Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
USD 110 In stock
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USD 570 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NVvaXII3TnWwY4Tpc44hSXO|YYm= NXL0VId4OTBizszN NVmxUm5YPiCq NFnNV3BqdmO{ZXHz[ZMheGixc4Doc5J6dGG2aX;uJI9nKG:4ZYLlfJBz\XO|ZXSgT2xJVDNiYYSgV|Q{Ow>? NXTVeZprOjZ2M{W0PVg>
Mo-DCs M37NXmZ2dmO2aX;uJGF{e2G7 M{WxWVUxKM7:TR?= NXyyS25JOjUkgJno MWTwdo9ud3SnczDJUE0zOyCycn;keYN1cW:wIHnuJJRp\SC|dYDldo5ifGGwdDDv[kB7gW2xc3HuJJN1cW23bHH0[YQhVW9vRFPzxsA> MXKyOlQyOjl2OB?=
RBMECs  NYnzSZpKTnWwY4Tpc44hSXO|YYm= M3SwW|XDqM7:TR?= NWe0fJZIOcLiaB?= MV7icI9kc3NidHjlJHJi[zFiaX7hZ5RqfmG2aX;uJIlv\HWlZXSgZpkhTU2DUD3JTS=> M3rjSlI3OzV6MEO5
INA-6 MWjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFrmN2QxNTFyMDFOwG0> NIG1fXU4OuLCiXi= NYSxU|NxcW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> MY[yOlMxPjZ{NB?=
OPM-2 NYm2NVVtS2WubDDWbYFjcWyrdImgRZN{[Xl? M3H4R|AuOTByIN88US=> M{HobFcz6oDLaB?= NH;a[2NqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> NX7yR|BzOjZ|ME[2NlQ>
U266 NVjuSHJJS2WubDDWbYFjcWyrdImgRZN{[Xl? NXvMZVV1OC1zMECg{txO MnX6O|LjiImq MUPpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= MXiyOlMxPjZ{NB?=
H929 NFPEUYFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M3LjOlAuOTByIN88US=> NIqy[5c4OuLCiXi= MlrGbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NGDON48zPjNyNk[yOC=>
RPMI 8226 Mm\0R4VtdCCYaXHibYxqfHliQYPzZZk> MWewMVExOCEQvF2= MlzuO|LjiImq MVHpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= NUXRV2Y{OjZ|ME[2NlQ>
MDCK  M{XBeWZ2dmO2aX;uJGF{e2G7 NFm1eZUyOCEEtV2= M{WxOVI1KGh? NHrZd2hFVVOR M{\ie5VxemWpdXzheIV{KHSqZTDlfJBz\XO|aX;uJI9nKFSJRj5OtlEh[W6mIFPUS2bDqA>? MmDqNlYzODJ|NUK=
MDCK  NW[4fGRSTnWwY4Tpc44hSXO|YYm= MUOxNEDDvU1? M1\C[lI1KGh? MmW2SG1UVw>? M{fhOolvcGmkaYTzJJRp\SCrbnPy[YF{\WRiZYjwdoV{e2mxbjDv[kBHViClYYXz[YQh[nliVFfGMe6zOQ>? NFPXTVgzPjJyMkO1Ni=>
Spinal cords  MVjGeY5kfGmxbjDBd5NigQ>? NHzFd2syyqEQvF2= MWizNEBucW5? NV\2[Y9ue3SrbYXsZZRmeyClQV3QJIxmfmWucx?= MYOyOlEzPjl{Nh?=
BeWo  M4HzU2Z2dmO2aX;uJGF{e2G7 M1TkUVI26oDLzszN NHqwfpAzPC92OD:3NkBp MnLucIVi\HNidH:gZY4hcW6lcnXhd4UhcW5idHjlJIV5eHKnc4Ppc44hd2Zib4To[ZIh\nW|aX;uJI1iemuncoO= Mor6NlYxPTN3NEm=
bovine oocytes Mo\1SpVv[3Srb36gRZN{[Xl? MYSxNFDDqM7:TR?= NUPRRVBzOTMEoHi= NF\lfoJqdmirYnn0d{B1cGViZX\m[YN1KG:oIF7QVGEh[W6mL3;yJG5RWENidH:gd5RqdXWuYYTlJJJme3WvcITpc44hd2ZibXXpc5Nqew>? MW[yOlA2OTZzMR?=
Caco-2  NFHuSo5HfW6ldHnvckBCe3OjeR?= MkfKNE4yNzFxMUCg{txO NFXIS|YzOMLibXnu NV3XU4E{cW6mdXPld{BiKGSxc3Wt[IVx\W6mZX70JIlv[3KnYYPlJIlvKGmwdILhZ4VtdHWuYYKgZ2FOWCCuZY\lcJM> NIfNSVQzPjB2OUGwNi=>
Caco-2  MnvDSpVv[3Srb36gRZN{[Xl? NHzMRW8xNjFxMT:xNEDPxE1? M{\zPFI1KGh? Mn\2bY5kemWjc3XzJG1TWDJicILveIVqdiCuZY\lcC=> MlnsNlYxPDlzMEK=
AML-12  NVfQbXd[TnWwY4Tpc44hSXO|YYm= MkjHNlAh|ryP MXOzJIg> M1jNNZVxemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ibHX2[Yx{KGG2IGTodk01OTFiYX7kJHNmei12OUO= MYeyOlA1QDl6NR?=
AML-12  NWm3e4xTTnWwY4Tpc44hSXO|YYm= Mn\JNlAh|ryP NXKycGM{OS16IHi= MV;pcoNz\WG|ZYOg[4x2[2:|ZTDwdo9lfWO2aX;u MonpNlYxPDh7OEW=
AML-12  NGHZRldHfW6ldHnvckBCe3OjeR?= NV3BNpFmOjBizszN NGq0Z2c{KGh? M1nCbpVxNXKnZ4XsZZRme8LiUHfjNYEtyqCSZYDjb{wh[W6mwrDHOpBkyqCvUl7BJIxmfmWucx?= NEXTOFIzPjB2OEm4OS=>
AML-12  MVHGeY5kfGmxbjDBd5NigQ>? MmXoNlAh|ryP NHfSS4U{KGh? NIj0OVhqdmS3Y3XzJJRp\SCmZYDoc5NxcG:{eXzheIlwdiCxZjDDVnREOsLi MUCyOlA1QDl6NR?=
RBMECs NV;aRm9[TnWwY4Tpc44hSXO|YYm= MV[1xsDPxE1? NIj2dIMyKGh? MoS1bY5pcWKrdIOgSW1CWC2LST3pcoR2[2WmIHnuZYN1cX[jdHnvckBw\iCUYYCxxsA> NHj4bIkzPjB2NE[2Ny=>
EndoC-βH1 NXjSTVJnTnWwY4Tpc44hSXO|YYm= NUXVNItTPcLizszN M1TQU|EhcA>? MorpdI91\W62aXH0[ZMh\2y3Y3;z[U1qdmS3Y3XkJIlve3WuaX6gd4VkemW2aX;uJIlvKHSqZTDwdoV{\W6lZTDv[kBodHWlb4Pl NVHBc29EOjZyMki1OlI>
EndoC-βH1 M17lO2Z2dmO2aX;uJGF{e2G7 M4\tXFXDqM7:TR?= NXzoU5E1OSCq NHy2V45t\WGmczD0c{BiKHO2cn;u[{BkSU2SIHnuZ5Jm[XOn M1K3[FI3ODJ6NU[y
SH-SY5Y Mm\RSpVv[3Srb36gRZN{[Xl? NEnuXVM{OCEQvF2= MkLxN|AhdWmw MnGxSG1UVw>? NFj5d|R{cWewaX\pZ4FvfGy7IHnuZ5Jm[XOnczD0bIUh[WO2aY\heIlwdiCxZjDQT2E> NVfxdVJ7OjZyMkWxN|c>
PC-3 NUn2emJLTnWwY4Tpc44hSXO|YYm= NW\mSWxQPDBiwsXN MXOyJIg> NGPlbpFFVVOR M13SU4xm[WS|IITvJHBROkFiYXP0bZZifGmxbh?= MXOyOlAzOzh|Nh?=
PC-3 M4XIbWNmdGxiVnnhZoltcXS7IFHzd4F6 M3S2R|QxKML3TR?= NIrwSGUzPC92OD:3NkBp NFHlO4hFVVOR Mn;V[IVkemWjc3XzJINmdGxidnnhZoltcXS7IITpcYUh\GWyZX7k[Y51dHl? NEnEeHEzPjB{M{izOi=>
SCG MX3GeY5kfGmxbjDBd5NigQ>? NVHpSWNoOjBizszNxsA> MXrEUXNQ MkPRdoV3\XK|aXLsfUB{fXCycnXzd4V{KEmNVjD3bZRpKGFiSVO1NEBw\iB{ND60JO69VQ>? NGPkbFEzPTl4MkGzNi=>
HEK-293 NIjTZWFHfW6ldHnvckBCe3OjeR?= MlzVN|Uh|ryPwrC= MkLzSG1UVw>? MUjpcoR2[2W|IHGgZ49ve3CrY4XveZMh6oDeaX7hZ5RqfmG2aX;u5qCeKG:oIITo[UBMfjJwMTDjeZJz\W62 NHjtfIIzPTl4MkGzNi=>
SCG MUfGeY5kfGmxbjDBd5NigQ>? NHnJbo4yODBizszNxsA> M2\1cmROW09? Ml;KdoVlfWOnczD0bIUh\XilaYThZoltcXS7IH;mJHNETyCwZYXyc45{ NWruW5BOOjV7NkKxN|I>
PCCL3 M4XCeWZ2dmO2aX;uJGF{e2G7 NYr6Sm1KOTBiwsXN NWHzWodTOjRiaB?= MVTlcohidmOnczDEeW95OiCycn;tc5RmeiC2cnHud4NzcXC2aX;uJIFkfGm4aYT5xsDjiIt? M4DsT|I2QTZyOUW2
3T3-L1 preadipocytes NH71[GpHfW6ldHnvckBCe3OjeR?= MUCxNEDPxE4EoB?= MmjPNVIhcA>? M2W4eolv\HWlZYOgR3JGSiCyaH;zdIhwenmuYYTpc44h[W6mIFOvSWJR|rJiZYjwdoV{e2mxbh?= NGDFO|QzPTl{OEC1PC=>
H295R  MnmxSpVv[3Srb36gRZN{[Xl? MVOxNOKh|ryP M3fuXVQ5yqCq NXfafZZkcW6lcnXhd4V{KHO2ZYLvbYQhdWW2YXLvcIl1\XNiaX6geIhmKGGwZILv[4VvNCCvaX7ldoFtdy1iYX7kJIdtfWOxY3;yeIlkd2mmIIDheIh4[Xm| MlLHNlU5Pjl3NU[=
PBMC NIPYZm9HfW6ldHnvckBCe3OjeR?= M2DGXFUxyqEQvF2= MnHKNlTDqGkEoB?= M1LvV4lvcGmkaYTzJJRp\SCrbnPy[YF{\WRic3XjdoV1cW:wIH;mJHRPTiCrbnT1Z4VlKGK7IITo[UBFWEV? MoTBNlU5PjZyN{m=
GLUTag  MlTsSpVv[3Srb36gRZN{[Xl? NULwV4xXOTEkgJpCuW0> MVewM|IwPCCq NWLROnJje3SrbYXsZZRmeyCJTGCtNUB{\WO{ZYTpc44h[2:2cnXheIVlKHerdHigTWJOYA>? MXSyOVg{OjZ|MR?=
GLUTag  M3LTSmZ2dmO2aX;uJGF{e2G7 MYqxNQKBkcL3TR?= M2XjUVQhcA>? M1P1Solv[3KnYYPld{B1cGVicFPSSWIhdGW4ZXzzJJdqfGhidHjlJGlDVVh? Mnf0NlU5OzJ4M{G=
BAECs M{TLR2Z2dmO2aX;uJGF{e2G7 M3vUbFI2KM7:TR?= NHrQZWkzPCCq MnHt[Y5p[W6lZYOgeIhmKGGldHn2ZZRqd25ib3[gVHBCWs7zIHL5JFUh|ryPIILld5ZmemG2cn;sMEBVPEiVLDDvdkA1NVCDUB?= MVKyOVc6QDh{Nh?=
PC12 M1PafWZ2dmO2aX;uJGF{e2G7 MXqyOeKh|ryP M4LyV|Q5KGh? M1q3[IFkfGm4YYTld{BkSU2S NEjGco4zPTd4OUOwOS=>
GH3 M2[4eWZ2dmO2aX;uJGF{e2G7 M4jST|HDqM7:TR?= NXTJcWhyPi2q NE[2cmVifHSnboXheIV{KHSqZTDjc5Jz\WyjdHnvckBj\XS5ZXXuJHBTVCCjbnSgRo1idDFiZYjwdoV{e2mxbh?= MX6yOVczPzBzOB?=
GH3 MYLGeY5kfGmxbjDBd5NigQ>? Mn\yNeKh|ryP M1PRTFYucA>? MlnCbY5lfWOnczDQVmwh[W6mIFLtZYwyNCCkdYSgco91KEOub3PrMEBuWk6DIHX4dJJme3Orb36= NXX1XIZbOjV5MkewNVg>
BeWo NHTNc3dHfW6ldHnvckBCe3OjeR?= NWj1OnFYOTEkgJtOwG3DqA>? MljUO|IhcA>? M1HjcmROW09? M{XNRY1m\GmjdHXzJGJmX29iY3XscEBlcW[oZYLlcpRq[XSrb36= MWKyOVcyOzR{NR?=
oocytes MYLGeY5kfGmxbjDBd5NigQ>? MoTJOUDPxE1? NX6xb49kOjRiaB?= M2jISIF1fGWwdXH0[ZMhemhvaX7zeYxqdiCjY4Tpc44hd25ib3;jfZRmKEeYQlSgd4lodmmoaXPhcpRtgcLi NXjZXGd[OjV5MEe4OVQ>
SC Moq2SpVv[3Srb36gRZN{[Xl? NXfqSWRYOC53IN88US=> NVfCfI97OjRiaB?= M4HubY1qdWmla4OgeIhmKGWoZnXjeEBw\iClQV3QJIFv[WyxZ4Ogc44hVzFiYX7kJG1DWCCneIDy[ZN{cW:w MkfWNlU4ODV6N{S=
SC M4XBPWZ2dmO2aX;uJGF{e2G7 NEjZRWUxNjVizszN MonaO|IhcA>? MoS1bY5kemWjc3XzJIJwfGhiS4LvfE0zOCCjbnSgU|Eh\XiycnXzd4lwdiCrbjDhfI9vNXKnbHH0[YQhW0O|IHL1eEBwdmy7IFvyc5guOjEEoB?= Mmm0NlU4ODV6N{S=
UACC-647  NH\Nc|FHfW6ldHnvckBCe3OjeR?= M2Tq[WROW09? NUHjZ5Q4dGWjZIOgeI8h[SC{aYPlJIlvKGODTWCgcIV3\Wy|IDjFR|UxyqB;wrCyNE4{QcLizszNLS=> NEXiPYczPTdyM{CyOS=>
UACC-647  M4PFXmZ2dmO2aX;uJGF{e2G7 MWexNOKh|ryP NWnPWXBbOTVibXnu M{DmWWROW09? NHPVVoxqdmirYnn0d{BGWkticHjvd5Bpd3K7bHH0bY9v MYOyOVcxOzB{NR?=
UACC-647  MnPjSpVv[3Srb36gRZN{[Xl? M2PW[VExyqEQvF2= NES3fm8yPSCvaX6= MW\EUXNQ NYP5fJpLcW6lcnXhd4V{KGWHRkKgdIhwe3Cqb4L5cIF1cW:wIHzleoVte8Li MV6yOVcxOzB{NR?=
SH-SY5Y  MmjQSpVv[3Srb36gRZN{[Xl? NXXQcG1JOTEEoN88US=> NELjfFEyyqCqwrC= NYntZYk5cW6lcnXhd4V{KEyXQzDhZ5Rqfmm2eR?= MXKyOVU6PzR|Mx?=
SH-SY5Y  MW\GeY5kfGmxbjDBd5NigQ>? MoC5NVDDqM7:TR?= M{XLeVHDqGkEoB?= MX7pcoNz\WG|ZYOgRWdEOSCvUl7BJIxmfmWu NUX5V4Z7OjV3OUe0N|M>
hADSCs MUfGeY5kfGmxbjDBd5NigQ>? M1XENVXjiIoEtV2= MoDnN|AhdWmw NWDSU5hRcW6lcnXhd4V{KGODTWCgcIV3\Wy| MYGyOVU6OTlyOB?=
HEK293  NX60No9rTnWwY4Tpc44hSXO|YYm= M3n1fVXjiIoEtV2= NH;sPJo{OCCvaX6= MW\pcoNz\WG|ZYOgZ2FOWCCuZY\lcJM> NHT4flgzPTV7MUmwPC=>
3T3-L1 NHnMdYZHfW6ldHnvckBCe3OjeR?= MX[yMlUwPSEQvF2= MVuyOEBpyqB? MlTQd4lodmmoaXPhcpRtgSCmZXPy[YF{\XNiQWTHUEBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiYXzsJIRwe2W|IITld5Rm\A>? NVLPcWhrOjV3OUC1PVc>
OCI-Ly1  MonUSpVv[3Srb36gRZN{[Xl? MVy0NOKh|ryP M1jHZVHDqGkEoB?= MWHEUXNQ MXvpcoR2[2W|IITo[UBqdmO{ZX3lcpQhd2ZiY1HNVEBkd26lZX70doF1cW:wcx?= NWrwTotHOjV3N{[yNlA>
OCI-Ly18  MnHvSpVv[3Srb36gRZN{[Xl? M2HvOlQxyqEQvF2= M4G1b|HDqGkEoB?= M{H5emROW09? NEXI[WVqdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> NY\zUW5XOjV3N{[yNlA>
BeWo M3PrdGZ2dmO2aX;uJGF{e2G7 M2n6flIxyqEEtV2= MXi0POKhcA>? NVzJbWlZTE2VTx?= NHvQcGxqdmO{ZXHz[ZMhfGinIHTp[oZmemWwdHnheIlwdiCxZjDC[XdwKGOnbHzz Mn;xNlU2PjZ5NEC=
BeWo NETJbJFHfW6ldHnvckBCe3OjeR?= Mof1NlDDqML3TR?= NFnTbIw1QMLiaB?= MWLEUXNQ NF3IZ4xqdmO{ZXHz[ZMhfGinIHHkbIV{cW:wIH;mJHRJWC1zIH3vco9kgXSncx?= NX[0SHdqOjV3Nk[3OFA>
LNCaP  MV3GeY5kfGmxbjDBd5NigQ>? MV[xNOKh|ryP NF3hXGUyOiCqwrC= NHz6R3pFVVOR MoXEbY5lfWOnczDhJIRz[W2jdHnjJIlv[3KnYYPlJI9nKEOURVKxJIFkfGm4aYT5 NHvNdJgzPTV2OEC5PS=>
ThGCs  M3fxdmZ2dmO2aX;uJGF{e2G7 M3KzfFEx6oDMzszN Ml60OQKBkmh? MWHheYdu\W62czDITWYySSCuZY\lcJMhfGijdDD3[ZJmKHO2aX31cIF1\WRiYomgR49EdDJ? NXvNXnNvOjV2M{OwNlc>
ThGCs  Moi3SpVv[3Srb36gRZN{[Xl? NFLHOmUyOOLCit88US=> NIT0cIU16oDMaB?= MYPpcoNz\WG|ZYOgR49EdDJvaX7keYNm\CCHRF6yxsBo\W6nIHX4dJJme3Orb36= M2HSS|I2PDN|MEK3
ThGCs  NXy2XmZOTnWwY4Tpc44hSXO|YYm= Ml24NVDjiIsQvF2= MomwN{Bp MX\pcohq[mm2czD0bIUh\W[oZXP0JI9nKEh{T{Kgc44hTUSQMjDtVm5C MUWyOVQ{OzB{Nx?=
RBMECs NG\o[lNHfW6ldHnvckBCe3OjeR?= NVW5[HpJOC5yNT:wMlUwPSEQvF2= NUK3U3ViOC5{NTDo M4DxNYlv[3KnYYPld{BkSU2SIHPvcoNmdnS{YYTpc44> M3nNUlI2PDF4NkWx
RBMECs NIHqVHNHfW6ldHnvckBCe3OjeR?= NV:0ZlBXPcLizszN NET4fI0yKGh? NVXRSG5w[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NFO2fWozPTRzNk[1NS=>
RBMECs MnHKSpVv[3Srb36gRZN{[Xl? NXq2Upl7PcLizszN MV6xJIg> MUHwdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> NVrKdlZZOjV2MU[2OVE>
RBMECs MmrhSpVv[3Srb36gRZN{[Xl? M37E[FXDqM7:TR?= MVOxJIg> MVfwdoV3\W62czD0bIUhcW6lcnXhd4UhcW5iSGLQJIZtfXhiYXPyc5N{KHSqZTDCWGIhcW6mdXPl[EBjgSBiRV3BVE1KUQ>? NUjsTYxQOjV2MU[2OVE>
RBMECs MU\GeY5kfGmxbjDBd5NigQ>? MUO1xsDPxE1? MnXmNUBp NIOxOWdqdmirYnn0d{B1cGViZHXjdoVie2WmIH;mJIFud3WwdDDv[kBbVy1zIHnuJG1HeyCrbnT1Z4VlKGK7IFXNRXAuUUl? NXG1SYZiOjV2MU[2OVE>
RBMECs MU\GeY5kfGmxbjDBd5NigQ>? NFX4THI2yqEQvF2= M4HuVVEhcA>? M1nWUZJmfmW{c3XzJJRp\SClaHHu[4V{KGmwIGrPMVEh\Gm|dILpZpV1cW:wIIPl[Y4hf2m2aDDFUWFRNUmLIITy[YF1dWWwdB?= Ml7aNlU1OTZ4NUG=
RBMECs MXzGeY5kfGmxbjDBd5NigQ>? NVXKfWVDPcLizszN M32zblEhcA>? M4jJZYJtd2OtczD0bIUhTU2DUD3JTU1qdmS3Y3XkJINp[W6pZTDpckBOVENicHjvd5Bpd3K7bHH0bY9v NYLCd2R[OjV2MU[2OVE>
RBMECs MUnGeY5kfGmxbjDBd5NigQ>? MoPoOeKh|ryP NVzBZ41KOSCq M4fpTYJtd2OtczD0bIUh[WO2aX6gZ5l1d3OtZXzleI9vKHKnYYLyZY5o\W2nboSgd4VmdiC5aYToJGVOSVBvSVmgeJJm[XSvZX70xsA> M2e3ZVI2PDF4NkWx
Primary bovine chondrocytes NXT3eYY6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4e2Z|XPxE1? M{e4O|Q5KGh? NX;i[mE6emW4ZYLz[ZMhfGinIHnubIljcXSxcomg[YZn\WO2IH;mJINmdGWlb4jpZkBwdiCycn;sbYZmemG2aX;uJIlvKGe{b4f0bEBxdGG2ZTDjbI9v\HKxY4n0[ZM> NF;2W5QzPTRyNkCxOi=>
EM1  MoWxSpVv[3Srb36gRZN{[Xl? M1fuRVE26oDMzszN NHu5NlM1QCCq NFPkdJdz\WS3Y3XzJJRp\SCneIDy[ZN{cW:wIH;mxsBNUUcEoH;yxsBRXEeVMtMgbY7DqEODTGKtJI9zyqCHUFHDNk1{cWynbnPl[EBGVTFiY3XscJPDqA>? M{HpOlI2Ozd6Nk[x
BeWo  MlXLSpVv[3Srb36gRZN{[Xl? NIDkSHYzOMLiwsXN MorxOFjDqGkEoB?= MV7EUXNQyqB? MYLpcoNz\WG|ZYOgeIhmKGKndHGtbGNIKHKnbHXhd4U> M4fEZVI2OzZ{Mk[w
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BeWo  MV7GeY5kfGmxbjDBd5NigQ>? NIPPPVMzOMLiwsXN M3KwV|Q5yqCqwrC= NWGwd|RITE2VT9Mg Mojy[I94dnKnZ4XsZZRmeyC2aHWgcIV3\Wxib3[gS2NONTF? Mn\ONlU{PjJ{NkC=
granulosa cells MkHGSpVv[3Srb36gRZN{[Xl? NH;0XVcyOCEQvF2= M1LuNlEzNzJ2IHi= MUDpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\sLiUlfTNuKhdVKQQR?= NGTCTm8zPTN|OUGwOS=>
granulosa cells NVXo[YgxTnWwY4Tpc44hSXO|YYm= M{TuWVExKM7:TR?= MYCxNk8zPCCq NFHMXWFqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDy[ZBwenSncjDhZ5Rqfmm2eTDmc5IhfGinIHzvcodme3RiZoLh[41mdnRiKPMIllg2PC9tMUjSS3MzNkyXQzm= NFf3OG0zPTN|OUGwOS=>
granulosa cells MYLGeY5kfGmxbjDBd5NigQ>? NIe1O2MyOCEQvF2= M3XRUFI1KGh? MYXpcoNz\WG|ZYOgeIhmKGmwdHXud4l1gSCxZjDEUmEweHKxdHXpckBkd22ybHX4 NGCxdVIzPTN|OUGwOS=>
granulosa cells MnL6SpVv[3Srb36gRZN{[Xl? MoDUNVAh|ryP MYiyOEBp NEHWNIhqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDSS3MzKHC{b33veIVzKGGldHn2bZR6 MXKyOVM{QTFyNR?=
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HEK‐CFTR MmLuSpVv[3Srb36gRZN{[Xl? MVWy5qCUPTEEoN88US=> MoXsNE0yOiCvaX6= MXvEUXNQyqB? NWrkWotCcW6mdXPld{BiKGSxc3ZihLBl\XCnbnTlcpQhcW:maXTlJIVn\my3eNMg M2PR[|I2OjZ|MkC3
L6 NGfrS|ZHfW6ldHnvckBCe3OjeR?= NH3nVnM1OCEEtV2= MVeyOEBp NV:zPIhOcW6qaXLpeJMhTE2KMT3pcoR2[2WmIFHreEBi[3SrdnH0bY9v M{T6XFI2OjR5NUWw
MIN6  MmPPSpVv[3Srb36gRZN{[Xl? MYGxNEDPxE4EoB?= NVq4WFd1OyCq NUO0dlBycW6lcnXhd4V{KER|IH3SUmEh\XiycnXzd4lwdg>? NHrBWoczPTJ2MUGyOC=>
ventricular cardiomyocytes  NITpWGJHfW6ldHnvckBCe3OjeR?= NVHacWw5OC5yMT2xNEDPxE1? MXrpcoNz\WG|ZYOgJINCVVBiYXPjeY12dGG2aX;u NETjVpUzPTJyM{GxNy=>
ventricular cardiomyocytes  NXz0Wo41TnWwY4Tpc44hSXO|YYm= M1SyZVAvODFvMUCg{txO MYjleo9s\XNiYX6gbY5wfHKxcHnjJJJme3CxboPlJFEzOMLzMUWlJIFjd3[nIHLhd4FtKHerdHigZY4hTUN3MNMgc4YhOi5{INM1US=> NELj[4QzPTJyM{GxNy=>
BeWo  MV7GeY5kfGmxbjDBd5NigQ>? NV\5UJlbOjBiwsXN NGLS[Ic1QCCq NFvUOmxFVVORwrC= NYTmcm52cW6mdXPld{Bk\WyuIH\1d4lwdg>? MmD0NlUyQDR2N{e=
THP-1  M4XoUWZ2dmO2aX;uJGF{e2G7 NHX0dVkyNzFyIN88US=> NGKwSZAzyqCq M{LmeGROW00EoB?= MYfzeZBxemW|c3XzJG1EWC1zIIDyc4R2[3Srb39CpC=> NGfjWYszPTF3NEi4Ni=>
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SW480 MofESpVv[3Srb36gRZN{[Xl? MkHqOFDDqM7:TR?= M4iyU|Q5yqCq MXnEUXNQ MVPhZ5RqfmG2ZYOgVHAzSQ>? M364VVI1QTl5NEWx
HT-29  Mk\uSpVv[3Srb36gRZN{[Xl? M2fBcVQxyqEQvF2= M4L2WFQ5yqCq M3f6ZmROW09? NYCxfFlP[WO2aY\heIV{KFCSMlG= NVjuZ3JmOjR7OUe0OVE>
SW480 Mny4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1jIdFQxyqEQvF2= NEHyTXMxNTd{IHi= NGLxOFhFVVOR NYSzNYhqcW6qaXLpeJMh[2WubDDndo94fGhidHnt[UBl\XCnbnTlcpRtgQ>? NIm0V2kzPDl7N{S1NS=>
HT-29  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPEWnJyPDEEoN88US=> MoT2NE04OiCq MYDEUXNQ NILJcVhqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lJIRmeGWwZHXueIx6 NGnhb5QzPDl7N{S1NS=>
SW480 MlmwSpVv[3Srb36gRZN{[Xl? MWS0NOKh|ryP MYe3JIQ> MnHGSG1UVw>? MV;y[YR2[2W|IHPvcI9vd3OyaHXy[UBnd3KvYYTpc44h[2GyYXLpcIl1gcLi NVT0VoRmOjR7OUe0OVE>
HT-29  NYfzZpB{TnWwY4Tpc44hSXO|YYm= NYntb4JnPDEEoN88US=> MUG3JIQ> NH36b4NFVVOR M{DRZZJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= NGP0d44zPDl7N{S1NS=>
SW480 NYTBT4FzSXCxcITvd4l{KEG|c3H5 M2DuW|QxyqEQvF2= NGPuU241QMLiaB?= NHS4Z5ZFVVOR NVrmbW8zcW6mdXPld{BidiCjY4TpeoF1cW:wIH;mJINie3Cjc3WgN{84 NEXvfHUzPDl7N{S1NS=>
HT-29  NVztPJRJSXCxcITvd4l{KEG|c3H5 MUC0NOKh|ryP NUm3Z2FbPDkEoHi= NF;FPXVFVVOR M1HZbIlv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> M3K5WlI1QTl5NEWx
SW480 MkfZRZBweHSxc3nzJGF{e2G7 NWfJcoh[PDEEoN88US=> NHHGdlg1QMLiaB?= MUTEUXNQ M{LpeIlv\HWlZYOgZ4hidmenczDpckB1cGVicHjvd5Bpd3K7bHH0bY9vKHO2YYT1d{Bw\iCSUELBJJRiemendIO= Ml[4NlQ6QTd2NUG=
HT-29  MWnBdI9xfG:|aYOgRZN{[Xl? MmnIOFDDqM7:TR?= NXzVeHd[PDkEoHi= NUOzV5AxTE2VTx?= Mom0bY5lfWOnczDjbIFv\2W|IHnuJJRp\SCyaH;zdIhwenmuYYTpc44he3SjdIXzJI9nKFCSMlGgeIFz\2W2cx?= MYSyOFk6PzR3MR?=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID