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Formula | C19H21ClN4 |
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Molecular Weight | 340.85 | CAS No. | 950455-15-9 | ||||
Solubility (25°C)* | In vitro | DMSO | 68 mg/mL (199.5 mM) | ||||
Ethanol | 34 mg/mL (99.75 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. | ||
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Targets |
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In vitro | Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).[1] | ||
In vivo | Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. [1] |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , Mol Psychiatry, 2017, 22(11):1520-1530]
Data from [Data independently produced by , , Cancer Res, 2017, 77(8):2064-2077]
Data from [Data independently produced by , , Redox Biol, 2017, 12:8-17]
7-Dehydrocholesterol dictates ferroptosis sensitivity [ Nature, 2024, 626(7998):411-418.] | PubMed: 38297130 |
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence [ Nat Commun, 2024, 15(1):1429] | PubMed: 38365899 |
Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11 [ J Exp Clin Cancer Res, 2024, 43(1):112] | PubMed: 38610018 |
The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury [ J Transl Med, 2024, 22(1):9] | PubMed: 38169402 |
Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells [ Cell Death Discov, 2024, 10(1):108] | PubMed: 38429255 |
PKCiota Inhibits the Ferroptosis of Esophageal Cancer Cells via Suppressing USP14-Mediated Autophagic Degradation of GPX4 [ Antioxidants (Basel), 2024, 13(1)114] | PubMed: 38247539 |
Liproxstatin-1 Alleviated Ischemia/Reperfusion-Induced Acute Kidney Injury via Inhibiting Ferroptosis [ Antioxidants (Basel), 2024, 13(2)182] | PubMed: 38397780 |
Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation [ Virol Sin, 2024, 39(1):144-155] | PubMed: 38104890 |
Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells [ J Virol, 2024, 98(3):e0189723] | PubMed: 38411946 |
Inhibition of ferroptosis by POLE2 in gastric cancer cells involves the activation of NRF2/GPX4 pathway [ J Cell Mol Med, 2024, 28(1):e17983] | PubMed: 38070189 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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