Otilonium Bromide

Catalog No.S3047

Otilonium bromide is an antimuscarinic.

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In DMSO USD 130 In stock
USD 97 In stock
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Otilonium Bromide Chemical Structure

Otilonium Bromide Chemical Structure
Molecular Weight: 563.57

Validation & Quality Control

Quality Control & MSDS

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Otilonium Bromide is available in the following compound libraries:

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Product Description

Biological Activity

Description Otilonium bromide is an antimuscarinic.
Targets mAChR [1]
In vitro Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. [1] This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect. [2]
In vivo
Features

Protocol(Only for Reference)

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)
1

References

[1] Maggi CA, et al. Arch Int Pharmacodyn Ther, 1983, 264(2), 305-323.

[2] Battaglia G, et al. Aliment Pharmacol Ther, 1998, 12(10), 1003-1010.

Chemical Information

Download Otilonium Bromide SDF
Molecular Weight (MW) 563.57
Formula

C29H43BrN2O4

CAS No. 26095-59-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO 113 mg/mL (200 mM)
Water 113 mg/mL (200 mM)
Ethanol 113 mg/mL (200 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1)

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Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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