LY2584702 Tosylate

Catalog No.S7704

LY2584702 Tosylate Chemical Structure

Molecular Weight(MW): 617.62

LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.

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1 Customer Review

  • Samples were processed and analyzed for S6 and phospho-S6 content as described in methods.

    PLoS One, 2017, 12(1):e0169804. LY2584702 Tosylate purchased from Selleck.

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Biological Activity

Description LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1.
Targets
p70S6K [1]
(Cell-free assay)
4 nM
In vitro

In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]

In vivo LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1]

Protocol

Animal Research:

[1]

+ Expand
  • Animal Models: U87MG glioblastoma and HCT116 colon carcinoma xenograft models
  • Formulation: --
  • Dosages: 12.5 mg/kg BID
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 7 mg/mL warmed (11.33 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 617.62
Formula

C28H27F4N7O3S

CAS No. 1082949-68-5
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01372085 Completed Tumors Eli Lilly and Company June 2011 Phase 1
NCT01241461 Completed Cancer Eli Lilly and Company November 2010 Phase 1
NCT01115803 Terminated Metastases, Neoplasm|Carcinoma, Non-small Cell Lung|Renal Cell Carcinoma|Neuroendocrine Tumors Eli Lilly and Company March 2010 Phase 1
NCT01394003 Terminated Advanced Cancer Eli Lilly and Company November 2008 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    What is the difference between S7698 and S7704? i.e, what does the tosylate group do?

  • Answer:

    S7698 is the free base of the compound and S7704 is its tosylate salt. Chemically, salt form is more stable and has a better solubility than free base, however, it also has a higher molecular weight. Biologically, these two forms have the same activities.

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S6 Kinase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID