Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 NUHrbppHTnWwY4Tpc44hSXO|YYm= M2HveVExKM7:TR?= MXu2JIg> MXfpcoNz\WG|ZYOgdIhwe3Cqb4L5cIF1cW:wIH;mJI93\XKneIDy[ZN{\WRiS1zIUFMh[XRiU{SzNy=> MY[yOlQ{PTR7OB?=
Mo-DCs NYrkZXpPTnWwY4Tpc44hSXO|YYm= MoPGOVAh|ryP M4HFflI16oDLaB?= MmO0dJJwdW:2ZYOgTWwuOjNicILv[JVkfGmxbjDpckB1cGVic4Xw[ZJv[XSjboSgc4Yhgnmvb4PhckB{fGmvdXzheIVlKE2xLVTDd:Kh NV7NOlhIOjZ2MUK5OFg>
RBMECs  NWfkN5YzTnWwY4Tpc44hSXO|YYm= NUjIWXQyPcLizszN MUSxxsBp NXS4UGxH[myxY3vzJJRp\SCUYXOxJIlv[WO2aY\heIlwdiCrbnT1Z4VlKGK7IFXNRXAuUUl? NGHwTGMzPjN3OECzPS=>
INA-6 M3TybWNmdGxiVnnhZoltcXS7IFHzd4F6 MlTaNE0yODBizszN NIj2eGI4OuLCiXi= MmrIbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NXL5eZI2OjZ|ME[2NlQ>
OPM-2 MkfCR4VtdCCYaXHibYxqfHliQYPzZZk> M3fEfFAuOTByIN88US=> MXW3NwKBkWh? NYfYNoUxcW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> NVvHNGJtOjZ|ME[2NlQ>
U266 MoXzR4VtdCCYaXHibYxqfHliQYPzZZk> NHvJRXYxNTFyMDFOwG0> M3nMNlcz6oDLaB?= NIS2colqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> NYT4TlhbOjZ|ME[2NlQ>
H929 NIXvdpFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? MnX0NE0yODBizszN NFi2dZU4OuLCiXi= MVfpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= MoTTNlY{ODZ4MkS=
RPMI 8226 MoXWR4VtdCCYaXHibYxqfHliQYPzZZk> MWGwMVExOCEQvF2= Mlu4O|LjiImq NHfTbVVqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> Ml;3NlY{ODZ4MkS=
MDCK  MYHGeY5kfGmxbjDBd5NigQ>? MUKxNEDDvU1? NYjyW|VsOjRiaB?= M2j6e2ROW09? NVjDfWoyfXC{ZXf1cIF1\XNidHjlJIV5eHKnc4Ppc44hd2ZiVFfGMe6zOSCjbnSgR3RITsLi M{[2NVI3OjB{M{Wy
MDCK  M13Y[2Z2dmO2aX;uJGF{e2G7 MYmxNEDDvU1? MV2yOEBp MljpSG1UVw>? Ml3LbY5pcWKrdIOgeIhmKGmwY4LlZZNm\CCneIDy[ZN{cW:wIH;mJGZPKGOjdYPl[EBjgSCWR1[t{tIy MkX2NlYzODJ|NUK=
Spinal cords  NVG1bFk4TnWwY4Tpc44hSXO|YYm= MV2xxsDPxE1? NV\PZms3OzBibXnu NUjFcVdUe3SrbYXsZZRmeyClQV3QJIxmfmWucx?= MXOyOlEzPjl{Nh?=
BeWo  NWr1cmRNTnWwY4Tpc44hSXO|YYm= NWjnZmVDOjYkgJpOwG0> Mk\vNlQwPDhxN{KgbC=> NWTTdJY{dGWjZIOgeI8h[W5iaX7jdoVie2ViaX6geIhmKGW6cILld5Nqd25ib3[gc5Rp\XJiZoXzbY9vKG2jcnvldpM> NUjUOopZOjZyNUO1OFk>
bovine oocytes NF\nc|JHfW6ldHnvckBCe3OjeR?= M3znW|ExOMLizszN NWTNc4ZZOTMEoHi= NIGzWVZqdmirYnn0d{B1cGViZX\m[YN1KG:oIF7QVGEh[W6mL3;yJG5RWENidH:gd5RqdXWuYYTlJJJme3WvcITpc44hd2ZibXXpc5Nqew>? MVqyOlA2OTZzMR?=
Caco-2  MV3GeY5kfGmxbjDBd5NigQ>? Mo\kNE4yNzFxMUCg{txO MlrlNlDDqG2rbh?= NIjQTFlqdmS3Y3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDjRW1RKGyndnXsdy=> NYTjT2hFOjZyNEmxNFI>
Caco-2  MYfGeY5kfGmxbjDBd5NigQ>? MWiwMlEwOS9zMDFOwG0> M{K3ZlI1KGh? NWLjTJg3cW6lcnXhd4V{KE2UUEKgdJJwfGWrbjDs[ZZmdA>? M4OyNVI3ODR7MUCy
AML-12  MYLGeY5kfGmxbjDBd5NigQ>? NFvzVnUzOCEQvF2= MmLiN{Bp NHTG[Y12eHKnZ4XsZZRmeyC2aHWgdIhwe3Cqb4L5cIF1cW:wIHzleoVteyCjdDDUbJIuPDFzIHHu[EBU\XJvNEmz MonDNlYxPDh7OEW=
AML-12  MV\GeY5kfGmxbjDBd5NigQ>? Mk\tNlAh|ryP MmfCNU05KGh? MlLBbY5kemWjc3XzJIdtfWOxc3WgdJJw\HWldHnvci=> MYqyOlA1QDl6NR?=
AML-12  NV;mTm92TnWwY4Tpc44hSXO|YYm= M2W5dVIxKM7:TR?= NW\uN5U3OyCq NXTIfVc3fXBvcnXneYxifGW|wrDQ[4My[S{EoGDldINsNCCjbnVCpGc3eGQEoH3SUmEhdGW4ZXzz MoL2NlYxPDh7OEW=
AML-12  NFjESIFHfW6ldHnvckBCe3OjeR?= NWSzOVlxOjBizszN NHj2R2I{KGh? M1rQcIlv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKG:oIFPSWGMzyqB? MUOyOlA1QDl6NR?=
RBMECs MonvSpVv[3Srb36gRZN{[Xl? NG\OZ5c2yqEQvF2= NWj5Z3NtOSCq MkDSbY5pcWKrdIOgSW1CWC2LST3pcoR2[2WmIHnuZYN1cX[jdHnvckBw\iCUYYCxxsA> MkHENlYxPDR4NkO=
EndoC-βH1 MWXGeY5kfGmxbjDBd5NigQ>? NHS5XJo2yqEQvF2= M4DEfVEhcA>? NWPXeWRqeG:2ZX70bYF1\XNiZ3z1Z49{\S2rbnT1Z4VlKGmwc4XsbY4he2WlcnX0bY9vKGmwIITo[UBxemW|ZX7j[UBw\iCpbIXjc5Nm M2P3dVI3ODJ6NU[y
EndoC-βH1 NVfJ[3l1TnWwY4Tpc44hSXO|YYm= NXTRW|Y3PcLizszN NIX6dpIyKGh? MV;s[YFleyC2bzDhJJN1em:wZzDjRW1RKGmwY4LlZZNm NIq5bYYzPjB{OEW2Ni=>
SH-SY5Y NIfSSI9HfW6ldHnvckBCe3OjeR?= MlX6N|Ah|ryP NX7pTnNxOzBibXnu M13zfmROW09? MXjzbYdvcW[rY3HueIx6KGmwY4LlZZNmeyC2aHWgZYN1cX[jdHnvckBw\iCSS1G= NH3ON3UzPjB{NUGzOy=>
PC-3 MVzGeY5kfGmxbjDBd5NigQ>? Ml3lOFAhyrWP NEG3R5kzKGh? NIHj[otFVVOR M4TTUoxm[WS|IITvJHBROkFiYXP0bZZifGmxbh?= NUfCfIc2OjZyMkO4N|Y>
PC-3 NXvmfZBpS2WubDDWbYFjcWyrdImgRZN{[Xl? MkTiOFAhyrWP MoPSNlQwPDhxN{KgbC=> MWjEUXNQ NHHwUHRl\WO{ZXHz[ZMh[2WubDD2bYFjcWyrdImgeIlu\SCmZYDlcoRmdnSueR?= NVywOWpiOjZyMkO4N|Y>
SCG M2LuN2Z2dmO2aX;uJGF{e2G7 NY\yVlQ5OjBizszNxsA> MnrsSG1UVw>? NGSwZXlz\X[ncoPpZox6KHO3cIDy[ZN{\XNiSVvWJJdqfGhiYTDJR|UxKG:oIEK0MlQh|ryP NXP1XZR5OjV7NkKxN|I>
HEK-293 M4q1e2Z2dmO2aX;uJGF{e2G7 NX;UO3FqOzVizszNxsA> MlLrSG1UVw>? MVHpcoR2[2W|IHGgZ49ve3CrY4XveZMh6oDeaX7hZ5RqfmG2aX;u5qCeKG:oIITo[UBMfjJwMTDjeZJz\W62 NFLN[m0zPTl4MkGzNi=>
SCG NHnnVINHfW6ldHnvckBCe3OjeR?= MWmxNFAh|ryPwrC= MX\EUXNQ MmP0doVlfWOnczD0bIUh\XilaYThZoltcXS7IH;mJHNETyCwZYXyc45{ M2LpTFI2QTZ{MUOy
PCCL3 NHXOfplHfW6ldHnvckBCe3OjeR?= NHjOelQyOCEEtV2= M4H2dFI1KGh? Mljo[Y5p[W6lZYOgSJVQgDJicILvcY91\XJidILhcpNkemmydHnvckBi[3Srdnn0feKh6oDN M3XMS|I2QTZyOUW2
3T3-L1 preadipocytes NFHwbFNHfW6ldHnvckBCe3OjeR?= MkfTNVAh|ryPwrC= MnnYNVIhcA>? NV\v[W9kcW6mdXPld{BEWkWEIIDoc5NxcG:{eXzheIlwdiCjbnSgR{9GSlEQsjDlfJBz\XO|aX;u NGrre2EzPTl{OEC1PC=>
H295R  MlTySpVv[3Srb36gRZN{[Xl? MWKxNOKh|ryP NIDT[Fc1QMLiaB?= NVjXOZp{cW6lcnXhd4V{KHO2ZYLvbYQhdWW2YXLvcIl1\XNiaX6geIhmKGGwZILv[4VvNCCvaX7ldoFtdy1iYX7kJIdtfWOxY3;yeIlkd2mmIIDheIh4[Xm| MYCyOVg3QTV3Nh?=
PBMC MoHZSpVv[3Srb36gRZN{[Xl? NED2SoQ2OMLizszN MX:yOOKhcMLi MVvpcohq[mm2czD0bIUhcW6lcnXhd4VlKHOnY4LleIlwdiCxZjDUUmYhcW6mdXPl[EBjgSC2aHWgSHBG MorMNlU5PjZyN{m=
GLUTag  MkPnSpVv[3Srb36gRZN{[Xl? M3vuXVEx6oDLwsXN MUSwM|IwPCCq NX:wbXJue3SrbYXsZZRmeyCJTGCtNUB{\WO{ZYTpc44h[2:2cnXheIVlKHerdHigTWJOYA>? M1PYSVI2QDN{NkOx
GLUTag  MlfJSpVv[3Srb36gRZN{[Xl? MWexNQKBkcL3TR?= NHm2W2E1KGh? Mli0bY5kemWjc3XzJJRp\SCyQ2LFRkBt\X[nbIOge4l1cCC2aHWgTWJOYA>? Mn;SNlU5OzJ4M{G=
BAECs NITEb2FHfW6ldHnvckBCe3OjeR?= M2\teFI2KM7:TR?= M{fXOVI1KGh? MnHG[Y5p[W6lZYOgeIhmKGGldHn2ZZRqd25ib3[gVHBCWs7zIHL5JFUh|ryPIILld5ZmemG2cn;sMEBVPEiVLDDvdkA1NVCDUB?= MlzrNlU4QTh6Mk[=
PC12 M4H1VWZ2dmO2aX;uJGF{e2G7 MYqyOeKh|ryP NHH5W2U1QCCq MVvhZ5RqfmG2ZYOgZ2FOWA>? MVSyOVc3QTNyNR?=
GH3 NWPWb2VOTnWwY4Tpc44hSXO|YYm= NXj2fGVQOcLizszN M1noNVYucA>? MnvIZZR1\W63YYTld{B1cGViY3;ydoVt[XSrb36gZoV1f2WnbjDQVmwh[W6mIFLtZYwyKGW6cILld5Nqd25? Mkf6NlU4OjdyMUi=
GH3 M4jXVWZ2dmO2aX;uJGF{e2G7 NEfVPGoyyqEQvF2= MUm2MYg> MVjpcoR2[2W|IGDSUEBidmRiQn3hcFEtKGK3dDDuc5QhS2yxY3usJI1TVkFiZYjwdoV{e2mxbh?= M3zlc|I2PzJ5MEG4
BeWo NGHveHdHfW6ldHnvckBCe3OjeR?= MnvYNVDjiIsQvF5CpC=> NXrpOWNrPzJiaB?= MWrEUXNQ MWjt[YRq[XSnczDC[XdwKGOnbHyg[Iln\mW{ZX70bYF1cW:w MlvINlU4OTN2MkW=
oocytes NGOyV|NHfW6ldHnvckBCe3OjeR?= M1XE[FUh|ryP MkfoNlQhcA>? NI\EfmJifHSnboXheIV{KHKqLXnud5VtcW5iYXP0bY9vKG:wIH;vZ5l1\SCJVlLEJJNq\26rZnnjZY51dHoEoB?= NFPBeVYzPTdyN{i1OC=>
SC M3rCcGZ2dmO2aX;uJGF{e2G7 Mo\FNE42KM7:TR?= MorINlQhcA>? M33C[Y1qdWmla4OgeIhmKGWoZnXjeEBw\iClQV3QJIFv[WyxZ4Ogc44hVzFiYX7kJG1DWCCneIDy[ZN{cW:w M1;uNVI2PzB3OEe0
SC MVLGeY5kfGmxbjDBd5NigQ>? MX2wMlUh|ryP NU[0cFd4PzJiaB?= NILQfZRqdmO{ZXHz[ZMh[m:2aDDLdo95NTJyIHHu[EBQOSCneIDy[ZN{cW:wIHnuJIF5d25vcnXsZZRm\CCVQ4OgZpV1KG:wbImgT5JwgC1{MNMg M2r1eFI2PzB3OEe0
UACC-647  NVLjS5F[TnWwY4Tpc44hSXO|YYm= MVTEUXNQ NIfhcIlt\WGmczD0c{BiKHKrc3WgbY4h[0GPUDDs[ZZmdHNiKFXDOVDDqD4EoEKwMlM6yqEQvF2p M{mwOVI2PzB|MEK1
UACC-647  NH\mcGtHfW6ldHnvckBCe3OjeR?= NEL0XFUyOMLizszN MX6xOUBucW5? NWC1OIJmTE2VTx?= MmXYbY5pcWKrdIOgSXJMKHCqb4PwbI9zgWyjdHnvci=> M4mwR|I2PzB|MEK1
UACC-647  MXzGeY5kfGmxbjDBd5NigQ>? MXmxNOKh|ryP M2K5dVE2KG2rbh?= MnflSG1UVw>? NUPrUGExcW6lcnXhd4V{KGWHRkKgdIhwe3Cqb4L5cIF1cW:wIHzleoVte8Li NVjpZ2JxOjV5MEOwNlU>
SH-SY5Y  MmLmSpVv[3Srb36gRZN{[Xl? M4\2OFExyqEQvF2= NUPCSWQyOcLiaNMg NU[0ZmZ6cW6lcnXhd4V{KEyXQzDhZ5Rqfmm2eR?= Ml\1NlU2QTd2M{O=
SH-SY5Y  MoPWSpVv[3Srb36gRZN{[Xl? MmXJNVDDqM7:TR?= NFHYWZIyyqCqwrC= Mk[2bY5kemWjc3XzJGFISzFibWLORUBt\X[nbB?= NF7hcpUzPTV7N{SzNy=>
hADSCs NG\wS5lHfW6ldHnvckBCe3OjeR?= NEm2eG426oDLwsXN MoXQN|AhdWmw NEn1S|hqdmO{ZXHz[ZMh[0GPUDDs[ZZmdHN? M1PwTFI2PTlzOUC4
HEK293  NGDPVGxHfW6ldHnvckBCe3OjeR?= M3TubVXjiIoEtV2= NX7PO3F2OzBibXnu MXfpcoNz\WG|ZYOgZ2FOWCCuZY\lcJM> NULBZ25yOjV3OUG5NFg>
3T3-L1 MmTpSpVv[3Srb36gRZN{[Xl? NGHUd5QzNjVxNTFOwG0> NYDyN5RGOjRiaNMg Mk\ad4lodmmoaXPhcpRtgSCmZXPy[YF{\XNiQWTHUEBxem:2ZXnuJIV5eHKnc4Ppc44h[XRiYXzsJIRwe2W|IITld5Rm\A>? MVyyOVU6ODV7Nx?=
OCI-Ly1  Mnj4SpVv[3Srb36gRZN{[Xl? MoSyOFDDqM7:TR?= Mk\ZNeKhcMLi M4TBT2ROW09? NE\o[21qdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> NFP2WIUzPTV5NkKyNC=>
OCI-Ly18  NFPmZmJHfW6ldHnvckBCe3OjeR?= NEXjc3I1OMLizszN NXXhWZJtOcLiaNMg NH7QNGNFVVOR MVnpcoR2[2W|IITo[UBqdmO{ZX3lcpQhd2ZiY1HNVEBkd26lZX70doF1cW:wcx?= NIrZTpMzPTV5NkKyNC=>
BeWo NWLDWWZLTnWwY4Tpc44hSXO|YYm= NXHCeWFTOjEEoNM1US=> MorOOFjDqGh? Moq2SG1UVw>? NF7qVItqdmO{ZXHz[ZMhfGinIHTp[oZmemWwdHnheIlwdiCxZjDC[XdwKGOnbHzz MonUNlU2PjZ5NEC=
BeWo NVv1U2kyTnWwY4Tpc44hSXO|YYm= Ml[0NlDDqML3TR?= M4HjelQ5yqCq MY\EUXNQ MlOybY5kemWjc3XzJJRp\SCjZHjld4lwdiCxZjDUTHAuOSCvb37vZ5l1\XN? MkL4NlU2PjZ5NEC=
LNCaP  NWLye4tlTnWwY4Tpc44hSXO|YYm= MXGxNOKh|ryP NHLofJMyOiCqwrC= MWnEUXNQ M4fP[olv\HWlZYOgZUBlemGvYYTpZ{BqdmO{ZXHz[UBw\iCFUlXCNUBi[3Srdnn0fS=> NXLQWFd2OjV3NEiwPVk>
ThGCs  Mn\iSpVv[3Srb36gRZN{[Xl? NHLzbIUyOOLCit88US=> M3vtd|TjiIqq MXHheYdu\W62czDITWYySSCuZY\lcJMhfGijdDD3[ZJmKHO2aX31cIF1\WRiYomgR49EdDJ? NX\lNGtWOjV2M{OwNlc>
ThGCs  NV3ZdXZwTnWwY4Tpc44hSXO|YYm= M{K3PFEx6oDMzszN M{T4cFTjiIqq NHHwcIdqdmO{ZXHz[ZMhS2:FbEKtbY5lfWOnZDDFSG4zyqCpZX7lJIV5eHKnc4Ppc44> MUOyOVQ{OzB{Nx?=
ThGCs  NEHyUG9HfW6ldHnvckBCe3OjeR?= Mli5NVDjiIsQvF2= MmLFN{Bp MnjpbY5pcWKrdIOgeIhmKGWoZnXjeEBw\iCKMl:yJI9vKEWGTkKgcXJPSQ>? MUiyOVQ{OzB{Nx?=
RBMECs NVv0[XlYTnWwY4Tpc44hSXO|YYm= NV[5[IJWOC5yNT:wMlUwPSEQvF2= NHuy[GExNjJ3IHi= NFj0[2hqdmO{ZXHz[ZMh[0GPUDDjc45k\W62cnH0bY9v NFHLOWYzPTRzNk[1NS=>
RBMECs M1PXcmZ2dmO2aX;uJGF{e2G7 NVnSd3dwPcLizszN NWDKPXh{OSCq NXrONYN1[myxY3vzJJRp\SCjY4TpeoF1cW:wIH;mJHJpd0FxUl;DT{BqdmS3Y3XkJIJ6KEWPQWCtTWk> NX36PWNwOjV2MU[2OVE>
RBMECs MoPrSpVv[3Srb36gRZN{[Xl? MUm1xsDPxE1? MXKxJIg> MVrwdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> NWny[ph[OjV2MU[2OVE>
RBMECs NHXIOndHfW6ldHnvckBCe3OjeR?= NUO5W2dkPcLizszN MnXPNUBp NHnYb5BxemW4ZX70d{B1cGViaX7jdoVie2ViaX6gTHJRKG[udYigZYNzd3O|IITo[UBDXEJiaX7keYNm\CCkeTCgSW1CWC2LSR?= MXGyOVQyPjZ3MR?=
RBMECs NVnhRYdlTnWwY4Tpc44hSXO|YYm= NF\KNHo2yqEQvF2= NXzSfVB5OSCq NVrvNlJGcW6qaXLpeJMhfGinIHTlZ5Jm[XOnZDDv[kBidW:3boSgc4YhYk9vMTDpckBOTnNiaX7keYNm\CCkeTDFUWFRNUmL NUD5[|NyOjV2MU[2OVE>
RBMECs NEnBRYFHfW6ldHnvckBCe3OjeR?= MWm1xsDPxE1? NX64cWY3OSCq NELtbnFz\X[ncoPld{B1cGViY3jhcodmeyCrbjDaU{0yKGSrc4TybYJ2fGmxbjDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboS= NIXicngzPTRzNk[1NS=>
RBMECs NHjZOIRHfW6ldHnvckBCe3OjeR?= MYC1xsDPxE1? MkC3NUBp Mo\HZoxw[2u|IITo[UBGVUGSLVnJMYlv\HWlZXSgZ4hidmenIHnuJG1NSyCyaH;zdIhwenmuYYTpc44> NFK0S28zPTRzNk[1NS=>
RBMECs MVPGeY5kfGmxbjDBd5NigQ>? NETuelc2yqEQvF2= Mo\MNUBp NVLiUZQx[myxY3vzJJRp\SCjY4TpckBkgXSxc3vlcIV1d25icnXhdpJidmenbXXueEB{\WWwIIfpeIghTU2DUD3JTUB1emWjdH3lcpTDqA>? M3nDS|I2PDF4NkWx
Primary bovine chondrocytes MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mln3Oe69VQ>? MUi0PEBp MoLjdoV3\XK|ZYOgeIhmKGmwaHnibZRwenliZX\m[YN1KG:oIHPlcIVkd3irYjDvckBxem:uaX\ldoF1cW:wIHnuJIdzd3e2aDDwcIF1\SClaH;u[JJw[3m2ZYO= MYWyOVQxPjBzNh?=
EM1  MkXySpVv[3Srb36gRZN{[Xl? NXnDUGxjOTYkgJtOwG0> MX60PEBp M2fnUpJm\HWlZYOgeIhmKGW6cILld5Nqd25ib3dCpGxKTsLib4NCpHBVT1N{wrDpcuKhS0GOUj2gc5LDqEWSQVOyMZNqdGWwY3XkJGVOOSClZXzsd:Kh MnLnNlU{Pzh4NkG=
BeWo  MnS4SpVv[3Srb36gRZN{[Xl? NXuzRW9nOjEEoNM1US=> Mn;JOFjDqGkEoB?= MYrEUXNQyqB? NYPpOpI5cW6lcnXhd4V{KHSqZTDi[ZRiNWiFRzDy[Yxm[XOn M1G5[lI2OzZ{Mk[w
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granulosa cells MVjGeY5kfGmxbjDBd5NigQ>? NHXrR4cyOCEQvF2= MkDnNVIwOjRiaB?= NGWwfIZqdmO{ZXHz[ZMhfGinIHzleoVteyCxZtMgVmdUOsLibWLORS=> NUPCdlN4OjV|M{mxNFU>
granulosa cells MkjzSpVv[3Srb36gRZN{[Xl? MWCxNEDPxE1? NWrEOJlkOTJxMkSgbC=> NVjnfWhZcW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gdoVxd3K2ZYKgZYN1cX[rdImg[o9zKHSqZTDsc45o\XO2IH\yZYdu\W62IDlijLI5PTRxK{G4VmdUOi6OVVOp MXuyOVM{QTFyNR?=
granulosa cells M1vib2Z2dmO2aX;uJGF{e2G7 NEL3bWMyOCEQvF2= M3jTcFI1KGh? NVXpbIc4cW6lcnXhd4V{KHSqZTDpcpRmdnOrdImgc4YhTE6DL4Dyc5RmcW5iY3;tdIxmgA>? MlPQNlU{OzlzMEW=
granulosa cells NEjEVXBHfW6ldHnvckBCe3OjeR?= MnjVNVAh|ryP MYOyOEBp NHO1UlhqdmO{ZXHz[ZMhfGinIHzleoVteyCxZjDSS3MzKHC{b33veIVzKGGldHn2bZR6 NGf3VJkzPTN|OUGwOS=>
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SK-N-AS  Mn;WSpVv[3Srb36gRZN{[Xl? NWTxWotTOTBizszNxsA> NFLodIYzPCCq NYDWNYpUcW6lcnXhd4V{KHSqZTDjRW1RKGyndnXsd:Kh M1PMSFI2OjZ4ME[z
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SK-N-AS  M2HjVWZ2dmO2aX;uJGF{e2G7 M{XzRlExKM7:TdMg Ml\uN|AhdWmw MXvpcoR2[2W|IIDoc5NxcG:{eXzheIlwdiCxZjFOtk1k[XSnbnnuJEh{\XJ4N{WpMEBxNUeVS{ROtkApe2W{OTmgZY5lKGOxbnPvcYl1[W62IHjp[4hmeiCuZY\lcJMhd2ZiYXP0bZZmNCC3boDoc5NxcG:{eXzheIVlNCEQsj3jZZRmdmmw MnO1NlUzPjZyNkO=
SK-N-AS  M{\RPWZ2dmO2aX;uJGF{e2G7 MmnONVAh|ryPwrC= MWWxNE8{OC94MDDtbY4> MVTpcoNz\WG|ZYOgcIV3\Wy|IH;mJJAu|rJvY3H0[Y5qdiBqc3XyOlc2MSCjbnSgbY5lfWOnczDhZ4N2dXWuYYTpc44hd2ZicD5Otk1k[XSnbnnuJEh{\XJ4N{WpJIlvKCiyZYLpLY52[2ynYYKgdoVocW:wcx?= M{jUWlI2OjZ4ME[z
SK-N-SH MUHD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MWWxNEDPxE4EoB?= M4nSdFQ5KGh? MmnV[Y5p[W6lZYOgV2suVi2VSDDu[ZVzd2KuYYP0c41iKGOnbHygeoli[mmuaYT5 MY[yOVI3PjB4Mx?=
HEK‐CFTR NI\DNHdHfW6ldHnvckBCe3OjeR?= MXGy5qCUPTEEoN88US=> Ml71NE0yOiCvaX6= M2D2UmROW00EoB?= MV\pcoR2[2W|IHGg[I9{\eLCkHTldIVv\GWwdDDpc4Rq\GViZX\mcJV5yqB? MmnsNlUzPjN{MEe=
L6 MnTmSpVv[3Srb36gRZN{[Xl? NFvaNGU1OCEEtV2= M{W3VlI1KGh? MV;pcohq[mm2czDEUWgyNWmwZIXj[YQhSWu2IHHjeIl3[XSrb36= NXj3bJlyOjV{NEe1OVA>
MIN6  Mli5SpVv[3Srb36gRZN{[Xl? M3nIOVExKM7:TdMg M4nqUFMhcA>? M2LXRYlv[3KnYYPld{BFOyCvUl7BJIV5eHKnc4Ppc44> NXOybWJ4OjV{NEGxNlQ>
ventricular cardiomyocytes  NFz4Ro9HfW6ldHnvckBCe3OjeR?= NELCcXkxNjBzLUGwJO69VQ>? NV;UZmVwcW6lcnXhd4V{KCClQV3QJIFk[3WvdXzheIlwdg>? NWHaT5N[OjV{MEOxNVM>
ventricular cardiomyocytes  NHfYS5lHfW6ldHnvckBCe3OjeR?= MX6wMlAyNTFyIN88US=> NW[3eI1z\X[xa3XzJIFvKGmwb4Tyc5Bq[yC{ZYPwc45{\SBzMkFCtVE2LSCjYn;2[UBj[XOjbDD3bZRpKGGwIFXDOVDDqG:oIEKuNkDDvU1? NGDCflczPTJyM{GxNy=>
BeWo  NXTKc|NXTnWwY4Tpc44hSXO|YYm= MoXoNlAhyrWP NHTTN2s1QCCq NE\yPY1FVVORwrC= MYrpcoR2[2W|IHPlcIwh\nW|aX;u MUCyOVE5PDR5Nx?=
THP-1  M3jROGZ2dmO2aX;uJGF{e2G7 MVixM|ExKM7:TR?= MmDBNuKhcA>? NVjORVBiTE2VT9Mg M4LsTpN2eHC{ZYPz[ZMhVUOSLUGgdJJw\HWldHnvcuKh NEPVOW8zPTF3NEi4Ni=>
Huh-7 MmXKSpVv[3Srb36gRZN{[Xl? MmTlNE0zOCEQvF2= MUGyJIjDqA>? MWry[ZN2dHS|IHnuJIEh\G:|ZT3k[ZBmdmSnboSgbY5kemWjc3WgbY4h[y2PeXOg[ZhxemW|c3nvckBifCC2aHWgdJJwfGWrbjDhcoQhdVKQQTDs[ZZmdHN? MX2yOVExQTh|NB?=
C6 NXfTXWU6TnWwY4Tpc44hSXO|YYm= NH;FVlkyOCEQvF5CpC=> MnLBNlAhdWmw M3;Eb4lv[3KnYYPld{BkSU2SIHHjZ5VufWyjdHnvci=> MV[yOVA3QTRzNx?=
SW480 MYfGeY5kfGmxbjDBd5NigQ>? NYr0dIJqPDEEoN88US=> NETWOWM1QMLiaB?= MYXEUXNQ NFnYZWli[3SrdnH0[ZMhWFB{QR?= NYrn[o9wOjR7OUe0OVE>
HT-29  M{TTUGZ2dmO2aX;uJGF{e2G7 M1LzOlQxyqEQvF2= M13lfFQ5yqCq NV;BVY9sTE2VTx?= M{j3ToFkfGm4YYTld{BRWDKD NXjTU5J6OjR7OUe0OVE>
SW480 NFLiWnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYG0NOKh|ryP NFrxbIsxNTd{IHi= NXXxVZFDTE2VTx?= Mk\HbY5pcWKrdIOgZ4VtdCCpcn;3eIghfGmvZTDk[ZBmdmSnboTsfS=> NVOyfZBSOjR7OUe0OVE>
HT-29  MlLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHPOFDDqM7:TR?= MVqwMVczKGh? NIHscHNFVVOR NETxVY5qdmirYnn0d{Bk\WyuIHfyc5d1cCC2aX3lJIRmeGWwZHXueIx6 MV6yOFk6PzR3MR?=
SW480 M{LhVmZ2dmO2aX;uJGF{e2G7 M4LzSVQxyqEQvF2= M1TROFch\A>? NWC4WI5TTE2VTx?= NWrOW3ZPemWmdXPld{Bkd2yxbn;zdIhmemViZn;ycYF1cW:wIHPhdIFjcWyrdIpCpC=> M2XCZlI1QTl5NEWx
HT-29  NW\r[4VSTnWwY4Tpc44hSXO|YYm= NYi2XnNtPDEEoN88US=> NIS0R484KGR? NVXE[nNHTE2VTx?= MmntdoVlfWOnczDjc4xwdm:|cHjldoUh\m:{bXH0bY9vKGOjcHHibYxqfHoEoB?= MUWyOFk6PzR3MR?=
SW480 MmrSRZBweHSxc3nzJGF{e2G7 NVHKb4d5PDEEoN88US=> MYm0POKhcA>? Mn;rSG1UVw>? MlfwbY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 M3HGZ|I1QTl5NEWx
HT-29  MYLBdI9xfG:|aYOgRZN{[Xl? NXrLW|BGPDEEoN88US=> NGX5Uoo1QMLiaB?= M2LDbWROW09? NGDWZlhqdmS3Y3XzJIFvKGGldHn2ZZRqd25ib3[gZ4F{eGG|ZTCzM|c> NILNWoczPDl7N{S1NS=>
SW480 MoP3RZBweHSxc3nzJGF{e2G7 NVXxWpZUPDEEoN88US=> NGD3fYg1QMLiaB?= MUjEUXNQ NIfPT|VqdmS3Y3XzJINp[W6pZYOgbY4hfGinIIDoc5NxcG:{eXzheIlwdiC|dHH0eZMhd2ZiUGCyRUB1[XKpZYTz NWe2N5FTOjR7OUe0OVE>
HT-29  M3nQcmFxd3C2b4Ppd{BCe3OjeR?= M3vZO|QxyqEQvF2= MYi0POKhcA>? MmLxSG1UVw>? NVv6epNOcW6mdXPld{BkcGGwZ3XzJIlvKHSqZTDwbI9{eGixconsZZRqd25ic4TheJV{KG:oIGDQNmEhfGG{Z3X0dy=> NVr5dpVqOjR7OUe0OVE>

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID