Hyoscyamine

Catalog No.S4014 Synonyms: Daturine

Hyoscyamine Chemical Structure

Molecular Weight(MW): 289.37

Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Biological Activity

Description Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
Features R-(+)-hyoscyamine is 30-fold lower in potency than that of the S-(-) enantiomer.
Targets
AChR [1]
7.5 nM
In vitro

L-hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. [2] R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. [3] Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. [4] S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%. [5]

In vivo L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. [6]

Protocol

Animal Research:[6]
+ Expand
  • Animal Models: Rats
  • Formulation: Saline
  • Dosages: 20 mg/kg
  • Administration: Intravenous injection
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 58 mg/mL (200.43 mM)
Ethanol 58 mg/mL (200.43 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% propylene glycol, 5% Tween 80, 65% D5W
5 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 289.37
Formula

C17H23NO3

CAS No. 101-31-5
Storage powder
Synonyms Daturine

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02389998 Recruiting Functional Abdominal Pain|Functional Dyspepsia|Irritable Bowel Syndrome|Functional Gastrointestinal Disorders Boston Children’s Hospital|Nationwide Childrens Hospital July 2014 --

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AChR Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID