Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MUjGeY5kfGmxbjDBd5NigQ>? MV2xNEDPxE1? M4LET|YhcA>? NVTQeVVpcW6lcnXhd4V{KHCqb4PwbI9zgWyjdHnvckBw\iCxdnXy[ZhxemW|c3XkJGtNUEx|IHH0JHM1OzN? MV6yOlQ{PTR7OB?=
Mo-DCs MoThSpVv[3Srb36gRZN{[Xl? M4niWFUxKM7:TR?= MYGyOQKBkWh? M2r0epBzd22xdHXzJGlNNTJ|IIDyc4R2[3Srb36gbY4hfGinIIP1dIVzdmG2YX70JI9nKHq7bX;zZY4he3SrbYXsZZRm\CCPbz3ER5PDqA>? NGf1ZWYzPjRzMkm0PC=>
RBMECs  MmG0SpVv[3Srb36gRZN{[Xl? NIDG[Yw2yqEQvF2= NEPw[nkyyqCq MV7icI9kc3NidHjlJHJi[zFiaX7hZ5RqfmG2aX;uJIlv\HWlZXSgZpkhTU2DUD3JTS=> M{nxbFI3OzV6MEO5
INA-6 M{TxRWNmdGxiVnnhZoltcXS7IFHzd4F6 M4ryPFAuOTByIN88US=> MVG3NwKBkWh? M{DN[olv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 M4PX[lI3OzB4NkK0
OPM-2 MVvD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NXrV[WNGOC1zMECg{txO NFLWbmo4OuLCiXi= Mn7sbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NVXoeJliOjZ|ME[2NlQ>
U266 MoPzR4VtdCCYaXHibYxqfHliQYPzZZk> MWiwMVExOCEQvF2= NXS4S5RJPzMkgJno Mnu5bY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MUOyOlMxPjZ{NB?=
H929 M2DNcGNmdGxiVnnhZoltcXS7IFHzd4F6 MUewMVExOCEQvF2= NHLCU3E4OuLCiXi= Mn3ibY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MYeyOlMxPjZ{NB?=
RPMI 8226 M2PMUmNmdGxiVnnhZoltcXS7IFHzd4F6 MlXJNE0yODBizszN MWe3NwKBkWh? Mn;EbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MYmyOlMxPjZ{NB?=
MDCK  MYPGeY5kfGmxbjDBd5NigQ>? M4fkdFExKML3TR?= Mm\2NlQhcA>? NXzhNYRvTE2VTx?= MX;1dJJm\3WuYYTld{B1cGViZYjwdoV{e2mxbjDv[kBVT0ZvzsKxJIFv\CCFVFfGxsA> MW[yOlIxOjN3Mh?=
MDCK  M4XUVmZ2dmO2aX;uJGF{e2G7 MlnSNVAhyrWP MXyyOEBp NIC3UYJFVVOR MXfpcohq[mm2czD0bIUhcW6lcnXhd4VlKGW6cILld5Nqd25ib3[gSm4h[2G3c3XkJIJ6KFSJRj5OtlE> M3XPXVI3OjB{M{Wy
Spinal cords  M33hPGZ2dmO2aX;uJGF{e2G7 MkXYNeKh|ryP Mkj6N|AhdWmw NYTITVRze3SrbYXsZZRmeyClQV3QJIxmfmWucx?= NXjCU|g3OjZzMk[5NlY>
BeWo  NGXoXpNHfW6ldHnvckBCe3OjeR?= M2j0cVI26oDLzszN M4rRcFI1NzR6L{eyJIg> M{LyO4xm[WS|IITvJIFvKGmwY4LlZZNmKGmwIITo[UBmgHC{ZYPzbY9vKG:oIH;0bIVzKG[3c3nvckBu[XKtZYLz MWSyOlA2OzV2OR?=
bovine oocytes MXzGeY5kfGmxbjDBd5NigQ>? M4O1SlExOMLizszN NYTmZY5wOTMEoHi= NXr0VXJ4cW6qaXLpeJMhfGinIHXm[oVkfCCxZjDOVHBCKGGwZD;vdkBPWFCFIITvJJN1cW23bHH0[UBz\XO3bYD0bY9vKG:oIH3lbY9{cXN? NGHDcnczPjB3MU[xNS=>
Caco-2  Mm\PSpVv[3Srb36gRZN{[Xl? NUDJeGUxOC5zL{GvNVAh|ryP NI\VUFgzOMLibXnu MWrpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7jdoVie2ViaX6gbY51emGlZXzseYxieiClQV3QJIxmfmWucx?= Ml3jNlYxPDlzMEK=
Caco-2  NIPrelVHfW6ldHnvckBCe3OjeR?= M2jzdFAvOS9zL{GwJO69VQ>? M{X6UFI1KGh? M2rtfIlv[3KnYYPld{BOWlB{IIDyc5RmcW5ibHX2[Yw> NUC5ZZN5OjZyNEmxNFI>
AML-12  M4KzSWZ2dmO2aX;uJGF{e2G7 MX:yNEDPxE1? M3jvUVMhcA>? M37HOZVxemWpdXzheIV{KHSqZTDwbI9{eGixconsZZRqd25ibHX2[Yx{KGG2IGTodk01OTFiYX7kJHNmei12OUO= M3vyTVI3ODR6OUi1
AML-12  NGPTZ4dHfW6ldHnvckBCe3OjeR?= NYDOVJFZOjBizszN M{TTOFEuQCCq Mnu2bY5kemWjc3XzJIdtfWOxc3WgdJJw\HWldHnvci=> NFSyflAzPjB2OEm4OS=>
AML-12  NVWzcZVDTnWwY4Tpc44hSXO|YYm= MWeyNEDPxE1? NWfMWlVsOyCq NFHaZYp2eC2{ZXf1cIF1\XQEoGDnZ|FiNMLiUHXwZ4stKGGwZNMgS|Zx[8LibWLORUBt\X[nbIO= NIrQR2ozPjB2OEm4OS=>
AML-12  MXvGeY5kfGmxbjDBd5NigQ>? MUCyNEDPxE1? MlK3N{Bp M37xeIlv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKG:oIFPSWGMzyqB? M{frd|I3ODR6OUi1
RBMECs NVP2XGN5TnWwY4Tpc44hSXO|YYm= Mlu4OeKh|ryP NVjzZoxJOSCq NY\oUJJWcW6qaXLpeJMhTU2DUD3JTU1qdmS3Y3XkJIlv[WO2aY\heIlwdiCxZjDSZZAyyqB? MkXINlYxPDR4NkO=
EndoC-βH1 NWnWO4IyTnWwY4Tpc44hSXO|YYm= NV;SNItpPcLizszN MYWxJIg> M{T4dJBwfGWwdHnheIV{KGeudXPvd4UucW6mdXPl[EBqdnO3bHnuJJNm[3KndHnvckBqdiC2aHWgdJJme2WwY3Wgc4Yh\2y3Y3;z[S=> MorQNlYxOjh3NkK=
EndoC-βH1 M2rGPWZ2dmO2aX;uJGF{e2G7 NFfR[pE2yqEQvF2= NUn5Umw{OSCq NVrVb4VNdGWjZIOgeI8h[SC|dILvcoch[0GPUDDpcoNz\WG|ZR?= MUeyOlAzQDV4Mh?=
SH-SY5Y M{PKRmZ2dmO2aX;uJGF{e2G7 M1y1Z|MxKM7:TR?= MkP0N|AhdWmw MVPEUXNQ MVjzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgZYN1cX[jdHnvckBw\iCSS1G= NX3QN2NyOjZyMkWxN|c>
PC-3 MnKySpVv[3Srb36gRZN{[Xl? MXO0NEDDvU1? MkTzNkBp NVvnc|RnTE2VTx?= MXrs[YFleyC2bzDQVFJCKGGldHn2ZZRqd25? NYHJN2s3OjZyMkO4N|Y>
PC-3 M4XUTGNmdGxiVnnhZoltcXS7IFHzd4F6 NILWdoo1OCEEtV2= NWHNfXN{OjRxNEivO|IhcA>? M3rabWROW09? NU\qS3ZK\GWlcnXhd4V{KGOnbHygeoli[mmuaYT5JJRqdWViZHXw[Y5l\W62bIm= MXGyOlAzOzh|Nh?=
SCG NEDNbYlHfW6ldHnvckBCe3OjeR?= NInjcW0zOCEQvF5CpC=> MVHEUXNQ MmLJdoV3\XK|aXLsfUB{fXCycnXzd4V{KEmNVjD3bZRpKGFiSVO1NEBw\iB{ND60JO69VQ>? NG\acmQzPTl4MkGzNi=>
HEK-293 MYHGeY5kfGmxbjDBd5NigQ>? M4r4blM2KM7:TdMg NGezNHlFVVOR MUXpcoR2[2W|IHGgZ49ve3CrY4XveZMh6oDeaX7hZ5RqfmG2aX;u5qCeKG:oIITo[UBMfjJwMTDjeZJz\W62 NETKRoszPTl4MkGzNi=>
SCG NYnYPIl1TnWwY4Tpc44hSXO|YYm= NWfVOm1DOTByIN88UeKh M1nVVmROW09? MXHy[YR2[2W|IITo[UBmgGOrdHHibYxqfHlib3[gV2NIKG6ndYLvcpM> NVnrT4VpOjV7NkKxN|I>
PCCL3 MmO3SpVv[3Srb36gRZN{[Xl? M4\oUVExKML3TR?= M4exeVI1KGh? NEXvd4pmdmijbnPld{BFfU:6MjDwdo9ud3SncjD0doFve2O{aYD0bY9vKGGldHn2bZR6yqEkgJu= NIPXVmMzPTl4MEm1Oi=>
3T3-L1 preadipocytes M{HtV2Z2dmO2aX;uJGF{e2G7 M2j0fFExKM7:TdMg NIjrOVgyOiCq MlPSbY5lfWOnczDDVmVDKHCqb4PwbI9zgWyjdHnvckBidmRiQz;FRnDPuiCneIDy[ZN{cW:w MlvjNlU6OjhyNUi=
H295R  NF;SNWFHfW6ldHnvckBCe3OjeR?= M1e2V|ExyqEQvF2= NYXsPWVUPDkEoHi= MUTpcoNz\WG|ZYOgd5Rmem:rZDDt[ZRi[m:uaYTld{BqdiC2aHWgZY5lem:pZX6sJI1qdmW{YXzvMUBidmRiZ3z1Z49kd3K2aXPvbYQheGG2aIfhfZM> M{j6Z|I2QDZ7NUW2
PBMC M3vOUGZ2dmO2aX;uJGF{e2G7 NEDWZXk2OMLizszN NW\ENFh{OjUEoHlCpC=> MkfkbY5pcWKrdIOgeIhmKGmwY4LlZZNm\CC|ZXPy[ZRqd25ib3[gWG5HKGmwZIXj[YQh[nlidHjlJGRRTQ>? M2TKN|I2QDZ4MEe5
GLUTag  MVrGeY5kfGmxbjDBd5NigQ>? Mk\qNVDjiIoEtV2= NXvweJNnOC9{L{SgbC=> MWHzeIlufWyjdHXzJGdNWC1zIIPlZ5JmfGmxbjDjc5Rz\WG2ZXSge4l1cCCLQl3Y NGWxZlIzPTh|Mk[zNS=>
GLUTag  NFvw[3VHfW6ldHnvckBCe3OjeR?= NV3mZWk1OTEkgJpCuW0> MWK0JIg> M{DHXIlv[3KnYYPld{B1cGVicFPSSWIhdGW4ZXzzJJdqfGhidHjlJGlDVVh? NEf0WYwzPTh|Mk[zNS=>
BAECs Mo\sSpVv[3Srb36gRZN{[Xl? NXLQSZNCOjVizszN MlvaNlQhcA>? MXvlcohidmOnczD0bIUh[WO2aY\heIlwdiCxZjDQVGFT|rFiYomgOUDPxE1icnXzeoVz[XS{b3ysJHQ1UFNuIH;yJFQuWEGS NYWwfohZOjV5OUi4NlY>
PC12 NISxblBHfW6ldHnvckBCe3OjeR?= NES0eGYzPcLizszN NWOyZlN1PDhiaB?= NXTTSXJn[WO2aY\heIV{KGODTWC= M2H5SlI2PzZ7M{C1
GH3 MVPGeY5kfGmxbjDBd5NigQ>? NWrxWVk5OcLizszN MXS2MYg> M2DIfoF1fGWwdXH0[ZMhfGinIHPvdpJmdGG2aX;uJIJmfHenZX6gVHJNKGGwZDDCcYFtOSCneIDy[ZN{cW:w NIDTS3ozPTd{N{CxPC=>
GH3 M{TadmZ2dmO2aX;uJGF{e2G7 NXPyUXozOcLizszN NWXjOFlyPi2q NFrTUpVqdmS3Y3XzJHBTVCCjbnSgRo1idDFuIHL1eEBvd3RiQ3zvZ4stKG2UTlGg[ZhxemW|c3nvci=> MWGyOVczPzBzOB?=
BeWo NVzoemhkTnWwY4Tpc44hSXO|YYm= M{mzWVEx6oDMzszNxsA> MUC3NkBp M3vUVWROW09? MoGxcYVlcWG2ZYOgRoVYdyClZXzsJIRq\m[ncnXueIlifGmxbh?= MX[yOVcyOzR{NR?=
oocytes MV;GeY5kfGmxbjDBd5NigQ>? NGH3[5k2KM7:TR?= M3TxTFI1KGh? NUSwW5dE[XS2ZX71ZZRmeyC{aD3pcpN2dGmwIHHjeIlwdiCxbjDvc4N6fGViR2\CSEB{cWewaX\pZ4FvfGy7wrC= NU\FWpFsOjV5MEe4OVQ>
SC M{HFZ2Z2dmO2aX;uJGF{e2G7 NVnMWWhOOC53IN88US=> MX6yOEBp MYHtbY1q[2u|IITo[UBm\m[nY4Sgc4Yh[0GPUDDhcoFtd2e|IH;uJG8yKGGwZDDNRnAh\XiycnXzd4lwdg>? NIDIUYMzPTdyNUi3OC=>
SC MX3GeY5kfGmxbjDBd5NigQ>? NEft[mwxNjVizszN M2jyOlczKGh? NHfHO2RqdmO{ZXHz[ZMh[m:2aDDLdo95NTJyIHHu[EBQOSCneIDy[ZN{cW:wIHnuJIF5d25vcnXsZZRm\CCVQ4OgZpV1KG:wbImgT5JwgC1{MNMg NVPObI9xOjV5MEW4O|Q>
UACC-647  NWLJZoF[TnWwY4Tpc44hSXO|YYm= NGLiUolFVVOR NGW0TXRt\WGmczD0c{BiKHKrc3WgbY4h[0GPUDDs[ZZmdHNiKFXDOVDDqD4EoEKwMlM6yqEQvF2p MYCyOVcxOzB{NR?=
UACC-647  NYXvbmxYTnWwY4Tpc44hSXO|YYm= MoX3NVDDqM7:TR?= MXuxOUBucW5? MnHiSG1UVw>? M3WzWolvcGmkaYTzJGVTUyCyaH;zdIhwenmuYYTpc44> Mom0NlU4ODNyMkW=
UACC-647  MXrGeY5kfGmxbjDBd5NigQ>? M4LDdVExyqEQvF2= MmmzNVUhdWmw MV\EUXNQ NWnHd4M6cW6lcnXhd4V{KGWHRkKgdIhwe3Cqb4L5cIF1cW:wIHzleoVte8Li M1T1XlI2PzB|MEK1
SH-SY5Y  MoHJSpVv[3Srb36gRZN{[Xl? NG[z[mMyOMLizszN MlH3NeKhcMLi M3[3XIlv[3KnYYPld{BNXUNiYXP0bZZqfHl? Mn;aNlU2QTd2M{O=
SH-SY5Y  M2PyR2Z2dmO2aX;uJGF{e2G7 MYOxNOKh|ryP NInXcYEyyqCqwrC= M3jCWYlv[3KnYYPld{BCT0NzIH3SUmEhdGW4ZXy= M4LD[lI2PTl5NEOz
hADSCs NWf4PZF4TnWwY4Tpc44hSXO|YYm= MUW15qCKyrWP MYizNEBucW5? MYTpcoNz\WG|ZYOgZ2FOWCCuZY\lcJM> M1XNflI2PTlzOUC4
HEK293  MUXGeY5kfGmxbjDBd5NigQ>? MlfTOgKBkcL3TR?= Ml3xN|AhdWmw NWPCfVBzcW6lcnXhd4V{KGODTWCgcIV3\Wy| Mn\NNlU2QTF7MEi=
3T3-L1 NXfsOWNlTnWwY4Tpc44hSXO|YYm= MV:yMlUwPSEQvF2= M{\vd|I1KGkEoB?= Mortd4lodmmoaXPhcpRtgSCmZXPy[YF{\XNiQWTHUEBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiYXzsJIRwe2W|IITld5Rm\A>? MUCyOVU6ODV7Nx?=
OCI-Ly1  NWfEOpZvTnWwY4Tpc44hSXO|YYm= MoLjOFDDqM7:TR?= MVSxxsBpyqB? M3:4ZmROW09? M{j6T4lv\HWlZYOgeIhmKGmwY4LlcYVvfCCxZjDjRW1RKGOxbnPlcpRz[XSrb37z NUS5Sox1OjV3N{[yNlA>
OCI-Ly18  M3\qdWZ2dmO2aX;uJGF{e2G7 MnvtOFDDqM7:TR?= M3fSfVHDqGkEoB?= MVHEUXNQ M1HQTolv\HWlZYOgeIhmKGmwY4LlcYVvfCCxZjDjRW1RKGOxbnPlcpRz[XSrb37z NVT1TWxJOjV3N{[yNlA>
BeWo M{HTcGZ2dmO2aX;uJGF{e2G7 MWqyNOKhyrWP NIHKdFQ1QMLiaB?= MnnJSG1UVw>? MWrpcoNz\WG|ZYOgeIhmKGSrZn\ldoVvfGmjdHnvckBw\iCEZWfvJINmdGy| NH23NG0zPTV4Nke0NC=>
BeWo NYO2b3E1TnWwY4Tpc44hSXO|YYm= MoDrNlDDqML3TR?= MVG0POKhcA>? Mn7DSG1UVw>? M3ryXolv[3KnYYPld{B1cGViYXTo[ZNqd25ib3[gWGhRNTFibX;uc4N6fGW| M{TmOVI2PTZ4N{Sw
LNCaP  NFn2bo1HfW6ldHnvckBCe3OjeR?= MUixNOKh|ryP NWfBUoZzOTJiaNMg NFO3NJBFVVOR Mn6zbY5lfWOnczDhJIRz[W2jdHnjJIlv[3KnYYPlJI9nKEOURVKxJIFkfGm4aYT5 NYfsXZpDOjV3NEiwPVk>
ThGCs  M{[0VGZ2dmO2aX;uJGF{e2G7 NELUeJYyOOLCit88US=> NYLvSJgyPOLCini= Mom0ZZVodWWwdIOgTGlHOUFibHX2[Yx{KHSqYYSge4Vz\SC|dHnteYxifGWmIHL5JGNwS2x{ MnfoNlU1OzNyMke=
ThGCs  MlzNSpVv[3Srb36gRZN{[Xl? MlLPNVDjiIsQvF2= NXniXphxPOLCini= MV7pcoNz\WG|ZYOgR49EdDJvaX7keYNm\CCHRF6yxsBo\W6nIHX4dJJme3Orb36= MX[yOVQ{OzB{Nx?=
ThGCs  MWDGeY5kfGmxbjDBd5NigQ>? MoPwNVDjiIsQvF2= M17We|MhcA>? MoC1bY5pcWKrdIOgeIhmKGWoZnXjeEBw\iCKMl:yJI9vKEWGTkKgcXJPSQ>? NHvXc4MzPTR|M{CyOy=>
RBMECs MULGeY5kfGmxbjDBd5NigQ>? MVGwMlA2NzBwNT:1JO69VQ>? M2XFfVAvOjViaB?= MojFbY5kemWjc3XzJINCVVBiY3;uZ4VvfHKjdHnvci=> NWHLRmhbOjV2MU[2OVE>
RBMECs MVfGeY5kfGmxbjDBd5NigQ>? NXjpNGZ6PcLizszN MYOxJIg> NXvXd|Nr[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NILUUVEzPTRzNk[1NS=>
RBMECs MV\GeY5kfGmxbjDBd5NigQ>? NFTrUGY2yqEQvF2= NWnaOFFNOSCq MX7wdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> NWjrRXpMOjV2MU[2OVE>
RBMECs NU[zZ45nTnWwY4Tpc44hSXO|YYm= M2PIfFXDqM7:TR?= MY[xJIg> MUnwdoV3\W62czD0bIUhcW6lcnXhd4UhcW5iSGLQJIZtfXhiYXPyc5N{KHSqZTDCWGIhcW6mdXPl[EBjgSBiRV3BVE1KUQ>? NXKxV|J2OjV2MU[2OVE>
RBMECs MlPqSpVv[3Srb36gRZN{[Xl? NVLUNZUxPcLizszN M1HuflEhcA>? MmnWbY5pcWKrdIOgeIhmKGSnY4LlZZNm\CCxZjDhcY92dnRib3[gXm8uOSCrbjDNSpMhcW6mdXPl[EBjgSCHTVHQMWlK NHLsS3IzPTRzNk[1NS=>
RBMECs MWjGeY5kfGmxbjDBd5NigQ>? MkHYOeKh|ryP NETQT4kyKGh? MYry[ZZmenOnczD0bIUh[2ijbnfld{BqdiCcTz2xJIRqe3S{aXL1eIlwdiC|ZXXuJJdqfGhiRV3BVE1KUSC2cnXheI1mdnR? NV2wcG13OjV2MU[2OVE>
RBMECs MY\GeY5kfGmxbjDBd5NigQ>? MW[1xsDPxE1? NVPqcYF5OSCq Ml\tZoxw[2u|IITo[UBGVUGSLVnJMYlv\HWlZXSgZ4hidmenIHnuJG1NSyCyaH;zdIhwenmuYYTpc44> NYHablFQOjV2MU[2OVE>
RBMECs MU\GeY5kfGmxbjDBd5NigQ>? M17SOFXDqM7:TR?= M3mzeVEhcA>? NIfNb2FjdG:la4OgeIhmKGGldHnuJIN6fG:|a3Xs[ZRwdiC{ZXHydoFv\2WvZX70JJNm\W5id3n0bEBGVUGSLVnJJJRz\WG2bXXueOKh NX\qUII2OjV2MU[2OVE>
Primary bovine chondrocytes M1Pqb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLkd4FrPc7:TR?= NX3wd3Z5PDhiaB?= NFHI[IRz\X[ncoPld{B1cGViaX7obYJqfG:{eTDl[oZm[3Rib3[gZ4Vt\WOxeHniJI9vKHC{b3zp[oVz[XSrb36gbY4h\3Kxd4ToJJBt[XSnIHPoc45lem:leYTldy=> Mnv4NlU1ODZyMU[=
EM1  MnLSSpVv[3Srb36gRZN{[Xl? NYTnNGtWOTYkgJtOwG0> MoS3OFghcA>? M2LQepJm\HWlZYOgeIhmKGW6cILld5Nqd25ib3dCpGxKTsLib4NCpHBVT1N{wrDpcuKhS0GOUj2gc5LDqEWSQVOyMZNqdGWwY3XkJGVOOSClZXzsd:Kh NYfoO3ZUOjV|N{i2OlE>
BeWo  MnnlSpVv[3Srb36gRZN{[Xl? NXnN[m1kOjEEoNM1US=> NWLocmdGPDkEoHlCpC=> MU\EUXNQyqB? NI\1O5FqdmO{ZXHz[ZMhfGinIHLleIEucEOJIILlcIVie2V? NETFfFEzPTN4MkK2NC=>
BeWo  NVjKNopoTnWwY4Tpc44hSXO|YYm= NFqwWXgzOMLiwsXN M{PEO|Q5yqCqwrC= MofPSG1UV8Li M4H2SoRwf26{ZXf1cIF1\XNidHjlJIxmfmWuIH;mJHROTU2IMU[= MofXNlU{PjJ{NkC=
BeWo  M3PETWZ2dmO2aX;uJGF{e2G7 MmrhNlDDqML3TR?= NWLJRlRHPDkEoHlCpC=> M4fWc2ROW00EoB?= NV;6PXFZ\G:5boLl[5Vt[XSnczD0bIUhdGW4ZXygc4YhT0OPLUG= M3HlRlI2OzZ{Mk[w
granulosa cells NX;2cJp{TnWwY4Tpc44hSXO|YYm= NHmwNGwyOCEQvF2= NUTRUlZGOTJxMkSgbC=> M{jENIlv[3KnYYPld{B1cGVibHX2[Yx{KG:owrDSS3MzyqCvUl7B MlvoNlU{OzlzMEW=
granulosa cells NUP3Umg{TnWwY4Tpc44hSXO|YYm= MkD0NVAh|ryP M2\GT|EzNzJ2IHi= MVHpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC{ZYDvdpRmeiCjY4Tpeol1gSCob4KgeIhmKGyxbnfld5Qh\nKjZ33lcpQhMOLKkki1OE8sOTiUR2OyMmxWSyl? M4XnTVI2OzN7MUC1
granulosa cells MkPSSpVv[3Srb36gRZN{[Xl? MWqxNEDPxE1? MUeyOEBp MkXHbY5kemWjc3XzJJRp\SCrboTlcpNqfHlib3[gSG5CN3C{b4TlbY4h[2:vcHzlfC=> NVX1N4NIOjV|M{mxNFU>
granulosa cells NH\M[FVHfW6ldHnvckBCe3OjeR?= M{PWXlExKM7:TR?= M4fBNVI1KGh? M3XFZYlv[3KnYYPld{B1cGVibHX2[Yx{KG:oIGLHV|IheHKxbX;0[ZIh[WO2aY\peJk> M{DxNFI2OzN7MUC1
SK-N-AS  M3fKTmNmdGxiVnnhZoltcXS7IFHzd4F6 M4faVFExKM7:TdMg NWLDT|I{OjRxNEigbC=> M1y0foVvcGGwY3XzJJRqdWVvZHXw[Y5l\W62bImgZ4VtdHWuYYKgeoli[mmuaYT5xsA> MVSyOVI3PjB4Mx?=
SK-N-AS  M2rUfWZ2dmO2aX;uJGF{e2G7 NXXnfZVrOTBizszNxsA> MoLqNlQhcA>? MULpcoNz\WG|ZYOgeIhmKGODTWCgcIV3\Wy|wrC= M4rPZVI2OjZ4ME[z
SK-N-AS  NYfreZdiTnWwY4Tpc44hSXO|YYm= M1XndVExKM7:TdMg MVuyOEBp MXrpcoNz\WG|ZYOgeIhmKGW6cILld5Nqd25ib3[gZ5lkdGmwIFSx MonuNlUzPjZyNkO=
SK-N-AS  M3jYcWZ2dmO2aX;uJGF{e2G7 M1nXNVExKM7:TdMg M2DpSlMxKG2rbh?= MnrnbY5lfWOnczDwbI9{eGixconsZZRqd25ib3[g{tIu[2G2ZX7pckApe2W{Nke1LUwheC2JU1uz{tIhMHOnckmpJIFv\CClb37jc41qfGGwdDDobYdp\XJibHX2[Yx{KG:oIHHjeIl3\SxidX7wbI9{eGixconsZZRm\CxizsKtZ4F1\W6rbh?= NW\xN3VNOjV{Nk[wOlM>
SK-N-AS  NXP6OmduTnWwY4Tpc44hSXO|YYm= NFrRT3kyOCEQvF5CpC=> NF;Jc|AyOC9|MD:2NEBucW5? M3vGS4lv[3KnYYPld{Bt\X[nbIOgc4YheC4Qsj3jZZRmdmmwIDjz[ZI3PzVrIHHu[EBqdmS3Y3XzJIFk[3WvdXzheIlwdiCxZjDwMe6zNWOjdHXubY4hMHOnck[3OUkhcW5iKIDldokqdnWlbHXhdkBz\Werb37z NHjrSYIzPTJ4NkC2Ny=>
SK-N-SH MYPD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NGP0RZUyOCEQvF5CpC=> M{PlUVQ5KGh? NYjF[Ipq\W6qYX7j[ZMhW0tvTj3TTEBv\XW{b3LsZZN1d22jIHPlcIwhfmmjYnnsbZR6 Mn7zNlUzPjZyNkO=
HEK‐CFTR MXHGeY5kfGmxbjDBd5NigQ>? NFzob48z6oDVNUFCpO69VQ>? MXSwMVEzKG2rbh?= MWPEUXNQyqB? NIPWfXBqdmS3Y3XzJIEh\G:|ZfMAlIRmeGWwZHXueEBqd2SrZHWg[YZndHW6wrC= NGnucpozPTJ4M{KwOy=>
L6 MYnGeY5kfGmxbjDBd5NigQ>? Mmj1OFAhyrWP MmLmNlQhcA>? Mm\0bY5pcWKrdIOgSG1JOS2rbnT1Z4VlKEGtdDDhZ5RqfmG2aX;u M2nF[FI2OjR5NUWw
MIN6  M4qweWZ2dmO2aX;uJGF{e2G7 M2ricFExKM7:TdMg MV[zJIg> MX\pcoNz\WG|ZYOgSFMhdVKQQTDlfJBz\XO|aX;u NUXXfW1[OjV{NEGxNlQ>
ventricular cardiomyocytes  MVrGeY5kfGmxbjDBd5NigQ>? MkDqNE4xOS1zMDFOwG0> MUjpcoNz\WG|ZYOgJINCVVBiYXPjeY12dGG2aX;u NHzZOYgzPTJyM{GxNy=>
ventricular cardiomyocytes  M3n3TmZ2dmO2aX;uJGF{e2G7 NF;VUVcxNjBzLUGwJO69VQ>? MnX1[ZZwc2W|IHHuJIlvd3S{b4DpZ{Bz\XOyb37z[UAyOjEEsUG1KUBi[m:4ZTDiZZNidCC5aYToJIFvKEWFNUFCpI9nKDJwMjFCuW0> NUe0cYdGOjV{MEOxNVM>
BeWo  MX3GeY5kfGmxbjDBd5NigQ>? Mk\6NlAhyrWP M2fDflQ5KGh? MXTEUXNQyqB? MkPhbY5lfWOnczDj[YxtKG[3c3nvci=> MkG5NlUyQDR2N{e=
THP-1  MlrwSpVv[3Srb36gRZN{[Xl? MY[xM|ExKM7:TR?= NFnsbpEzyqCq MkH3SG1UV8Li M{e5V5N2eHC{ZYPz[ZMhVUOSLUGgdJJw\HWldHnvcuKh MXqyOVE2PDh6Mh?=
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SW480 NGDZ[IRHfW6ldHnvckBCe3OjeR?= MWe0NOKh|ryP NHP4U3o1QMLiaB?= MYnEUXNQ NYrudmpK[WO2aY\heIV{KFCSMlG= MlSwNlQ6QTd2NUG=
HT-29  MUHGeY5kfGmxbjDBd5NigQ>? NH7FSZc1OMLizszN MXm0POKhcA>? NXHpXZhiTE2VTx?= NXrRcG4z[WO2aY\heIV{KFCSMlG= Mni2NlQ6QTd2NUG=
SW480 MoPlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHBfJY1OMLizszN MVywMVczKGh? MoTESG1UVw>? NXf2b4pYcW6qaXLpeJMh[2WubDDndo94fGhidHnt[UBl\XCnbnTlcpRtgQ>? NUnlT4k5OjR7OUe0OVE>
HT-29  Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\uXIpWPDEEoN88US=> M1LOVlAuPzJiaB?= NUXD[W9{TE2VTx?= NW\5ZlFRcW6qaXLpeJMh[2WubDDndo94fGhidHnt[UBl\XCnbnTlcpRtgQ>? MonNNlQ6QTd2NUG=
SW480 M3TNOmZ2dmO2aX;uJGF{e2G7 M2rHcFQxyqEQvF2= MnjHO{Bl MknxSG1UVw>? MXny[YR2[2W|IHPvcI9vd3OyaHXy[UBnd3KvYYTpc44h[2GyYXLpcIl1gcLi M{jFS|I1QTl5NEWx
HT-29  MlLoSpVv[3Srb36gRZN{[Xl? M3f0WlQxyqEQvF2= MU[3JIQ> M{LRWGROW09? NWnHPW5yemWmdXPld{Bkd2yxbn;zdIhmemViZn;ycYF1cW:wIHPhdIFjcWyrdIpCpC=> M{O0VVI1QTl5NEWx
SW480 M4iweWFxd3C2b4Ppd{BCe3OjeR?= M{XlWlQxyqEQvF2= NYnVdpE{PDkEoHi= MmHoSG1UVw>? NV70dIdLcW6mdXPld{BidiCjY4TpeoF1cW:wIH;mJINie3Cjc3WgN{84 M3jjeVI1QTl5NEWx
HT-29  MmTtRZBweHSxc3nzJGF{e2G7 MoD1OFDDqM7:TR?= MV60POKhcA>? M1XJeGROW09? NHPKU4FqdmS3Y3XzJIFvKGGldHn2ZZRqd25ib3[gZ4F{eGG|ZTCzM|c> NIPifXYzPDl7N{S1NS=>
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HT-29  NWjVVmFNSXCxcITvd4l{KEG|c3H5 NICwRXk1OMLizszN M{XiWVQ5yqCq NWHOSJd3TE2VTx?= M1\P[olv\HWlZYOgZ4hidmenczDpckB1cGVicHjvd5Bpd3K7bHH0bY9vKHO2YYT1d{Bw\iCSUELBJJRiemendIO= NHrUOGYzPDl7N{S1NS=>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID