Catalog No.S4014 Synonyms: Daturine
Molecular Weight(MW): 289.37
Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.
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|Description||Hyoscyamine is an AChR inhibitor with IC50 of 7.5 nM.|
|Features||R-(+)-hyoscyamine is 30-fold lower in potency than that of the S-(-) enantiomer.|
L-hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements.  R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively.  Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells.  S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%. 
|In vivo||L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. |
-  Schmeller T, et al. Pharmazie, 1995, 50(7), 493-495.
-  Tota MR, et al. Biochemistry, 1987, 26(25), 8175-8182.
-  Dong GZ, et al. J Pharmacol Exp Ther, 1995, 274(1), 378-384.
|In vitro||DMSO||58 mg/mL (200.43 mM)|
|Ethanol||58 mg/mL (200.43 mM)|
|In vivo||Add solvents individually and in order:
30% propylene glycol, 5% Tween 80, 65% D5W
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02389998||Recruiting||Functional Abdominal Pain|Functional Dyspepsia|Irritable Bowel Syndrome|Functional Gastrointestinal Disorders||Boston Children’s Hospital|Nationwide Childrens Hospital||July 2014||--|
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