Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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USD 270 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MlXVSpVv[3Srb36gRZN{[Xl? M1PUO|ExKM7:TR?= M3;wSVYhcA>? M2rTcIlv[3KnYYPld{BxcG:|cHjvdplt[XSrb36gc4Yhd3[ncnX4dJJme3OnZDDLUGhNOyCjdDDTOFM{ MVuyOlQ{PTR7OB?=
Mo-DCs NXjqNWFPTnWwY4Tpc44hSXO|YYm= Mk[xOVAh|ryP NGnYU5IzPOLCiXi= NIC4Uo9xem:vb4Tld{BKVC1{MzDwdo9lfWO2aX;uJIlvKHSqZTDzeZBmem6jdHHueEBw\iC8eX3vd4FvKHO2aX31cIF1\WRiTX:tSGN{yqB? M4\yOVI3PDF{OUS4
RBMECs  NFf5UnBHfW6ldHnvckBCe3OjeR?= NUnxXZBpPcLizszN NH\aWXEyyqCq MU\icI9kc3NidHjlJHJi[zFiaX7hZ5RqfmG2aX;uJIlv\HWlZXSgZpkhTU2DUD3JTS=> MVmyOlM2QDB|OR?=
INA-6 MlH2R4VtdCCYaXHibYxqfHliQYPzZZk> M{XYV|AuOTByIN88US=> MW[3NwKBkWh? M{nGZYlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 NXrnc5pDOjZ|ME[2NlQ>
OPM-2 MVnD[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFfXZXUxNTFyMDFOwG0> MXW3NwKBkWh? NWTSfoJicW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> MUCyOlMxPjZ{NB?=
U266 MkHhR4VtdCCYaXHibYxqfHliQYPzZZk> MmL6NE0yODBizszN NIqwbHU4OuLCiXi= MnOwbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NX25VpN{OjZ|ME[2NlQ>
H929 NVXTUm84S2WubDDWbYFjcWyrdImgRZN{[Xl? M{\YVlAuOTByIN88US=> NFnMfZc4OuLCiXi= NEfUWFBqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> NYX3UI9uOjZ|ME[2NlQ>
RPMI 8226 M1jCXGNmdGxiVnnhZoltcXS7IFHzd4F6 M3\RZVAuOTByIN88US=> NGPK[3c4OuLCiXi= M1zudolv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 MoL0NlY{ODZ4MkS=
MDCK  NUHUTGhITnWwY4Tpc44hSXO|YYm= Mn\qNVAhyrWP MVmyOEBp MlPBSG1UVw>? M{f6S5VxemWpdXzheIV{KHSqZTDlfJBz\XO|aX;uJI9nKFSJRj5OtlEh[W6mIFPUS2bDqA>? M1PVRVI3OjB{M{Wy
MDCK  MX;GeY5kfGmxbjDBd5NigQ>? NH\UbZIyOCEEtV2= MY[yOEBp M4nMd2ROW09? NWHEWXB1cW6qaXLpeJMhfGinIHnuZ5Jm[XOnZDDlfJBz\XO|aX;uJI9nKE[QIHPheZNm\CCkeTDUS2Yu|rJz MYGyOlIxOjN3Mh?=
Spinal cords  Ml\LSpVv[3Srb36gRZN{[Xl? NETNeFcyyqEQvF2= M17J[VMxKG2rbh?= MXPzeIlufWyjdHXzJINCVVBibHX2[Yx{ NWrzOWF{OjZzMk[5NlY>
BeWo  NVnIT2d4TnWwY4Tpc44hSXO|YYm= M2\1PVI26oDLzszN NH\oUlkzPC92OD:3NkBp M4\uT4xm[WS|IITvJIFvKGmwY4LlZZNmKGmwIITo[UBmgHC{ZYPzbY9vKG:oIH;0bIVzKG[3c3nvckBu[XKtZYLz MnPUNlYxPTN3NEm=
bovine oocytes NH3l[pZHfW6ldHnvckBCe3OjeR?= M1fGc|ExOMLizszN M1TJcFEzyqCq NYHWZnhpcW6qaXLpeJMhfGinIHXm[oVkfCCxZjDOVHBCKGGwZD;vdkBPWFCFIITvJJN1cW23bHH0[UBz\XO3bYD0bY9vKG:oIH3lbY9{cXN? MoLBNlYxPTF4MUG=
Caco-2  MorqSpVv[3Srb36gRZN{[Xl? MYqwMlEwOS9zMDFOwG0> M3KxcVIxyqCvaX6= M4fLb4lv\HWlZYOgZUBld3OnLXTldIVv\GWwdDDpcoNz\WG|ZTDpckBqdnS{YXPlcIx2dGG{IHPBUXAhdGW4ZXzz NHf4SmIzPjB2OUGwNi=>
Caco-2  NW\xW25FTnWwY4Tpc44hSXO|YYm= NHXkdoYxNjFxMT:xNEDPxE1? NGfpUVYzPCCq NXPUZ3BvcW6lcnXhd4V{KE2UUEKgdJJwfGWrbjDs[ZZmdA>? MX2yOlA1QTFyMh?=
AML-12  NIOzXlNHfW6ldHnvckBCe3OjeR?= NFztRVczOCEQvF2= MXSzJIg> Ml\peZBz\We3bHH0[ZMhfGinIIDoc5NxcG:{eXzheIlwdiCuZY\lcJMh[XRiVHjyMVQyOSCjbnSgV4VzNTR7Mx?= NYjPcnk6OjZyNEi5PFU>
AML-12  M4fLO2Z2dmO2aX;uJGF{e2G7 NUGyU2hNOjBizszN M2K1XFEuQCCq Mm\wbY5kemWjc3XzJIdtfWOxc3WgdJJw\HWldHnvci=> NU\DU3FVOjZyNEi5PFU>
AML-12  NUnEWGdLTnWwY4Tpc44hSXO|YYm= M{S0elIxKM7:TR?= M2PLdFMhcA>? M4nzbZVxNXKnZ4XsZZRme8LiUHfjNYEtyqCSZYDjb{wh[W6mwrDHOpBkyqCvUl7BJIxmfmWucx?= MWmyOlA1QDl6NR?=
AML-12  M{foO2Z2dmO2aX;uJGF{e2G7 MmPqNlAh|ryP MlHnN{Bp M2CzOYlv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKG:oIFPSWGMzyqB? MXiyOlA1QDl6NR?=
RBMECs M3HDXmZ2dmO2aX;uJGF{e2G7 NWHGe2VNPcLizszN NX36OGh[OSCq MUfpcohq[mm2czDFUWFRNUmLLXnu[JVk\WRiaX7hZ5RqfmG2aX;uJI9nKFKjcEJCpC=> MX:yOlA1PDZ4Mx?=
EndoC-βH1 NX3jfIhYTnWwY4Tpc44hSXO|YYm= M{PHVlXDqM7:TR?= MmLrNUBp NIO5NYxxd3SnboTpZZRmeyCpbIXjc5NmNWmwZIXj[YQhcW6|dXzpckB{\WO{ZYTpc44hcW5idHjlJJBz\XOnbnPlJI9nKGeudXPvd4U> MnLuNlYxOjh3NkK=
EndoC-βH1 MXzGeY5kfGmxbjDBd5NigQ>? M2PYO|XDqM7:TR?= NWnCWWVnOSCq NGnZToRt\WGmczD0c{BiKHO2cn;u[{BkSU2SIHnuZ5Jm[XOn NULSSotOOjZyMki1OlI>
SH-SY5Y MVnGeY5kfGmxbjDBd5NigQ>? MmTGN|Ah|ryP M4HybVMxKG2rbh?= NWjJT4NDTE2VTx?= M3GyS5Nq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBi[3SrdnH0bY9vKG:oIGDLRS=> MXKyOlAzPTF|Nx?=
PC-3 MnraSpVv[3Srb36gRZN{[Xl? M1K5SVQxKML3TR?= MY[yJIg> M4Hs[GROW09? M3T5fYxm[WS|IITvJHBROkFiYXP0bZZifGmxbh?= MXeyOlAzOzh|Nh?=
PC-3 Mn;TR4VtdCCYaXHibYxqfHliQYPzZZk> M3zNPFQxKML3TR?= MYCyOE81QC95MjDo MmDYSG1UVw>? NF:2W3hl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgeIlu\SCmZYDlcoRmdnSueR?= M3HwWVI3ODJ|OEO2
SCG MXzGeY5kfGmxbjDBd5NigQ>? NFH1d3czOCEQvF5CpC=> NGnwWFZFVVOR M4nwV5JmfmW{c3nicJkhe3WycILld5NmeyCLS2[ge4l1cCCjIFnDOVAhd2ZiMkSuOEDPxE1? MUKyOVk3OjF|Mh?=
HEK-293 Mo\jSpVv[3Srb36gRZN{[Xl? NHrH[lk{PSEQvF5CpC=> Mm\uSG1UVw>? MYTpcoR2[2W|IHGgZ49ve3CrY4XveZMh6oDeaX7hZ5RqfmG2aX;u5qCeKG:oIITo[UBMfjJwMTDjeZJz\W62 NYj1TmY2OjV7NkKxN|I>
SCG NVvydWJoTnWwY4Tpc44hSXO|YYm= NFXwN2syODBizszNxsA> NHzP[YtFVVOR NV32d28yemWmdXPld{B1cGViZYjjbZRi[mmuaYT5JI9nKFOFRzDu[ZVzd26| NF;UPI8zPTl4MkGzNi=>
PCCL3 MXzGeY5kfGmxbjDBd5NigQ>? MmrxNVAhyrWP NUfBPYtZOjRiaB?= MVjlcohidmOnczDEeW95OiCycn;tc5RmeiC2cnHud4NzcXC2aX;uJIFkfGm4aYT5xsDjiIt? MUmyOVk3ODl3Nh?=
3T3-L1 preadipocytes M17jfmZ2dmO2aX;uJGF{e2G7 M32wdVExKM7:TdMg MYKxNkBp M3\2eIlv\HWlZYOgR3JGSiCyaH;zdIhwenmuYYTpc44h[W6mIFOvSWJR|rJiZYjwdoV{e2mxbh?= M1;KTlI2QTJ6MEW4
H295R  M{TPdGZ2dmO2aX;uJGF{e2G7 MXqxNOKh|ryP M1fkR|Q5yqCq NE\BWo5qdmO{ZXHz[ZMhe3Sncn;p[EBu\XSjYn;sbZRmeyCrbjD0bIUh[W6mcn;n[Y4tKG2rbnXyZYxwNSCjbnSg[4x2[2:lb4L0bYNwcWRicHH0bJdigXN? M1O5S|I2QDZ7NUW2
PBMC M1\rU2Z2dmO2aX;uJGF{e2G7 NEHne2E2OMLizszN NWPUVHd{OjUEoHlCpC=> M1nwNIlvcGmkaYTzJJRp\SCrbnPy[YF{\WRic3XjdoV1cW:wIH;mJHRPTiCrbnT1Z4VlKGK7IITo[UBFWEV? MWeyOVg3PjB5OR?=
GLUTag  NV;pXWtlTnWwY4Tpc44hSXO|YYm= M1q2bVEx6oDLwsXN MYewM|IwPCCq MUjzeIlufWyjdHXzJGdNWC1zIIPlZ5JmfGmxbjDjc5Rz\WG2ZXSge4l1cCCLQl3Y NFHjN5MzPTh|Mk[zNS=>
GLUTag  M{LuO2Z2dmO2aX;uJGF{e2G7 NIrCbXQyOOLCidM1US=> MUS0JIg> MUTpcoNz\WG|ZYOgeIhmKHCFUlXCJIxmfmWuczD3bZRpKHSqZTDJRm1Z NXnTSmlPOjV6M{K2N|E>
BAECs MnjvSpVv[3Srb36gRZN{[Xl? Mom1NlUh|ryP NVu0WGxyOjRiaB?= MV3lcohidmOnczD0bIUh[WO2aY\heIlwdiCxZjDQVGFT|rFiYomgOUDPxE1icnXzeoVz[XS{b3ysJHQ1UFNuIH;yJFQuWEGS MYiyOVc6QDh{Nh?=
PC12 MmLkSpVv[3Srb36gRZN{[Xl? NETRfHEzPcLizszN M3f2ZVQ5KGh? M{fD[IFkfGm4YYTld{BkSU2S Mmj0NlU4Pjl|MEW=
GH3 NVe1ZmRLTnWwY4Tpc44hSXO|YYm= Mn;LNeKh|ryP Mki2Ok1p M3LqXIF1fGWwdXH0[ZMhfGinIHPvdpJmdGG2aX;uJIJmfHenZX6gVHJNKGGwZDDCcYFtOSCneIDy[ZN{cW:w NFPGPIwzPTd{N{CxPC=>
GH3 MXzGeY5kfGmxbjDBd5NigQ>? NWfJWmM4OcLizszN MnHlOk1p M{S0fYlv\HWlZYOgVHJNKGGwZDDCcYFtOSxiYoX0JI5wfCCFbH;jb{whdVKQQTDlfJBz\XO|aX;u NX7Ve4d5OjV5MkewNVg>
BeWo M{DubmZ2dmO2aX;uJGF{e2G7 M2HmblEx6oDMzszNxsA> NHnI[2w4OiCq Mn\5SG1UVw>? MnXXcYVlcWG2ZYOgRoVYdyClZXzsJIRq\m[ncnXueIlifGmxbh?= M4LaNVI2PzF|NEK1
oocytes NVfmNIQ{TnWwY4Tpc44hSXO|YYm= NXPqTWM{PSEQvF2= NFXEdoszPCCq NXHVWoVM[XS2ZX71ZZRmeyC{aD3pcpN2dGmwIHHjeIlwdiCxbjDvc4N6fGViR2\CSEB{cWewaX\pZ4FvfGy7wrC= Mm\oNlU4ODd6NUS=
SC MlrKSpVv[3Srb36gRZN{[Xl? M32xOVAvPSEQvF2= MX[yOEBp MXrtbY1q[2u|IITo[UBm\m[nY4Sgc4Yh[0GPUDDhcoFtd2e|IH;uJG8yKGGwZDDNRnAh\XiycnXzd4lwdg>? MXWyOVcxPTh5NB?=
SC Mlq5SpVv[3Srb36gRZN{[Xl? NFu0fFIxNjVizszN MVm3NkBp Mlm1bY5kemWjc3XzJIJwfGhiS4LvfE0zOCCjbnSgU|Eh\XiycnXzd4lwdiCrbjDhfI9vNXKnbHH0[YQhW0O|IHL1eEBwdmy7IFvyc5guOjEEoB?= NYLSWGFkOjV5MEW4O|Q>
UACC-647  NI\FNpBHfW6ldHnvckBCe3OjeR?= Ml[3SG1UVw>? NXrPdIhKdGWjZIOgeI8h[SC{aYPlJIlvKGODTWCgcIV3\Wy|IDjFR|UxyqB;wrCyNE4{QcLizszNLS=> MVKyOVcxOzB{NR?=
UACC-647  MlzwSpVv[3Srb36gRZN{[Xl? M{jtflExyqEQvF2= MV[xOUBucW5? MUDEUXNQ NVLxTJV5cW6qaXLpeJMhTVKNIIDoc5NxcG:{eXzheIlwdg>? MnT2NlU4ODNyMkW=
UACC-647  NXzLdGtTTnWwY4Tpc44hSXO|YYm= M2jaVFExyqEQvF2= M3jIZ|E2KG2rbh?= M4C5SWROW09? Ml;XbY5kemWjc3XzJIVGTjJicHjvd5Bpd3K7bHH0bY9vKGyndnXsd:Kh NGPLbZYzPTdyM{CyOS=>
SH-SY5Y  MUHGeY5kfGmxbjDBd5NigQ>? MXmxNOKh|ryP M4XtNVHDqGkEoB?= MX\pcoNz\WG|ZYOgUHVEKGGldHn2bZR6 MlHGNlU2QTd2M{O=
SH-SY5Y  NVHFOppLTnWwY4Tpc44hSXO|YYm= MUWxNOKh|ryP M1HMTlHDqGkEoB?= NUf4OINMcW6lcnXhd4V{KEGJQ{GgcXJPSSCuZY\lcC=> MUmyOVU6PzR|Mx?=
hADSCs Ml\WSpVv[3Srb36gRZN{[Xl? MnXOOgKBkcL3TR?= NH7DfoU{OCCvaX6= M3Pj[Ylv[3KnYYPld{BkSU2SIHzleoVtew>? NUjoS2V{OjV3OUG5NFg>
HEK293  MkfWSpVv[3Srb36gRZN{[Xl? MmnuOgKBkcL3TR?= MoraN|AhdWmw NGrvTppqdmO{ZXHz[ZMh[0GPUDDs[ZZmdHN? NV7IRZpSOjV3OUG5NFg>
3T3-L1 MUjGeY5kfGmxbjDBd5NigQ>? MXqyMlUwPSEQvF2= M3uyd|I1KGkEoB?= NGfaV5N{cWewaX\pZ4FvfGy7IHTlZ5Jm[XOnczDBWGdNKHC{b4TlbY4h\XiycnXzd4lwdiCjdDDhcIwh\G:|ZYOgeIV{fGWm MXSyOVU6ODV7Nx?=
OCI-Ly1  NFv3[2hHfW6ldHnvckBCe3OjeR?= Mn;UOFDDqM7:TR?= M{\PflHDqGkEoB?= NUmxO|hbTE2VTx?= NWX1OmFlcW6mdXPld{B1cGViaX7jdoVu\W62IH;mJINCVVBiY3;uZ4VvfHKjdHnvcpM> MVGyOVU4PjJ{MB?=
OCI-Ly18  M{PzbGZ2dmO2aX;uJGF{e2G7 NVnPVZROPDEEoN88US=> NVzYRW5tOcLiaNMg Ml;JSG1UVw>? M4XmZYlv\HWlZYOgeIhmKGmwY4LlcYVvfCCxZjDjRW1RKGOxbnPlcpRz[XSrb37z M3TvUVI2PTd4MkKw
BeWo M2LHNGZ2dmO2aX;uJGF{e2G7 M1vpOFIxyqEEtV2= MV:0POKhcA>? NYjwR2s4TE2VTx?= M{PIfolv[3KnYYPld{B1cGViZHnm[oVz\W62aXH0bY9vKG:oIFLlW48h[2WubIO= MYKyOVU3Pjd2MB?=
BeWo MYTGeY5kfGmxbjDBd5NigQ>? MlvNNlDDqML3TR?= NF;uXWI1QMLiaB?= M3HHZmROW09? MUPpcoNz\WG|ZYOgeIhmKGGmaHXzbY9vKG:oIGTIVE0yKG2xbn;jfZRmew>? M3ezcVI2PTZ4N{Sw
LNCaP  MmjYSpVv[3Srb36gRZN{[Xl? NIDVfmkyOMLizszN MYmxNkBpyqB? NXvGO|N1TE2VTx?= MkPubY5lfWOnczDhJIRz[W2jdHnjJIlv[3KnYYPlJI9nKEOURVKxJIFkfGm4aYT5 NEnwfWkzPTV2OEC5PS=>
ThGCs  NFzIOHhHfW6ldHnvckBCe3OjeR?= MkPZNVDjiIsQvF2= M3P6ZlTjiIqq M376N4F2\22nboTzJGhKTjGDIHzleoVteyC2aHH0JJdmemVic4TpcZVt[XSnZDDifUBEd0OuMh?= NX\jVWw6OjV2M{OwNlc>
ThGCs  MXXGeY5kfGmxbjDBd5NigQ>? NETLPXAyOOLCit88US=> NYTq[49HPOLCini= MoTlbY5kemWjc3XzJGNwS2x{LXnu[JVk\WRiRVTONuKh\2WwZTDlfJBz\XO|aX;u NYjidVdbOjV2M{OwNlc>
ThGCs  NE\PcWRHfW6ldHnvckBCe3OjeR?= M4j6TVEx6oDMzszN MY[zJIg> Mn7xbY5pcWKrdIOgeIhmKGWoZnXjeEBw\iCKMl:yJI9vKEWGTkKgcXJPSQ>? NH\ON3czPTR|M{CyOy=>
RBMECs NUPhc5o4TnWwY4Tpc44hSXO|YYm= NY\zTFdKOC5yNT:wMlUwPSEQvF2= M2f4dlAvOjViaB?= MX7pcoNz\WG|ZYOgZ2FOWCClb37j[Y51emG2aX;u M3rQS|I2PDF4NkWx
RBMECs MnvuSpVv[3Srb36gRZN{[Xl? NX30NI85PcLizszN MmHSNUBp NVq3eJV4[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NVvz[XJVOjV2MU[2OVE>
RBMECs MnfBSpVv[3Srb36gRZN{[Xl? M4rQeFXDqM7:TR?= NWnRTIhrOSCq MXfwdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> MWGyOVQyPjZ3MR?=
RBMECs NWraeG43TnWwY4Tpc44hSXO|YYm= MoDTOeKh|ryP MVexJIg> M1zsVZBz\X[nboTzJJRp\SCrbnPy[YF{\SCrbjDIVnAh\my3eDDhZ5Jwe3NidHjlJGJVSiCrbnT1Z4VlKGK7IDDFUWFRNUmL MVGyOVQyPjZ3MR?=
RBMECs NXTDNZBZTnWwY4Tpc44hSXO|YYm= M4CyflXDqM7:TR?= M330Z|EhcA>? M4PkNYlvcGmkaYTzJJRp\SCmZXPy[YF{\WRib3[gZY1wfW62IH;mJHpQNTFiaX6gUWZ{KGmwZIXj[YQh[nliRV3BVE1KUQ>? M37FR|I2PDF4NkWx
RBMECs NUnReGZxTnWwY4Tpc44hSXO|YYm= NFrWNW82yqEQvF2= NUXQeZpSOSCq M{TWfZJmfmW{c3XzJJRp\SClaHHu[4V{KGmwIGrPMVEh\Gm|dILpZpV1cW:wIIPl[Y4hf2m2aDDFUWFRNUmLIITy[YF1dWWwdB?= NV7V[Gx{OjV2MU[2OVE>
RBMECs MV;GeY5kfGmxbjDBd5NigQ>? MVS1xsDPxE1? Ml2zNUBp M{HsXYJtd2OtczD0bIUhTU2DUD3JTU1qdmS3Y3XkJINp[W6pZTDpckBOVENicHjvd5Bpd3K7bHH0bY9v NFK4UGszPTRzNk[1NS=>
RBMECs NX7adFV1TnWwY4Tpc44hSXO|YYm= Ml7yOeKh|ryP M3HKUVEhcA>? Mln0Zoxw[2u|IITo[UBi[3SrbjDjfZRwe2unbHX0c44hemWjcoLhcodmdWWwdDDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboVCpC=> NIOxVnQzPTRzNk[1NS=>
Primary bovine chondrocytes M2TD[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[1{txO NEX5R401QCCq NXfmXmhVemW4ZYLz[ZMhfGinIHnubIljcXSxcomg[YZn\WO2IH;mJINmdGWlb4jpZkBwdiCycn;sbYZmemG2aX;uJIlvKGe{b4f0bEBxdGG2ZTDjbI9v\HKxY4n0[ZM> NGjsPY0zPTRyNkCxOi=>
EM1  MVTGeY5kfGmxbjDBd5NigQ>? M{LaNlE26oDMzszN NFmwbGU1QCCq M2X2Z5Jm\HWlZYOgeIhmKGW6cILld5Nqd25ib3dCpGxKTsLib4NCpHBVT1N{wrDpcuKhS0GOUj2gc5LDqEWSQVOyMZNqdGWwY3XkJGVOOSClZXzsd:Kh NXHjN5hOOjV|N{i2OlE>
BeWo  MV\GeY5kfGmxbjDBd5NigQ>? MnvMNlDDqML3TR?= Mn;YOFjDqGkEoB?= NV;WXmlNTE2VT9Mg NHnJ[4ZqdmO{ZXHz[ZMhfGinIHLleIEucEOJIILlcIVie2V? MXWyOVM3OjJ4MB?=
BeWo  MU\GeY5kfGmxbjDBd5NigQ>? MXWyNOKhyrWP NIKxNIw1QMLiaNMg Mn\2SG1UV8Li NVrTc416\G:5boLl[5Vt[XSnczD0bIUhdGW4ZXygc4YhXE2HTV[xOi=> MV:yOVM3OjJ4MB?=
BeWo  NHnEcm1HfW6ldHnvckBCe3OjeR?= M3PPeFIxyqEEtV2= M{\ob|Q5yqCqwrC= NX[xepBXTE2VT9Mg M2LGRYRwf26{ZXf1cIF1\XNidHjlJIxmfmWuIH;mJGdEVS1z MXSyOVM3OjJ4MB?=
granulosa cells M2DLe2Z2dmO2aX;uJGF{e2G7 MXOxNEDPxE1? M3HHdlEzNzJ2IHi= MX7pcoNz\WG|ZYOgeIhmKGyndnXsd{Bw\sLiUlfTNuKhdVKQQR?= NUDvTZZlOjV|M{mxNFU>
granulosa cells MYPGeY5kfGmxbjDBd5NigQ>? NX;GRndPOTBizszN NG\0PY8yOi9{NDDo NGf2[FBqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDy[ZBwenSncjDhZ5Rqfmm2eTDmc5IhfGinIHzvcodme3RiZoLh[41mdnRiKPMIllg2PC9tMUjSS3MzNkyXQzm= M1zSb|I2OzN7MUC1
granulosa cells MWDGeY5kfGmxbjDBd5NigQ>? NYXsOHE4OTBizszN NV;1XmxFOjRiaB?= NInjVXJqdmO{ZXHz[ZMhfGinIHnueIVve2m2eTDv[kBFVkFxcILveIVqdiClb33wcIV5 MmPtNlU{OzlzMEW=
granulosa cells M3KxemZ2dmO2aX;uJGF{e2G7 MljiNVAh|ryP M3:w[FI1KGh? MnXzbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZiUlfTNkBxem:vb4TldkBi[3Srdnn0fS=> MXiyOVM{QTFyNR?=
SK-N-AS  MV3D[YxtKF[rYXLpcIl1gSCDc4PhfS=> NFr3dVEyOCEQvF5CpC=> NEfpZmEzPC92ODDo MWLlcohidmOnczD0bY1mNWSncHXu[IVvfGy7IHPlcIx2dGG{II\pZYJqdGm2edMg MW[yOVI3PjB4Mx?=
SK-N-AS  MVzGeY5kfGmxbjDBd5NigQ>? MXexNEDPxE4EoB?= MYSyOEBp NWfldoxQcW6lcnXhd4V{KHSqZTDjRW1RKGyndnXsd:Kh M3LpRlI2OjZ4ME[z
SK-N-AS  M2fZfmZ2dmO2aX;uJGF{e2G7 MlvENVAh|ryPwrC= MWeyOEBp Ml7hbY5kemWjc3XzJJRp\SCneIDy[ZN{cW:wIH;mJIN6[2yrbjDENS=> NIn2PGIzPTJ4NkC2Ny=>
SK-N-AS  NHnzXG5HfW6ldHnvckBCe3OjeR?= M{Py[FExKM7:TdMg NVjrNY9QOzBibXnu NXi0VWVEcW6mdXPld{BxcG:|cHjvdplt[XSrb36gc4Yh|rJvY3H0[Y5qdiBqc3XyOlc2MSxicD3HV2s{|rJiKIPldlkqKGGwZDDjc45kd22rdHHueEBpcWeqZYKgcIV3\Wy|IH;mJIFkfGm4ZTygeY5xcG:|cHjvdplt[XSnZDyg{tIu[2G2ZX7pci=> M3y2VFI2OjZ4ME[z
SK-N-AS  MW\GeY5kfGmxbjDBd5NigQ>? NXPlRmlYOTBizszNxsA> MXOxNE8{OC94MDDtbY4> NFTGdohqdmO{ZXHz[ZMhdGW4ZXzzJI9nKHBvzsKtZ4F1\W6rbjCod4VzPjd3KTDhcoQhcW6mdXPld{Bi[2O3bYXsZZRqd25ib3[gdE3Pui2lYYTlcolvKCi|ZYK2O|UqKGmwIDjw[ZJqMW63Y3zlZZIhemWpaX;udy=> NWT3PZdpOjV{Nk[wOlM>
SK-N-SH Mn7UR4VtdCCYaXHibYxqfHliQYPzZZk> NFTMeHYyOCEQvF5CpC=> M4jTZVQ5KGh? MVflcohidmOnczDTT{1PNVOKIH7leZJw[myjc4TvcYEh[2WubDD2bYFjcWyrdIm= MVGyOVI3PjB4Mx?=
HEK‐CFTR MontSpVv[3Srb36gRZN{[Xl? NF;tRWMz6oDVNUFCpO69VQ>? MVOwMVEzKG2rbh?= M4\P[2ROW00EoB?= MoG0bY5lfWOnczDhJIRwe2YkgKDk[ZBmdmSnboSgbY9lcWSnIHXm[ox2gMLi MXuyOVI3OzJyNx?=
L6 NVThcphpTnWwY4Tpc44hSXO|YYm= NWf6TXhDPDBiwsXN MWiyOEBp NHzscWtqdmirYnn0d{BFVUhzLXnu[JVk\WRiQXv0JIFkfGm4YYTpc44> NE\LS24zPTJ2N{W1NC=>
MIN6  NXHkXoR7TnWwY4Tpc44hSXO|YYm= NEPyR5AyOCEQvF5CpC=> MX2zJIg> M3zybYlv[3KnYYPld{BFOyCvUl7BJIV5eHKnc4Ppc44> NGK3eIEzPTJ2MUGyOC=>
ventricular cardiomyocytes  NWfObGkyTnWwY4Tpc44hSXO|YYm= MWqwMlAyNTFyIN88US=> MkXobY5kemWjc3XzJEBkSU2SIHHjZ5VufWyjdHnvci=> Mn3BNlUzODNzMUO=
ventricular cardiomyocytes  M1fQOGZ2dmO2aX;uJGF{e2G7 NUnuZlBsOC5yMT2xNEDPxE1? MU\leo9s\XNiYX6gbY5wfHKxcHnjJJJme3CxboPlJFEzOMLzMUWlJIFjd3[nIHLhd4FtKHerdHigZY4hTUN3MNMgc4YhOi5{INM1US=> NYG4c5IzOjV{MEOxNVM>
BeWo  MlfQSpVv[3Srb36gRZN{[Xl? M{TVbFIxKML3TR?= MV20PEBp NVe1eVhYTE2VT9Mg MXnpcoR2[2W|IHPlcIwh\nW|aX;u NUe5NFMxOjVzOES0O|c>
THP-1  MXjGeY5kfGmxbjDBd5NigQ>? M1\wU|EwOTBizszN NGLBfVczyqCq M3ewcmROW00EoB?= NVHRO4N1e3WycILld5NmeyCPQ2CtNUBxem:mdXP0bY9vyqB? MX2yOVE2PDh6Mh?=
Huh-7 MnPaSpVv[3Srb36gRZN{[Xl? MnrjNE0zOCEQvF2= NHK4OXczKGkEoB?= NWrZfoZ4emW|dXz0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KGmwY4LlZZNmKGmwIHOtUZlkKGW6cILld5Nqd25iYYSgeIhmKHC{b4TlbY4h[W6mIH3SUmEhdGW4ZXzz MWCyOVExQTh|NB?=
C6 MlnoSpVv[3Srb36gRZN{[Xl? M3z4dFExKM7:TdMg M3fkUFIxKG2rbh?= NV7zXWl2cW6lcnXhd4V{KGODTWCgZYNkfW23bHH0bY9v NFPTdHczPTB4OUSxOy=>
SW480 MoTKSpVv[3Srb36gRZN{[Xl? MoDtOFDDqM7:TR?= NHXwbpc1QMLiaB?= NFzC[5dFVVOR NYPrVJZ{[WO2aY\heIV{KFCSMlG= MojFNlQ6QTd2NUG=
HT-29  NV3US|BvTnWwY4Tpc44hSXO|YYm= NIHjUW01OMLizszN NFT2S5o1QMLiaB?= MXLEUXNQ MW\hZ5RqfmG2ZYOgVHAzSQ>? NXj4ToFsOjR7OUe0OVE>
SW480 NVjaOJBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFTvNHk1OMLizszN MV2wMVczKGh? MVXEUXNQ NWrlVpQ4cW6qaXLpeJMh[2WubDDndo94fGhidHnt[UBl\XCnbnTlcpRtgQ>? M4DKbFI1QTl5NEWx
HT-29  MnrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXK0NOKh|ryP MUewMVczKGh? NITZdFBFVVOR NInxcWtqdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lJIRmeGWwZHXueIx6 Mnz4NlQ6QTd2NUG=
SW480 NXr4R2JjTnWwY4Tpc44hSXO|YYm= M1;WV|QxyqEQvF2= NH25WVM4KGR? NY[3RXA6TE2VTx?= M2DEXZJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= M{TTUVI1QTl5NEWx
HT-29  MVLGeY5kfGmxbjDBd5NigQ>? NVPyfmlrPDEEoN88US=> NFnpTmc4KGR? MkjsSG1UVw>? MnXldoVlfWOnczDjc4xwdm:|cHjldoUh\m:{bXH0bY9vKGOjcHHibYxqfHoEoB?= NInD[3AzPDl7N{S1NS=>
SW480 NIOwZmpCeG:ydH;zbZMhSXO|YYm= MXW0NOKh|ryP NGnBOFI1QMLiaB?= Ml64SG1UVw>? M4i0Solv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> NELzcGwzPDl7N{S1NS=>
HT-29  NFXofplCeG:ydH;zbZMhSXO|YYm= MWm0NOKh|ryP M3ft[lQ5yqCq M2DPS2ROW09? MV3pcoR2[2W|IHHuJIFkfGm4YYTpc44hd2ZiY3HzdIF{\SB|L{e= MoLlNlQ6QTd2NUG=
SW480 MVXBdI9xfG:|aYOgRZN{[Xl? NV;m[ZZUPDEEoN88US=> MX20POKhcA>? MX3EUXNQ MkTzbY5lfWOnczDjbIFv\2W|IHnuJJRp\SCyaH;zdIhwenmuYYTpc44he3SjdIXzJI9nKFCSMlGgeIFz\2W2cx?= MorUNlQ6QTd2NUG=
HT-29  NVL6[5BnSXCxcITvd4l{KEG|c3H5 NITG[ZE1OMLizszN MojtOFjDqGh? NIPsWldFVVOR MWHpcoR2[2W|IHPoZY5o\XNiaX6geIhmKHCqb4PwbI9zgWyjdHnvckB{fGG2dYOgc4YhWFB{QTD0ZZJo\XS| MmD1NlQ6QTd2NUG=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
in solvent
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID