PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rKc2lEPTB;MD64NlAzPCEQvF2= NHi5OW5USU6JRWK=
UACC-893 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTaOXdKSzVyPUWuNVk5QDZizszN M3mwWnNCVkeHUh?=
A427 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXne3RKSzVyPUWuO|I2PjdizszN NGrhUGpUSU6JRWK=
OCUB-M M2TUVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vFbWlEPTB;Nj62OlExOiEQvF2= MojuV2FPT0WU
SW684 NGTrUIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LHTWlEPTB;Nz61NlI3QCEQvF2= NHfhfHBUSU6JRWK=
SK-LMS-1 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYW5RmpYUUN3ME25MlAyOzB{IN88US=> Mnz6V2FPT0WU
CP50-MEL-B MoiyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnXRWJKSzVyPUmuN|A1OTlizszN MoTXV2FPT0WU
NCI-H1651 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTFyLkCyO|Yh|ryP NHzGcFRUSU6JRWK=
ABC-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vaSmlEPTB;MUCuNVA{PyEQvF2= M2PMfnNCVkeHUh?=
OE19 Mk\PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1K2RWlEPTB;MUCuNVc{OyEQvF2= MkXPV2FPT0WU
DSH1 NHnUcIJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFyLki4O|kh|ryP MY\TRW5ITVJ?
SW13 Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmGyTWM2OD1zMT65N|E6KM7:TR?= MYjTRW5ITVJ?
MDA-MB-453 NYPOfWZxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{nKVWlEPTB;MUKuNVYxOyEQvF2= MX\TRW5ITVJ?
647-V NIrXVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnKdnBKSzVyPUGyMlM2QDJizszN MVvTRW5ITVJ?
NCI-H2342 NGPHbJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrPTWM2OD1zMj6zPVk2KM7:TR?= M3[3fnNCVkeHUh?=
LB2241-RCC MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTF{LkW3O|kh|ryP NG\h[mtUSU6JRWK=
UACC-257 M4\lc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3e5SWlEPTB;MUOuOFQ2OyEQvF2= MVjTRW5ITVJ?
NCI-H661 NX\xbGd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTF|Lk[0OFkh|ryP MlvUV2FPT0WU
FADU M1TrR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTF|Lk[5PVIh|ryP NGHMOGxUSU6JRWK=
A2780 M1HVS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTF|LkiwOFEh|ryP NF\ZfHhUSU6JRWK=
NCI-H1793 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXwboEyUUN3ME2xOE41ODh3IN88US=> NUXYb4hzW0GQR1XS
TE-8 M3P1Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\VTWM2OD1zNT6zOFY2KM7:TR?= NWnpS4wxW0GQR1XS
HGC-27 MljMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPxTWM2OD1zNj6xOlQ1KM7:TR?= NXzZcJBSW0GQR1XS
MMAC-SF NYXoXnlXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV7Nc5BMUUN3ME2xO{4{PzJ5IN88US=> NWD1cpFuW0GQR1XS
Calu-6 NWDTN5lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV32WG9NUUN3ME2xPE4yPTF|IN88US=> M1OwN3NCVkeHUh?=
HUTU-80 NHSxeW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGG2NVZKSzVyPUG4MlM6PTlizszN NWr5Ulh[W0GQR1XS
SAS M4S3fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWq3OoV2UUN3ME2xPE43PDV3IN88US=> MV;TRW5ITVJ?
IST-MES1 NIXN[oVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\KVmlEPTB;MUiuOlUxQCEQvF2= MnroV2FPT0WU
C3A M4nKb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\GfYVjUUN3ME2xPE44QTF7IN88US=> NFzPRmpUSU6JRWK=
ES3 NXXYe49rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfyTWM2OD1zOD64N|Y1KM7:TR?= MkfyV2FPT0WU
HSC-2 M4fUdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\NXYZZUUN3ME2xPU43PTRzIN88US=> Mn3aV2FPT0WU
T47D M2PHd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jsWmlEPTB;MkCuNVQ5PSEQvF2= MoXnV2FPT0WU
EW-7 NY\ROGd4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfKb3VKSzVyPUKwMlg2QDhizszN NUjxZ4NJW0GQR1XS
LN-405 NWizfmFYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK1W5RKSzVyPUKwMlg6PjVizszN Mmf1V2FPT0WU
U031 M4nMW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHTnSoNKSzVyPUKxMlQ5ODJizszN MYDTRW5ITVJ?
A549 M1;jfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJzLki0PVEh|ryP NWPtNoZlW0GQR1XS
RMG-I M4Lue2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjQUFRKSzVyPUKyMlI3PjhizszN NXi2W3NHW0GQR1XS
BT-474 MkDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITvR5lKSzVyPUKyMlY2PTFizszN MUTTRW5ITVJ?
NB69 M1rtO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HNbGlEPTB;MkOuNVUzKM7:TR?= M1ja[3NCVkeHUh?=
NB7 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEK4UJhKSzVyPUK0MlE5QCEQvF2= MoHDV2FPT0WU
HCC1569 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL0TWM2OD1{ND62NVI2KM7:TR?= MVPTRW5ITVJ?
MEL-JUSO NW\xSGVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPGNYxKSzVyPUK0MlY6ODhizszN NHPhTGJUSU6JRWK=
MDA-MB-175-VII NVjt[3puT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknSTWM2OD1{NT6yOVE4KM7:TR?= MVzTRW5ITVJ?
HCC1419 MlvzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M16zTGlEPTB;MkWuOlAxOyEQvF2= NWW5bYhbW0GQR1XS
Ca9-22 NEf0cmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn2UVJsUUN3ME2yOU43PDN{IN88US=> MoHUV2FPT0WU
KGN NVvjUpFlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGW4OG1KSzVyPUK1Mlc2PDdizszN MoXtV2FPT0WU
LB373-MEL-D MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13IfGlEPTB;Mk[uNVk{QCEQvF2= NGHUN|VUSU6JRWK=
NCI-H1755 M{jZSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrGTWM2OD1{Nj64PFQyKM7:TR?= NWXG[ZZ3W0GQR1XS
D-423MG M4KxcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJ5LkC3NVUh|ryP MknCV2FPT0WU
DK-MG NVy1fHBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvJSW1PUUN3ME2yPE44QDR4IN88US=> M1zDSXNCVkeHUh?=
NCI-H1623 M{fvRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M32wVmlEPTB;MkiuPFM1OiEQvF2= NUe0c496W0GQR1XS
KU-19-19 MmjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGnmbWZKSzVyPUK4Mlk6PSEQvF2= MWfTRW5ITVJ?
C-33-A NFTZdnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7TS2pzUUN3ME2yPU4zOTl6IN88US=> M2nrTHNCVkeHUh?=
SCC-4 MknDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDQS2h[UUN3ME2zNE4{OzV2IN88US=> MVHTRW5ITVJ?
MG-63 MnTJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTNyLkW5PVQh|ryP NXnSUJJMW0GQR1XS
LNCaP-Clone-FGC NX;XTWFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTNzLkS5NlEh|ryP MlHJV2FPT0WU
CAPAN-1 NXjlNYl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTNzLkWyPFYh|ryP MV7TRW5ITVJ?
GI-ME-N MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUGzUmRGUUN3ME2zNU42OzV|IN88US=> NHrUN3RUSU6JRWK=
RERF-LC-MS M{foXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlv6TWM2OD1|Mj62O|Q4KM7:TR?= NVvyeFRRW0GQR1XS
KLE NFjEdZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTN|LkSzN|Qh|ryP MWLTRW5ITVJ?
KNS-81-FD NUW2UYloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrT[ox4UUN3ME2zN{42ODB6IN88US=> MmruV2FPT0WU
DOK NHr0T29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILzTnZKSzVyPUO0MlY3OTJizszN NVjze|dEW0GQR1XS
ACHN NIH4WWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTN3LkG1PFgh|ryP NGS2Nm5USU6JRWK=
KYSE-520 NEC0TYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjZVFNKSzVyPUO1MlI{PjFizszN NIHFWWpUSU6JRWK=
SBC-5 NXziZmFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[ybWlEPTB;M{WuOVEyPiEQvF2= NYLZU4plW0GQR1XS
NCI-H28 MmLNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUfJR|UxRTN3Lk[2PVUh|ryP NVPXUVBDW0GQR1XS
ES7 Mm[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrVXYNKSzVyPUO2MlIzPDlizszN NEDFeY5USU6JRWK=
A172 NInwUY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XL[GlEPTB;M{[uOFE5PyEQvF2= MUPTRW5ITVJ?
UM-UC-3 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLVTWM2OD1|Nz64O|Q3KM7:TR?= MYHTRW5ITVJ?
LXF-289 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjvPXRKSzVyPUO4MlAxPDdizszN NH;OTFhUSU6JRWK=
KP-4 Mor5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HSR2lEPTB;M{iuOFc{QSEQvF2= Ml;hV2FPT0WU
TE-1 NYnDb4xMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{P5O2lEPTB;M{muOlU5QSEQvF2= MkTBV2FPT0WU
G-402 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37wPWlEPTB;NECuNFYyKM7:TR?= NXPkbYwyW0GQR1XS
786-0 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTRyLkmwPVYh|ryP NV3rWmN7W0GQR1XS
K5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\hd2lEPTB;NEGuN|Y5PiEQvF2= NULzW2R1W0GQR1XS
SK-N-DZ MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjvTWM2OD12MT6zPFI{KM7:TR?= NH7TdGRUSU6JRWK=
OVCAR-4 M1Tpfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\kTWM2OD12MT63OVY5KM7:TR?= MlTLV2FPT0WU
T84 MmHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjl[5pGUUN3ME20Nk4yOjZ|IN88US=> Ml7NV2FPT0WU
GCIY NVrpbZpiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHsNYtKSzVyPUSzMlA5ODNizszN MnT2V2FPT0WU
BB49-HNC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTR|LkOzOFgh|ryP MV3TRW5ITVJ?
SNU-C2B MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDRfmEzUUN3ME20N{43PDN4IN88US=> M1jE[XNCVkeHUh?=
TE-6 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4OwdmlEPTB;NEOuPFg6PCEQvF2= MUfTRW5ITVJ?
23132-87 M1HXTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHsbI1KSzVyPUS0MlI6PzhizszN M3XySHNCVkeHUh?=
DMS-53 NIfQRoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESwd2dKSzVyPUS0MlM{QDRizszN MoTzV2FPT0WU
ONS-76 NFm1ZZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDhTWREUUN3ME20OE44PjZzIN88US=> MXTTRW5ITVJ?
DMS-273 M1vEPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnO5TWM2OD12ND65OFMh|ryP NYHDeWdWW0GQR1XS
COLO-824 NVTST5ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTR3Lki3O|Uh|ryP NYPrb3lmW0GQR1XS
DMS-114 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTR3Lki5Nlch|ryP MXjTRW5ITVJ?
YKG-1 M1fyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny4TWM2OD12Nj6wN|U2KM7:TR?= MX\TRW5ITVJ?
RH-18 MmPZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nDNWlEPTB;NE[uN|c{OyEQvF2= MoO0V2FPT0WU
NCI-H1355 M4nrfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTR4Lk[xPEDPxE1? NIDhNnhUSU6JRWK=
NCI-H2170 NU\HUWdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\rS4JKSzVyPUS3Mlc2QDRizszN M4nvVnNCVkeHUh?=
OC-314 NVL4THdsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjsWGVKSzVyPUS3Mlg1PzhizszN NEK5R4xUSU6JRWK=
NCI-H2030 NFLTUlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rVdGlEPTB;NEeuPFkxPiEQvF2= NFntW3JUSU6JRWK=
22RV1 M3W2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\TTWM2OD12Nz65NFE2KM7:TR?= MVPTRW5ITVJ?
G-401 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkn2TWM2OD12OD60OFE2KM7:TR?= MX7TRW5ITVJ?
YAPC MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlruTWM2OD12OT64NFc{KM7:TR?= M{TyN3NCVkeHUh?=
SW1573 NHLTV29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTVyLkK0N|Uh|ryP NILOO|FUSU6JRWK=
COLO-792 NWfRSmVGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTVyLk[yN|ch|ryP NIX6XmVUSU6JRWK=
KNS-62 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTVyLke1NFgh|ryP MUDTRW5ITVJ?
NB5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEC5R3VKSzVyPUWxMlQ2ODlizszN NI\afVZUSU6JRWK=
CP66-MEL M4KxZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzMc2tKSzVyPUWxMlY1ODhizszN NYTKeYZ3W0GQR1XS
CaR-1 M324UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mxZWlEPTB;NUKuNFYxPiEQvF2= MVXTRW5ITVJ?
CAL-54 NVP4TFB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPyTY9LUUN3ME21Nk4yOTB{IN88US=> NH7hNG5USU6JRWK=
8305C NIf2XWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXRTWM2OD13Mj6zNVUh|ryP M1\V[XNCVkeHUh?=
Calu-3 NF6xdHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTNcIEzUUN3ME21Nk4{PzN|IN88US=> NEjpS3NUSU6JRWK=
AU565 M3rFfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2KxZWlEPTB;NUKuOVUxQSEQvF2= MULTRW5ITVJ?
CW-2 NVHycoR3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\ZWIplUUN3ME21Nk45PjV2IN88US=> MVfTRW5ITVJ?
BEN MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjSd4R7UUN3ME21N{44QDZ{IN88US=> NXH4UJhGW0GQR1XS
NCI-H1975 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTV|Lki5OlYh|ryP M3OwbHNCVkeHUh?=
HCT-116 NWDsPWNmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknHTWM2OD13ND6wN|I4KM7:TR?= NUe1RVQyW0GQR1XS
SH-4 M4\jW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo[2TWM2OD13ND6xN|gh|ryP MX3TRW5ITVJ?
NCI-H1693 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\zcZdVUUN3ME21OE4zOTB|IN88US=> NVzkc3hzW0GQR1XS
BPH-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTV3LkK4PVIh|ryP MVjTRW5ITVJ?
CAMA-1 Mlv5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTV3LkixNVYh|ryP NWLqVpRyW0GQR1XS
A388 NH\vTI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTV4LkC5PFUh|ryP NHzIUIJUSU6JRWK=
C2BBe1 NWPPe5pPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTV4LkK2N|Qh|ryP NVj1U4NQW0GQR1XS
GAMG NWe3N5ExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4[zXWlEPTB;NU[uOVk2PSEQvF2= MnXQV2FPT0WU
MKN28 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqzTWM2OD13Nj64NFE{KM7:TR?= M2fvU3NCVkeHUh?=
VA-ES-BJ NYraXIhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmzbIdKSzVyPUW2Mlg4PDVizszN MWPTRW5ITVJ?
HuCCT1 NUi3XodjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3HTWM2OD13Nz6wOFkzKM7:TR?= M1\PVnNCVkeHUh?=
BFTC-905 NXXVb|VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnHXI5KSzVyPUW3MlI5QThizszN NYHNO49JW0GQR1XS
LS-123 NY\McHN4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXz3e25pUUN3ME21O{42PjZ6IN88US=> MoPCV2FPT0WU
LB996-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrFTWM2OD13OD6wNlg4KM7:TR?= MnvqV2FPT0WU
NCI-H1048 M3fQR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mof3TWM2OD13OD6yNVg5KM7:TR?= NVXGRXk5W0GQR1XS
COR-L105 NVrOXZNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnH6TWM2OD13OD63N|M4KM7:TR?= MYrTRW5ITVJ?
OVCAR-8 NVfYcXFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjaTWM2OD13OT6xO|E3KM7:TR?= MmO0V2FPT0WU
SK-N-FI MlLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{fLTmlEPTB;NUmuN|IxPyEQvF2= NGToNWdUSU6JRWK=
MES-SA M4Lr[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHiwfHVKSzVyPUW5MlQ2ODlizszN MUXTRW5ITVJ?
SCC-9 NF7WXmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XMeGlEPTB;NUmuOFc2OyEQvF2= NF\md4pUSU6JRWK=
EFO-27 NUC0NmdET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DQcmlEPTB;NUmuPVQ{KM7:TR?= MX7TRW5ITVJ?
GT3TKB M2HidWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1qzXmlEPTB;NkCuOlA1QCEQvF2= MkntV2FPT0WU
HCC38 MljnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPQR4J5UUN3ME22NU41Ozd7IN88US=> MYLTRW5ITVJ?
MLMA NFracmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWWzclhGUUN3ME22NU43OTZ|IN88US=> NUC5PGRSW0GQR1XS
D-566MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLwTWM2OD14Mz61NlI1KM7:TR?= Mn\wV2FPT0WU
SF295 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfNTWM2OD14Mz62OlU2KM7:TR?= M{DuUHNCVkeHUh?=
ES4 NHvC[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVviblFuUUN3ME22OE41PzF7IN88US=> MnTjV2FPT0WU
CAKI-1 NEjrWJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjHbpZmUUN3ME22OE42PzJzIN88US=> NYi4ZYJRW0GQR1XS
OAW-28 M4jF[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTZ2Lkm2OFch|ryP NHjwepVUSU6JRWK=
NCI-H460 NWr3fXNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnu4TWM2OD14NT6wPFk4KM7:TR?= MWPTRW5ITVJ?
JAR MnrKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEDCSplKSzVyPU[1MlU2OTZizszN MVLTRW5ITVJ?
SNU-449 NF\Jd|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDXV2pTUUN3ME22OU44PjF4IN88US=> MWHTRW5ITVJ?
D-392MG MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTOTWM2OD14NT65OFM1KM7:TR?= M13GbXNCVkeHUh?=
EW-22 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXXJR|UxRTZ4LkO5OUDPxE1? M1\YWXNCVkeHUh?=
GCT NFTHVXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHX2XnFKSzVyPU[3MlA1PDNizszN MlvLV2FPT0WU
NOS-1 Mn;aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfWUWxKSzVyPU[3MlY5PjdizszN NYjuU4FrW0GQR1XS
RH-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYLJR|UxRTZ6LkW1OVkh|ryP MX;TRW5ITVJ?
HuH-7 NXXnUHY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnToTWM2OD14OT6xNFAzKM7:TR?= NYDZbHc6W0GQR1XS
NUGC-3 NHzxSXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nTVGlEPTB;N{CuPVY1PCEQvF2= MnfMV2FPT0WU
IST-SL1 NUjXV3JsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHuzd29KSzVyPUexMlI{OjRizszN NULJVmNXW0GQR1XS
SHP-77 NInhO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHrTWM2OD15Mj6xNVkh|ryP NVvWPHNCW0GQR1XS
SW1116 NV64OFU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIHNdnFKSzVyPUeyMlE1ODdizszN NELtU3lUSU6JRWK=
LK-2 Mk\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn0dFZiUUN3ME23Nk45PjF{IN88US=> M333SXNCVkeHUh?=
U-2-OS MnfES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fhNWlEPTB;N{OuNVgzQCEQvF2= M4X4fnNCVkeHUh?=
KYSE-150 NV\0cXdCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfVVIxGUUN3ME23N{43OTF6IN88US=> MXjTRW5ITVJ?
U251 MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6xTWM2OD15Mz64NVY5KM7:TR?= MmfFV2FPT0WU
HT-1080 NUjP[lAzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTd2LkK1O|Qh|ryP M3\BWnNCVkeHUh?=
NCI-H1437 M1npemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3SeJRKSzVyPUe0MlY{OjZizszN NH3yZVFUSU6JRWK=
HPAF-II MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHr4bmdKSzVyPUe0MlY1OTVizszN M2XtNnNCVkeHUh?=
Becker Mny2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPsTWM2OD15NT6xNVA2KM7:TR?= NYrNTlBiW0GQR1XS
PANC-10-05 NV22e3YzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjOXXZtUUN3ME23OU4zQDZ3IN88US=> MXvTRW5ITVJ?
TYK-nu M2f6SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTd3LkOxNFIh|ryP MUfTRW5ITVJ?
SKG-IIIa NX7nUXhJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4j0V2lEPTB;N{WuN|M1OSEQvF2= NIHydmhUSU6JRWK=
NCI-H1993 Mn\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFj6VmZKSzVyPUe1Mlc{QTdizszN NF\1V|NUSU6JRWK=
S-117 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HHZ2lEPTB;N{WuO|U2KM7:TR?= NFjQ[HJUSU6JRWK=
HuO9 MoTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTd4LkCwOFgh|ryP NHv0WnpUSU6JRWK=
CAL-51 NWHqeIR[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHwdZl5UUN3ME23Ok4yODB4IN88US=> Mn7KV2FPT0WU
BT-20 NXjWdlhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXVUJFKSzVyPUe2MlIyPjhizszN NFqzS|dUSU6JRWK=
LB831-BLC MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPBZoNKSzVyPUe2MlMzOTdizszN M{O2bHNCVkeHUh?=
LB1047-RCC M1XKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTH[5BRUUN3ME23Ok44PjF7IN88US=> MmPsV2FPT0WU
ES8 NX76N|ZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGn5RZdKSzVyPUe4MlAxPzNizszN M4TUPXNCVkeHUh?=
UMC-11 M2O0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTd6LkC4PFQh|ryP MXXTRW5ITVJ?
NCI-H226 M1LPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTd6LkGzNVUh|ryP MonxV2FPT0WU
IGROV-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTd6LkW1OUDPxE1? NUH3dJg6W0GQR1XS
BHY M3PqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTd7LkW5OkDPxE1? NVSye5JCW0GQR1XS
MKN45 NVrab4J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[5TWM2OD16MD6zNVc1KM7:TR?= MV7TRW5ITVJ?
IA-LM NXyxSXZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmHqTWM2OD16MD6zOVEyKM7:TR?= NIixZ|JUSU6JRWK=
WM-115 NHTxSlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTRTWM2OD16MT60NVE1KM7:TR?= NEHO[XpUSU6JRWK=
VMRC-RCZ MlGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLUV4ZCUUN3ME24NU41PDJ3IN88US=> NYm5S3ZWW0GQR1XS
NCI-H2291 NVXUU|dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7qSpRKSzVyPUixMlY5PDJizszN M3L6W3NCVkeHUh?=
MCF7 M4G4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPzfIdKSzVyPUizMlI5QTdizszN MkLMV2FPT0WU
639-V NVPWcoVbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLZTWM2OD16ND62NVI6KM7:TR?= NWPvZpBCW0GQR1XS
RT4 NH3UPXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TQVWlEPTB;OEWuNlQxOyEQvF2= NV7J[XZZW0GQR1XS
NCI-H2405 MmrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTh3LkK5PVch|ryP NH3TRVRUSU6JRWK=
CAL-33 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37xOGlEPTB;OEWuOlMyPSEQvF2= M4TsdXNCVkeHUh?=
BT-549 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTh3LkmzPFIh|ryP MlTaV2FPT0WU
HT-1197 NUTiZ|lzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTh6LkGwO|ch|ryP NWnYe3cyW0GQR1XS
G-361 MmXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mom2TWM2OD16OD6xOFc1KM7:TR?= NUm3ToFrW0GQR1XS
LS-411N M1rRcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLqUFg5UUN3ME24PU4{Ozh6IN88US=> NGDUWo5USU6JRWK=
HT-144 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTh7LkW5PVIh|ryP MlrlV2FPT0WU
DJM-1 Mni0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTh7Lki4OFUh|ryP NGPUVZNUSU6JRWK=
CAL-12T NXq0RoIxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;aTWM2OD17MD63PFk2KM7:TR?= MmrNV2FPT0WU
MKN7 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTlzLkO1OVEh|ryP NI\xO|ZUSU6JRWK=
HuP-T3 MkXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PZeGlEPTB;OU[uNVAxPCEQvF2= NWDydFRFW0GQR1XS
SK-MG-1 NHfzUGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHWTWM2OD17Nj6xN|Q5KM7:TR?= MlPOV2FPT0WU
NCI-H2347 MnHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\LTWM2OD17OD6xNFQzKM7:TR?= NWLxeXF{W0GQR1XS
SW872 NH\HW4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PTc2lEPTB;MUCwMlQ2PiEQvF2= NEnze2JUSU6JRWK=
COLO-829 NYLkXXU6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\TTWM2OD1zMECuOVU{KM7:TR?= NV7NbYJKW0GQR1XS
MC-IXC MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PrOWlEPTB;MUCwMlYyPSEQvF2= MVLTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID