PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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  • Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnyNlMxUUN3ME2wMlgzODJ2IN88US=> M1W5WnNCVkeHUh?=
UACC-893 NGLHfJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XPOWlEPTB;NT6xPVg5PiEQvF2= NETNelZUSU6JRWK=
A427 M2XiWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWHYcXFMUUN3ME21MlczPTZ5IN88US=> NUjaUXlZW0GQR1XS
OCUB-M NX63W|I4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTtW4lqUUN3ME22MlY3OTB{IN88US=> M4jPSHNCVkeHUh?=
SW684 MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfNXY9GUUN3ME23MlUzOjZ6IN88US=> M4qwOHNCVkeHUh?=
SK-LMS-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTlwMEGzNFIh|ryP MX3TRW5ITVJ?
CP50-MEL-B M1\5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIHuenVKSzVyPUmuN|A1OTlizszN M4X6NnNCVkeHUh?=
NCI-H1651 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVK1S|lsUUN3ME2xNE4xOjd4IN88US=> NUf3eI5kW0GQR1XS
ABC-1 M3f0bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTFyLkGwN|ch|ryP NGnq[4tUSU6JRWK=
OE19 NH73TWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\iSm9{UUN3ME2xNE4yPzN|IN88US=> NYnRVZRLW0GQR1XS
DSH1 NVjSNlc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC3VodPUUN3ME2xNE45QDd7IN88US=> NFj1NFdUSU6JRWK=
SW13 NEjKe4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHhTWM2OD1zMT65N|E6KM7:TR?= NXLve4ZsW0GQR1XS
MDA-MB-453 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIC3eGhKSzVyPUGyMlE3ODNizszN NI\O[JpUSU6JRWK=
647-V MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLUTWM2OD1zMj6zOVgzKM7:TR?= M3;jZXNCVkeHUh?=
NCI-H2342 MmLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXvUZJKSzVyPUGyMlM6QTVizszN MVzTRW5ITVJ?
LB2241-RCC Ml3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTF{LkW3O|kh|ryP M1TNTnNCVkeHUh?=
UACC-257 NXq0eGtwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHWTWM2OD1zMz60OFU{KM7:TR?= NHjoWJZUSU6JRWK=
NCI-H661 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVu5PWlCUUN3ME2xN{43PDR7IN88US=> NXvoWmhDW0GQR1XS
FADU MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXCbZlKSzVyPUGzMlY6QTJizszN Mk\jV2FPT0WU
A2780 NWrZfJdMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWmy[mJmUUN3ME2xN{45ODRzIN88US=> M1vqbHNCVkeHUh?=
NCI-H1793 NUL5S2p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTF2LkSwPFUh|ryP Mn\XV2FPT0WU
TE-8 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrsPYFKSzVyPUG1MlM1PjVizszN NXLMdmtyW0GQR1XS
HGC-27 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHQR|NTUUN3ME2xOk4yPjR2IN88US=> NUTIT2w6W0GQR1XS
MMAC-SF NXK4elNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXzTWM2OD1zNz6zO|I4KM7:TR?= M1W4Z3NCVkeHUh?=
Calu-6 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjXTXZKSzVyPUG4MlE2OTNizszN MUDTRW5ITVJ?
HUTU-80 MmnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLkTWM2OD1zOD6zPVU6KM7:TR?= MoHIV2FPT0WU
SAS Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrMNJZKSzVyPUG4MlY1PTVizszN NFzYbHBUSU6JRWK=
IST-MES1 NXfwcmF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFO2VVNKSzVyPUG4MlY2ODhizszN M2q5[nNCVkeHUh?=
C3A NIHHfHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4WzSGlEPTB;MUiuO|kyQSEQvF2= NFHhXXNUSU6JRWK=
ES3 M173TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHtTWM2OD1zOD64N|Y1KM7:TR?= MmLuV2FPT0WU
HSC-2 NXXvSo55T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF7Lk[1OFEh|ryP M1TMXXNCVkeHUh?=
T47D MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTJyLkG0PFUh|ryP M2OzTHNCVkeHUh?=
EW-7 NVHhRXJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm3TWM2OD1{MD64OVg5KM7:TR?= NXf4VJQ4W0GQR1XS
LN-405 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33ubmlEPTB;MkCuPFk3PSEQvF2= NX[2Z49KW0GQR1XS
U031 M3PVb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\xS5BKSzVyPUKxMlQ5ODJizszN MX3TRW5ITVJ?
A549 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TkZWlEPTB;MkGuPFQ6OSEQvF2= NWXFcIp1W0GQR1XS
RMG-I MkPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPRTWM2OD1{Mj6yOlY5KM7:TR?= MYDTRW5ITVJ?
BT-474 M3HtdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmqyTWM2OD1{Mj62OVUyKM7:TR?= M2\VSXNCVkeHUh?=
NB69 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTJ|LkG1NkDPxE1? Ml3FV2FPT0WU
NB7 MlXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTJ2LkG4PEDPxE1? MUPTRW5ITVJ?
HCC1569 M37GRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWrJR|UxRTJ2Lk[xNlUh|ryP M{nxe3NCVkeHUh?=
MEL-JUSO NFXn[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGm4VHZKSzVyPUK0MlY6ODhizszN MWXTRW5ITVJ?
MDA-MB-175-VII MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HQOGlEPTB;MkWuNlUyPyEQvF2= Mor6V2FPT0WU
HCC1419 NYDGV|BMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJ3Lk[wNFMh|ryP NITiWZVUSU6JRWK=
Ca9-22 NFewdGRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{DKeWlEPTB;MkWuOlQ{OiEQvF2= MnnWV2FPT0WU
KGN MkH4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O2SmlEPTB;MkWuO|U1PyEQvF2= M1jo[HNCVkeHUh?=
LB373-MEL-D NUnTVmZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTJ4LkG5N|gh|ryP MXPTRW5ITVJ?
NCI-H1755 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\XdWlEPTB;Mk[uPFg1OSEQvF2= M4\2eHNCVkeHUh?=
D-423MG MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ5LkC3NVUh|ryP NGP3W3pUSU6JRWK=
DK-MG NGDleFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJ6Lke4OFYh|ryP NFjIeXBUSU6JRWK=
NCI-H1623 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfITWM2OD1{OD64N|QzKM7:TR?= MVnTRW5ITVJ?
KU-19-19 M1zDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\jS5RyUUN3ME2yPE46QTVizszN M1vNZXNCVkeHUh?=
C-33-A NHjMPXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3zDWmlEPTB;MkmuNlE6QCEQvF2= Mm[2V2FPT0WU
SCC-4 NX[5[3g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfUc4ZKSzVyPUOwMlM{PTRizszN MnTDV2FPT0WU
MG-63 NEXXT3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTNyLkW5PVQh|ryP MmDJV2FPT0WU
LNCaP-Clone-FGC NYrkPIJ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTNzLkS5NlEh|ryP NFjUfZlUSU6JRWK=
CAPAN-1 NXvF[25PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2XpfWlEPTB;M{GuOVI5PiEQvF2= NGLnWVNUSU6JRWK=
GI-ME-N NYXxO4ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVS3SHp6UUN3ME2zNU42OzV|IN88US=> MmTvV2FPT0WU
RERF-LC-MS NH:yN3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoPETWM2OD1|Mj62O|Q4KM7:TR?= MW\TRW5ITVJ?
KLE NVfjfmJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;SXI1KSzVyPUOzMlQ{OzRizszN MXLTRW5ITVJ?
KNS-81-FD MkDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;pZmlEPTB;M{OuOVAxQCEQvF2= MYXTRW5ITVJ?
DOK NFTMW3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN2Lk[2NVIh|ryP NIq4ZmNUSU6JRWK=
ACHN MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUT2fFE{UUN3ME2zOU4yPTh6IN88US=> MoPQV2FPT0WU
KYSE-520 NFzpW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDtcXZlUUN3ME2zOU4zOzZzIN88US=> NWHlNpB1W0GQR1XS
SBC-5 MoDPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3Xyd2lEPTB;M{WuOVEyPiEQvF2= NUTWPY1GW0GQR1XS
NCI-H28 NYjFc|J2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTlc5lLUUN3ME2zOU43Pjl3IN88US=> M4XrN3NCVkeHUh?=
ES7 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;Nc2lEPTB;M{[uNlI1QSEQvF2= M4D1eHNCVkeHUh?=
A172 M4fw[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\TbIpKSzVyPUO2MlQyQDdizszN MlrWV2FPT0WU
UM-UC-3 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTN5Lki3OFYh|ryP NWLHTXh1W0GQR1XS
LXF-289 NGDlZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTN6LkCwOFch|ryP NIj4[VJUSU6JRWK=
KP-4 MlXHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\t[29KSzVyPUO4MlQ4OzlizszN NYXpdWw4W0GQR1XS
TE-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlvJTWM2OD1|OT62OVg6KM7:TR?= NV:2PYxDW0GQR1XS
G-402 MoOyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPzb2QxUUN3ME20NE4xPjFizszN NHPaOW1USU6JRWK=
786-0 NELaW45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTRyLkmwPVYh|ryP MVXTRW5ITVJ?
K5 NWrKc4M4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTRzLkO2PFYh|ryP NVnQPYVoW0GQR1XS
SK-N-DZ NUXxNIJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDCblJKSzVyPUSxMlM5OjNizszN NH\5RllUSU6JRWK=
OVCAR-4 NXT4O3lOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGr1bG1KSzVyPUSxMlc2PjhizszN NH;yZXpUSU6JRWK=
T84 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;Yd5pKSzVyPUSyMlEzPjNizszN MVXTRW5ITVJ?
GCIY M{XON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jkS2lEPTB;NEOuNFgxOyEQvF2= NHTqbIFUSU6JRWK=
BB49-HNC NE[5PFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTR|LkOzOFgh|ryP NWDWeZQyW0GQR1XS
SNU-C2B NWrSbG1UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUX0V3h3UUN3ME20N{43PDN4IN88US=> MVTTRW5ITVJ?
TE-6 NUnJdHBuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTR|Lki4PVQh|ryP NYP2d5Z4W0GQR1XS
23132-87 NVvsTldyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPFXI9KSzVyPUS0MlI6PzhizszN M2PRdHNCVkeHUh?=
DMS-53 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M373[GlEPTB;NESuN|M5PCEQvF2= NX;EXZJRW0GQR1XS
ONS-76 M4TqXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX3uSXdUUUN3ME20OE44PjZzIN88US=> Mnj1V2FPT0WU
DMS-273 NWe5WIFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGWzcpNKSzVyPUS0Mlk1OyEQvF2= NVvxdpY5W0GQR1XS
COLO-824 MoLzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PYVGlEPTB;NEWuPFc4PSEQvF2= M{\pcnNCVkeHUh?=
DMS-114 NFjhNopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTR3Lki5Nlch|ryP Mme2V2FPT0WU
YKG-1 NX\ZUXFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHK5bW5KSzVyPUS2MlA{PTVizszN MWrTRW5ITVJ?
RH-18 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrDcGRJUUN3ME20Ok4{PzN|IN88US=> MlPiV2FPT0WU
NCI-H1355 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTR4Lk[xPEDPxE1? MlrEV2FPT0WU
NCI-H2170 M1S5RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTR5Lke1PFQh|ryP MorpV2FPT0WU
OC-314 NVHidJl3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTR5Lki0O|gh|ryP MoXRV2FPT0WU
NCI-H2030 NXni[nhKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXiSZRKSzVyPUS3Mlg6ODZizszN MoHRV2FPT0WU
22RV1 M1z5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHBTWM2OD12Nz65NFE2KM7:TR?= NIT1R|FUSU6JRWK=
G-401 Mo[yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrDTWM2OD12OD60OFE2KM7:TR?= NYHwWGUyW0GQR1XS
YAPC MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLlTWM2OD12OT64NFc{KM7:TR?= NXfWWXQ5W0GQR1XS
SW1573 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTVyLkK0N|Uh|ryP M2L4cXNCVkeHUh?=
COLO-792 NFHENIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vaRWlEPTB;NUCuOlI{PyEQvF2= MX;TRW5ITVJ?
KNS-62 MnTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTVyLke1NFgh|ryP NILZNnpUSU6JRWK=
NB5 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHXVSJRKSzVyPUWxMlQ2ODlizszN NFfDbmVUSU6JRWK=
CP66-MEL NHWyXm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHMZ3VKSzVyPUWxMlY1ODhizszN Ml\TV2FPT0WU
CaR-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfoTWM2OD13Mj6wOlA3KM7:TR?= NULhWFVXW0GQR1XS
CAL-54 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fDfWlEPTB;NUKuNVExOiEQvF2= MmH1V2FPT0WU
8305C M{DCc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHj1VFZKSzVyPUWyMlMyPSEQvF2= M4DIZ3NCVkeHUh?=
Calu-3 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTV{LkO3N|Mh|ryP MkHLV2FPT0WU
AU565 MnvOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjmUlVKSzVyPUWyMlU2ODlizszN NVX5PXN7W0GQR1XS
CW-2 M{LOUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGD1bWRKSzVyPUWyMlg3PTRizszN M2nyVnNCVkeHUh?=
BEN NFyxXGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTKWWNxUUN3ME21N{44QDZ{IN88US=> NGPl[VVUSU6JRWK=
NCI-H1975 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHvPVFRKSzVyPUWzMlg6PjZizszN Mnr1V2FPT0WU
HCT-116 MknhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfMTWM2OD13ND6wN|I4KM7:TR?= MYTTRW5ITVJ?
SH-4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV:3ZmNFUUN3ME21OE4yOzhizszN MmXrV2FPT0WU
NCI-H1693 NWrUcGh[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTV2LkKxNFMh|ryP MkWyV2FPT0WU
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BT-20 NHn3UIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W4S2lEPTB;N{[uNlE3QCEQvF2= NGmxOHJUSU6JRWK=
LB831-BLC M3rFNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXnTWM2OD15Nj6zNlE4KM7:TR?= NInpeYxUSU6JRWK=
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NCI-H226 M1Xrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP3TWM2OD15OD6xN|E2KM7:TR?= MVjTRW5ITVJ?
IGROV-1 MkXqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjLfHRWUUN3ME23PE42PTVizszN MlLaV2FPT0WU
BHY MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHHTWM2OD15OT61PVYh|ryP M{O4NnNCVkeHUh?=
MKN45 M33iVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7k[llKSzVyPUiwMlMyPzRizszN M17WbXNCVkeHUh?=
IA-LM NGP2[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRThyLkO1NVEh|ryP MXPTRW5ITVJ?
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NCI-H2291 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLTOVlQUUN3ME24NU43QDR{IN88US=> NXvxSG9sW0GQR1XS
MCF7 MkC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7Y[mpnUUN3ME24N{4zQDl5IN88US=> MmjzV2FPT0WU
639-V M4rTPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LNcWlEPTB;OESuOlEzQSEQvF2= M2fCbnNCVkeHUh?=
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CAL-33 M4PXSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;6bJJKSzVyPUi1MlY{OTVizszN NIL3dlVUSU6JRWK=
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HT-1197 M2nifWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmTGTWM2OD16OD6xNFc4KM7:TR?= MoXJV2FPT0WU
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LS-411N M4PzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlfZTWM2OD16OT6zN|g5KM7:TR?= MlLLV2FPT0WU
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DJM-1 MojTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTVN|ZKSzVyPUi5Mlg5PDVizszN NVfLXFl3W0GQR1XS
CAL-12T NV\FXIxLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPzflBHUUN3ME25NE44QDl3IN88US=> NHnGNGRUSU6JRWK=
MKN7 MmC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFKwUGFKSzVyPUmxMlM2PTFizszN M4jidXNCVkeHUh?=
HuP-T3 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTl4LkGwNFQh|ryP NWXTU3BTW0GQR1XS
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COLO-829 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfaTWM2OD1zMECuOVU{KM7:TR?= NYewV4w1W0GQR1XS
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... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID