PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 M2XYVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVv0VWtCUUN3ME2wMlgzODJ2IN88US=> MljYV2FPT0WU
UACC-893 NGO1elZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjsUYM4UUN3ME21MlE6QDh4IN88US=> NHHwfWVUSU6JRWK=
A427 M3\w[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjZTWM2OD13LkeyOVY4KM7:TR?= MV7TRW5ITVJ?
OCUB-M M3nyTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVO3UY1IUUN3ME22MlY3OTB{IN88US=> M3X3Z3NCVkeHUh?=
SW684 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fsWGlEPTB;Nz61NlI3QCEQvF2= NEDJe|hUSU6JRWK=
SK-LMS-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzsTWM2OD17LkCxN|AzKM7:TR?= MmL4V2FPT0WU
CP50-MEL-B MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2Hl[mlEPTB;OT6zNFQyQSEQvF2= NWDDbItxW0GQR1XS
NCI-H1651 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD2WIhvUUN3ME2xNE4xOjd4IN88US=> MU\TRW5ITVJ?
ABC-1 M2D1dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTFyLkGwN|ch|ryP NFrtV45USU6JRWK=
OE19 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDNe3dKSzVyPUGwMlE4OzNizszN NXP2U2JHW0GQR1XS
DSH1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknyTWM2OD1zMD64PFc6KM7:TR?= M4j2T3NCVkeHUh?=
SW13 NV;0Z4sxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWGzeY1mUUN3ME2xNU46OzF7IN88US=> Mo[zV2FPT0WU
MDA-MB-453 NVX4c|huT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vteWlEPTB;MUKuNVYxOyEQvF2= NIrFT|BUSU6JRWK=
647-V NF7zPGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\6OWJzUUN3ME2xNk4{PTh{IN88US=> MWDTRW5ITVJ?
NCI-H2342 M1nLbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLOTVdmUUN3ME2xNk4{QTl3IN88US=> NWLLOmFDW0GQR1XS
LB2241-RCC MkH5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LsRmlEPTB;MUKuOVc4QSEQvF2= NVHWUHZiW0GQR1XS
UACC-257 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF|LkS0OVMh|ryP MYDTRW5ITVJ?
NCI-H661 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml20TWM2OD1zMz62OFQ6KM7:TR?= NHPyV3pUSU6JRWK=
FADU NHviXXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITYOpZKSzVyPUGzMlY6QTJizszN NWjHUmtJW0GQR1XS
A2780 M4HrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETOeHNKSzVyPUGzMlgxPDFizszN MV3TRW5ITVJ?
NCI-H1793 M37GbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW[5Zop7UUN3ME2xOE41ODh3IN88US=> NF2zfllUSU6JRWK=
TE-8 NGLTO5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rrW2lEPTB;MUWuN|Q3PSEQvF2= MW\TRW5ITVJ?
HGC-27 MorXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\lcmpuUUN3ME2xOk4yPjR2IN88US=> NIfNdIpUSU6JRWK=
MMAC-SF NUPDOGR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWP3PHJUUUN3ME2xO{4{PzJ5IN88US=> NHPXU5hUSU6JRWK=
Calu-6 MkS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTF6LkG1NVMh|ryP NGTYeIVUSU6JRWK=
HUTU-80 M1H0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTF6LkO5OVkh|ryP NH\zVlBUSU6JRWK=
SAS MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfRXmtKSzVyPUG4MlY1PTVizszN NF71SnpUSU6JRWK=
IST-MES1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTF6Lk[1NFgh|ryP M2ftb3NCVkeHUh?=
C3A M2\sfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYHJR|UxRTF6Lke5NVkh|ryP NFPNcFZUSU6JRWK=
ES3 NGXrenRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDHc2RKSzVyPUG4Mlg{PjRizszN M37QenNCVkeHUh?=
HSC-2 NFXM[lBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HaRmlEPTB;MUmuOlU1OSEQvF2= M4LTcXNCVkeHUh?=
T47D M4frbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TOdWlEPTB;MkCuNVQ5PSEQvF2= NX\SWIdEW0GQR1XS
EW-7 NEfWe|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rHRWlEPTB;MkCuPFU5QCEQvF2= NEixTVhUSU6JRWK=
LN-405 NUj2Nm5[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXkbJZKSzVyPUKwMlg6PjVizszN MkHCV2FPT0WU
U031 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\NTWM2OD1{MT60PFAzKM7:TR?= NIHrblRUSU6JRWK=
A549 M1jq[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPIOVdKSzVyPUKxMlg1QTFizszN MYHTRW5ITVJ?
RMG-I M4\2fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4j6bGlEPTB;MkKuNlY3QCEQvF2= MkTpV2FPT0WU
BT-474 M1u2ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKwc4pKSzVyPUKyMlY2PTFizszN M3OxVXNCVkeHUh?=
NB69 NWnaPHJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknwTWM2OD1{Mz6xOVIh|ryP NV3WO4pmW0GQR1XS
NB7 M4W3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJ2LkG4PEDPxE1? Mmf1V2FPT0WU
HCC1569 MmL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXLUYV[UUN3ME2yOE43OTJ3IN88US=> NYXh[HJ5W0GQR1XS
MEL-JUSO MoXOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTJ2Lk[5NFgh|ryP MlXJV2FPT0WU
MDA-MB-175-VII MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{L6[WlEPTB;MkWuNlUyPyEQvF2= M4TNOnNCVkeHUh?=
HCC1419 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTJ3Lk[wNFMh|ryP NYTUZpdNW0GQR1XS
Ca9-22 NHPa[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z1fmlEPTB;MkWuOlQ{OiEQvF2= MWPTRW5ITVJ?
KGN MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnORpBKSzVyPUK1Mlc2PDdizszN MY\TRW5ITVJ?
LB373-MEL-D NGTYUllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHCVVBKSzVyPUK2MlE6OzhizszN NXrNSGM6W0GQR1XS
NCI-H1755 NULKZYNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPZflRKSzVyPUK2Mlg5PDFizszN Ml25V2FPT0WU
D-423MG MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fDfWlEPTB;MkeuNFcyPSEQvF2= NYTrXJpQW0GQR1XS
DK-MG NUPKUGI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2W2U2lEPTB;MkiuO|g1PiEQvF2= NXPo[GZZW0GQR1XS
NCI-H1623 NGXIZ4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3v3RmlEPTB;MkiuPFM1OiEQvF2= NVjmVoNPW0GQR1XS
KU-19-19 NXjyOlVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJ6Lkm5OUDPxE1? NGHPdGxUSU6JRWK=
C-33-A M3PYRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DTUmlEPTB;MkmuNlE6QCEQvF2= NW\YNlNpW0GQR1XS
SCC-4 NV3VXXNCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILEbWhKSzVyPUOwMlM{PTRizszN NHr4OYhUSU6JRWK=
MG-63 NXvmbWIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4XHXGlEPTB;M{CuOVk6PCEQvF2= MVLTRW5ITVJ?
LNCaP-Clone-FGC NXnpSGk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXXTWM2OD1|MT60PVIyKM7:TR?= MVPTRW5ITVJ?
CAPAN-1 M3m2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXsTWM2OD1|MT61Nlg3KM7:TR?= MUHTRW5ITVJ?
GI-ME-N MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTNzLkWzOVMh|ryP M3\2ZnNCVkeHUh?=
RERF-LC-MS NWmwNpNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPYSXRKSzVyPUOyMlY4PDdizszN MnHwV2FPT0WU
KLE NV;RfIJXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTN|LkSzN|Qh|ryP M{jrbHNCVkeHUh?=
KNS-81-FD Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnKWm5YUUN3ME2zN{42ODB6IN88US=> MULTRW5ITVJ?
DOK NIPW[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17ubWlEPTB;M{SuOlYyOiEQvF2= MYLTRW5ITVJ?
ACHN NIrycYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjUbVhpUUN3ME2zOU4yPTh6IN88US=> MXHTRW5ITVJ?
KYSE-520 Mnr4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nqN2lEPTB;M{WuNlM3OSEQvF2= MoGwV2FPT0WU
SBC-5 NGfjOWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHoUFBKSzVyPUO1MlUyOTZizszN MW\TRW5ITVJ?
NCI-H28 NXTNbGhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvrRo9KSzVyPUO1MlY3QTVizszN NI\wV4JUSU6JRWK=
ES7 MnXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1zmUWlEPTB;M{[uNlI1QSEQvF2= NVy4RnJrW0GQR1XS
A172 NIXUOIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S1d2lEPTB;M{[uOFE5PyEQvF2= MV7TRW5ITVJ?
UM-UC-3 M{nlTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF2yT3JKSzVyPUO3Mlg4PDZizszN NGOxUnlUSU6JRWK=
LXF-289 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\STWM2OD1|OD6wNFQ4KM7:TR?= MUnTRW5ITVJ?
KP-4 M1TZdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofzTWM2OD1|OD60O|M6KM7:TR?= MnnBV2FPT0WU
TE-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvISldKSzVyPUO5MlY2QDlizszN NUfUdWI4W0GQR1XS
G-402 Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTOWIFbUUN3ME20NE4xPjFizszN NVK2d3plW0GQR1XS
786-0 NXW4dFVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXewcohbUUN3ME20NE46ODl4IN88US=> NXnBZ3RbW0GQR1XS
K5 M{XHUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTRzLkO2PFYh|ryP NGizeINUSU6JRWK=
SK-N-DZ MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX6fINKSzVyPUSxMlM5OjNizszN MlzJV2FPT0WU
OVCAR-4 M{nuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPFSIJKSzVyPUSxMlc2PjhizszN MoPtV2FPT0WU
T84 NIrOOm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzKc4JvUUN3ME20Nk4yOjZ|IN88US=> MVjTRW5ITVJ?
GCIY NH;BNJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV[4[YZUUUN3ME20N{4xQDB|IN88US=> M2TQNnNCVkeHUh?=
BB49-HNC NXvaZmhkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHYTWM2OD12Mz6zN|Q5KM7:TR?= MoLCV2FPT0WU
SNU-C2B NE\VcWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXRTWM2OD12Mz62OFM3KM7:TR?= NYTjb|BDW0GQR1XS
TE-6 MnnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmjhTWM2OD12Mz64PFk1KM7:TR?= MW\TRW5ITVJ?
23132-87 MnfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzOTmhxUUN3ME20OE4zQTd6IN88US=> M2XybXNCVkeHUh?=
DMS-53 MoLSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTDcnVKSzVyPUS0MlM{QDRizszN MlnCV2FPT0WU
ONS-76 Mo[xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Trb2lEPTB;NESuO|Y3OSEQvF2= M{DWZXNCVkeHUh?=
DMS-273 NHzaSWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrTTWM2OD12ND65OFMh|ryP NHHNSWlUSU6JRWK=
COLO-824 NH;jSoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XEVGlEPTB;NEWuPFc4PSEQvF2= NYjRc3V{W0GQR1XS
DMS-114 M2izeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4PXPWlEPTB;NEWuPFkzPyEQvF2= M17SdXNCVkeHUh?=
YKG-1 NWexNlQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTR4LkCzOVUh|ryP MV\TRW5ITVJ?
RH-18 M3HNZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\adG1pUUN3ME20Ok4{PzN|IN88US=> MlXFV2FPT0WU
NCI-H1355 MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL3PYZIUUN3ME20Ok43OThizszN MYPTRW5ITVJ?
NCI-H2170 MoHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTR5Lke1PFQh|ryP Mn[4V2FPT0WU
OC-314 M{PEVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDSTWM2OD12Nz64OFc5KM7:TR?= NH;BVo1USU6JRWK=
NCI-H2030 M3zZRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPXTWM2OD12Nz64PVA3KM7:TR?= MWfTRW5ITVJ?
22RV1 MmDrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoqxTWM2OD12Nz65NFE2KM7:TR?= MmPoV2FPT0WU
G-401 NV\mNlFsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPSRW1KSzVyPUS4MlQ1OTVizszN M1rifHNCVkeHUh?=
YAPC NXPsXpB1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLHTWM2OD12OT64NFc{KM7:TR?= MlzIV2FPT0WU
SW1573 NGjsTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zQZ2lEPTB;NUCuNlQ{PSEQvF2= M1exb3NCVkeHUh?=
COLO-792 M1LuS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGf6bZpKSzVyPUWwMlYzOzdizszN NFS3OXlUSU6JRWK=
KNS-62 M3Toe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX[2SVR3UUN3ME21NE44PTB6IN88US=> MWLTRW5ITVJ?
NB5 MmXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTVzLkS1NFkh|ryP NYPC[5pOW0GQR1XS
CP66-MEL NWX1e4ZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXsTWM2OD13MT62OFA5KM7:TR?= NEj2OVZUSU6JRWK=
CaR-1 M1;pTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XHeWlEPTB;NUKuNFYxPiEQvF2= M3PsV3NCVkeHUh?=
CAL-54 NUT6b|Y4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfWbIxKSzVyPUWyMlEyODJizszN MmrWV2FPT0WU
8305C NWHtfZBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTV{LkOxOUDPxE1? M1zzb3NCVkeHUh?=
Calu-3 NWDGXJJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fae2lEPTB;NUKuN|c{OyEQvF2= MmjOV2FPT0WU
AU565 M{H5WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXVTWM2OD13Mj61OVA6KM7:TR?= MlvoV2FPT0WU
CW-2 MoXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTV{Lki2OVQh|ryP MoCwV2FPT0WU
BEN MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITzOnpKSzVyPUWzMlc5PjJizszN Ml;kV2FPT0WU
NCI-H1975 MmrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\IUG5FUUN3ME21N{45QTZ4IN88US=> MVHTRW5ITVJ?
HCT-116 M3j4Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XadmlEPTB;NUSuNFMzPyEQvF2= NGjrfGxUSU6JRWK=
SH-4 NVSybo9lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1HaN2lEPTB;NUSuNVM5KM7:TR?= NUfHUlg6W0GQR1XS
NCI-H1693 NX;pbIk5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTV2LkKxNFMh|ryP M4[2WXNCVkeHUh?=
BPH-1 MkDUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TkNmlEPTB;NUWuNlg6OiEQvF2= MXPTRW5ITVJ?
CAMA-1 NITCdJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLJPGxTUUN3ME21OU45OTF4IN88US=> MoTtV2FPT0WU
A388 MmDKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17DWGlEPTB;NU[uNFk5PSEQvF2= MnnmV2FPT0WU
C2BBe1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{joUWlEPTB;NU[uNlY{PCEQvF2= NETIVHJUSU6JRWK=
GAMG MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\4cmlyUUN3ME21Ok42QTV3IN88US=> NIL0eWVUSU6JRWK=
MKN28 NUDXOXBjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkmzTWM2OD13Nj64NFE{KM7:TR?= MlfpV2FPT0WU
VA-ES-BJ MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfrUlI4UUN3ME21Ok45PzR3IN88US=> NFW5OlRUSU6JRWK=
HuCCT1 M{K2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nHVWlEPTB;NUeuNFQ6OiEQvF2= MoLsV2FPT0WU
BFTC-905 NIewbXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUnJR|UxRTV5LkK4PVgh|ryP MYrTRW5ITVJ?
LS-123 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoXiTWM2OD13Nz61OlY5KM7:TR?= NEnTd4FUSU6JRWK=
LB996-RCC NGnz[XZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHLTWM2OD13OD6wNlg4KM7:TR?= M{DJ[3NCVkeHUh?=
NCI-H1048 NUP6XlAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLzSYpIUUN3ME21PE4zOTh6IN88US=> NGLKeY9USU6JRWK=
COR-L105 NUey[GNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ntVmlEPTB;NUiuO|M{PyEQvF2= MkLRV2FPT0WU
OVCAR-8 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTV7LkG3NVYh|ryP MmLuV2FPT0WU
SK-N-FI MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTV7LkOyNFch|ryP NWjJ[VBLW0GQR1XS
MES-SA MlvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIL0[pJKSzVyPUW5MlQ2ODlizszN NHjTfmVUSU6JRWK=
SCC-9 NIP6WYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLiTWM2OD13OT60O|U{KM7:TR?= MXHTRW5ITVJ?
EFO-27 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;B[mlEPTB;NUmuPVQ{KM7:TR?= MVXTRW5ITVJ?
GT3TKB Ml\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfmb4RKSzVyPU[wMlYxPDhizszN MWDTRW5ITVJ?
HCC38 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXL0XY9tUUN3ME22NU41Ozd7IN88US=> Mn;RV2FPT0WU
MLMA NHTJRlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmryTWM2OD14MT62NVY{KM7:TR?= NVjUcGZbW0GQR1XS
D-566MG NXX6N4xxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7ZN441UUN3ME22N{42OjJ2IN88US=> MmnuV2FPT0WU
SF295 MkHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTZ|Lk[2OVUh|ryP MYDTRW5ITVJ?
ES4 NI\HbFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPMdGFKSzVyPU[0MlQ4OTlizszN NFS0OpFUSU6JRWK=
CAKI-1 NVz6WFRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjoUpFKSzVyPU[0MlU4OjFizszN MlX6V2FPT0WU
OAW-28 NILQXHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\ERVRKSzVyPU[0Mlk3PDdizszN NFHHb|RUSU6JRWK=
NCI-H460 NWDXNlRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlTOTWM2OD14NT6wPFk4KM7:TR?= M{\4ZXNCVkeHUh?=
JAR MnHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlflTWM2OD14NT61OVE3KM7:TR?= MX;TRW5ITVJ?
SNU-449 Mlu0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFSwZZdKSzVyPU[1Mlc3OTZizszN M3H6PXNCVkeHUh?=
D-392MG NIC2RnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofuTWM2OD14NT65OFM1KM7:TR?= Mnj5V2FPT0WU
EW-22 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XjcmlEPTB;Nk[uN|k2KM7:TR?= MnPBV2FPT0WU
GCT M2q3dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXi5WJJqUUN3ME22O{4xPDR|IN88US=> MmjnV2FPT0WU
NOS-1 NH:xdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr3bFR2UUN3ME22O{43QDZ5IN88US=> MoX5V2FPT0WU
RH-1 NUXkPVdpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{THdWlEPTB;NkiuOVU2QSEQvF2= M3GzdXNCVkeHUh?=
HuH-7 M3fobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTZ7LkGwNFIh|ryP NV3wW41WW0GQR1XS
NUGC-3 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFS4W2JKSzVyPUewMlk3PDRizszN MnTqV2FPT0WU
IST-SL1 MmfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\JV5p6UUN3ME23NU4zOzJ2IN88US=> MVfTRW5ITVJ?
SHP-77 NV;ZSnVFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYOwVnZYUUN3ME23Nk4yOTlizszN MWHTRW5ITVJ?
SW1116 NFPMR2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PNeGlEPTB;N{KuNVQxPyEQvF2= NVLSbZhmW0GQR1XS
LK-2 M4jJOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37EXWlEPTB;N{KuPFYyOiEQvF2= NYrQdVlQW0GQR1XS
U-2-OS MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnL1TWM2OD15Mz6xPFI5KM7:TR?= MlHQV2FPT0WU
KYSE-150 M1PpN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTd|Lk[xNVgh|ryP MmTCV2FPT0WU
U251 NVPuUWVyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TPfWlEPTB;N{OuPFE3QCEQvF2= NF3MdpJUSU6JRWK=
HT-1080 NWHYXXNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPBTWM2OD15ND6yOVc1KM7:TR?= NHPQRmtUSU6JRWK=
NCI-H1437 M3z5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rHc2lEPTB;N{SuOlMzPiEQvF2= MoPSV2FPT0WU
HPAF-II NIq4PFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnGfYdKSzVyPUe0MlY1OTVizszN M4XkPXNCVkeHUh?=
Becker MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnMV2M6UUN3ME23OU4yOTB3IN88US=> Ml;aV2FPT0WU
PANC-10-05 MoLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXn0b3FEUUN3ME23OU4zQDZ3IN88US=> NHPJ[YNUSU6JRWK=
TYK-nu MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vUbGlEPTB;N{WuN|ExOiEQvF2= MoTxV2FPT0WU
SKG-IIIa NHq5fpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nXRWlEPTB;N{WuN|M1OSEQvF2= NYrvPWMyW0GQR1XS
NCI-H1993 M2i1fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEflUllKSzVyPUe1Mlc{QTdizszN MYXTRW5ITVJ?
S-117 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HKR2lEPTB;N{WuO|U2KM7:TR?= MorxV2FPT0WU
HuO9 NWrSWJFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXO3ZYt[UUN3ME23Ok4xODR6IN88US=> M3PtSHNCVkeHUh?=
CAL-51 NHXLTXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTd4LkGwNFYh|ryP M3;YUXNCVkeHUh?=
BT-20 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\ucZJKSzVyPUe2MlIyPjhizszN NXO1NGYxW0GQR1XS
LB831-BLC NITufYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzqbZVKSzVyPUe2MlMzOTdizszN M3W1WnNCVkeHUh?=
LB1047-RCC M4P5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFW3WmFKSzVyPUe2Mlc3OTlizszN NVzuZ|JmW0GQR1XS
ES8 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;6Ro1kUUN3ME23PE4xODd|IN88US=> MkLEV2FPT0WU
UMC-11 Mnq1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHoNYpUUUN3ME23PE4xQDh2IN88US=> NXf2[mY1W0GQR1XS
NCI-H226 NELDXolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2fObGlEPTB;N{iuNVMyPSEQvF2= MV;TRW5ITVJ?
IGROV-1 M3TWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLzdYFqUUN3ME23PE42PTVizszN M3TqbnNCVkeHUh?=
BHY NEjHPHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTd7LkW5OkDPxE1? MYfTRW5ITVJ?
MKN45 M{LNb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLI[YZ{UUN3ME24NE4{OTd2IN88US=> MVvTRW5ITVJ?
IA-LM NH3S[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XzPWlEPTB;OECuN|UyOSEQvF2= MojnV2FPT0WU
WM-115 M2rKNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLycY9KSzVyPUixMlQyOTRizszN M3SzdnNCVkeHUh?=
VMRC-RCZ NV;R[WtiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrvT5J7UUN3ME24NU41PDJ3IN88US=> M37Td3NCVkeHUh?=
NCI-H2291 NVLveItoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3qxbWlEPTB;OEGuOlg1OiEQvF2= NWHLdpo3W0GQR1XS
MCF7 M1G1VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\4fGRKSzVyPUizMlI5QTdizszN NECwN2FUSU6JRWK=
639-V NHr5eW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEO2U5ZKSzVyPUi0MlYyOjlizszN NWLENJkxW0GQR1XS
RT4 MlXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTh3LkK0NFMh|ryP NWfJW3ROW0GQR1XS
NCI-H2405 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfMTWM2OD16NT6yPVk4KM7:TR?= M1n2PHNCVkeHUh?=
CAL-33 NVLhOJJGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\jSVR2UUN3ME24OU43OzF3IN88US=> MnHsV2FPT0WU
BT-549 NE[zPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Moi1TWM2OD16NT65N|gzKM7:TR?= M{LQPHNCVkeHUh?=
HT-1197 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3oSItTUUN3ME24PE4yODd5IN88US=> MWjTRW5ITVJ?
G-361 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7tO2Q2UUN3ME24PE4yPDd2IN88US=> NUHxO4xGW0GQR1XS
LS-411N M4T3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoTDTWM2OD16OT6zN|g5KM7:TR?= M1;nNXNCVkeHUh?=
HT-144 Mn;lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULJbXhxUUN3ME24PU42QTl{IN88US=> M2n4OHNCVkeHUh?=
DJM-1 M{ntZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37qfWlEPTB;OEmuPFg1PSEQvF2= MYHTRW5ITVJ?
CAL-12T NWD2TYtsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nQUmlEPTB;OUCuO|g6PSEQvF2= MkLDV2FPT0WU
MKN7 NWnxR2JoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTlzLkO1OVEh|ryP NYHNWXUxW0GQR1XS
HuP-T3 MlnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jpR2lEPTB;OU[uNVAxPCEQvF2= NF\5[FRUSU6JRWK=
SK-MG-1 Mn;BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;k[HJKSzVyPUm2MlE{PDhizszN M33ibXNCVkeHUh?=
NCI-H2347 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmX2TWM2OD17OD6xNFQzKM7:TR?= M3PxeXNCVkeHUh?=
SW872 NU\YXZE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTTTWM2OD1zMECuOFU3KM7:TR?= NVfFdoVFW0GQR1XS
COLO-829 NVjk[4xJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[3[WlEPTB;MUCwMlU2OyEQvF2= Mlf1V2FPT0WU
MC-IXC NHvNbJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7vTWM2OD1zMECuOlE2KM7:TR?= NXP3c2tXW0GQR1XS

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Related Antibodies

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID