Liproxstatin-1

Catalog No.S7699

Liproxstatin-1 Chemical Structure

Molecular Weight(MW): 340.85

Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.

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3 Customer Reviews

  • (D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.

    Liproxstatin-1 purchased from Selleck.

    Western blots showing attenuated neurodegeneration (NeuN, Synaptophysin, SNAP25) and neuroinflammation (GFAP) in HC of Gpx4BIKO-VED mice treated with the ferroptosis inhibitor liproxstatin-1 compared to Gpx4BIKO-VED mice treated with vehicle (DMSO) at 1 week post TAM treatment (n=5 for all groups). * p<0.05 versus Con-VED; #p<0.05 versus Gpx4BIKO-VED treated with DMSO.

    Redox Biol, 2017, 12:8-17. Liproxstatin-1 purchased from Selleck.

  • (C) Baicalein is a strong inhibitor of ferroptosis, but not apoptosis. PANC1 cells were treated with the ferroptosis inducer (erastin, 20 μM) or the apoptosis inducer staurosporine (0.5 μM) in the absence or presence of baicalein and indicated inhibitors for 24 h. Cell viability was assayed using the CCK-8 kit.

    Biochem Biophys Res Commun, 2016, 473(4):775-80.. Liproxstatin-1 purchased from Selleck.

Purity & Quality Control

Choose Selective Ferroptosis Inhibitors

Biological Activity

Description Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
Targets
ferroptosis [1]
(Cell-free assay)
22 nM
In vitro

Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).[1]

In vivo Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. [1]

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: Gpx4−/−cells
  • Concentrations: ~200 nM
  • Incubation Time: ~72 h
  • Method:

    Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH).


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: GreERT2; Gpx4fI/fI mice
  • Formulation: 1% DMSO in PBS
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 68 mg/mL (199.5 mM)
Ethanol 21 mg/mL warmed (61.61 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
3mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 340.85
Formula

C19H21ClN4

CAS No. 950455-15-9
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID