PF-4708671

Licensed and Manufactured by Pfizer Catalog No.S2163

PF-4708671 Chemical Structure

Molecular Weight(MW): 390.41

PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.

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In DMSO USD 191 In stock
USD 147 In stock
USD 270 In stock
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4 Customer Reviews

  • (F) EGR-2 and GFI-1 abundance (n = 5).

    Front Immunol, 2017, 7:685. PF-4708671 purchased from Selleck.

    Tumor sections were examined for DNA fragmentation (TUNEL) or stained with Ki-76 antibody. The representative images are shown. The brown color indicates the positively stained cells; scale bar, 50 mm.

    Mol Cancer Ther, 2015, 14(3): 799-809. PF-4708671 purchased from Selleck.

  • C. Cell lines were treated with the indicated compounds for 24h. ABC cells are colored in red. GCB are colored in blue. Intermediate cells are colored in gray.

    Oncotarget, 2016, 7(8):9163-74. PF-4708671 purchased from Selleck.

    After treated with PF-4708671 (PF, 10 uM) and 4EGI-1 (50 uM) for 48 h, GRP78 and ATF4 in QBC939, RBE and HCCC-9810 cells were analyzed using western blot.

    PLoS One 2014 9(2), e90388. PF-4708671 purchased from Selleck.

Purity & Quality Control

Choose Selective S6 Kinase Inhibitors

Biological Activity

Description PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. First S6K1-specific inhibitor to be reported.
Targets
p70 S6K1 [1]
(Cell-free assay)
160 nM
In vitro

PF-4708671 is a piperazinyl-pyrimidine analogue and the first S6K1-specific inhibitor. PF-4708671 does not significantly inhibit the activity of the closely related S6K2 isoform or a number of other AGC kinases (Akt1, Akt2, PKA, PKCα, PKCϵ, PRK2, ROCK2, RSK1, RSK2 or SGK1) . PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMA-induced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. PF-4708671 is also found to induce phosphorylation of the T-loop and hydrophobic motif of S6K1, an effect that is dependent upon mTORC1 (mTOR complex 1). PF-4708671 does not affect activity of mTORC1. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
BHT-101 NGHhdFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\STWM2OD1yLkiyNFI1KM7:TR?= NV7DR205W0GQR1XS
UACC-893 NETU[m5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTVwMUm4PFYh|ryP MYjTRW5ITVJ?
A427 MoLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknYTWM2OD13LkeyOVY4KM7:TR?= NGXvXmxUSU6JRWK=
OCUB-M MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnBfllZUUN3ME22MlY3OTB{IN88US=> NHOzZmhUSU6JRWK=
SW684 NHrWcmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWPQXJhWUUN3ME23MlUzOjZ6IN88US=> MmCyV2FPT0WU
SK-LMS-1 NYnFcFZTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDQWHVKSzVyPUmuNFE{ODJizszN NWPER5NiW0GQR1XS
CP50-MEL-B MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofhTWM2OD17LkOwOFE6KM7:TR?= MY\TRW5ITVJ?
NCI-H1651 NGHHXWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy2[3JKSzVyPUGwMlAzPzZizszN M1vMWHNCVkeHUh?=
ABC-1 NEHOc|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PTdGlEPTB;MUCuNVA{PyEQvF2= NELwb5lUSU6JRWK=
OE19 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITQdpdKSzVyPUGwMlE4OzNizszN MUDTRW5ITVJ?
DSH1 NUTtcnNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPSTWM2OD1zMD64PFc6KM7:TR?= MWHTRW5ITVJ?
SW13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTFzLkmzNVkh|ryP NXzBSHpuW0GQR1XS
MDA-MB-453 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXSxNmZ[UUN3ME2xNk4yPjB|IN88US=> NIPXO|RUSU6JRWK=
647-V NV3wfFEzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fVVGlEPTB;MUKuN|U5OiEQvF2= MXnTRW5ITVJ?
NCI-H2342 NH7XNFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTF{LkO5PVUh|ryP MnjNV2FPT0WU
LB2241-RCC NUfIdYE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{[2e2lEPTB;MUKuOVc4QSEQvF2= MYDTRW5ITVJ?
UACC-257 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTF|LkS0OVMh|ryP M4\W[nNCVkeHUh?=
NCI-H661 NFjaRoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\TU2ZIUUN3ME2xN{43PDR7IN88US=> MXjTRW5ITVJ?
FADU NXnnVml6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGftVItKSzVyPUGzMlY6QTJizszN MmXOV2FPT0WU
A2780 NVrJbmlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF70fmVKSzVyPUGzMlgxPDFizszN MUfTRW5ITVJ?
NCI-H1793 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7STWM2OD1zND60NFg2KM7:TR?= MmfxV2FPT0WU
TE-8 M4fpdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTF3LkO0OlUh|ryP M3;qSXNCVkeHUh?=
HGC-27 NULIfolVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUPKNXRtUUN3ME2xOk4yPjR2IN88US=> MorTV2FPT0WU
MMAC-SF NIO3fGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTF5LkO3Nlch|ryP NVXGWYlKW0GQR1XS
Calu-6 M2XOfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlyyTWM2OD1zOD6xOVE{KM7:TR?= M4PFUHNCVkeHUh?=
HUTU-80 NVnpNYdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTF6LkO5OVkh|ryP Ml\kV2FPT0WU
SAS NGrQSlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr6c4RKSzVyPUG4MlY1PTVizszN M{XwVXNCVkeHUh?=
IST-MES1 NW[5RmR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\GTWM2OD1zOD62OVA5KM7:TR?= NI\GUFhUSU6JRWK=
C3A MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlz3TWM2OD1zOD63PVE6KM7:TR?= NGrFSGlUSU6JRWK=
ES3 NUTMT|VLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWrJR|UxRTF6LkizOlQh|ryP NWPmeHRoW0GQR1XS
HSC-2 NWG2VlI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnXTWM2OD1zOT62OVQyKM7:TR?= NV33ZZE{W0GQR1XS
T47D NXP4XIRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVu0XWROUUN3ME2yNE4yPDh3IN88US=> Mlv3V2FPT0WU
EW-7 MojJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlLtTWM2OD1{MD64OVg5KM7:TR?= NF2zT21USU6JRWK=
LN-405 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrES|dKSzVyPUKwMlg6PjVizszN MWTTRW5ITVJ?
U031 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz1SXBKSzVyPUKxMlQ5ODJizszN MnvVV2FPT0WU
A549 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTJzLki0PVEh|ryP NYHzdWpRW0GQR1XS
RMG-I NInYdohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\JVmlEPTB;MkKuNlY3QCEQvF2= MYjTRW5ITVJ?
BT-474 NH7NcHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLNWYFKSzVyPUKyMlY2PTFizszN NFv1dXlUSU6JRWK=
NB69 Mmr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfI[pJKSzVyPUKzMlE2OiEQvF2= M4\udXNCVkeHUh?=
NB7 M2XE[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPmfW15UUN3ME2yOE4yQDhizszN MWfTRW5ITVJ?
HCC1569 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLLTpRKSzVyPUK0MlYyOjVizszN NEnkdnRUSU6JRWK=
MEL-JUSO M{[zTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHD[m5vUUN3ME2yOE43QTB6IN88US=> MWTTRW5ITVJ?
MDA-MB-175-VII NYXPdItFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJ3LkK1NVch|ryP MojEV2FPT0WU
HCC1419 M4fDbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vFRmlEPTB;MkWuOlAxOyEQvF2= M4nRXXNCVkeHUh?=
Ca9-22 NIj0RllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPOTYtKSzVyPUK1MlY1OzJizszN MYTTRW5ITVJ?
KGN M4fBNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXmO|VKSzVyPUK1Mlc2PDdizszN M{X3XXNCVkeHUh?=
LB373-MEL-D MmPxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrkTWM2OD1{Nj6xPVM5KM7:TR?= Mmr4V2FPT0WU
NCI-H1755 NYO0U5dwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLuTWM2OD1{Nj64PFQyKM7:TR?= MlzlV2FPT0WU
D-423MG NVjwXpdoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M17lVWlEPTB;MkeuNFcyPSEQvF2= Mny5V2FPT0WU
DK-MG NX23OIRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILhNG9KSzVyPUK4Mlc5PDZizszN NGDaSpZUSU6JRWK=
NCI-H1623 MmPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLVfmZKSzVyPUK4Mlg{PDJizszN MU\TRW5ITVJ?
KU-19-19 NFzOfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7pe2hKSzVyPUK4Mlk6PSEQvF2= M4WwN3NCVkeHUh?=
C-33-A NYf5To1oT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTJ7LkKxPVgh|ryP M1H4SnNCVkeHUh?=
SCC-4 NVz3Tm9IT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33FR2lEPTB;M{CuN|M2PCEQvF2= M3TnUXNCVkeHUh?=
MG-63 NXm0UZlkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTJTWM2OD1|MD61PVk1KM7:TR?= M4LRe3NCVkeHUh?=
LNCaP-Clone-FGC NYi2TmpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{T3bWlEPTB;M{GuOFkzOSEQvF2= NIXIUWdUSU6JRWK=
CAPAN-1 M2XFeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDaTWM2OD1|MT61Nlg3KM7:TR?= NIHJbWFUSU6JRWK=
GI-ME-N MkH1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHrxWpZKSzVyPUOxMlU{PTNizszN NFiyXGhUSU6JRWK=
RERF-LC-MS MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLGXoR5UUN3ME2zNk43PzR5IN88US=> Ml75V2FPT0WU
KLE MlrpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;6bGJKSzVyPUOzMlQ{OzRizszN MojrV2FPT0WU
KNS-81-FD MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HVeWlEPTB;M{OuOVAxQCEQvF2= NEWwRphUSU6JRWK=
DOK M{HzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWW1WVdiUUN3ME2zOE43PjF{IN88US=> M{GxVHNCVkeHUh?=
ACHN NETSWG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;iTmlEPTB;M{WuNVU5QCEQvF2= NGXzdYNUSU6JRWK=
KYSE-520 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TtW2lEPTB;M{WuNlM3OSEQvF2= M4qxfnNCVkeHUh?=
SBC-5 M1jERWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTN3LkWxNVYh|ryP Mn6xV2FPT0WU
NCI-H28 MnvkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1;MfmlEPTB;M{WuOlY6PSEQvF2= MWrTRW5ITVJ?
ES7 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnod5VZUUN3ME2zOk4zOjR7IN88US=> NFK0e|VUSU6JRWK=
A172 M1nmWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjOTGs1UUN3ME2zOk41OTh5IN88US=> NUG3dmF4W0GQR1XS
UM-UC-3 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33WbGlEPTB;M{euPFc1PiEQvF2= M1fKdXNCVkeHUh?=
LXF-289 NEHMcYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jjUGlEPTB;M{iuNFA1PyEQvF2= NWWyRWlYW0GQR1XS
KP-4 NUTqS2k3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTN6LkS3N|kh|ryP MkfwV2FPT0WU
TE-1 MkHCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jwZ2lEPTB;M{muOlU5QSEQvF2= Mnn0V2FPT0WU
G-402 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{i4VWlEPTB;NECuNFYyKM7:TR?= NGDwd5dUSU6JRWK=
786-0 NFLwS3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3M[pVyUUN3ME20NE46ODl4IN88US=> NGCyc21USU6JRWK=
K5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYTkb2NpUUN3ME20NU4{Pjh4IN88US=> Mli4V2FPT0WU
SK-N-DZ MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTrSmw1UUN3ME20NU4{QDJ|IN88US=> MVnTRW5ITVJ?
OVCAR-4 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHHTWM2OD12MT63OVY5KM7:TR?= Mnm2V2FPT0WU
T84 NFLVOphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\SRWlEPTB;NEKuNVI3OyEQvF2= NHrxc4ZUSU6JRWK=
GCIY MlzxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDpXnZwUUN3ME20N{4xQDB|IN88US=> MXXTRW5ITVJ?
BB49-HNC M{HoNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHRZ48zUUN3ME20N{4{OzR6IN88US=> MWfTRW5ITVJ?
SNU-C2B M2\Rc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzPeGdzUUN3ME20N{43PDN4IN88US=> M{Py[3NCVkeHUh?=
TE-6 NX64fY9DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHFbWtKSzVyPUSzMlg5QTRizszN NXH3SXhMW0GQR1XS
23132-87 NWDIc2wyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zOSGlEPTB;NESuNlk4QCEQvF2= MnvlV2FPT0WU
DMS-53 NV\MeINMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjXTWM2OD12ND6zN|g1KM7:TR?= M1vXXXNCVkeHUh?=
ONS-76 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn7lTWM2OD12ND63OlYyKM7:TR?= NUCydY1uW0GQR1XS
DMS-273 MkL2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInUXIdKSzVyPUS0Mlk1OyEQvF2= NWnOV3NuW0GQR1XS
COLO-824 Mk\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7iTWM2OD12NT64O|c2KM7:TR?= NX\qWndRW0GQR1XS
DMS-114 M4X6cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkX5TWM2OD12NT64PVI4KM7:TR?= NYfYc|FbW0GQR1XS
YKG-1 M173R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:2TWM2OD12Nj6wN|U2KM7:TR?= NH[0Vm5USU6JRWK=
RH-18 M1P6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnzTWM2OD12Nj6zO|M{KM7:TR?= MojEV2FPT0WU
NCI-H1355 Mn7WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jzfGlEPTB;NE[uOlE5KM7:TR?= NXfEeoVLW0GQR1XS
NCI-H2170 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLUTWM2OD12Nz63OVg1KM7:TR?= NVPzTYRGW0GQR1XS
OC-314 M37Gcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4Dr[WlEPTB;NEeuPFQ4QCEQvF2= MX;TRW5ITVJ?
NCI-H2030 NX64[2VDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLjToFPUUN3ME20O{45QTB4IN88US=> MlLkV2FPT0WU
22RV1 MorBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPNW4tKSzVyPUS3MlkxOTVizszN NHXZN|RUSU6JRWK=
G-401 NInJZpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTR6LkS0NVUh|ryP MVHTRW5ITVJ?
YAPC MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;BTWM2OD12OT64NFc{KM7:TR?= MUjTRW5ITVJ?
SW1573 MnvDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTVyLkK0N|Uh|ryP NVHycHEzW0GQR1XS
COLO-792 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTVyLk[yN|ch|ryP NFHpUJRUSU6JRWK=
KNS-62 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTVyLke1NFgh|ryP NWf6SIhQW0GQR1XS
NB5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3VmlEPTB;NUGuOFUxQSEQvF2= M4DhZ3NCVkeHUh?=
CP66-MEL MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTVzLk[0NFgh|ryP M1LrS3NCVkeHUh?=
CaR-1 NIL6[lVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYTETZVvUUN3ME21Nk4xPjB4IN88US=> NULyWGxvW0GQR1XS
CAL-54 NGK4XmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV62SXAxUUN3ME21Nk4yOTB{IN88US=> MkS3V2FPT0WU
8305C NE\aWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTV{LkOxOUDPxE1? MkP1V2FPT0WU
Calu-3 NXXPW2UzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TUT2lEPTB;NUKuN|c{OyEQvF2= M2fOO3NCVkeHUh?=
AU565 NWrGN2lJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTV{LkW1NFkh|ryP M3LhVHNCVkeHUh?=
CW-2 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYDJR|UxRTV{Lki2OVQh|ryP Mnr0V2FPT0WU
BEN MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWqzUnpyUUN3ME21N{44QDZ{IN88US=> NVXaZ4F3W0GQR1XS
NCI-H1975 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlP5TWM2OD13Mz64PVY3KM7:TR?= MXHTRW5ITVJ?
HCT-116 NE\4e49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\TTWM2OD13ND6wN|I4KM7:TR?= M3PnSXNCVkeHUh?=
SH-4 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MojQTWM2OD13ND6xN|gh|ryP NHPN[WxUSU6JRWK=
NCI-H1693 NEnLNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVvsTYU6UUN3ME21OE4zOTB|IN88US=> NXXkcllHW0GQR1XS
BPH-1 MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\aTWM2OD13NT6yPFkzKM7:TR?= MljSV2FPT0WU
CAMA-1 MlznS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\O[ZNKSzVyPUW1MlgyOTZizszN MnLjV2FPT0WU
A388 MoHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7MS5J7UUN3ME21Ok4xQTh3IN88US=> MYTTRW5ITVJ?
C2BBe1 MkO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFO3[nFKSzVyPUW2MlI3OzRizszN MXrTRW5ITVJ?
GAMG MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PTPGlEPTB;NU[uOVk2PSEQvF2= NX;TNVUzW0GQR1XS
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VA-ES-BJ NV3lTIkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Xo[2lEPTB;NU[uPFc1PSEQvF2= M3;kS3NCVkeHUh?=
HuCCT1 NHfnVXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlruTWM2OD13Nz6wOFkzKM7:TR?= M4LpdHNCVkeHUh?=
BFTC-905 M1ThbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO1e25KSzVyPUW3MlI5QThizszN NF:zTVNUSU6JRWK=
LS-123 M2raXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHXxVnZKSzVyPUW3MlU3PjhizszN MXrTRW5ITVJ?
LB996-RCC NGPGXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDMTWM2OD13OD6wNlg4KM7:TR?= MX\TRW5ITVJ?
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COR-L105 M{DJUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7iTWM2OD13OD63N|M4KM7:TR?= NV[5ZWhlW0GQR1XS
OVCAR-8 NXHye281T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD1Vm45UUN3ME21PU4yPzF4IN88US=> MljOV2FPT0WU
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MES-SA MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTV7LkS1NFkh|ryP Moe5V2FPT0WU
SCC-9 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7QPYU3UUN3ME21PU41PzV|IN88US=> MmPwV2FPT0WU
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GT3TKB M37PZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvO[GJKSzVyPU[wMlYxPDhizszN NXHCRWpPW0GQR1XS
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MLMA NGjBb3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3[wcGlEPTB;NkGuOlE3OyEQvF2= NFfaPGdUSU6JRWK=
D-566MG NVr5[Vd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYW0eVFoUUN3ME22N{42OjJ2IN88US=> MX\TRW5ITVJ?
SF295 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUL2TW4zUUN3ME22N{43PjV3IN88US=> MnjDV2FPT0WU
ES4 M2LtcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTZ2LkS3NVkh|ryP M1vUUXNCVkeHUh?=
CAKI-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHT[XhKSzVyPU[0MlU4OjFizszN Ml3mV2FPT0WU
OAW-28 NYLvU4dYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTZ2Lkm2OFch|ryP NX;IdZNjW0GQR1XS
NCI-H460 NX;j[HFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;yXYhEUUN3ME22OU4xQDl5IN88US=> M{mzV3NCVkeHUh?=
JAR NGD6cG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XSV2lEPTB;NkWuOVUyPiEQvF2= MVTTRW5ITVJ?
SNU-449 NGjPdXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTZ3Lke2NVYh|ryP NIq2SZNUSU6JRWK=
D-392MG NIjzb|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml;ETWM2OD14NT65OFM1KM7:TR?= NFHFXpNUSU6JRWK=
EW-22 Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTZ4LkO5OUDPxE1? MoDWV2FPT0WU
GCT M4fHT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jibmlEPTB;NkeuNFQ1OyEQvF2= M{nvVHNCVkeHUh?=
NOS-1 NGPTW2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf1NVJbUUN3ME22O{43QDZ5IN88US=> M132RXNCVkeHUh?=
RH-1 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MULJR|UxRTZ6LkW1OVkh|ryP MV3TRW5ITVJ?
HuH-7 M1TRUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLDcG5KSzVyPU[5MlExODJizszN MmXKV2FPT0WU
NUGC-3 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTdyLkm2OFQh|ryP MWfTRW5ITVJ?
IST-SL1 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTdzLkKzNlQh|ryP MUjTRW5ITVJ?
SHP-77 MkixS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2qxfWlEPTB;N{KuNVE6KM7:TR?= NWTrVHRnW0GQR1XS
SW1116 NEj4NWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTd{LkG0NFch|ryP NGXqXlBUSU6JRWK=
LK-2 M122bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfTTWM2OD15Mj64OlEzKM7:TR?= MWTTRW5ITVJ?
U-2-OS MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTd|LkG4Nlgh|ryP NWr3blVqW0GQR1XS
KYSE-150 MmnXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnETWM2OD15Mz62NVE5KM7:TR?= MYDTRW5ITVJ?
U251 M2TQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33T[2lEPTB;N{OuPFE3QCEQvF2= MV;TRW5ITVJ?
HT-1080 Mk\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTd2LkK1O|Qh|ryP MonLV2FPT0WU
NCI-H1437 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Phc2lEPTB;N{SuOlMzPiEQvF2= Mnv0V2FPT0WU
HPAF-II M3j2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7uW|ZDUUN3ME23OE43PDF3IN88US=> NILseZFUSU6JRWK=
Becker NVn4WpBzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTd3LkGxNFUh|ryP MYDTRW5ITVJ?
PANC-10-05 MlnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmHvTWM2OD15NT6yPFY2KM7:TR?= NYj5fnVZW0GQR1XS
TYK-nu NHPwV|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTd3LkOxNFIh|ryP MXnTRW5ITVJ?
SKG-IIIa MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\QTWM2OD15NT6zN|QyKM7:TR?= NELLb|hUSU6JRWK=
NCI-H1993 M2r3fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXPNZRrUUN3ME23OU44Ozl5IN88US=> M1LvbnNCVkeHUh?=
S-117 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTd3Lke1OUDPxE1? NGrlVZlUSU6JRWK=
HuO9 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTd4LkCwOFgh|ryP NGnWZoZUSU6JRWK=
CAL-51 NV7NUoZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;Mb2lEPTB;N{[uNVAxPiEQvF2= NX;UW2JxW0GQR1XS
BT-20 MmDBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPBTWM2OD15Nj6yNVY5KM7:TR?= NUfWfGdiW0GQR1XS
LB831-BLC M4LhOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PvfGlEPTB;N{[uN|IyPyEQvF2= MmGyV2FPT0WU
LB1047-RCC MkLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEWzOnJKSzVyPUe2Mlc3OTlizszN NYrRNlNmW0GQR1XS
ES8 NVm5dFZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnMTWM2OD15OD6wNFc{KM7:TR?= MlvOV2FPT0WU
UMC-11 NEjGRnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTd6LkC4PFQh|ryP MlLNV2FPT0WU
NCI-H226 NHnJRlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTd6LkGzNVUh|ryP NHKwR4dUSU6JRWK=
IGROV-1 M3vPT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\mUXluUUN3ME23PE42PTVizszN NX3GO5NTW0GQR1XS
BHY NGGyeJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NESwe3BKSzVyPUe5MlU6PiEQvF2= MoHuV2FPT0WU
MKN45 M1PnN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS0TZdKSzVyPUiwMlMyPzRizszN MVnTRW5ITVJ?
IA-LM MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXld|BKSzVyPUiwMlM2OTFizszN MV3TRW5ITVJ?
WM-115 Mn3GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Hyb2lEPTB;OEGuOFEyPCEQvF2= M3u3UXNCVkeHUh?=
VMRC-RCZ MmHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnNTWM2OD16MT60OFI2KM7:TR?= M1LYZ3NCVkeHUh?=
NCI-H2291 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3R[4prUUN3ME24NU43QDR{IN88US=> NIi3cWJUSU6JRWK=
MCF7 MofrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTh|LkK4PVch|ryP NXHxTpJjW0GQR1XS
639-V MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{P4b2lEPTB;OESuOlEzQSEQvF2= MUPTRW5ITVJ?
RT4 M3;uXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[4VWhtUUN3ME24OU4zPDB|IN88US=> MY\TRW5ITVJ?
NCI-H2405 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHKeJoyUUN3ME24OU4zQTl5IN88US=> NWS5Omp4W0GQR1XS
CAL-33 M1X2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTh3Lk[zNVUh|ryP NVjiNnd6W0GQR1XS
BT-549 NYHBb2ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTh3LkmzPFIh|ryP MkjyV2FPT0WU
HT-1197 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO3TWM2OD16OD6xNFc4KM7:TR?= MnrPV2FPT0WU
G-361 M4PRWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzGTWM2OD16OD6xOFc1KM7:TR?= Mnz2V2FPT0WU
LS-411N MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:xXmVKSzVyPUi5MlM{QDhizszN MUfTRW5ITVJ?
HT-144 NUnCTWMzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWnJR|UxRTh7LkW5PVIh|ryP MXHTRW5ITVJ?
DJM-1 MmXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTh7Lki4OFUh|ryP NWn0ZZhxW0GQR1XS
CAL-12T M{nobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NES0ZnNKSzVyPUmwMlc5QTVizszN M1OzdHNCVkeHUh?=
MKN7 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTlzLkO1OVEh|ryP MlLLV2FPT0WU
HuP-T3 NIjRXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXnTms6UUN3ME25Ok4yODB2IN88US=> MkXoV2FPT0WU
SK-MG-1 NH\TOHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTl4LkGzOFgh|ryP NXGyNoRuW0GQR1XS
NCI-H2347 M2XQOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUL0V4NqUUN3ME25PE4yODR{IN88US=> MW\TRW5ITVJ?
SW872 NH;KS5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFLvbVlKSzVyPUGwNE41PTZizszN NWHKPIw5W0GQR1XS
COLO-829 MojGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHHTWM2OD1zMECuOVU{KM7:TR?= MX3TRW5ITVJ?
MC-IXC MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorhTWM2OD1zMECuOlE2KM7:TR?= MXzTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 30 mg/mL (76.84 mM)
Ethanol 8 mg/mL (20.49 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% PEG400+0.5% Tween80+5% propylene glycol
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 390.41
Formula

C19H21F3N6

CAS No. 1255517-76-0
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID