Molecular Weight(MW): 340.85
Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.
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(D) Indicated NRF2 knockdown HCC cells were treated with erastin (10 μM) and sorafenib (5 μM) with or without indicated inhibitors (ferrostatin-1, 1 μM; liproxstatin-1, 100 nM; ZVAD-FMK, 10 μM; necrostatin-1, 10 μM; necrosulfonamide, 0.5 μM) for 24 hours, and cell viability was assayed (n 5 3, *P < 0.05). Abbreviation: GAPDH, glyceraldehyde 3-phosphate dehydrogenase.
Liproxstatin-1 purchased from Selleck.
Western blots showing attenuated neurodegeneration (NeuN, Synaptophysin, SNAP25) and neuroinflammation (GFAP) in HC of Gpx4BIKO-VED mice treated with the ferroptosis inhibitor liproxstatin-1 compared to Gpx4BIKO-VED mice treated with vehicle (DMSO) at 1 week post TAM treatment (n=5 for all groups). * p<0.05 versus Con-VED; #p<0.05 versus Gpx4BIKO-VED treated with DMSO.
Redox Biol, 2017, 12:8-17. Liproxstatin-1 purchased from Selleck.
(C) Baicalein is a strong inhibitor of ferroptosis, but not apoptosis. PANC1 cells were treated with the ferroptosis inducer (erastin, 20 μM) or the apoptosis inducer staurosporine (0.5 μM) in the absence or presence of baicalein and indicated inhibitors for 24 h. Cell viability was assayed using the CCK-8 kit.
Biochem Biophys Res Commun, 2016, 473(4):775-80.. Liproxstatin-1 purchased from Selleck.
Purity & Quality Control
Choose Selective Ferroptosis Inhibitors
|Description||Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM.|
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).
|In vivo||Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. |
|In vitro||DMSO||68 mg/mL (199.5 mM)|
|Ethanol||21 mg/mL warmed (61.61 mM)|
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