Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
USD 110 In stock
USD 270 In stock
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USD 570 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NFO4WoVHfW6ldHnvckBCe3OjeR?= NITNUJEyOCEQvF2= NXXXZoF4PiCq MWnpcoNz\WG|ZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJI93\XKneIDy[ZN{\WRiS1zIUFMh[XRiU{SzNy=> MnPPNlY1OzV2OUi=
Mo-DCs M3fnNmZ2dmO2aX;uJGF{e2G7 M{jSXlUxKM7:TR?= MnnPNlTjiImq MoGydJJwdW:2ZYOgTWwuOjNicILv[JVkfGmxbjDpckB1cGVic4Xw[ZJv[XSjboSgc4Yhgnmvb4PhckB{fGmvdXzheIVlKE2xLVTDd:Kh MYqyOlQyOjl2OB?=
RBMECs  NY\xbFBJTnWwY4Tpc44hSXO|YYm= MkXNOeKh|ryP NFfZOJMyyqCq MUDicI9kc3NidHjlJHJi[zFiaX7hZ5RqfmG2aX;uJIlv\HWlZXSgZpkhTU2DUD3JTS=> NVTzfG5SOjZ|NUiwN|k>
INA-6 MmHWR4VtdCCYaXHibYxqfHliQYPzZZk> NX6wSFV4OC1zMECg{txO MVm3NwKBkWh? MXnpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= MlrrNlY{ODZ4MkS=
OPM-2 NXPofYh2S2WubDDWbYFjcWyrdImgRZN{[Xl? M1HGbVAuOTByIN88US=> NYi5TXk1PzMkgJno MmLjbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MYKyOlMxPjZ{NB?=
U266 M33S[mNmdGxiVnnhZoltcXS7IFHzd4F6 NIH0dZUxNTFyMDFOwG0> NUOzOFg2PzMkgJno NVS3ZmRJcW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> NXq3T2F4OjZ|ME[2NlQ>
H929 MnzLR4VtdCCYaXHibYxqfHliQYPzZZk> MVWwMVExOCEQvF2= M3TwXVcz6oDLaB?= NVvJd5ZZcW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> M1XBVlI3OzB4NkK0
RPMI 8226 MmDhR4VtdCCYaXHibYxqfHliQYPzZZk> NHHRR|YxNTFyMDFOwG0> NIrETVQ4OuLCiXi= NFywfXBqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> M1zW[lI3OzB4NkK0
MDCK  M3zvS2Z2dmO2aX;uJGF{e2G7 MmO3NVAhyrWP NGTTclEzPCCq NWDKSJB1TE2VTx?= MUT1dJJm\3WuYYTld{B1cGViZYjwdoV{e2mxbjDv[kBVT0ZvzsKxJIFv\CCFVFfGxsA> MkWwNlYzODJ|NUK=
MDCK  NGPucolHfW6ldHnvckBCe3OjeR?= MXqxNEDDvU1? M3zGOVI1KGh? M3vycmROW09? MVjpcohq[mm2czD0bIUhcW6lcnXhd4VlKGW6cILld5Nqd25ib3[gSm4h[2G3c3XkJIJ6KFSJRj5OtlE> NHW4b5YzPjJyMkO1Ni=>
Spinal cords  MV3GeY5kfGmxbjDBd5NigQ>? NIG1RZIyyqEQvF2= NGXtdZA{OCCvaX6= MYnzeIlufWyjdHXzJINCVVBibHX2[Yx{ M37XfFI3OTJ4OUK2
BeWo  M4T3[mZ2dmO2aX;uJGF{e2G7 MWSyOgKBkc7:TR?= NIHsNXgzPC92OD:3NkBp M{PPdoxm[WS|IITvJIFvKGmwY4LlZZNmKGmwIITo[UBmgHC{ZYPzbY9vKG:oIH;0bIVzKG[3c3nvckBu[XKtZYLz M16zTlI3ODV|NUS5
bovine oocytes MXvGeY5kfGmxbjDBd5NigQ>? MVixNFDDqM7:TR?= NYjKdIxSOTMEoHi= NFTKZodqdmirYnn0d{B1cGViZX\m[YN1KG:oIF7QVGEh[W6mL3;yJG5RWENidH:gd5RqdXWuYYTlJJJme3WvcITpc44hd2ZibXXpc5Nqew>? MlTiNlYxPTF4MUG=
Caco-2  M2XWemZ2dmO2aX;uJGF{e2G7 NVq0[3dSOC5zL{GvNVAh|ryP M37ReFIxyqCvaX6= MnvrbY5lfWOnczDhJIRwe2VvZHXw[Y5l\W62IHnuZ5Jm[XOnIHnuJIlvfHKjY3XscJVt[XJiY1HNVEBt\X[nbIO= MUKyOlA1QTFyMh?=
Caco-2  NGLWZ2NHfW6ldHnvckBCe3OjeR?= NGjUfmIxNjFxMT:xNEDPxE1? MWOyOEBp NH\ZUndqdmO{ZXHz[ZMhVVKSMjDwdo91\WmwIHzleoVt Mlu5NlYxPDlzMEK=
AML-12  NITweIxHfW6ldHnvckBCe3OjeR?= MUGyNEDPxE1? M1jl[|MhcA>? NHrFd212eHKnZ4XsZZRmeyC2aHWgdIhwe3Cqb4L5cIF1cW:wIHzleoVteyCjdDDUbJIuPDFzIHHu[EBU\XJvNEmz MX2yOlA1QDl6NR?=
AML-12  NVSycI8{TnWwY4Tpc44hSXO|YYm= MYWyNEDPxE1? NIji[WkyNThiaB?= NXjxSlg3cW6lcnXhd4V{KGeudXPvd4UheHKxZIXjeIlwdg>? MY[yOlA1QDl6NR?=
AML-12  MVLGeY5kfGmxbjDBd5NigQ>? MVWyNEDPxE1? MWezJIg> MXj1dE1z\We3bHH0[ZPDqFCpY{HhMOKhWGWyY3usJIFv\MLiR{\wZ:KhdVKQQTDs[ZZmdHN? MX[yOlA1QDl6NR?=
AML-12  NVfYfVV5TnWwY4Tpc44hSXO|YYm= NVTwcVE5OjBizszN MoHsN{Bp NVLx[4RvcW6mdXPld{B1cGViZHXwbI9{eGixconsZZRqd25ib3[gR3JVSzMEoB?= MlvjNlYxPDh7OEW=
RBMECs Ml;RSpVv[3Srb36gRZN{[Xl? MmT3OeKh|ryP MonoNUBp NV3ZZZc3cW6qaXLpeJMhTU2DUD3JTU1qdmS3Y3XkJIlv[WO2aY\heIlwdiCxZjDSZZAyyqB? NYPCXHdYOjZyNES2OlM>
EndoC-βH1 MkHhSpVv[3Srb36gRZN{[Xl? MlLaOeKh|ryP MXyxJIg> Mm\tdI91\W62aXH0[ZMh\2y3Y3;z[U1qdmS3Y3XkJIlve3WuaX6gd4VkemW2aX;uJIlvKHSqZTDwdoV{\W6lZTDv[kBodHWlb4Pl MXmyOlAzQDV4Mh?=
EndoC-βH1 MVLGeY5kfGmxbjDBd5NigQ>? MWC1xsDPxE1? MVyxJIg> M3\MN4xm[WS|IITvJIEhe3S{b37nJINCVVBiaX7jdoVie2V? M4LNZlI3ODJ6NU[y
SH-SY5Y Ml3OSpVv[3Srb36gRZN{[Xl? Mn[3N|Ah|ryP NFnTbnc{OCCvaX6= MX;EUXNQ MYLzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgZYN1cX[jdHnvckBw\iCSS1G= NUH6[5NHOjZyMkWxN|c>
PC-3 NWLyN4NtTnWwY4Tpc44hSXO|YYm= MmW3OFAhyrWP M{jZd|IhcA>? NIS4dpRFVVOR NVfGdnU4dGWjZIOgeI8hWFB{QTDhZ5RqfmG2aX;u MkHFNlYxOjN6M{[=
PC-3 M{njVGNmdGxiVnnhZoltcXS7IFHzd4F6 NX3KPGxIPDBiwsXN MoeyNlQwPDhxN{KgbC=> MlL5SG1UVw>? M4rqR4Rm[3KnYYPld{Bk\WyuII\pZYJqdGm2eTD0bY1mKGSncHXu[IVvfGy7 MnuwNlYxOjN6M{[=
SCG Mn7tSpVv[3Srb36gRZN{[Xl? NIjmfY4zOCEQvF5CpC=> MkTMSG1UVw>? MkjZdoV3\XK|aXLsfUB{fXCycnXzd4V{KEmNVjD3bZRpKGFiSVO1NEBw\iB{ND60JO69VQ>? NF;uN2UzPTl4MkGzNi=>
HEK-293 NY\afHRVTnWwY4Tpc44hSXO|YYm= MkmwN|Uh|ryPwrC= Mn7MSG1UVw>? MoG0bY5lfWOnczDhJINwdnOyaXP1c5V{KOLCnHnuZYN1cX[jdHnvcwKBpSCxZjD0bIUhU3Z{LkGgZ5VzemWwdB?= NXi4cm5YOjV7NkKxN|I>
SCG M2XLPGZ2dmO2aX;uJGF{e2G7 NVe3eoZwOTByIN88UeKh MmKxSG1UVw>? NV3QUGxCemWmdXPld{B1cGViZYjjbZRi[mmuaYT5JI9nKFOFRzDu[ZVzd26| MkjpNlU6PjJzM{K=
PCCL3 MmToSpVv[3Srb36gRZN{[Xl? M1TyZ|ExKML3TR?= NHL6OVAzPCCq NHTBN3VmdmijbnPld{BFfU:6MjDwdo9ud3SncjD0doFve2O{aYD0bY9vKGGldHn2bZR6yqEkgJu= MXeyOVk3ODl3Nh?=
3T3-L1 preadipocytes M3Xy[GZ2dmO2aX;uJGF{e2G7 MUmxNEDPxE4EoB?= NW\GV|JHOTJiaB?= MmG4bY5lfWOnczDDVmVDKHCqb4PwbI9zgWyjdHnvckBidmRiQz;FRnDPuiCneIDy[ZN{cW:w M{nYO|I2QTJ6MEW4
H295R  MXvGeY5kfGmxbjDBd5NigQ>? MkG3NVDDqM7:TR?= NXrTOYU3PDkEoHi= NGjPSlZqdmO{ZXHz[ZMhe3Sncn;p[EBu\XSjYn;sbZRmeyCrbjD0bIUh[W6mcn;n[Y4tKG2rbnXyZYxwNSCjbnSg[4x2[2:lb4L0bYNwcWRicHH0bJdigXN? M3zmPVI2QDZ7NUW2
PBMC NGPub3dHfW6ldHnvckBCe3OjeR?= M4LS[lUxyqEQvF2= NIPpOVUzPMLiaNMg NWHyZnpJcW6qaXLpeJMhfGinIHnuZ5Jm[XOnZDDz[YNz\XSrb36gc4YhXE6IIHnu[JVk\WRiYomgeIhmKESSRR?= NYeydIxjOjV6Nk[wO|k>
GLUTag  M2rGc2Z2dmO2aX;uJGF{e2G7 M{L3SVEx6oDLwsXN MX2wM|IwPCCq NWPXNJdDe3SrbYXsZZRmeyCJTGCtNUB{\WO{ZYTpc44h[2:2cnXheIVlKHerdHigTWJOYA>? NV7YNYxrOjV6M{K2N|E>
GLUTag  Mo\RSpVv[3Srb36gRZN{[Xl? Mom2NVDjiIoEtV2= NFjPeoc1KGh? M{\mZYlv[3KnYYPld{B1cGVicFPSSWIhdGW4ZXzzJJdqfGhidHjlJGlDVVh? MUeyOVg{OjZ|MR?=
BAECs M1;Xd2Z2dmO2aX;uJGF{e2G7 NIP6ZWMzPSEQvF2= NFewO4QzPCCq NEP4cIJmdmijbnPld{B1cGViYXP0bZZifGmxbjDv[kBRWEGUzsGgZpkhPSEQvF2gdoV{fmW{YYTyc4wtKFR2SGOsJI9zKDRvUFHQ MYmyOVc6QDh{Nh?=
PC12 NWm5Zph7TnWwY4Tpc44hSXO|YYm= NVv1eXJ6OjYEoN88US=> MkPvOFghcA>? MWnhZ5RqfmG2ZYOgZ2FOWA>? Mn\TNlU4Pjl|MEW=
GH3 NV7EOHJzTnWwY4Tpc44hSXO|YYm= MoXtNeKh|ryP NE\LeGQ3NWh? MkXzZZR1\W63YYTld{B1cGViY3;ydoVt[XSrb36gZoV1f2WnbjDQVmwh[W6mIFLtZYwyKGW6cILld5Nqd25? MV:yOVczPzBzOB?=
GH3 M3jjcWZ2dmO2aX;uJGF{e2G7 NHy5fnIyyqEQvF2= MUC2MYg> M2DvPIlv\HWlZYOgVHJNKGGwZDDCcYFtOSxiYoX0JI5wfCCFbH;jb{whdVKQQTDlfJBz\XO|aX;u NUS2S21{OjV5MkewNVg>
BeWo MlTmSpVv[3Srb36gRZN{[Xl? NWn4Omx7OTEkgJtOwG3DqA>? NVnN[pppPzJiaB?= NFS3ZXFFVVOR M{jaS41m\GmjdHXzJGJmX29iY3XscEBlcW[oZYLlcpRq[XSrb36= Mo\GNlU4OTN2MkW=
oocytes NHfNU4pHfW6ldHnvckBCe3OjeR?= MWC1JO69VQ>? M1roOlI1KGh? MXHheJRmdnWjdHXzJJJpNWmwc4XsbY4h[WO2aX;uJI9vKG:xY4n0[UBIXkKGIIPp[45q\mmlYX70cJnDqA>? NXHkc4ZLOjV5MEe4OVQ>
SC NVeyVYtDTnWwY4Tpc44hSXO|YYm= MoDtNE42KM7:TR?= NYDxNYoxOjRiaB?= MYPtbY1q[2u|IITo[UBm\m[nY4Sgc4Yh[0GPUDDhcoFtd2e|IH;uJG8yKGGwZDDNRnAh\XiycnXzd4lwdg>? NGi2O40zPTdyNUi3OC=>
SC MULGeY5kfGmxbjDBd5NigQ>? MmXyNE42KM7:TR?= NWf0R|J1PzJiaB?= MXzpcoNz\WG|ZYOgZo91cCCNcn;4MVIxKGGwZDDPNUBmgHC{ZYPzbY9vKGmwIHH4c44uemWuYYTl[EBUS3NiYoX0JI9vdHliS4LvfE0zOMLi Ml60NlU4ODV6N{S=
UACC-647  Mo\hSpVv[3Srb36gRZN{[Xl? NEHvXXNFVVOR M3HmV4xm[WS|IITvJIEhemm|ZTDpckBkSU2SIHzleoVteyBqRVO1NOKhRcLiMkCuN|nDqM7:TTm= M1zq[VI2PzB|MEK1
UACC-647  NHTBe3dHfW6ldHnvckBCe3OjeR?= MmjDNVDDqM7:TR?= NUHZfWFCOTVibXnu NITOd45FVVOR MWrpcohq[mm2czDFVmsheGixc4Doc5J6dGG2aX;u M{HLXFI2PzB|MEK1
UACC-647  NEPu[INHfW6ldHnvckBCe3OjeR?= NIPt[lEyOMLizszN M{W5ZlE2KG2rbh?= NEezWpVFVVOR MXzpcoNz\WG|ZYOg[WVHOiCyaH;zdIhwenmuYYTpc44hdGW4ZXzzxsA> M4TjeFI2PzB|MEK1
SH-SY5Y  MYjGeY5kfGmxbjDBd5NigQ>? MkjGNVDDqM7:TR?= MYWxxsBpyqB? NWLZWJRlcW6lcnXhd4V{KEyXQzDhZ5Rqfmm2eR?= NHjVNnUzPTV7N{SzNy=>
SH-SY5Y  Mne3SpVv[3Srb36gRZN{[Xl? MlvVNVDDqM7:TR?= MkT2NeKhcMLi MoC2bY5kemWjc3XzJGFISzFibWLORUBt\X[nbB?= MXiyOVU6PzR|Mx?=
hADSCs Mn[3SpVv[3Srb36gRZN{[Xl? NUD1eWFjPeLCidM1US=> Mn7lN|AhdWmw Mn[xbY5kemWjc3XzJINCVVBibHX2[Yx{ MVyyOVU6OTlyOB?=
HEK293  NVLDV3g2TnWwY4Tpc44hSXO|YYm= NXK1cpBqPeLCidM1US=> NFSzbIY{OCCvaX6= MkjFbY5kemWjc3XzJINCVVBibHX2[Yx{ MWiyOVU6OTlyOB?=
3T3-L1 Ml\LSpVv[3Srb36gRZN{[Xl? NYC3bFhLOi53L{Wg{txO NELJemEzPCCqwrC= Morjd4lodmmoaXPhcpRtgSCmZXPy[YF{\XNiQWTHUEBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiYXzsJIRwe2W|IITld5Rm\A>? NULVdFNUOjV3OUC1PVc>
OCI-Ly1  MUTGeY5kfGmxbjDBd5NigQ>? M3SxWVQxyqEQvF2= NIXnS|EyyqCqwrC= MljWSG1UVw>? NFfqbYxqdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> NWLoWGZsOjV3N{[yNlA>
OCI-Ly18  MkDXSpVv[3Srb36gRZN{[Xl? NEHMNlA1OMLizszN M2P4dlHDqGkEoB?= NVPqcpIyTE2VTx?= MoLibY5lfWOnczD0bIUhcW6lcnXt[Y51KG:oIHPBUXAh[2:wY3XueJJifGmxboO= NWfVcI1MOjV3N{[yNlA>
BeWo MUPGeY5kfGmxbjDBd5NigQ>? M{fUXVIxyqEEtV2= M{LSZVQ5yqCq M{HRTWROW09? MoL1bY5kemWjc3XzJJRp\SCmaX\m[ZJmdnSrYYTpc44hd2ZiQnXXc{Bk\Wyucx?= M{X1XVI2PTZ4N{Sw
BeWo MULGeY5kfGmxbjDBd5NigQ>? MXGyNOKhyrWP MWG0POKhcA>? MmrmSG1UVw>? MYDpcoNz\WG|ZYOgeIhmKGGmaHXzbY9vKG:oIGTIVE0yKG2xbn;jfZRmew>? NYm4VXZvOjV3Nk[3OFA>
LNCaP  MmToSpVv[3Srb36gRZN{[Xl? MlTYNVDDqM7:TR?= M{G4WFEzKGkEoB?= MVvEUXNQ M2LlSolv\HWlZYOgZUBlemGvYYTpZ{BqdmO{ZXHz[UBw\iCFUlXCNUBi[3Srdnn0fS=> NVjLWm1GOjV3NEiwPVk>
ThGCs  NU\RZoh[TnWwY4Tpc44hSXO|YYm= Mo[wNVDjiIsQvF2= NUT5eHVvPOLCini= NHzZZ|VifWevZX70d{BJUUZzQTDs[ZZmdHNidHjheEB4\XKnIIP0bY12dGG2ZXSgZpkhS2:FbEK= MXKyOVQ{OzB{Nx?=
ThGCs  MV7GeY5kfGmxbjDBd5NigQ>? NETXcI0yOOLCit88US=> M1\RT|TjiIqq M{XGXYlv[3KnYYPld{BEd0OuMj3pcoR2[2WmIFXEUlLDqGenbnWg[ZhxemW|c3nvci=> NYLCWI5LOjV2M{OwNlc>
ThGCs  M3PNNWZ2dmO2aX;uJGF{e2G7 MUexNQKBks7:TR?= NYTacmppOyCq NFO0S|hqdmirYnn0d{B1cGViZX\m[YN1KG:oIFiyU|Ihd25iRVTONkBuWk6D M1LzfVI2PDN|MEK3
RBMECs NIHNWZJHfW6ldHnvckBCe3OjeR?= MknkNE4xPS9yLkWvOUDPxE1? NYnC[3dDOC5{NTDo M3fWe4lv[3KnYYPld{BkSU2SIHPvcoNmdnS{YYTpc44> NV2zUJhZOjV2MU[2OVE>
RBMECs MXPGeY5kfGmxbjDBd5NigQ>? MljIOeKh|ryP NIHoW44yKGh? NV;FUppx[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NX7uToNlOjV2MU[2OVE>
RBMECs M33jdWZ2dmO2aX;uJGF{e2G7 M4izNVXDqM7:TR?= MWqxJIg> NIPnPVVxemW4ZX70d{B1cGViRV3BVE1KUS2rbnT1Z4VlKFSHRWKgeoFtfWViZHXjdoVie2V? NFjYc24zPTRzNk[1NS=>
RBMECs NYTxNlI6TnWwY4Tpc44hSXO|YYm= NXrZR|RkPcLizszN NELaSHEyKGh? MXTwdoV3\W62czD0bIUhcW6lcnXhd4UhcW5iSGLQJIZtfXhiYXPyc5N{KHSqZTDCWGIhcW6mdXPl[EBjgSBiRV3BVE1KUQ>? MUGyOVQyPjZ3MR?=
RBMECs MnrlSpVv[3Srb36gRZN{[Xl? NF;lcGM2yqEQvF2= NXf0e|JGOSCq NWrMVXJScW6qaXLpeJMhfGinIHTlZ5Jm[XOnZDDv[kBidW:3boSgc4YhYk9vMTDpckBOTnNiaX7keYNm\CCkeTDFUWFRNUmL M361[lI2PDF4NkWx
RBMECs MmTKSpVv[3Srb36gRZN{[Xl? NG\4ZmI2yqEQvF2= NITQTYEyKGh? NWrMb4lmemW4ZYLz[ZMhfGinIHPoZY5o\XNiaX6gXm8uOSCmaYP0doljfXSrb36gd4VmdiC5aYToJGVOSVBvSVmgeJJm[XSvZX70 M1fz[lI2PDF4NkWx
RBMECs NGK2N5hHfW6ldHnvckBCe3OjeR?= MVu1xsDPxE1? M4LqNVEhcA>? M2TQPIJtd2OtczD0bIUhTU2DUD3JTU1qdmS3Y3XkJINp[W6pZTDpckBOVENicHjvd5Bpd3K7bHH0bY9v MmXMNlU1OTZ4NUG=
RBMECs M33WTmZ2dmO2aX;uJGF{e2G7 MoeyOeKh|ryP NXrZS2Z2OSCq Moq4Zoxw[2u|IITo[UBi[3SrbjDjfZRwe2unbHX0c44hemWjcoLhcodmdWWwdDDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboVCpC=> M1vSOFI2PDF4NkWx
Primary bovine chondrocytes M{jBUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYrOOI1DPc7:TR?= NVvVbphTPDhiaB?= NHfqbXRz\X[ncoPld{B1cGViaX7obYJqfG:{eTDl[oZm[3Rib3[gZ4Vt\WOxeHniJI9vKHC{b3zp[oVz[XSrb36gbY4h\3Kxd4ToJJBt[XSnIHPoc45lem:leYTldy=> NEPCUIUzPTRyNkCxOi=>
EM1  NF[zTY9HfW6ldHnvckBCe3OjeR?= MnLoNVXjiIsQvF2= NHvwWJU1QCCq M33ifZJm\HWlZYOgeIhmKGW6cILld5Nqd25ib3dCpGxKTsLib4NCpHBVT1N{wrDpcuKhS0GOUj2gc5LDqEWSQVOyMZNqdGWwY3XkJGVOOSClZXzsd:Kh NGPsOI8zPTN5OE[2NS=>
BeWo  NGraR4FHfW6ldHnvckBCe3OjeR?= MYOyNOKhyrWP M37p[FQ5yqCqwrC= M4\nUWROW00EoB?= MUTpcoNz\WG|ZYOgeIhmKGKndHGtbGNIKHKnbHXhd4U> NV\BWVR[OjV|NkKyOlA>
BeWo  MWrGeY5kfGmxbjDBd5NigQ>? MWqyNOKhyrWP MXq0POKhcMLi NYfiOZM{TE2VT9Mg MlTw[I94dnKnZ4XsZZRmeyC2aHWgcIV3\Wxib3[gWG1GVUZzNh?= NV21e45bOjV|NkKyOlA>
BeWo  MWjGeY5kfGmxbjDBd5NigQ>? NEK0T|MzOMLiwsXN MlfzOFjDqGkEoB?= MorvSG1UV8Li Mmf0[I94dnKnZ4XsZZRmeyC2aHWgcIV3\Wxib3[gS2NONTF? MVOyOVM3OjJ4MB?=
granulosa cells NW[yZ5VkTnWwY4Tpc44hSXO|YYm= MYexNEDPxE1? MmTsNVIwOjRiaB?= M2m4e4lv[3KnYYPld{B1cGVibHX2[Yx{KG:owrDSS3MzyqCvUl7B NWLhd3c{OjV|M{mxNFU>
granulosa cells MmLMSpVv[3Srb36gRZN{[Xl? MWqxNEDPxE1? NYDE[5p5OTJxMkSgbC=> MXzpcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\iC{ZYDvdpRmeiCjY4Tpeol1gSCob4KgeIhmKGyxbnfld5Qh\nKjZ33lcpQhMOLKkki1OE8sOTiUR2OyMmxWSyl? M2jjNVI2OzN7MUC1
granulosa cells NEj3ZZFHfW6ldHnvckBCe3OjeR?= MV:xNEDPxE1? NIrzTW8zPCCq MlG3bY5kemWjc3XzJJRp\SCrboTlcpNqfHlib3[gSG5CN3C{b4TlbY4h[2:vcHzlfC=> MVGyOVM{QTFyNR?=
granulosa cells M4DMRWZ2dmO2aX;uJGF{e2G7 M1G2OFExKM7:TR?= MoTFNlQhcA>? MofGbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZiUlfTNkBxem:vb4TldkBi[3Srdnn0fS=> MYeyOVM{QTFyNR?=
SK-N-AS  NV[3N41FS2WubDDWbYFjcWyrdImgRZN{[Xl? MoL4NVAh|ryPwrC= M3rKU|I1NzR6IHi= NE\UcZRmdmijbnPld{B1cW2nLXTldIVv\GWwdHz5JINmdGy3bHHyJJZq[WKrbHn0feKh M2ntZlI2OjZ4ME[z
SK-N-AS  NVy2OWxlTnWwY4Tpc44hSXO|YYm= NWPPeI1HOTBizszNxsA> MV6yOEBp MU\pcoNz\WG|ZYOgeIhmKGODTWCgcIV3\Wy|wrC= MlzXNlUzPjZyNkO=
SK-N-AS  MlnYSpVv[3Srb36gRZN{[Xl? MWqxNEDPxE4EoB?= NHvsfFczPCCq NH\GToRqdmO{ZXHz[ZMhfGinIHX4dJJme3Orb36gc4Yh[3mlbHnuJGQy M1jQSlI2OjZ4ME[z
SK-N-AS  NHPjRXNHfW6ldHnvckBCe3OjeR?= M2HzOVExKM7:TdMg MnSwN|AhdWmw NUjSVFl7cW6mdXPld{BxcG:|cHjvdplt[XSrb36gc4Yh|rJvY3H0[Y5qdiBqc3XyOlc2MSxicD3HV2s{|rJiKIPldlkqKGGwZDDjc45kd22rdHHueEBpcWeqZYKgcIV3\Wy|IH;mJIFkfGm4ZTygeY5xcG:|cHjvdplt[XSnZDyg{tIu[2G2ZX7pci=> M4jJ[|I2OjZ4ME[z
SK-N-AS  M3r0NWZ2dmO2aX;uJGF{e2G7 M4roblExKM7:TdMg NGTVd4wyOC9|MD:2NEBucW5? NG\ZWXhqdmO{ZXHz[ZMhdGW4ZXzzJI9nKHBvzsKtZ4F1\W6rbjCod4VzPjd3KTDhcoQhcW6mdXPld{Bi[2O3bYXsZZRqd25ib3[gdE3Pui2lYYTlcolvKCi|ZYK2O|UqKGmwIDjw[ZJqMW63Y3zlZZIhemWpaX;udy=> M{G0U|I2OjZ4ME[z
SK-N-SH MmTrR4VtdCCYaXHibYxqfHliQYPzZZk> MYixNEDPxE4EoB?= NXzCemdmPDhiaB?= NIXnVYFmdmijbnPld{BUUy2QLWPIJI5mfXKxYnzhd5RwdWFiY3XscEB3cWGkaXzpeJk> MWCyOVI3PjB4Mx?=
HEK‐CFTR M4XGWmZ2dmO2aX;uJGF{e2G7 NIqySo0z6oDVNUFCpO69VQ>? NIezVIoxNTF{IH3pci=> NGLyVWhFVVORwrC= MlzVbY5lfWOnczDhJIRwe2YkgKDk[ZBmdmSnboSgbY9lcWSnIHXm[ox2gMLi M37ye|I2OjZ|MkC3
L6 MUfGeY5kfGmxbjDBd5NigQ>? MoX1OFAhyrWP NGTkRoMzPCCq M{\IPYlvcGmkaYTzJGROUDFvaX7keYNm\CCDa4SgZYN1cX[jdHnvci=> NGm4O4IzPTJ2N{W1NC=>
MIN6  MnTZSpVv[3Srb36gRZN{[Xl? MkThNVAh|ryPwrC= MoPtN{Bp M1jTN4lv[3KnYYPld{BFOyCvUl7BJIV5eHKnc4Ppc44> M2Dh[|I2OjRzMUK0
ventricular cardiomyocytes  MV\GeY5kfGmxbjDBd5NigQ>? MXqwMlAyNTFyIN88US=> M2nyTYlv[3KnYYPld{Ah[0GPUDDhZ4N2dXWuYYTpc44> NWLpOVRDOjV{MEOxNVM>
ventricular cardiomyocytes  MYDGeY5kfGmxbjDBd5NigQ>? NY\YeY1mOC5yMT2xNEDPxE1? NHHxOmZmfm:tZYOgZY4hcW6xdILvdIlkKHKnc4DvcpNmKDF{MNMxNVUmKGGkb4\lJIJie2GuIIfpeIgh[W5iRVO1NOKhd2ZiMj6yJOK2VQ>? NIqzNlAzPTJyM{GxNy=>
BeWo  NWDJNYFOTnWwY4Tpc44hSXO|YYm= NWPLXo81OjBiwsXN M4D1OlQ5KGh? Mnm2SG1UV8Li NV3iNZMycW6mdXPld{Bk\WyuIH\1d4lwdg>? MnTONlUyQDR2N{e=
THP-1  NVfIWmh7TnWwY4Tpc44hSXO|YYm= NH3B[XcyNzFyIN88US=> MlHFNuKhcA>? MojnSG1UV8Li MmL3d5VxeHKnc4Pld{BOS1BvMTDwdo9lfWO2aX;uxsA> NVTrNIVyOjVzNUS4PFI>
Huh-7 MVPGeY5kfGmxbjDBd5NigQ>? NUm4elFmOC1{MDFOwG0> M3vo[lIhcMLi M4DWZ5Jme3WudIOgbY4h[SCmb4PlMYRmeGWwZHXueEBqdmO{ZXHz[UBqdiClLV35Z{BmgHC{ZYPzbY9vKGG2IITo[UBxem:2ZXnuJIFv\CCvUl7BJIxmfmWucx?= M2fnSVI2OTB7OEO0
C6 NY[yPIZ1TnWwY4Tpc44hSXO|YYm= M3T6WFExKM7:TdMg NFL6fmwzOCCvaX6= MUDpcoNz\WG|ZYOgZ2FOWCCjY3P1cZVt[XSrb36= NHXXS5UzPTB4OUSxOy=>
SW480 MnLISpVv[3Srb36gRZN{[Xl? M4PRNFQxyqEQvF2= MYe0POKhcA>? Mn7DSG1UVw>? MkiwZYN1cX[jdHXzJHBROkF? NWjvcIY3OjR7OUe0OVE>
HT-29  MUPGeY5kfGmxbjDBd5NigQ>? M1fHXVQxyqEQvF2= NIPVXJA1QMLiaB?= Mn\USG1UVw>? NUfj[ZV[[WO2aY\heIV{KFCSMlG= MXGyOFk6PzR3MR?=
SW480 MorSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHSOFDDqM7:TR?= MlLxNE04OiCq MoP4SG1UVw>? MWXpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nIHTldIVv\GWwdHz5 MlrpNlQ6QTd2NUG=
HT-29  NHTKZ4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGKy[Gk1OMLizszN MX2wMVczKGh? MmfCSG1UVw>? M{j0W4lvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> MVqyOFk6PzR3MR?=
SW480 M4GzRWZ2dmO2aX;uJGF{e2G7 Mn62OFDDqM7:TR?= MnPkO{Bl NWnMZVI3TE2VTx?= NVG2d2k2emWmdXPld{Bkd2yxbn;zdIhmemViZn;ycYF1cW:wIHPhdIFjcWyrdIpCpC=> NUHWXHRCOjR7OUe0OVE>
HT-29  NUDHb3N1TnWwY4Tpc44hSXO|YYm= M3PvUVQxyqEQvF2= Ml;RO{Bl Mkn5SG1UVw>? NFuy[ZRz\WS3Y3XzJINwdG:wb4PwbIVz\SCob4LtZZRqd25iY3HwZYJqdGm2edMg M4LQVVI1QTl5NEWx
SW480 NUTjbWlMSXCxcITvd4l{KEG|c3H5 MXK0NOKh|ryP NX\GRm1WPDkEoHi= MmjjSG1UVw>? Mn3UbY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 NXywUY9{OjR7OUe0OVE>
HT-29  NF7Ee4tCeG:ydH;zbZMhSXO|YYm= NHzaSlk1OMLizszN MlvjOFjDqGh? NH2wZ5hFVVOR M{T4Wolv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> M{PrfFI1QTl5NEWx
SW480 MlfaRZBweHSxc3nzJGF{e2G7 NV7jN4hoPDEEoN88US=> NUfaV5FUPDkEoHi= M3XENmROW09? M{C4OIlv\HWlZYOgZ4hidmenczDpckB1cGVicHjvd5Bpd3K7bHH0bY9vKHO2YYT1d{Bw\iCSUELBJJRiemendIO= M3XkVVI1QTl5NEWx
HT-29  M1rQWmFxd3C2b4Ppd{BCe3OjeR?= MofROFDDqM7:TR?= MVe0POKhcA>? NIq0eXNFVVOR MUTpcoR2[2W|IHPoZY5o\XNiaX6geIhmKHCqb4PwbI9zgWyjdHnvckB{fGG2dYOgc4YhWFB{QTD0ZZJo\XS| MmrRNlQ6QTd2NUG=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID