tT2NrW0GQR1XS
T47D NEmzbVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLMbmlKSzVyPUKwMlE1QDVizszN M4DQNXNCVkeHUh?=
EW-7 NIHi[JRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XmXGlEPTB;MkCuPFU5QCEQvF2= MYLTRW5ITVJ?
LN-405 M1K5d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3f0SWlEPTB;MkCuPFk3PSEQvF2= NEP5dVZUSU6JRWK=
U031 NEPWem1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHoW3pKSzVyPUKxMlQ5ODJizszN MlLOV2FPT0WU
A549 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLGVmJJUUN3ME2yNU45PDlzIN88US=> NYq1U453W0GQR1XS
RMG-I M{HlVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTJ{LkK2Olgh|ryP M4DZUHNCVkeHUh?=
BT-474 MmPqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fhVmlEPTB;MkKuOlU2OSEQvF2= M{\3OXNCVkeHUh?=
NB69 NIjrW4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mon2TWM2OD1{Mz6xOVIh|ryP MlizV2FPT0WU
NB7 MoK1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PpRWlEPTB;MkSuNVg5KM7:TR?= NXXxb5B4W0GQR1XS
HCC1569 MnPWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3L[lRKSzVyPUK0MlYyOjVizszN MnHyV2FPT0WU
MEL-JUSO MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWSyXmVbUUN3ME2yOE43QTB6IN88US=> Mn:zV2FPT0WU
MDA-MB-175-VII MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXvpeVd5UUN3ME2yOU4zPTF5IN88US=> NV7WZmNoW0GQR1XS
HCC1419 M3[0ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn32TWM2OD1{NT62NFA{KM7:TR?= Mlj3V2FPT0WU
Ca9-22 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnZfZhKSzVyPUK1MlY1OzJizszN MXrTRW5ITVJ?
KGN NUexfHAxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7BTWM2OD1{NT63OVQ4KM7:TR?= M1\BfHNCVkeHUh?=
LB373-MEL-D MkTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXzOGk6UUN3ME2yOk4yQTN6IN88US=> NVXONZZ1W0GQR1XS
NCI-H1755 NWXuNFhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLUTWM2OD1{Nj64PFQyKM7:TR?= M3nKR3NCVkeHUh?=
D-423MG MmSyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPiTWM2OD1{Nz6wO|E2KM7:TR?= MljCV2FPT0WU
DK-MG MoD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHVeZFKSzVyPUK4Mlc5PDZizszN NVzud5VNW0GQR1XS
NCI-H1623 M3LHPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTJ6LkizOFIh|ryP MmD3V2FPT0WU
KU-19-19 MlXGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLXfGRKSzVyPUK4Mlk6PSEQvF2= NG\xb5BUSU6JRWK=
C-33-A MlLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{D3NmlEPTB;MkmuNlE6QCEQvF2= MUfTRW5ITVJ?
SCC-4 NWLnSG1pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXxVpFKSzVyPUOwMlM{PTRizszN NFi4SotUSU6JRWK=
MG-63 M4PsRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkm0TWM2OD1|MD61PVk1KM7:TR?= M1fkR3NCVkeHUh?=
LNCaP-Clone-FGC NWP1flJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPyTWM2OD1|MT60PVIyKM7:TR?= NVqwWWtSW0GQR1XS
CAPAN-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnO3TWM2OD1|MT61Nlg3KM7:TR?= MnGzV2FPT0WU
GI-ME-N MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTNzLkWzOVMh|ryP M1zJTHNCVkeHUh?=
RERF-LC-MS M2\EeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN{Lk[3OFch|ryP NYTpWGJ5W0GQR1XS
KLE NYDrdlhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjUSmJKSzVyPUOzMlQ{OzRizszN NHvxSIRUSU6JRWK=
KNS-81-FD MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\UbWlEPTB;M{OuOVAxQCEQvF2= NGS3dZdUSU6JRWK=
DOK Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHWbYdKSzVyPUO0MlY3OTJizszN MUHTRW5ITVJ?
ACHN NIruO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFO3cJhKSzVyPUO1MlE2QDhizszN MofMV2FPT0WU
KYSE-520 MlHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTN3LkKzOlEh|ryP MX\TRW5ITVJ?
SBC-5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;mPHhMUUN3ME2zOU42OTF4IN88US=> NYrCPFh2W0GQR1XS
NCI-H28 NYLzeZhNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\XPINlUUN3ME2zOU43Pjl3IN88US=> M2D3V3NCVkeHUh?=
ES7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\1TWM2OD1|Nj6yNlQ6KM7:TR?= NFK1bYlUSU6JRWK=
A172 NULURoM5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELISnZKSzVyPUO2MlQyQDdizszN NGTTfodUSU6JRWK=
UM-UC-3 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTN5Lki3OFYh|ryP NV3Se4NGW0GQR1XS
LXF-289 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWq5N4k2UUN3ME2zPE4xODR5IN88US=> M2PxbXNCVkeHUh?=
KP-4 NHvyXmlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTXPYtKSzVyPUO4MlQ4OzlizszN MULTRW5ITVJ?
TE-1 M3fCVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnFZ|hZUUN3ME2zPU43PTh7IN88US=> MoT0V2FPT0WU
G-402 NGCyW5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vKRWlEPTB;NECuNFYyKM7:TR?= NYjuN4lqW0GQR1XS
786-0 M3fx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFy0UlVKSzVyPUSwMlkxQTZizszN MVjTRW5ITVJ?
K5 NV\Cem1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCyTWM2OD12MT6zOlg3KM7:TR?= NWT1Xos4W0GQR1XS
SK-N-DZ NIrTOWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTRzLkO4NlMh|ryP NUf0XVVMW0GQR1XS
OVCAR-4 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXz[4YyUUN3ME20NU44PTZ6IN88US=> NYrG[mZDW0GQR1XS
T84 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m4[mlEPTB;NEKuNVI3OyEQvF2= NX7NdpE4W0GQR1XS
GCIY NYS3PWtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWflbI1VUUN3ME20N{4xQDB|IN88US=> MXHTRW5ITVJ?
BB49-HNC NVO5UYJTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTR|LkOzOFgh|ryP NETu[JdUSU6JRWK=
SNU-C2B MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXyVoIyUUN3ME20N{43PDN4IN88US=> MXPTRW5ITVJ?
TE-6 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTR|Lki4PVQh|ryP MUnTRW5ITVJ?
23132-87 M4fW[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;UTWM2OD12ND6yPVc5KM7:TR?= NX3rWWNDW0GQR1XS
DMS-53 NEHFOZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7R[VhKSzVyPUS0MlM{QDRizszN MkDqV2FPT0WU
ONS-76 M3Xv[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHTXGlKSzVyPUS0Mlc3PjFizszN NUS2[pl3W0GQR1XS
DMS-273 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTR2Lkm0N{DPxE1? M4DBT3NCVkeHUh?=
COLO-824 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTR3Lki3O|Uh|ryP NUXROIpoW0GQR1XS
DMS-114 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDVTWM2OD12NT64PVI4KM7:TR?= NFr3[GRUSU6JRWK=
YKG-1 NHTodJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\NWWlEPTB;NE[uNFM2PSEQvF2= MoHlV2FPT0WU
RH-18 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfKTWM2OD12Nj6zO|M{KM7:TR?= NV7hbZpMW0GQR1XS
NCI-H1355 NI\1[YpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInvdJhKSzVyPUS2MlYyQCEQvF2= MoHsV2FPT0WU
NCI-H2170 NVm5[2c6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELlTnZKSzVyPUS3Mlc2QDRizszN MWHTRW5ITVJ?
OC-314 NUnNTW9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrMTWM2OD12Nz64OFc5KM7:TR?= M2LRWnNCVkeHUh?=
NCI-H2030 NFzxZZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3CTWM2OD12Nz64PVA3KM7:TR?= MkPqV2FPT0WU
22RV1 M{i0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfCTWM2OD12Nz65NFE2KM7:TR?= M4XxeXNCVkeHUh?=
G-401 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWX5VHJ4UUN3ME20PE41PDF3IN88US=> M2XKenNCVkeHUh?=
YAPC NEnnb5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz1dWI5UUN3ME20PU45ODd|IN88US=> NIm4XJBUSU6JRWK=
SW1573 NYfo[4EyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLlRYNYUUN3ME21NE4zPDN3IN88US=> NYGwNVY4W0GQR1XS
COLO-792 M3v5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrNS3VKSzVyPUWwMlYzOzdizszN Mn;ZV2FPT0WU
KNS-62 M{fsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[zfFlKSzVyPUWwMlc2ODhizszN M2D0[HNCVkeHUh?=
NB5 M3zHVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHMTWM2OD13MT60OVA6KM7:TR?= MYfTRW5ITVJ?
CP66-MEL MkTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIG4bFRKSzVyPUWxMlY1ODhizszN NXGzRmE2W0GQR1XS
CaR-1 NU\6cGgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHQTWM2OD13Mj6wOlA3KM7:TR?= M2TnS3NCVkeHUh?=
CAL-54 M3Ta[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nqNWlEPTB;NUKuNVExOiEQvF2= MVTTRW5ITVJ?
8305C NH6xVHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjmTWM2OD13Mj6zNVUh|ryP MYjTRW5ITVJ?
Calu-3 NYThcGM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm5ZYxxUUN3ME21Nk4{PzN|IN88US=> NX\WbIFvW0GQR1XS
AU565 NX7WcWVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELJTpJKSzVyPUWyMlU2ODlizszN NFfETnlUSU6JRWK=
CW-2 Mn24S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPDZ4tKSzVyPUWyMlg3PTRizszN Ml7vV2FPT0WU
BEN NYK1XmdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTV|Lke4OlIh|ryP NVLycFdHW0GQR1XS
NCI-H1975 NELLT4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PZSmlEPTB;NUOuPFk3PiEQvF2= Mn7XV2FPT0WU
HCT-116 NYXUcFFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fvZ2lEPTB;NUSuNFMzPyEQvF2= Mn;LV2FPT0WU
SH-4 NYPVXGdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTnPJRlUUN3ME21OE4yOzhizszN NWPPTpFyW0GQR1XS
NCI-H1693 NUjGRXNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTV2LkKxNFMh|ryP MX3TRW5ITVJ?
BPH-1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPVTWM2OD13NT6yPFkzKM7:TR?= NYmzUll2W0GQR1XS
CAMA-1 M{m1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELRRpJKSzVyPUW1MlgyOTZizszN NI\KcGxUSU6JRWK=
A388 NGe0XIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkX0TWM2OD13Nj6wPVg2KM7:TR?= MYHTRW5ITVJ?
C2BBe1 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nabWlEPTB;NU[uNlY{PCEQvF2= NIrnSpJUSU6JRWK=
GAMG M2H3TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWK3VpR2UUN3ME21Ok42QTV3IN88US=> NVrwcINLW0GQR1XS
MKN28 M33Ke2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHZO286UUN3ME21Ok45ODF|IN88US=> M{nkSXNCVkeHUh?=
VA-ES-BJ NEn6cphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17xZmlEPTB;NU[uPFc1PSEQvF2= NFLW[pRUSU6JRWK=
HuCCT1 NVHPNJFjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\RSGtKSzVyPUW3MlA1QTJizszN M{TnVnNCVkeHUh?=
BFTC-905 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLVT4tKSzVyPUW3MlI5QThizszN MYrTRW5ITVJ?
LS-123 NGrTe2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGO3WG5KSzVyPUW3MlU3PjhizszN MknJV2FPT0WU
LB996-RCC NHrWXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPwTWM2OD13OD6wNlg4KM7:TR?= MmnIV2FPT0WU
NCI-H1048 NELOO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoO4TWM2OD13OD6yNVg5KM7:TR?= M{T0TnNCVkeHUh?=
COR-L105 M3;rU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTV6LkezN|ch|ryP NVTBN2FXW0GQR1XS
OVCAR-8 NHHwW3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLPTWM2OD13OT6xO|E3KM7:TR?= MVvTRW5ITVJ?
SK-N-FI NUDDb5E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TISmlEPTB;NUmuN|IxPyEQvF2= Ml;lV2FPT0WU
MES-SA MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XEPWlEPTB;NUmuOFUxQSEQvF2= M1PR[XNCVkeHUh?=
SCC-9 M3;BRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTV7LkS3OVMh|ryP NX7Pe4RSW0GQR1XS
EFO-27 M4fITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fuR2lEPTB;NUmuPVQ{KM7:TR?= NFr1ZVBUSU6JRWK=
GT3TKB MmXLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXrTWM2OD14MD62NFQ5KM7:TR?= NYmwdVl3W0GQR1XS
HCC38 M1\BZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnf0TWM2OD14MT60N|c6KM7:TR?= Mlj2V2FPT0WU
MLMA MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTCTWM2OD14MT62NVY{KM7:TR?= NVTa[XhmW0GQR1XS
D-566MG MoTMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHs[HdKSzVyPU[zMlUzOjRizszN NXW0NmZ2W0GQR1XS
SF295 NFXGXlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTZ|Lk[2OVUh|ryP NHvLW4hUSU6JRWK=
ES4 MnKyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTZ2LkS3NVkh|ryP MlPRV2FPT0WU
CAKI-1 MmK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XFUmlEPTB;NkSuOVczOSEQvF2= M1;Ub3NCVkeHUh?=
OAW-28 MkfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LpS2lEPTB;NkSuPVY1PyEQvF2= NF;N[ZNUSU6JRWK=
NCI-H460 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTZ3LkC4PVch|ryP M4n5S3NCVkeHUh?=
JAR MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7Vd4RKSzVyPU[1MlU2OTZizszN NGjaO|FUSU6JRWK=
SNU-449 NGfKV3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnOeZIxUUN3ME22OU44PjF4IN88US=> MnrqV2FPT0WU
D-392MG NHvqboxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3qZYVKSzVyPU[1Mlk1OzRizszN NXXsdVZ{W0GQR1XS
EW-22 M3y3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTZ4LkO5OUDPxE1? NIXVfYRUSU6JRWK=
GCT NVG3TWZHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTyOVlIUUN3ME22O{4xPDR|IN88US=> Mn;oV2FPT0WU
NOS-1 MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\JcmlEPTB;NkeuOlg3PyEQvF2= M3vDU3NCVkeHUh?=
RH-1 NEWwcGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTTdoxWUUN3ME22PE42PTV7IN88US=> MmGwV2FPT0WU
HuH-7 NFnTbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4n2VGlEPTB;NkmuNVAxOiEQvF2= NX;SSIlYW0GQR1XS
NUGC-3 Mn7zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHJe3pKUUN3ME23NE46PjR2IN88US=> MoPGV2FPT0WU
IST-SL1 NFTHOlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFu1blBKSzVyPUexMlI{OjRizszN NWjP[FFiW0GQR1XS
SHP-77 MmrSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2XCWGlEPTB;N{KuNVE6KM7:TR?= NH3uUFhUSU6JRWK=
SW1116 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPNdFBKSzVyPUeyMlE1ODdizszN M3jrV3NCVkeHUh?=
LK-2 NV;wZWl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTd{Lki2NVIh|ryP M{jVVHNCVkeHUh?=
U-2-OS NWjUZ21qT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7JTWM2OD15Mz6xPFI5KM7:TR?= Mlm5V2FPT0WU
KYSE-150 Ml7PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nTV2lEPTB;N{OuOlEyQCEQvF2= M1vhVnNCVkeHUh?=
U251 M1TsWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTd|LkixOlgh|ryP NE\SNpBUSU6JRWK=
HT-1080 NInVXYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfDdWZtUUN3ME23OE4zPTd2IN88US=> MVXTRW5ITVJ?
NCI-H1437 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjFTWM2OD15ND62N|I3KM7:TR?= NHfJ[IVUSU6JRWK=
HPAF-II MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\PR2lEPTB;N{SuOlQyPSEQvF2= M2HUd3NCVkeHUh?=
Becker NVm1[WNMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXtTWM2OD15NT6xNVA2KM7:TR?= M2HuSHNCVkeHUh?=
PANC-10-05 MojNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPweWhKSzVyPUe1MlI5PjVizszN NGn1VnRUSU6JRWK=
TYK-nu Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfjW5FKSzVyPUe1MlMyODJizszN Mn7JV2FPT0WU
SKG-IIIa NXPrZndyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rIXWlEPTB;N{WuN|M1OSEQvF2= NFHiNZpUSU6JRWK=
NCI-H1993 NXLQXndJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTd3LkezPVch|ryP MXPTRW5ITVJ?
S-117 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;2UmJnUUN3ME23OU44PTVizszN NETPR4NUSU6JRWK=
HuO9 M3zhTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3TIXGlEPTB;N{[uNFA1QCEQvF2= NU\2PXg6W0GQR1XS
CAL-51 NHroPVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTGTWM2OD15Nj6xNFA3KM7:TR?= NWPVU3ZZW0GQR1XS
BT-20 NWnXelhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jqOWlEPTB;N{[uNlE3QCEQvF2= M{WwPHNCVkeHUh?=
LB831-BLC MlewS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfuPJJKSzVyPUe2MlMzOTdizszN NY\ycoNxW0GQR1XS
LB1047-RCC NWLWWodzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHKy[HZKSzVyPUe2Mlc3OTlizszN MVnTRW5ITVJ?
ES8 NYnHZ2I{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTd6LkCwO|Mh|ryP NU\UTHRKW0GQR1XS
UMC-11 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPXTWM2OD15OD6wPFg1KM7:TR?= NGjaR4pUSU6JRWK=
NCI-H226 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVT1dnRxUUN3ME23PE4yOzF3IN88US=> MnfRV2FPT0WU
IGROV-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLxXVJKSzVyPUe4MlU2PSEQvF2= MkHyV2FPT0WU
BHY NITTe2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2q0S2lEPTB;N{muOVk3KM7:TR?= MXXTRW5ITVJ?
MKN45 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRThyLkOxO|Qh|ryP NWjk[INKW0GQR1XS
IA-LM NInKNWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRThyLkO1NVEh|ryP NVzkXWVDW0GQR1XS
WM-115 MlPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHPeXNKSzVyPUixMlQyOTRizszN Ml:0V2FPT0WU
VMRC-RCZ NUPF[2NuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLi[pBKSzVyPUixMlQ1OjVizszN MWjTRW5ITVJ?
NCI-H2291 M{LqUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfXUppOUUN3ME24NU43QDR{IN88US=> NH;w[5JUSU6JRWK=
MCF7 NVToOpFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTh|LkK4PVch|ryP MX\TRW5ITVJ?
639-V MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEDGNHFKSzVyPUi0MlYyOjlizszN M1vNcHNCVkeHUh?=
RT4 NGm0R5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTh3LkK0NFMh|ryP M2LaS3NCVkeHUh?=
NCI-H2405 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTvTWM2OD16NT6yPVk4KM7:TR?= M1y5NXNCVkeHUh?=
CAL-33 NFHxdoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTh3Lk[zNVUh|ryP NGLieXpUSU6JRWK=
BT-549 M1Hpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHyd3RKSzVyPUi1Mlk{QDJizszN NGn6TnJUSU6JRWK=
HT-1197 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PWc2lEPTB;OEiuNVA4PyEQvF2= NFjubHhUSU6JRWK=
G-361 Ml;jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvpU4lvUUN3ME24PE4yPDd2IN88US=> M4\XSHNCVkeHUh?=
LS-411N M13JfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1SycmlEPTB;OEmuN|M5QCEQvF2= M1;PN3NCVkeHUh?=
HT-144 M1W0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:1WmlEPTB;OEmuOVk6OiEQvF2= M1rGbHNCVkeHUh?=
DJM-1 MmDqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonBTWM2OD16OT64PFQ2KM7:TR?= Mm\QV2FPT0WU
CAL-12T M373cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3kTWM2OD17MD63PFk2KM7:TR?= M3vJfnNCVkeHUh?=
MKN7 NXfUWYVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHUTWM2OD17MT6zOVUyKM7:TR?= MWnTRW5ITVJ?
HuP-T3 MmjSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHPcVhKSzVyPUm2MlExODRizszN NUHTXnNKW0GQR1XS
SK-MG-1 MonqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvBcpZKSzVyPUm2MlE{PDhizszN MoT1V2FPT0WU
NCI-H2347 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTl6LkGwOFIh|ryP NYLjfVBwW0GQR1XS
SW872 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTFyMD60OVYh|ryP NVTobo5HW0GQR1XS
COLO-829 NYj4Z441T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPhVIJiUUN3ME2xNFAvPTV|IN88US=> M{X3fHNCVkeHUh?=
MC-IXC NYS1endrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTFyMD62NVUh|ryP NX;WdW5nW0GQR1XS

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water slightly soluble or insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID