Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 M4rsN2Z2dmO2aX;uJGF{e2G7 M1LtT|ExKM7:TR?= NHm1Xng3KGh? Mk\VbY5kemWjc3XzJJBpd3OyaH;yfYxifGmxbjDv[kBwfmW{ZYjwdoV{e2WmIFvMTGw{KGG2IGO0N|M> MXuyOlQ{PTR7OB?=
Mo-DCs NWnBTXpJTnWwY4Tpc44hSXO|YYm= MYW1NEDPxE1? NVu4[XliOjUkgJno MkeydJJwdW:2ZYOgTWwuOjNicILv[JVkfGmxbjDpckB1cGVic4Xw[ZJv[XSjboSgc4Yhgnmvb4PhckB{fGmvdXzheIVlKE2xLVTDd:Kh MnPQNlY1OTJ7NEi=
RBMECs  NY[yWnpbTnWwY4Tpc44hSXO|YYm= M{HkUVXDqM7:TR?= NGLscmkyyqCq M{DVdoJtd2OtczD0bIUhWmGlMTDpcoFkfGm4YYTpc44hcW6mdXPl[EBjgSCHTVHQMWlK NUnaVHJDOjZ|NUiwN|k>
INA-6 M2fkfmNmdGxiVnnhZoltcXS7IFHzd4F6 NYXtOG8xOC1zMECg{txO MUK3NwKBkWh? NWHBTmFvcW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> MofsNlY{ODZ4MkS=
OPM-2 MljSR4VtdCCYaXHibYxqfHliQYPzZZk> NXnBbVFiOC1zMECg{txO NGTEfIg4OuLCiXi= MknrbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NF3WN|UzPjNyNk[yOC=>
U266 M2jSTmNmdGxiVnnhZoltcXS7IFHzd4F6 MWqwMVExOCEQvF2= M{nHNlcz6oDLaB?= MofubY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= M3H0WFI3OzB4NkK0
H929 NIjXe|BE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M{WxflAuOTByIN88US=> MoLVO|LjiImq NHvSWYNqdmS3Y3XzJINmdGxiZHXheIgh\G:|ZTDk[ZBmdmSnboTsfS=> NF\5ZVUzPjNyNk[yOC=>
RPMI 8226 NF3pbphE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NX\xb5AyOC1zMECg{txO M2DvRlcz6oDLaB?= MYTpcoR2[2W|IHPlcIwh\GWjdHig[I9{\SCmZYDlcoRmdnSueR?= NEnkPGIzPjNyNk[yOC=>
MDCK  M3HENmZ2dmO2aX;uJGF{e2G7 NFnvd|EyOCEEtV2= M3vvUFI1KGh? NITNRnlFVVOR NFvBNHN2eHKnZ4XsZZRmeyC2aHWg[ZhxemW|c3nvckBw\iCWR1[t{tIyKGGwZDDDWGdHyqB? NV6zS5NLOjZ{MEKzOVI>
MDCK  Mo\uSpVv[3Srb36gRZN{[Xl? MVixNEDDvU1? M{XueVI1KGh? MV\EUXNQ NFzZVYhqdmirYnn0d{B1cGViaX7jdoVie2WmIHX4dJJme3Orb36gc4YhTk5iY3H1d4VlKGK7IGTHSk3PujF? NIDzZ5czPjJyMkO1Ni=>
Spinal cords  M1i3dmZ2dmO2aX;uJGF{e2G7 NI[wZm4yyqEQvF2= NF7OSJI{OCCvaX6= Mojpd5RqdXWuYYTld{BkSU2SIHzleoVtew>? M2LuWlI3OTJ4OUK2
BeWo  M2fBVWZ2dmO2aX;uJGF{e2G7 NULSNIt7OjYkgJpOwG0> MknqNlQwPDhxN{KgbC=> NGewU5Zt\WGmczD0c{BidiCrbnPy[YF{\SCrbjD0bIUh\XiycnXzd4lwdiCxZjDveIhmeiCodYPpc44hdWG{a3Xydy=> M17abFI3ODV|NUS5
bovine oocytes MWnGeY5kfGmxbjDBd5NigQ>? M2\Fd|ExOMLizszN MVWxNuKhcA>? NE\qNGVqdmirYnn0d{B1cGViZX\m[YN1KG:oIF7QVGEh[W6mL3;yJG5RWENidH:gd5RqdXWuYYTlJJJme3WvcITpc44hd2ZibXXpc5Nqew>? NEPIcFIzPjB3MU[xNS=>
Caco-2  MkGySpVv[3Srb36gRZN{[Xl? NETDOmgxNjFxMT:xNEDPxE1? M2X3N|IxyqCvaX6= NEHiRXpqdmS3Y3XzJIEh\G:|ZT3k[ZBmdmSnboSgbY5kemWjc3WgbY4hcW62cnHj[YxtfWyjcjDjRW1RKGyndnXsdy=> NGOzeo8zPjB2OUGwNi=>
Caco-2  NGi5[nhHfW6ldHnvckBCe3OjeR?= Moj1NE4yNzFxMUCg{txO NIP3emMzPCCq NY\hXWxrcW6lcnXhd4V{KE2UUEKgdJJwfGWrbjDs[ZZmdA>? NX7QO2VjOjZyNEmxNFI>
AML-12  NYntPI9ZTnWwY4Tpc44hSXO|YYm= MYSyNEDPxE1? M{SwTFMhcA>? MnLqeZBz\We3bHH0[ZMhfGinIIDoc5NxcG:{eXzheIlwdiCuZY\lcJMh[XRiVHjyMVQyOSCjbnSgV4VzNTR7Mx?= NXnaVWV1OjZyNEi5PFU>
AML-12  M3OydWZ2dmO2aX;uJGF{e2G7 NWDUXGdHOjBizszN MWexMVghcA>? MUXpcoNz\WG|ZYOg[4x2[2:|ZTDwdo9lfWO2aX;u MWqyOlA1QDl6NR?=
AML-12  MlTvSpVv[3Srb36gRZN{[Xl? NInOUoszOCEQvF2= MnLKN{Bp MWj1dE1z\We3bHH0[ZPDqFCpY{HhMOKhWGWyY3usJIFv\MLiR{\wZ:KhdVKQQTDs[ZZmdHN? MYSyOlA1QDl6NR?=
AML-12  Ml3WSpVv[3Srb36gRZN{[Xl? NW\p[ot1OjBizszN NEjuVYE{KGh? Mlm1bY5lfWOnczD0bIUh\GWyaH;zdIhwenmuYYTpc44hd2ZiQ2LUR|LDqA>? NVOzTnUyOjZyNEi5PFU>
RBMECs M1frS2Z2dmO2aX;uJGF{e2G7 MlXqOeKh|ryP MlzqNUBp NUTBeodLcW6qaXLpeJMhTU2DUD3JTU1qdmS3Y3XkJIlv[WO2aY\heIlwdiCxZjDSZZAyyqB? NHjsO2QzPjB2NE[2Ny=>
EndoC-βH1 MWHGeY5kfGmxbjDBd5NigQ>? M{XkNlXDqM7:TR?= NGnaVJkyKGh? NHTTRZRxd3SnboTpZZRmeyCpbIXjc5NmNWmwZIXj[YQhcW6|dXzpckB{\WO{ZYTpc44hcW5idHjlJJBz\XOnbnPlJI9nKGeudXPvd4U> NGDw[nYzPjB{OEW2Ni=>
EndoC-βH1 MX\GeY5kfGmxbjDBd5NigQ>? MXG1xsDPxE1? M1rWO|EhcA>? Ml3OcIVi\HNidH:gZUB{fHKxbnegZ2FOWCCrbnPy[YF{\Q>? MV6yOlAzQDV4Mh?=
SH-SY5Y MYDGeY5kfGmxbjDBd5NigQ>? NFv3U4M{OCEQvF2= M{jV[VMxKG2rbh?= MkjaSG1UVw>? M1\kN5Nq\26rZnnjZY51dHliaX7jdoVie2W|IITo[UBi[3SrdnH0bY9vKG:oIGDLRS=> NES0eW4zPjB{NUGzOy=>
PC-3 NWDMRYY6TnWwY4Tpc44hSXO|YYm= NUe1R|J[PDBiwsXN M1PvNFIhcA>? MXfEUXNQ MV3s[YFleyC2bzDQVFJCKGGldHn2ZZRqd25? NFy2S3MzPjB{M{izOi=>
PC-3 MnXTR4VtdCCYaXHibYxqfHliQYPzZZk> NXnNZlRrPDBiwsXN MWWyOE81QC95MjDo NF;kfmpFVVOR MnWy[IVkemWjc3XzJINmdGxidnnhZoltcXS7IITpcYUh\GWyZX7k[Y51dHl? MY[yOlAzOzh|Nh?=
SCG NFv1THdHfW6ldHnvckBCe3OjeR?= NWP3UZBKOjBizszNxsA> NV7VUmQzTE2VTx?= MknIdoV3\XK|aXLsfUB{fXCycnXzd4V{KEmNVjD3bZRpKGFiSVO1NEBw\iB{ND60JO69VQ>? NUj6VW1nOjV7NkKxN|I>
HEK-293 M1X6UWZ2dmO2aX;uJGF{e2G7 NHjyO|Q{PSEQvF5CpC=> NG\VRphFVVOR M3;He4lv\HWlZYOgZUBkd26|cHnjeY92eyEkgKzpcoFkfGm4YYTpc47jiJ1ib3[geIhmKEu4Mj6xJIN2enKnboS= NVPp[pUxOjV7NkKxN|I>
SCG NEG2O5dHfW6ldHnvckBCe3OjeR?= MoruNVAxKM7:TdMg M365OmROW09? NVL1UnN4emWmdXPld{B1cGViZYjjbZRi[mmuaYT5JI9nKFOFRzDu[ZVzd26| MWKyOVk3OjF|Mh?=
PCCL3 MUPGeY5kfGmxbjDBd5NigQ>? Mn7rNVAhyrWP MUWyOEBp NGPuS2FmdmijbnPld{BFfU:6MjDwdo9ud3SncjD0doFve2O{aYD0bY9vKGGldHn2bZR6yqEkgJu= MYKyOVk3ODl3Nh?=
3T3-L1 preadipocytes M2G5cWZ2dmO2aX;uJGF{e2G7 MYWxNEDPxE4EoB?= M{[5eVEzKGh? NIHVRnpqdmS3Y3XzJGNTTUJicHjvd5Bpd3K7bHH0bY9vKGGwZDDDM2VDWM7{IHX4dJJme3Orb36= MlfTNlU6OjhyNUi=
H295R  MYXGeY5kfGmxbjDBd5NigQ>? NY\KdXQ5OTEEoN88US=> MlrmOFjDqGh? M4jYW4lv[3KnYYPld{B{fGW{b3nkJI1mfGGkb3zpeIV{KGmwIITo[UBidmS{b3flckwhdWmwZYLhcI8uKGGwZDDncJVkd2OxcoTpZ49q\CCyYYToe4F6ew>? NYC0[Fg1OjV6Nkm1OVY>
PBMC MX3GeY5kfGmxbjDBd5NigQ>? MX21NOKh|ryP NVno[m5JOjUEoHlCpC=> M1LZNolvcGmkaYTzJJRp\SCrbnPy[YF{\WRic3XjdoV1cW:wIH;mJHRPTiCrbnT1Z4VlKGK7IITo[UBFWEV? MX:yOVg3PjB5OR?=
GLUTag  NIX0PHlHfW6ldHnvckBCe3OjeR?= NWLqcIV1OTEkgJpCuW0> NG\NdWMxNzJxNDDo NGewXlV{fGmvdXzheIV{KEeOUD2xJJNm[3KndHnvckBkd3S{ZXH0[YQhf2m2aDDJRm1Z NXH4XXBEOjV6M{K2N|E>
GLUTag  MmLvSpVv[3Srb36gRZN{[Xl? M3TkXlEx6oDLwsXN M3XDeVQhcA>? MUXpcoNz\WG|ZYOgeIhmKHCFUlXCJIxmfmWuczD3bZRpKHSqZTDJRm1Z MlG4NlU5OzJ4M{G=
BAECs MW\GeY5kfGmxbjDBd5NigQ>? Mm\5NlUh|ryP NXy5fGFZOjRiaB?= NF2xPHNmdmijbnPld{B1cGViYXP0bZZifGmxbjDv[kBRWEGUzsGgZpkhPSEQvF2gdoV{fmW{YYTyc4wtKFR2SGOsJI9zKDRvUFHQ NELCW5kzPTd7OEiyOi=>
PC12 M1f4VGZ2dmO2aX;uJGF{e2G7 NWnTN3cyOjYEoN88US=> NHfK[FU1QCCq MX\hZ5RqfmG2ZYOgZ2FOWA>? NW\4UmF[OjV5NkmzNFU>
GH3 NHux[2lHfW6ldHnvckBCe3OjeR?= NF;pZ|AyyqEQvF2= MmHjOk1p MXjheJRmdnWjdHXzJJRp\SClb4Ly[YxifGmxbjDi[ZR4\WWwIGDSUEBidmRiQn3hcFEh\XiycnXzd4lwdg>? NH73SFIzPTd{N{CxPC=>
GH3 NYDYWGh7TnWwY4Tpc44hSXO|YYm= NH\IRZIyyqEQvF2= MXm2MYg> M4Gxe4lv\HWlZYOgVHJNKGGwZDDCcYFtOSxiYoX0JI5wfCCFbH;jb{whdVKQQTDlfJBz\XO|aX;u MWiyOVczPzBzOB?=
BeWo NWDMd|d{TnWwY4Tpc44hSXO|YYm= MoT4NVDjiIsQvF5CpC=> MX:3NkBp MnTHSG1UVw>? M3u2RY1m\GmjdHXzJGJmX29iY3XscEBlcW[oZYLlcpRq[XSrb36= NV64dFROOjV5MUO0NlU>
oocytes NYPNbmlRTnWwY4Tpc44hSXO|YYm= MoXuOUDPxE1? M{j5bVI1KGh? MWHheJRmdnWjdHXzJJJpNWmwc4XsbY4h[WO2aX;uJI9vKG:xY4n0[UBIXkKGIIPp[45q\mmlYX70cJnDqA>? NH\4O5EzPTdyN{i1OC=>
SC M1L1c2Z2dmO2aX;uJGF{e2G7 M3qycFAvPSEQvF2= M{HE[VI1KGh? MVTtbY1q[2u|IITo[UBm\m[nY4Sgc4Yh[0GPUDDhcoFtd2e|IH;uJG8yKGGwZDDNRnAh\XiycnXzd4lwdg>? NFnxS3IzPTdyNUi3OC=>
SC MnPoSpVv[3Srb36gRZN{[Xl? NEKwOpYxNjVizszN MXu3NkBp MX;pcoNz\WG|ZYOgZo91cCCNcn;4MVIxKGGwZDDPNUBmgHC{ZYPzbY9vKGmwIHH4c44uemWuYYTl[EBUS3NiYoX0JI9vdHliS4LvfE0zOMLi MU[yOVcxPTh5NB?=
UACC-647  NWO5c2I2TnWwY4Tpc44hSXO|YYm= M1y3ZmROW09? NGjFZ5Zt\WGmczD0c{BiKHKrc3WgbY4h[0GPUDDs[ZZmdHNiKFXDOVDDqD4EoEKwMlM6yqEQvF2p MofpNlU4ODNyMkW=
UACC-647  M1PyemZ2dmO2aX;uJGF{e2G7 MWexNOKh|ryP NVrScnNyOTVibXnu NHTvOo5FVVOR Mn7LbY5pcWKrdIOgSXJMKHCqb4PwbI9zgWyjdHnvci=> M2[wZ|I2PzB|MEK1
UACC-647  NGLST2xHfW6ldHnvckBCe3OjeR?= MYmxNOKh|ryP NEPIZoQyPSCvaX6= NV3te3NITE2VTx?= MoPHbY5kemWjc3XzJIVGTjJicHjvd5Bpd3K7bHH0bY9vKGyndnXsd:Kh NVTpVoU5OjV5MEOwNlU>
SH-SY5Y  NFTTXGRHfW6ldHnvckBCe3OjeR?= MVqxNOKh|ryP NIO5[XMyyqCqwrC= MYTpcoNz\WG|ZYOgUHVEKGGldHn2bZR6 MXuyOVU6PzR|Mx?=
SH-SY5Y  NGWzbZNHfW6ldHnvckBCe3OjeR?= NGTZ[4MyOMLizszN M4L6U|HDqGkEoB?= M2i4d4lv[3KnYYPld{BCT0NzIH3SUmEhdGW4ZXy= MYeyOVU6PzR|Mx?=
hADSCs NGf3WIZHfW6ldHnvckBCe3OjeR?= MXy15qCKyrWP MkT5N|AhdWmw NWnOWmpkcW6lcnXhd4V{KGODTWCgcIV3\Wy| MVqyOVU6OTlyOB?=
HEK293  NH;lc3NHfW6ldHnvckBCe3OjeR?= M4HKNVXjiIoEtV2= Mn3DN|AhdWmw NFTybZVqdmO{ZXHz[ZMh[0GPUDDs[ZZmdHN? NWPme3QzOjV3OUG5NFg>
3T3-L1 M4PJS2Z2dmO2aX;uJGF{e2G7 M{HabVIvPS93IN88US=> M{HqTFI1KGkEoB?= MUjzbYdvcW[rY3HueIx6KGSnY4LlZZNmeyCDVFfMJJBzd3SnaX6g[ZhxemW|c3nvckBifCCjbHyg[I9{\XNidHXzeIVl M3qw[FI2PTlyNUm3
OCI-Ly1  Mnf6SpVv[3Srb36gRZN{[Xl? NH\HOFQ1OMLizszN M4WzfFHDqGkEoB?= M4PsTWROW09? NFO1XIZqdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> MkW1NlU2PzZ{MkC=
OCI-Ly18  MnnMSpVv[3Srb36gRZN{[Xl? NV3hb|ZwPDEEoN88US=> NFjUZ|cyyqCqwrC= NV;r[|AyTE2VTx?= NH7xVFFqdmS3Y3XzJJRp\SCrbnPy[Y1mdnRib3[gZ2FOWCClb37j[Y51emG2aX;udy=> MlTLNlU2PzZ{MkC=
BeWo NWrzRoRDTnWwY4Tpc44hSXO|YYm= NGPJUpAzOMLiwsXN NWf2OG5oPDkEoHi= MYfEUXNQ M3rFU4lv[3KnYYPld{B1cGViZHnm[oVz\W62aXH0bY9vKG:oIFLlW48h[2WubIO= NGT4[JczPTV4Nke0NC=>
BeWo NEXWO5ZHfW6ldHnvckBCe3OjeR?= MUGyNOKhyrWP MnHyOFjDqGh? MUnEUXNQ NHzqTJhqdmO{ZXHz[ZMhfGinIHHkbIV{cW:wIH;mJHRJWC1zIH3vco9kgXSncx?= NVjXN3FTOjV3Nk[3OFA>
LNCaP  NXv0bplRTnWwY4Tpc44hSXO|YYm= NWjPN4FCOTEEoN88US=> NX3mNJBrOTJiaNMg MYXEUXNQ MXzpcoR2[2W|IHGg[JJidWG2aXOgbY5kemWjc3Wgc4YhS1KHQkGgZYN1cX[rdIm= NHXU[3ozPTV2OEC5PS=>
ThGCs  MYfGeY5kfGmxbjDBd5NigQ>? MUKxNQKBks7:TR?= M3XGVlTjiIqq M33VZoF2\22nboTzJGhKTjGDIHzleoVteyC2aHH0JJdmemVic4TpcZVt[XSnZDDifUBEd0OuMh?= NVfNXplpOjV2M{OwNlc>
ThGCs  M2fxbmZ2dmO2aX;uJGF{e2G7 NF;XSYYyOOLCit88US=> NYDk[4Y6POLCini= MmjDbY5kemWjc3XzJGNwS2x{LXnu[JVk\WRiRVTONuKh\2WwZTDlfJBz\XO|aX;u MnzwNlU1OzNyMke=
ThGCs  NWrhUFRyTnWwY4Tpc44hSXO|YYm= Mn;0NVDjiIsQvF2= NX34[VN2OyCq NUex[odscW6qaXLpeJMhfGinIHXm[oVkfCCxZjDINm8zKG:wIFXEUlIhdVKQQR?= NF[y[oUzPTR|M{CyOy=>
RBMECs NUXjPWhITnWwY4Tpc44hSXO|YYm= MoK0NE4xPS9yLkWvOUDPxE1? NXnFXZlkOC5{NTDo NHzvXXZqdmO{ZXHz[ZMh[0GPUDDjc45k\W62cnH0bY9v M33mO|I2PDF4NkWx
RBMECs NWnOe213TnWwY4Tpc44hSXO|YYm= NWX0eXhJPcLizszN NWPzO3hpOSCq M1K3OYJtd2OtczD0bIUh[WO2aY\heIlwdiCxZjDSbI9CN1KRQ1ugbY5lfWOnZDDifUBGVUGSLVnJ MoPmNlU1OTZ4NUG=
RBMECs M4DBfGZ2dmO2aX;uJGF{e2G7 MX[1xsDPxE1? NHvtSXQyKGh? MkO0dJJmfmWwdIOgeIhmKEWPQWCtTWkucW6mdXPl[EBVTUWUII\hcJVmKGSnY4LlZZNm Mlv3NlU1OTZ4NUG=
RBMECs M37kWWZ2dmO2aX;uJGF{e2G7 M2LFRlXDqM7:TR?= NFnxWI4yKGh? Mlu1dJJmfmWwdIOgeIhmKGmwY4LlZZNmKGmwIFjSVEBndHW6IHHjdo9{eyC2aHWgRnRDKGmwZIXj[YQh[nliIFXNRXAuUUl? M4HZSlI2PDF4NkWx
RBMECs M2Wy[2Z2dmO2aX;uJGF{e2G7 M{WwdVXDqM7:TR?= M1jaNFEhcA>? NVW3[nZ6cW6qaXLpeJMhfGinIHTlZ5Jm[XOnZDDv[kBidW:3boSgc4YhYk9vMTDpckBOTnNiaX7keYNm\CCkeTDFUWFRNUmL NXr0bJJKOjV2MU[2OVE>
RBMECs M1zOUGZ2dmO2aX;uJGF{e2G7 M3K3b|XDqM7:TR?= M1PGTlEhcA>? MkPFdoV3\XK|ZYOgeIhmKGOqYX7n[ZMhcW5iWl:tNUBlcXO2cnnieZRqd25ic3XlckB4cXSqIFXNRXAuUUlidILlZZRu\W62 NYjTOlRZOjV2MU[2OVE>
RBMECs MYrGeY5kfGmxbjDBd5NigQ>? Mn;YOeKh|ryP NF[zNoUyKGh? MXvicI9kc3NidHjlJGVOSVBvSVmtbY5lfWOnZDDjbIFv\2ViaX6gUWxEKHCqb4PwbI9zgWyjdHnvci=> M1W5O|I2PDF4NkWx
RBMECs NHTtUGJHfW6ldHnvckBCe3OjeR?= MkjQOeKh|ryP Mnz2NUBp NYXp[nN5[myxY3vzJJRp\SCjY4TpckBkgXSxc3vlcIV1d25icnXhdpJidmenbXXueEB{\WWwIIfpeIghTU2DUD3JTUB1emWjdH3lcpTDqA>? MmfiNlU1OTZ4NUG=
Primary bovine chondrocytes NYDyVJQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG1{txO MmHNOFghcA>? MofudoV3\XK|ZYOgeIhmKGmwaHnibZRwenliZX\m[YN1KG:oIHPlcIVkd3irYjDvckBxem:uaX\ldoF1cW:wIHnuJIdzd3e2aDDwcIF1\SClaH;u[JJw[3m2ZYO= M2jNVVI2PDB4MEG2
EM1  Mmf3SpVv[3Srb36gRZN{[Xl? MYmxOgKBks7:TR?= NHrmSVE1QCCq M1LlXZJm\HWlZYOgeIhmKGW6cILld5Nqd25ib3dCpGxKTsLib4NCpHBVT1N{wrDpcuKhS0GOUj2gc5LDqEWSQVOyMZNqdGWwY3XkJGVOOSClZXzsd:Kh NIj3TVkzPTN5OE[2NS=>
BeWo  MV3GeY5kfGmxbjDBd5NigQ>? M4rxflIxyqEEtV2= MmG0OFjDqGkEoB?= MlX6SG1UV8Li NELE[pVqdmO{ZXHz[ZMhfGinIHLleIEucEOJIILlcIVie2V? Mo\YNlU{PjJ{NkC=
BeWo  NGTzXpFHfW6ldHnvckBCe3OjeR?= NUf0Z|lbOjEEoNM1US=> M2Loc|Q5yqCqwrC= NXLsfFJtTE2VT9Mg MnTj[I94dnKnZ4XsZZRmeyC2aHWgcIV3\Wxib3[gWG1GVUZzNh?= MmTUNlU{PjJ{NkC=
BeWo  NHjDdlRHfW6ldHnvckBCe3OjeR?= NUC0WYI1OjEEoNM1US=> MVe0POKhcMLi MV3EUXNQyqB? M1\ld4Rwf26{ZXf1cIF1\XNidHjlJIxmfmWuIH;mJGdEVS1z MnHpNlU{PjJ{NkC=
granulosa cells NULMSnVrTnWwY4Tpc44hSXO|YYm= M2nqO|ExKM7:TR?= MVWxNk8zPCCq NWXUUWd7cW6lcnXhd4V{KHSqZTDs[ZZmdHNib3dCpHJIWzMEoH3SUmE> NFTaZlIzPTN|OUGwOS=>
granulosa cells Ml3JSpVv[3Srb36gRZN{[Xl? MYKxNEDPxE1? MUexNk8zPCCq MlTVbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZicnXwc5J1\XJiYXP0bZZqfHliZn;yJJRp\SCub37n[ZN1KG[{YXft[Y51KCkkiKK4OVQwMzF6UlfTNk5NXUNr NYjSepRROjV|M{mxNFU>
granulosa cells M{LNW2Z2dmO2aX;uJGF{e2G7 M4n4ZlExKM7:TR?= NI[3ZVAzPCCq Mm[2bY5kemWjc3XzJJRp\SCrboTlcpNqfHlib3[gSG5CN3C{b4TlbY4h[2:vcHzlfC=> MnPZNlU{OzlzMEW=
granulosa cells M371fWZ2dmO2aX;uJGF{e2G7 NHHMcowyOCEQvF2= MUeyOEBp MoDQbY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZiUlfTNkBxem:vb4TldkBi[3Srdnn0fS=> NVm0TldROjV|M{mxNFU>
SK-N-AS  NWTVV4x2S2WubDDWbYFjcWyrdImgRZN{[Xl? NXzMS2dLOTBizszNxsA> NIf0TnEzPC92ODDo MUjlcohidmOnczD0bY1mNWSncHXu[IVvfGy7IHPlcIx2dGG{II\pZYJqdGm2edMg MX:yOVI3PjB4Mx?=
SK-N-AS  Mn63SpVv[3Srb36gRZN{[Xl? MV:xNEDPxE4EoB?= M2raSlI1KGh? NH7MVIhqdmO{ZXHz[ZMhfGinIHPBUXAhdGW4ZXzzxsA> NIrCW4UzPTJ4NkC2Ny=>
SK-N-AS  M3[3R2Z2dmO2aX;uJGF{e2G7 NFvxboIyOCEQvF5CpC=> Ml\ENlQhcA>? MXrpcoNz\WG|ZYOgeIhmKGW6cILld5Nqd25ib3[gZ5lkdGmwIFSx NGXH[2UzPTJ4NkC2Ny=>
SK-N-AS  NYfMeJZnTnWwY4Tpc44hSXO|YYm= NHvKR2MyOCEQvF5CpC=> MV2zNEBucW5? NXzu[4N3cW6mdXPld{BxcG:|cHjvdplt[XSrb36gc4Yh|rJvY3H0[Y5qdiBqc3XyOlc2MSxicD3HV2s{|rJiKIPldlkqKGGwZDDjc45kd22rdHHueEBpcWeqZYKgcIV3\Wy|IH;mJIFkfGm4ZTygeY5xcG:|cHjvdplt[XSnZDyg{tIu[2G2ZX7pci=> NGnNTWIzPTJ4NkC2Ny=>
SK-N-AS  NWHZb5FWTnWwY4Tpc44hSXO|YYm= NX\Zc3pwOTBizszNxsA> MVKxNE8{OC94MDDtbY4> NWjJb|JRcW6lcnXhd4V{KGyndnXsd{Bw\iCyLd8yMYNifGWwaX6gLJNmejZ5NTmgZY5lKGmwZIXj[ZMh[WOldX31cIF1cW:wIH;mJJAu|rJvY3H0[Y5qdiBqc3XyOlc2MSCrbjCodIVzcSmwdXPs[YFzKHKnZ3nvcpM> MV:yOVI3PjB4Mx?=
SK-N-SH M4DvUmNmdGxiVnnhZoltcXS7IFHzd4F6 NX;iSWk{OTBizszNxsA> MVe0PEBp NHLzboFmdmijbnPld{BUUy2QLWPIJI5mfXKxYnzhd5RwdWFiY3XscEB3cWGkaXzpeJk> NEDQUI4zPTJ4NkC2Ny=>
HEK‐CFTR M3\O[mZ2dmO2aX;uJGF{e2G7 MlHVNwKBmzVywrFOwG0> M2\w[VAuOTJibXnu NXHVUFU3TE2VT9Mg M{jkO4lv\HWlZYOgZUBld3On4pEQ[IVx\W6mZX70JIlw\GmmZTDl[oZtfXkEoB?= NGrPTJIzPTJ4M{KwOy=>
L6 Mlq5SpVv[3Srb36gRZN{[Xl? M2r5fFQxKML3TR?= NIDSfmkzPCCq NWPFUHdIcW6qaXLpeJMhTE2KMT3pcoR2[2WmIFHreEBi[3SrdnH0bY9v MUWyOVI1PzV3MB?=
MIN6  NVTlfZc{TnWwY4Tpc44hSXO|YYm= MXOxNEDPxE4EoB?= NXXrbHFKOyCq Mon0bY5kemWjc3XzJGQ{KG2UTlGg[ZhxemW|c3nvci=> NE\Hb4QzPTJ2MUGyOC=>
ventricular cardiomyocytes  Mo\jSpVv[3Srb36gRZN{[Xl? MkDFNE4xOS1zMDFOwG0> NEnVeHZqdmO{ZXHz[ZMhKGODTWCgZYNkfW23bHH0bY9v Mnn6NlUzODNzMUO=
ventricular cardiomyocytes  NXjvOmd3TnWwY4Tpc44hSXO|YYm= NX63bZpsOC5yMT2xNEDPxE1? MlT2[ZZwc2W|IHHuJIlvd3S{b4DpZ{Bz\XOyb37z[UAyOjEEsUG1KUBi[m:4ZTDiZZNidCC5aYToJIFvKEWFNUFCpI9nKDJwMjFCuW0> M4rheFI2OjB|MUGz
BeWo  MUPGeY5kfGmxbjDBd5NigQ>? NYHtcGJnOjBiwsXN NW\pWZFiPDhiaB?= MkfiSG1UV8Li M1L5ZYlv\HWlZYOgZ4VtdCCodYPpc44> MV:yOVE5PDR5Nx?=
THP-1  MWfGeY5kfGmxbjDBd5NigQ>? MoiyNU8yOCEQvF2= MYeyxsBp NGLJUmpFVVORwrC= MonVd5VxeHKnc4Pld{BOS1BvMTDwdo9lfWO2aX;uxsA> Mnm3NlUyPTR6OEK=
Huh-7 Mlv4SpVv[3Srb36gRZN{[Xl? MXuwMVIxKM7:TR?= NITvPIgzKGkEoB?= MkHTdoV{fWy2czDpckBiKGSxc3Wt[IVx\W6mZX70JIlv[3KnYYPlJIlvKGNvTYnjJIV5eHKnc4Ppc44h[XRidHjlJJBzd3SnaX6gZY5lKG2UTlGgcIV3\Wy| NEHwd2QzPTFyOUizOC=>
C6 NGDGZZhHfW6ldHnvckBCe3OjeR?= MkK2NVAh|ryPwrC= M2HFcFIxKG2rbh?= M3PubYlv[3KnYYPld{BkSU2SIHHjZ5VufWyjdHnvci=> NH\WPVkzPTB4OUSxOy=>
SW480 NE\5fnBHfW6ldHnvckBCe3OjeR?= MmntOFDDqM7:TR?= MonTOFjDqGh? MkL6SG1UVw>? MXPhZ5RqfmG2ZYOgVHAzSQ>? M3e1VVI1QTl5NEWx
HT-29  MXHGeY5kfGmxbjDBd5NigQ>? MkfmOFDDqM7:TR?= M4nQcFQ5yqCq MWXEUXNQ NH22SZdi[3SrdnH0[ZMhWFB{QR?= M1;6c|I1QTl5NEWx
SW480 MmS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1i1PVQxyqEQvF2= NYLrSFBSOC15MjDo M1XxPGROW09? M1HT[YlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> NVLwU|ZROjR7OUe0OVE>
HT-29  MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzSU3o1OMLizszN M{H5W|AuPzJiaB?= NFPISVFFVVOR M4TpOYlvcGmkaYTzJINmdGxiZ4Lve5RpKHSrbXWg[IVx\W6mZX70cJk> NH;LemkzPDl7N{S1NS=>
SW480 Ml3CSpVv[3Srb36gRZN{[Xl? M1;qRVQxyqEQvF2= NFTZVFE4KGR? NEmyWXVFVVOR NULMUYNYemWmdXPld{Bkd2yxbn;zdIhmemViZn;ycYF1cW:wIHPhdIFjcWyrdIpCpC=> Mny0NlQ6QTd2NUG=
HT-29  NV\aUJhMTnWwY4Tpc44hSXO|YYm= Mn3SOFDDqM7:TR?= NY\3dVF7PyCm M4LUT2ROW09? MkHkdoVlfWOnczDjc4xwdm:|cHjldoUh\m:{bXH0bY9vKGOjcHHibYxqfHoEoB?= MWKyOFk6PzR3MR?=
SW480 MlPPRZBweHSxc3nzJGF{e2G7 MlO3OFDDqM7:TR?= Ml\YOFjDqGh? NWDRWpVLTE2VTx?= MnfmbY5lfWOnczDhckBi[3SrdnH0bY9vKG:oIHPhd5Bie2ViMz:3 NGD1bYgzPDl7N{S1NS=>
HT-29  NHLKNHNCeG:ydH;zbZMhSXO|YYm= NUf0WW0xPDEEoN88US=> NIKwSYc1QMLiaB?= NUjZeld[TE2VTx?= M3nWdIlv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> NIjjSJozPDl7N{S1NS=>
SW480 M2rsfmFxd3C2b4Ppd{BCe3OjeR?= M1nJXFQxyqEQvF2= NVLXNYliPDkEoHi= NHW0VGdFVVOR MVvpcoR2[2W|IHPoZY5o\XNiaX6geIhmKHCqb4PwbI9zgWyjdHnvckB{fGG2dYOgc4YhWFB{QTD0ZZJo\XS| MVyyOFk6PzR3MR?=
HT-29  M3\ESWFxd3C2b4Ppd{BCe3OjeR?= NF3xWYQ1OMLizszN M{HzeVQ5yqCq MoXVSG1UVw>? NWr6bYs{cW6mdXPld{BkcGGwZ3XzJIlvKHSqZTDwbI9{eGixconsZZRqd25ic4TheJV{KG:oIGDQNmEhfGG{Z3X0dy=> M1roelI1QTl5NEWx

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID