PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

Size Price Stock Quantity  
In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

2 Customer Reviews

  • Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Click to view more

Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 NI\uTHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NECw[ItKSzVyPUCuPFIxOjRizszN MkXlV2FPT0WU
UACC-893 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1W3emlEPTB;NT6xPVg5PiEQvF2= NVnRUWtYW0GQR1XS
A427 NVjneI03T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrqVHdTUUN3ME21MlczPTZ5IN88US=> M324NnNCVkeHUh?=
OCUB-M MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTZwNk[xNFIh|ryP MkPQV2FPT0WU
SW684 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTdwNUKyOlgh|ryP NUfyPYc2W0GQR1XS
SK-LMS-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYq2bZdXUUN3ME25MlAyOzB{IN88US=> NXf2SZFxW0GQR1XS
CP50-MEL-B Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjBR25KSzVyPUmuN|A1OTlizszN NFLPW|hUSU6JRWK=
NCI-H1651 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[2eXd{UUN3ME2xNE4xOjd4IN88US=> NV7D[|YyW0GQR1XS
ABC-1 NUDxeohLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P2UGlEPTB;MUCuNVA{PyEQvF2= M3uxT3NCVkeHUh?=
OE19 M4PrdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHBN4lKSzVyPUGwMlE4OzNizszN M4\oeXNCVkeHUh?=
DSH1 NEnkUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVT6TpJvUUN3ME2xNE45QDd7IN88US=> MWTTRW5ITVJ?
SW13 NF7scWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILke3RKSzVyPUGxMlk{OTlizszN M4nJTXNCVkeHUh?=
MDA-MB-453 NIjidVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF{LkG2NFMh|ryP NWHPXpNCW0GQR1XS
647-V Ml7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XDfmlEPTB;MUKuN|U5OiEQvF2= NEnQZnFUSU6JRWK=
NCI-H2342 Mle1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTF{LkO5PVUh|ryP MY\TRW5ITVJ?
LB2241-RCC NXfsT5VVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlXhTWM2OD1zMj61O|c6KM7:TR?= NFOwfGFUSU6JRWK=
UACC-257 NFL5b3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnxbIdUUUN3ME2xN{41PDV|IN88US=> NUPuOGpCW0GQR1XS
NCI-H661 M1e2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTF|Lk[0OFkh|ryP NXe4eWpKW0GQR1XS
FADU M4H6OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O1fWlEPTB;MUOuOlk6OiEQvF2= MXXTRW5ITVJ?
A2780 M1zZcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILTPVdKSzVyPUGzMlgxPDFizszN MVrTRW5ITVJ?
NCI-H1793 M1r6Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\TTWM2OD1zND60NFg2KM7:TR?= NEjVWGRUSU6JRWK=
TE-8 Ml\3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fVdGlEPTB;MUWuN|Q3PSEQvF2= Mn;tV2FPT0WU
HGC-27 NGLmZWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXz4eo9lUUN3ME2xOk4yPjR2IN88US=> NFywdpNUSU6JRWK=
MMAC-SF NFzsNlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoH3TWM2OD1zNz6zO|I4KM7:TR?= M2DVNHNCVkeHUh?=
Calu-6 NIj4cWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLrZWZKSzVyPUG4MlE2OTNizszN NX3JPWRiW0GQR1XS
HUTU-80 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTF6LkO5OVkh|ryP MofRV2FPT0WU
SAS NHTkd5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi4[HlCUUN3ME2xPE43PDV3IN88US=> MYLTRW5ITVJ?
IST-MES1 NWXnepNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\BZ5lKSzVyPUG4MlY2ODhizszN M1fJNXNCVkeHUh?=
C3A Mk\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPXTWM2OD1zOD63PVE6KM7:TR?= MkHyV2FPT0WU
ES3 NY\oOVdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF6LkizOlQh|ryP NHW3SndUSU6JRWK=
HSC-2 M2X2PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jhR2lEPTB;MUmuOlU1OSEQvF2= NXHnbXFCW0GQR1XS
T47D MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVfwPIxIUUN3ME2yNE4yPDh3IN88US=> M3XkNnNCVkeHUh?=
EW-7 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{[wVWlEPTB;MkCuPFU5QCEQvF2= MmXNV2FPT0WU
LN-405 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTJyLki5OlUh|ryP MofOV2FPT0WU
U031 NFLEVHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH3TWM2OD1{MT60PFAzKM7:TR?= MUXTRW5ITVJ?
A549 M3Tze2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXuOVZKUUN3ME2yNU45PDlzIN88US=> NYfZfmhtW0GQR1XS
RMG-I M2m0W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEWwTndKSzVyPUKyMlI3PjhizszN NULRRWNLW0GQR1XS
BT-474 NV3aXllnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nuVGlEPTB;MkKuOlU2OSEQvF2= MWnTRW5ITVJ?
NB69 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUH4TXhOUUN3ME2yN{4yPTJizszN NGjKV3ZUSU6JRWK=
NB7 MkDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPQfWxKSzVyPUK0MlE5QCEQvF2= MXrTRW5ITVJ?
HCC1569 NYHjRZV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jMfGlEPTB;MkSuOlEzPSEQvF2= NV21dWFiW0GQR1XS
MEL-JUSO MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LhVmlEPTB;MkSuOlkxQCEQvF2= NHTLXZFUSU6JRWK=
MDA-MB-175-VII M3vhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12zWWlEPTB;MkWuNlUyPyEQvF2= NYrTb|RnW0GQR1XS
HCC1419 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2K3c2lEPTB;MkWuOlAxOyEQvF2= MWfTRW5ITVJ?
Ca9-22 Mn:3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r6[2lEPTB;MkWuOlQ{OiEQvF2= NX;PbZlFW0GQR1XS
KGN M{TxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoO0TWM2OD1{NT63OVQ4KM7:TR?= MnHlV2FPT0WU
LB373-MEL-D MlrNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17qTWlEPTB;Mk[uNVk{QCEQvF2= MkjEV2FPT0WU
NCI-H1755 M{DNd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NITlNFRKSzVyPUK2Mlg5PDFizszN MlTTV2FPT0WU
D-423MG NFy3bVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPlZ|RKSzVyPUK3MlA4OTVizszN MkHrV2FPT0WU
DK-MG NG\MSWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vUXGlEPTB;MkiuO|g1PiEQvF2= NWX4eZlKW0GQR1XS
NCI-H1623 Mm\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4OycmlEPTB;MkiuPFM1OiEQvF2= M1nBSHNCVkeHUh?=
KU-19-19 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVL2XnZ1UUN3ME2yPE46QTVizszN NYP2RpY5W0GQR1XS
C-33-A M4[x[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2iyO2lEPTB;MkmuNlE6QCEQvF2= MXvTRW5ITVJ?
SCC-4 Moe5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTNyLkOzOVQh|ryP NUS3S3F4W0GQR1XS
MG-63 NHXuTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknqTWM2OD1|MD61PVk1KM7:TR?= NIXjb25USU6JRWK=
LNCaP-Clone-FGC MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTNzLkS5NlEh|ryP NWTJ[VE5W0GQR1XS
CAPAN-1 NEfKO3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTqUJhKSzVyPUOxMlUzQDZizszN NFz1RXZUSU6JRWK=
GI-ME-N NGSwe5BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIK3S29KSzVyPUOxMlU{PTNizszN NHvYTlNUSU6JRWK=
RERF-LC-MS M{HtOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDCXm54UUN3ME2zNk43PzR5IN88US=> NIrXNZNUSU6JRWK=
KLE NIrRdFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nzVmlEPTB;M{OuOFM{PCEQvF2= M4jIe3NCVkeHUh?=
KNS-81-FD NXexXXhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnGwTWM2OD1|Mz61NFA5KM7:TR?= NW\2PFUyW0GQR1XS
DOK MoK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1ewcWlEPTB;M{SuOlYyOiEQvF2= Moq2V2FPT0WU
ACHN NHnK[FRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGmwSIVKSzVyPUO1MlE2QDhizszN NYXWfWUxW0GQR1XS
KYSE-520 MkDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHryXW1KSzVyPUO1MlI{PjFizszN NWfGb4RYW0GQR1XS
SBC-5 NVy3b4JOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;4SYhFUUN3ME2zOU42OTF4IN88US=> MWnTRW5ITVJ?
NCI-H28 NFPEWYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjMPZZqUUN3ME2zOU43Pjl3IN88US=> MYDTRW5ITVJ?
ES7 M4Cxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTN4LkKyOFkh|ryP NYfzUm1OW0GQR1XS
A172 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmnPTWM2OD1|Nj60NVg4KM7:TR?= M4HE[XNCVkeHUh?=
UM-UC-3 NES1dZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XVeWlEPTB;M{euPFc1PiEQvF2= NX3GXphHW0GQR1XS
LXF-289 M1SzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jXRWlEPTB;M{iuNFA1PyEQvF2= Mm\VV2FPT0WU
KP-4 NFTWVm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHvOoRKSzVyPUO4MlQ4OzlizszN MVrTRW5ITVJ?
TE-1 NFjtSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\Sc4ZYUUN3ME2zPU43PTh7IN88US=> NYTkclhHW0GQR1XS
G-402 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnFTWM2OD12MD6wOlEh|ryP NGqzTohUSU6JRWK=
786-0 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUfYdoNZUUN3ME20NE46ODl4IN88US=> NH6x[mZUSU6JRWK=
K5 MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPyWXRKSzVyPUSxMlM3QDZizszN MoSxV2FPT0WU
SK-N-DZ MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrwNVhGUUN3ME20NU4{QDJ|IN88US=> MVfTRW5ITVJ?
OVCAR-4 NV73UIhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTRzLke1Olgh|ryP Mn\HV2FPT0WU
T84 NUHQbIZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi2TWM2OD12Mj6xNlY{KM7:TR?= MXTTRW5ITVJ?
GCIY NGjZUmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXNOHJKSzVyPUSzMlA5ODNizszN M4X4[nNCVkeHUh?=
BB49-HNC MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTR|LkOzOFgh|ryP M1\2cnNCVkeHUh?=
SNU-C2B M{XzXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\ub3dKSzVyPUSzMlY1OzZizszN MmDUV2FPT0WU
TE-6 NHXpT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEnpcWpKSzVyPUSzMlg5QTRizszN M3eybnNCVkeHUh?=
23132-87 MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NE\sWGZKSzVyPUS0MlI6PzhizszN MWXTRW5ITVJ?
DMS-53 M3fu[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\teGlEPTB;NESuN|M5PCEQvF2= M17BWXNCVkeHUh?=
ONS-76 M4jh[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR2Lke2OlEh|ryP NUfLTW86W0GQR1XS
DMS-273 M{f1Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDTVG9KSzVyPUS0Mlk1OyEQvF2= NWHVNHU{W0GQR1XS
COLO-824 M3jM[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXMTWM2OD12NT64O|c2KM7:TR?= M3P0ZXNCVkeHUh?=
DMS-114 NWTLbI4xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHLTWM2OD12NT64PVI4KM7:TR?= NX3hXXJ4W0GQR1XS
YKG-1 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TUZ2lEPTB;NE[uNFM2PSEQvF2= Mn\mV2FPT0WU
RH-18 NXXXUWJyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjh[VZqUUN3ME20Ok4{PzN|IN88US=> M{js[3NCVkeHUh?=
NCI-H1355 M2fySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLLTWM2OD12Nj62NVgh|ryP M{CzbXNCVkeHUh?=
NCI-H2170 NGrYPGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTxTWM2OD12Nz63OVg1KM7:TR?= M{PIbnNCVkeHUh?=
OC-314 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTR5Lki0O|gh|ryP NIPGeHJUSU6JRWK=
NCI-H2030 NX3jTJIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEiyNXdKSzVyPUS3Mlg6ODZizszN NIPyfW1USU6JRWK=
22RV1 M3rrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTJVoZsUUN3ME20O{46ODF3IN88US=> MnLMV2FPT0WU
G-401 MoHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfYTWM2OD12OD60OFE2KM7:TR?= MnX5V2FPT0WU
YAPC NHfrfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLES3lKSzVyPUS5MlgxPzNizszN NF[0UIlUSU6JRWK=
SW1573 M1PGWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnyTWM2OD13MD6yOFM2KM7:TR?= M3vERXNCVkeHUh?=
COLO-792 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzzUYhKSzVyPUWwMlYzOzdizszN MVnTRW5ITVJ?
KNS-62 NYX1TYw3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD4SplRUUN3ME21NE44PTB6IN88US=> M{\KPXNCVkeHUh?=
NB5 NUHkZZQ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vyemlEPTB;NUGuOFUxQSEQvF2= MVTTRW5ITVJ?
CP66-MEL M{D1Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\lW4xTUUN3ME21NU43PDB6IN88US=> NIPyXlZUSU6JRWK=
CaR-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTV{LkC2NFYh|ryP M3rFWXNCVkeHUh?=
CAL-54 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;5TWM2OD13Mj6xNVAzKM7:TR?= NIf4[4FUSU6JRWK=
8305C MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfab5VKSzVyPUWyMlMyPSEQvF2= M1XJZ3NCVkeHUh?=
Calu-3 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTV{LkO3N|Mh|ryP MVLTRW5ITVJ?
AU565 M2LaNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjDSYhJUUN3ME21Nk42PTB7IN88US=> NXPCS49IW0GQR1XS
CW-2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mon5TWM2OD13Mj64OlU1KM7:TR?= NIT4do1USU6JRWK=
BEN MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTV|Lke4OlIh|ryP Ml7mV2FPT0WU
NCI-H1975 NXrtbm9PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmKzTWM2OD13Mz64PVY3KM7:TR?= NX7mWGpwW0GQR1XS
HCT-116 NEDIXXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jOXmlEPTB;NUSuNFMzPyEQvF2= Mkn0V2FPT0WU
SH-4 NXPsUoIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYDxdpN6UUN3ME21OE4yOzhizszN MnLGV2FPT0WU
NCI-H1693 NVLPflNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVTJR|UxRTV2LkKxNFMh|ryP NYLLUFdRW0GQR1XS
BPH-1 NHPQdlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mnr1TWM2OD13NT6yPFkzKM7:TR?= M{jLeXNCVkeHUh?=
CAMA-1 M{jhUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHsTWM2OD13NT64NVE3KM7:TR?= NH:3PGVUSU6JRWK=
A388 Ml\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHoe4tKSzVyPUW2MlA6QDVizszN Mm\MV2FPT0WU
C2BBe1 NXfCSGxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLwTWM2OD13Nj6yOlM1KM7:TR?= MUDTRW5ITVJ?
GAMG NUToS3V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnNTWM2OD13Nj61PVU2KM7:TR?= MoL3V2FPT0WU
MKN28 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37n[GlEPTB;NU[uPFAyOyEQvF2= M4O0ZnNCVkeHUh?=
VA-ES-BJ NVW2SIVRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEn5VllKSzVyPUW2Mlg4PDVizszN MXzTRW5ITVJ?
HuCCT1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTV5LkC0PVIh|ryP MXzTRW5ITVJ?
BFTC-905 M3P4XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj4XIxNUUN3ME21O{4zQDl6IN88US=> MXzTRW5ITVJ?
LS-123 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\3dWlEPTB;NUeuOVY3QCEQvF2= MUPTRW5ITVJ?
LB996-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPqTWM2OD13OD6wNlg4KM7:TR?= NWDSXHkxW0GQR1XS
NCI-H1048 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvnNYxwUUN3ME21PE4zOTh6IN88US=> MmDBV2FPT0WU
COR-L105 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVm0OWZ6UUN3ME21PE44OzN5IN88US=> NWLMeHEzW0GQR1XS
OVCAR-8 NGjHVYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL3TWM2OD13OT6xO|E3KM7:TR?= NXHI[WRCW0GQR1XS
SK-N-FI NGfSOoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;HN4I6UUN3ME21PU4{OjB5IN88US=> MkXxV2FPT0WU
MES-SA M1;tZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTV7LkS1NFkh|ryP MYLTRW5ITVJ?
SCC-9 NXPVc5BqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzVTWM2OD13OT60O|U{KM7:TR?= MYjTRW5ITVJ?
EFO-27 NUfUNJpCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXXTWM2OD13OT65OFMh|ryP NXTmWZc3W0GQR1XS
GT3TKB MkXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfpTXdKSzVyPU[wMlYxPDhizszN NFryPFJUSU6JRWK=
HCC38 NF\RWY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrlTWM2OD14MT60N|c6KM7:TR?= NYLRclVvW0GQR1XS
MLMA NHfnVXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILHVWlKSzVyPU[xMlYyPjNizszN NInneWdUSU6JRWK=
D-566MG NYftc4l5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXsTWM2OD14Mz61NlI1KM7:TR?= MoC1V2FPT0WU
SF295 M4LMeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLGRnUzUUN3ME22N{43PjV3IN88US=> MWHTRW5ITVJ?
ES4 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXLSHVXUUN3ME22OE41PzF7IN88US=> MkTtV2FPT0WU
CAKI-1 NUD1W|lPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnITWM2OD14ND61O|IyKM7:TR?= MXrTRW5ITVJ?
OAW-28 NVHISI85T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF:yPXBKSzVyPU[0Mlk3PDdizszN MYrTRW5ITVJ?
NCI-H460 NV\l[HVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY[4dZV3UUN3ME22OU4xQDl5IN88US=> MlP5V2FPT0WU
JAR MljCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT4XphKSzVyPU[1MlU2OTZizszN MX3TRW5ITVJ?
SNU-449 NGHscY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYPadVlxUUN3ME22OU44PjF4IN88US=> NUHZdppxW0GQR1XS
D-392MG NX7jVXM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T4bWlEPTB;NkWuPVQ{PCEQvF2= NHnSdldUSU6JRWK=
EW-22 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\qUGg4UUN3ME22Ok4{QTVizszN MUnTRW5ITVJ?
GCT MkfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjHfVBKSzVyPU[3MlA1PDNizszN MoXZV2FPT0WU
NOS-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPTTWM2OD14Nz62PFY4KM7:TR?= NWrVZotVW0GQR1XS
RH-1 M17kUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPwbndKSzVyPU[4MlU2PTlizszN NF64b2ZUSU6JRWK=
HuH-7 NUfxfoZST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG2N5RKSzVyPU[5MlExODJizszN NYHQU4N2W0GQR1XS
NUGC-3 M{GyNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnhblVKSzVyPUewMlk3PDRizszN M4DYenNCVkeHUh?=
IST-SL1 NVn2enlWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrGXW5rUUN3ME23NU4zOzJ2IN88US=> NXX1OlJQW0GQR1XS
SHP-77 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\LcZFuUUN3ME23Nk4yOTlizszN NFzMW|lUSU6JRWK=
SW1116 Ml64S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXHjWZY3UUN3ME23Nk4yPDB5IN88US=> MkHQV2FPT0WU
LK-2 M1qxWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYj1WVJmUUN3ME23Nk45PjF{IN88US=> MnTPV2FPT0WU
U-2-OS NF\LSXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEHUdm1KSzVyPUezMlE5OjhizszN NHzuZXRUSU6JRWK=
KYSE-150 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPHVG14UUN3ME23N{43OTF6IN88US=> M{\tVXNCVkeHUh?=
U251 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEPxTlVKSzVyPUezMlgyPjhizszN NWTxN3ZpW0GQR1XS
HT-1080 Ml7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTd2LkK1O|Qh|ryP M3nRNnNCVkeHUh?=
NCI-H1437 M{DNfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ezfWlEPTB;N{SuOlMzPiEQvF2= Mn3rV2FPT0WU
HPAF-II NVn3foxbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7hNYpKSzVyPUe0MlY1OTVizszN MYXTRW5ITVJ?
Becker MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnmyTWM2OD15NT6xNVA2KM7:TR?= M1H3PHNCVkeHUh?=
PANC-10-05 NHv2[HZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjnTWM2OD15NT6yPFY2KM7:TR?= NVnKVHhTW0GQR1XS
TYK-nu M{i2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DaSmlEPTB;N{WuN|ExOiEQvF2= NGjIcZVUSU6JRWK=
SKG-IIIa NVnvTYlLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7EeZpbUUN3ME23OU4{OzRzIN88US=> MlvNV2FPT0WU
NCI-H1993 M{K5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTd3LkezPVch|ryP M4L6T3NCVkeHUh?=
S-117 M4exdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTd3Lke1OUDPxE1? NGrRZnFUSU6JRWK=
HuO9 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlGyTWM2OD15Nj6wNFQ5KM7:TR?= NYPr[HR[W0GQR1XS
CAL-51 NFLISm1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTd4LkGwNFYh|ryP M1nscXNCVkeHUh?=
BT-20 MmHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfJTWM2OD15Nj6yNVY5KM7:TR?= Ml\zV2FPT0WU
LB831-BLC NH[2SnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjITWM2OD15Nj6zNlE4KM7:TR?= NIC3PGpUSU6JRWK=
LB1047-RCC NWS1cYxnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzxTWM2OD15Nj63OlE6KM7:TR?= M1fUb3NCVkeHUh?=
ES8 NXW5UFBIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkTITWM2OD15OD6wNFc{KM7:TR?= NXTPSmhXW0GQR1XS
UMC-11 M1nISWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTd6LkC4PFQh|ryP NGm5NZdUSU6JRWK=
NCI-H226 NFHpeGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTd6LkGzNVUh|ryP Mk\kV2FPT0WU
IGROV-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTd6LkW1OUDPxE1? NHLze2JUSU6JRWK=
BHY NUX4VHNRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG1U2RKSzVyPUe5MlU6PiEQvF2= MUfTRW5ITVJ?
MKN45 MmjlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD5Z4REUUN3ME24NE4{OTd2IN88US=> NIfNeIVUSU6JRWK=
IA-LM MlnTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonyTWM2OD16MD6zOVEyKM7:TR?= MlvUV2FPT0WU
WM-115 NWfiNIRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rhc2lEPTB;OEGuOFEyPCEQvF2= NWWyWFFHW0GQR1XS
VMRC-RCZ NXexW3pUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkS4TWM2OD16MT60OFI2KM7:TR?= NGfo[IFUSU6JRWK=
NCI-H2291 M3GzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRThzLk[4OFIh|ryP MkD4V2FPT0WU
MCF7 NH;Sb2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTh|LkK4PVch|ryP MYDTRW5ITVJ?
639-V NIfNZ2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTh2Lk[xNlkh|ryP MVvTRW5ITVJ?
RT4 M3rlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTh3LkK0NFMh|ryP MYHTRW5ITVJ?
NCI-H2405 NHXyZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4OxbmlEPTB;OEWuNlk6PyEQvF2= MljFV2FPT0WU
CAL-33 MkLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLxTWM2OD16NT62N|E2KM7:TR?= M3HIenNCVkeHUh?=
BT-549 MkCwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLzd4VKSzVyPUi1Mlk{QDJizszN Ml;yV2FPT0WU
HT-1197 NIfWWINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTwcGJKSzVyPUi4MlExPzdizszN M3\VbnNCVkeHUh?=
G-361 NEK5NpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2C3fGlEPTB;OEiuNVQ4PCEQvF2= MXPTRW5ITVJ?
LS-411N NFi3[GpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLhbJhKSzVyPUi5MlM{QDhizszN NF7GUnZUSU6JRWK=
HT-144 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPhTWM2OD16OT61PVkzKM7:TR?= NELBZ3FUSU6JRWK=
DJM-1 M4H6T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILXTnFKSzVyPUi5Mlg5PDVizszN NWLSVVFkW0GQR1XS
CAL-12T MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\iTWM2OD17MD63PFk2KM7:TR?= M4\RUHNCVkeHUh?=
MKN7 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;kTWM2OD17MT6zOVUyKM7:TR?= Mo\4V2FPT0WU
HuP-T3 M{G5WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG0T4RKSzVyPUm2MlExODRizszN NYjPUoFsW0GQR1XS
SK-MG-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTl4LkGzOFgh|ryP MXHTRW5ITVJ?
NCI-H2347 NH60PWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTl6LkGwOFIh|ryP NXH2Z2dsW0GQR1XS
SW872 Mm\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPS[G9KSzVyPUGwNE41PTZizszN M2LlXnNCVkeHUh?=
COLO-829 NYfs[pJvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTFyMD61OVMh|ryP M33vVnNCVkeHUh?=
MC-IXC NWLLSmc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnfVTWM2OD1zMECuOlE2KM7:TR?= MlrsV2FPT0WU

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water <1 mg/mL
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 30 mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

Related S6 Kinase Products

Tags: buy PF-4708671 | PF-4708671 supplier | purchase PF-4708671 | PF-4708671 cost | PF-4708671 manufacturer | order PF-4708671 | PF-4708671 distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID