Forskolin

Catalog No.S2449 Synonyms: Coleonol

Forskolin Chemical Structure

Molecular Weight(MW): 410.5

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

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In DMSO USD 140 In stock
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2 Customer Reviews

  • Eur J Cancer 2014 50(7), 1310-20. Forskolin purchased from Selleck.

    Measurement of cAMP accumulation in INS-1 cells. (A) INS-1, or (B) INS-1 transfected with murine GPR109A for 24 h, or (C) INS-1 transfected with human GPR109A for 24 h were incubated in DMEM (2.5 mM glucose) media with or without PTX (100 ng/ml) for 24 h. Cells were then incubated in KRB supplemented with 2.5 mM glucose, 500 μM IBMX, 10 μM forskolin, and with/without 10 or 100 μM NA for 1 h. After lysis with HCl (0.1 M), cells were sonicated and spun. The supernatants were saved for cAMP measurement by ELISA. (D) Reduction of cAMP accumulation in INS-1 and INS-1 cells transfected with GPR109A in the presence of 10 or 100 μM NA. White bar: INS-1 cells, grey bar: INS-1 cells transfected with murine GPR109A; black bar: INS-1 cells transfected with human GPR109A. (∗ and #p < 0.05, ∗ and ##p < 0.001). (n = 5).

    Gen Comp Endocrinol, 2016, 237:98-108. Forskolin purchased from Selleck.

Purity & Quality Control

Choose Selective cAMP Inhibitors

Biological Activity

Description Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.
Targets
Adenylyl cyclase (AC) [1]
(A wide variety of cell types)
In vitro

Forskolin increases cAMP levels in preparations of membranes, cells, or tissues. Forskolin not only activates AC but also interacts with certain other proteins, including glucose transporters and ion channels. Forskolin is able to promote activation of nine different transmembrane iso-forms of AC, albeit with somewhat less efficacy for AC9, which could be used to provides a means to identify and quantify high-affinity binding sites, i.e., G-proteins (Gs)–AC complexes. Activation of s by GPCRs contributes to Forskolin-stimulated cAMP generation in cells because of s-Forskolin potentiation of AC activity. [1] Forskolin stimulates adenylate cyclase activity without interacting with cell surface receptors. Forskolin's potentiation of cAMP in turn inhibits basophil and mast cell degranulation and histamine release, lowers blood pressure and intraocular pressure, inhibits platelet aggregation, promotes vasodilation, bronchodilation, and thyroid hormone secretion, and stimulates lipolysis in fat cells. Forskolin inhibits the binding of platelet-activating factor (PAF), independently of cAMP formation, which may be a result of Forskolin's direct effect on PAF or via interference with PAF binding to receptor sites. Forskolin also appears to have an effect on several membrane transport proteins, and inhibits glucose transport in erythrocytes, adipocytes, platelets, and other cells. Forskolin is used to treat with glaucoma. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HEK293 MnyxSpVv[3Srb36gRZN{[Xl? NHOze2syOCEQvF2= NUXqd21kPiCq NXXWbYtvcW6lcnXhd4V{KHCqb4PwbI9zgWyjdHnvckBw\iCxdnXy[ZhxemW|c3XkJGtNUEx|IHH0JHM1OzN? MV6yOlQ{PTR7OB?=
Mo-DCs MoHqSpVv[3Srb36gRZN{[Xl? MYS1NEDPxE1? NV3jSIdDOjUkgJno MUTwdo9ud3SnczDJUE0zOyCycn;keYN1cW:wIHnuJJRp\SC|dYDldo5ifGGwdDDv[kB7gW2xc3HuJJN1cW23bHH0[YQhVW9vRFPzxsA> NEmxfIczPjRzMkm0PC=>
RBMECs  MUXGeY5kfGmxbjDBd5NigQ>? NITBU3Y2yqEQvF2= MWexxsBp M3jJV4Jtd2OtczD0bIUhWmGlMTDpcoFkfGm4YYTpc44hcW6mdXPl[EBjgSCHTVHQMWlK MVuyOlM2QDB|OR?=
INA-6 M37jPWNmdGxiVnnhZoltcXS7IFHzd4F6 M1r3XlAuOTByIN88US=> NVzy[G1MPzMkgJno MkHDbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= NEPPNmkzPjNyNk[yOC=>
OPM-2 NFPid3FE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NGD1XWYxNTFyMDFOwG0> MVq3NwKBkWh? MmXZbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= M4nveFI3OzB4NkK0
U266 MV;D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MlLXNE0yODBizszN NIP5PFY4OuLCiXi= M{OzdYlv\HWlZYOgZ4VtdCCmZXH0bEBld3OnIHTldIVv\GWwdHz5 MXGyOlMxPjZ{NB?=
H929 NUHrepBlS2WubDDWbYFjcWyrdImgRZN{[Xl? M1zDUVAuOTByIN88US=> MoT1O|LjiImq MmTnbY5lfWOnczDj[YxtKGSnYYToJIRwe2ViZHXw[Y5l\W62bIm= MVOyOlMxPjZ{NB?=
RPMI 8226 MnfyR4VtdCCYaXHibYxqfHliQYPzZZk> NWfrfZd[OC1zMECg{txO M{LmXVcz6oDLaB?= NUjOO4t[cW6mdXPld{Bk\WyuIHTlZZRpKGSxc3Wg[IVx\W6mZX70cJk> MWiyOlMxPjZ{NB?=
MDCK  MYXGeY5kfGmxbjDBd5NigQ>? Mk\rNVAhyrWP MlXyNlQhcA>? M4HxWmROW09? M1TQUJVxemWpdXzheIV{KHSqZTDlfJBz\XO|aX;uJI9nKFSJRj5OtlEh[W6mIFPUS2bDqA>? M4DEd|I3OjB{M{Wy
MDCK  MYTGeY5kfGmxbjDBd5NigQ>? M4i2[VExKML3TR?= NE\hR2gzPCCq NFnqU4NFVVOR NVHZO4JVcW6qaXLpeJMhfGinIHnuZ5Jm[XOnZDDlfJBz\XO|aX;uJI9nKE[QIHPheZNm\CCkeTDUS2Yu|rJz NH73SWozPjJyMkO1Ni=>
Spinal cords  MmS3SpVv[3Srb36gRZN{[Xl? NVjuc2c6OcLizszN NWH5ToVTOzBibXnu NGXBdnp{fGmvdXzheIV{KGODTWCgcIV3\Wy| NGn5UY4zPjF{NkmyOi=>
BeWo  NH:zO5VHfW6ldHnvckBCe3OjeR?= MojHNlXjiIoQvF2= NXrySZVbOjRxNEivO|IhcA>? M4WyPYxm[WS|IITvJIFvKGmwY4LlZZNmKGmwIITo[UBmgHC{ZYPzbY9vKG:oIH;0bIVzKG[3c3nvckBu[XKtZYLz NWXnOmlwOjZyNUO1OFk>
bovine oocytes MkfjSpVv[3Srb36gRZN{[Xl? NHH0ZmwyODEEoN88US=> M{LDUVEzyqCq MoWzbY5pcWKrdIOgeIhmKGWoZnXjeEBw\iCQUGDBJIFv\C:xcjDOVHBEKHSxIIP0bY12dGG2ZTDy[ZN2dXC2aX;uJI9nKG2naX;zbZM> NFqxOIwzPjB3MU[xNS=>
Caco-2  NFfU[GNHfW6ldHnvckBCe3OjeR?= NGHnTpMxNjFxMT:xNEDPxE1? M4Dyc|IxyqCvaX6= MYPpcoR2[2W|IHGg[I9{\S2mZYDlcoRmdnRiaX7jdoVie2ViaX6gbY51emGlZXzseYxieiClQV3QJIxmfmWucx?= NGDOSFgzPjB2OUGwNi=>
Caco-2  NELwV|hHfW6ldHnvckBCe3OjeR?= MVWwMlEwOS9zMDFOwG0> MVOyOEBp MYLpcoNz\WG|ZYOgUXJROiCycn;0[YlvKGyndnXs NHmyXI8zPjB2OUGwNi=>
AML-12  MknFSpVv[3Srb36gRZN{[Xl? NHfXXIszOCEQvF2= MoXKN{Bp MlzreZBz\We3bHH0[ZMhfGinIIDoc5NxcG:{eXzheIlwdiCuZY\lcJMh[XRiVHjyMVQyOSCjbnSgV4VzNTR7Mx?= M2DESFI3ODR6OUi1
AML-12  NYLmd3FtTnWwY4Tpc44hSXO|YYm= MYGyNEDPxE1? MoPMNU05KGh? NHm0cppqdmO{ZXHz[ZMh\2y3Y3;z[UBxem:mdXP0bY9v NVHZfndHOjZyNEi5PFU>
AML-12  MoriSpVv[3Srb36gRZN{[Xl? MnHiNlAh|ryP MXmzJIg> NV:0fZRIfXBvcnXneYxifGW|wrDQ[4My[S{EoGDldINsNCCjbnVCpGc3eGQEoH3SUmEhdGW4ZXzz NF;tclgzPjB2OEm4OS=>
AML-12  NUTmb|VNTnWwY4Tpc44hSXO|YYm= NXfySJdVOjBizszN MUCzJIg> M2jhT4lv\HWlZYOgeIhmKGSncHjvd5Bpd3K7bHH0bY9vKG:oIFPSWGMzyqB? M4PxeFI3ODR6OUi1
RBMECs NHX5bohHfW6ldHnvckBCe3OjeR?= MWq1xsDPxE1? MWOxJIg> MlXabY5pcWKrdIOgSW1CWC2LST3pcoR2[2WmIHnuZYN1cX[jdHnvckBw\iCUYYCxxsA> MV2yOlA1PDZ4Mx?=
EndoC-βH1 NV;pUYY{TnWwY4Tpc44hSXO|YYm= MUG1xsDPxE1? Mn:yNUBp NWK2eZRUeG:2ZX70bYF1\XNiZ3z1Z49{\S2rbnT1Z4VlKGmwc4XsbY4he2WlcnX0bY9vKGmwIITo[UBxemW|ZX7j[UBw\iCpbIXjc5Nm NFjHO4szPjB{OEW2Ni=>
EndoC-βH1 M3fHdWZ2dmO2aX;uJGF{e2G7 M175XVXDqM7:TR?= MUSxJIg> MXHs[YFleyC2bzDhJJN1em:wZzDjRW1RKGmwY4LlZZNm NGjMWYozPjB{OEW2Ni=>
SH-SY5Y M{XzSGZ2dmO2aX;uJGF{e2G7 NFzQZWM{OCEQvF2= Mn\6N|AhdWmw MoHVSG1UVw>? Mn3Bd4lodmmoaXPhcpRtgSCrbnPy[YF{\XNidHjlJIFkfGm4YYTpc44hd2ZiUFvB MmHJNlYxOjVzM{e=
PC-3 NFPEO3hHfW6ldHnvckBCe3OjeR?= NI[2c2Y1OCEEtV2= M3rrclIhcA>? M4\Fb2ROW09? NFLhOpVt\WGmczD0c{BRWDKDIHHjeIl3[XSrb36= NGTNR2wzPjB{M{izOi=>
PC-3 NGjkem5E\WyuIG\pZYJqdGm2eTDBd5NigQ>? NV:1NVM6PDBiwsXN NHvHbpQzPC92OD:3NkBp NEHVNohFVVOR MnG1[IVkemWjc3XzJINmdGxidnnhZoltcXS7IITpcYUh\GWyZX7k[Y51dHl? NHTLfIEzPjB{M{izOi=>
SCG M4Tn[GZ2dmO2aX;uJGF{e2G7 MUKyNEDPxE4EoB?= MVrEUXNQ NInn[2Jz\X[ncoPpZox6KHO3cIDy[ZN{\XNiSVvWJJdqfGhiYTDJR|UxKG:oIEK0MlQh|ryP NFL6TW0zPTl4MkGzNi=>
HEK-293 M2jQZWZ2dmO2aX;uJGF{e2G7 M4WwWVM2KM7:TdMg M4DPd2ROW09? MlfEbY5lfWOnczDhJINwdnOyaXP1c5V{KOLCnHnuZYN1cX[jdHnvcwKBpSCxZjD0bIUhU3Z{LkGgZ5VzemWwdB?= MnLRNlU6PjJzM{K=
SCG MkjOSpVv[3Srb36gRZN{[Xl? NFLmNpgyODBizszNxsA> M1W2R2ROW09? NGjPN5dz\WS3Y3XzJJRp\SCneHPpeIFjcWyrdImgc4YhW0OJIH7leZJwdnN? Mn3uNlU6PjJzM{K=
PCCL3 M{TMUmZ2dmO2aX;uJGF{e2G7 NFK3VHoyOCEEtV2= NGLyd3gzPCCq M3jTPYVvcGGwY3XzJGR2V3h{IIDyc41wfGW{IITyZY5{[3KrcITpc44h[WO2aY\peJnDqOLCix?= MVeyOVk3ODl3Nh?=
3T3-L1 preadipocytes MlyzSpVv[3Srb36gRZN{[Xl? M4rmPVExKM7:TdMg Mn2zNVIhcA>? NIricodqdmS3Y3XzJGNTTUJicHjvd5Bpd3K7bHH0bY9vKGGwZDDDM2VDWM7{IHX4dJJme3Orb36= Mn;iNlU6OjhyNUi=
H295R  NVvNbFVZTnWwY4Tpc44hSXO|YYm= NHrPTpQyOMLizszN MY[0POKhcA>? M{ewTIlv[3KnYYPld{B{fGW{b3nkJI1mfGGkb3zpeIV{KGmwIITo[UBidmS{b3flckwhdWmwZYLhcI8uKGGwZDDncJVkd2OxcoTpZ49q\CCyYYToe4F6ew>? MUKyOVg3QTV3Nh?=
PBMC MWDGeY5kfGmxbjDBd5NigQ>? NInuVJI2OMLizszN MoH6NlTDqGkEoB?= MmDBbY5pcWKrdIOgeIhmKGmwY4LlZZNm\CC|ZXPy[ZRqd25ib3[gWG5HKGmwZIXj[YQh[nlidHjlJGRRTQ>? MnnCNlU5PjZyN{m=
GLUTag  MlXvSpVv[3Srb36gRZN{[Xl? NV7FcJE2OTEkgJpCuW0> NUPVbJdSOC9{L{SgbC=> NFTG[mR{fGmvdXzheIV{KEeOUD2xJJNm[3KndHnvckBkd3S{ZXH0[YQhf2m2aDDJRm1Z MofJNlU5OzJ4M{G=
GLUTag  Ml\lSpVv[3Srb36gRZN{[Xl? MlHoNVDjiIoEtV2= MVu0JIg> MoLLbY5kemWjc3XzJJRp\SCyQ2LFRkBt\X[nbIOge4l1cCC2aHWgTWJOYA>? M3XjclI2QDN{NkOx
BAECs MnvCSpVv[3Srb36gRZN{[Xl? Mnu4NlUh|ryP NYfKb3FDOjRiaB?= MnSw[Y5p[W6lZYOgeIhmKGGldHn2ZZRqd25ib3[gVHBCWs7zIHL5JFUh|ryPIILld5ZmemG2cn;sMEBVPEiVLDDvdkA1NVCDUB?= NGTSVpozPTd7OEiyOi=>
PC12 NVTCb|NkTnWwY4Tpc44hSXO|YYm= MX6yOeKh|ryP MlvzOFghcA>? NIf6bYFi[3SrdnH0[ZMh[0GPUB?= MnT2NlU4Pjl|MEW=
GH3 M17BVmZ2dmO2aX;uJGF{e2G7 MnHFNeKh|ryP NIf1XYw3NWh? NGfXT|FifHSnboXheIV{KHSqZTDjc5Jz\WyjdHnvckBj\XS5ZXXuJHBTVCCjbnSgRo1idDFiZYjwdoV{e2mxbh?= NH3Md|gzPTd{N{CxPC=>
GH3 NFnRU|dHfW6ldHnvckBCe3OjeR?= NHmxN|IyyqEQvF2= MXG2MYg> NU\JOGtDcW6mdXPld{BRWkxiYX7kJGJu[WxzLDDieZQhdm:2IFPsc4NsNCCvUl7BJIV5eHKnc4Ppc44> MlvRNlU4OjdyMUi=
BeWo M37oXWZ2dmO2aX;uJGF{e2G7 M4nFNlEx6oDMzszNxsA> Mn7PO|IhcA>? M{jDd2ROW09? NX3Wc3k6dWWmaXH0[ZMhSmWZbzDj[YxtKGSrZn\ldoVvfGmjdHnvci=> NFn4RYczPTdzM{SyOS=>
oocytes NF;oPHRHfW6ldHnvckBCe3OjeR?= M1;vW|Uh|ryP NI\LS2gzPCCq MYDheJRmdnWjdHXzJJJpNWmwc4XsbY4h[WO2aX;uJI9vKG:xY4n0[UBIXkKGIIPp[45q\mmlYX70cJnDqA>? MXiyOVcxPzh3NB?=
SC NWfGVnlNTnWwY4Tpc44hSXO|YYm= MXKwMlUh|ryP M4XrTVI1KGh? M4\jZY1qdWmla4OgeIhmKGWoZnXjeEBw\iClQV3QJIFv[WyxZ4Ogc44hVzFiYX7kJG1DWCCneIDy[ZN{cW:w NE[0[JIzPTdyNUi3OC=>
SC M3;MOmZ2dmO2aX;uJGF{e2G7 M2fvUFAvPSEQvF2= M1O4R|czKGh? MoPKbY5kemWjc3XzJIJwfGhiS4LvfE0zOCCjbnSgU|Eh\XiycnXzd4lwdiCrbjDhfI9vNXKnbHH0[YQhW0O|IHL1eEBwdmy7IFvyc5guOjEEoB?= MnrxNlU4ODV6N{S=
UACC-647  Mmi3SpVv[3Srb36gRZN{[Xl? Mk\1SG1UVw>? MUHs[YFleyC2bzDhJJJqe2ViaX6gZ2FOWCCuZY\lcJMhMEWFNUFCpF3DqDJyLkO5xsDPxE1r M3HsSlI2PzB|MEK1
UACC-647  M1TEdmZ2dmO2aX;uJGF{e2G7 NGTCU4EyOMLizszN NYH4Nm9iOTVibXnu NFLaZW5FVVOR NHX1R4xqdmirYnn0d{BGWkticHjvd5Bpd3K7bHH0bY9v NIX2UpIzPTdyM{CyOS=>
UACC-647  MkLaSpVv[3Srb36gRZN{[Xl? NVXVR29ZOTEEoN88US=> M3X4RVE2KG2rbh?= MYXEUXNQ M{L2XYlv[3KnYYPld{BmTUZ{IIDoc5NxcG:{eXzheIlwdiCuZY\lcJPDqA>? NIT4eVYzPTdyM{CyOS=>
SH-SY5Y  M2X5bGZ2dmO2aX;uJGF{e2G7 NWToS4tOOTEEoN88US=> MnT5NeKhcMLi M1viRYlv[3KnYYPld{BNXUNiYXP0bZZqfHl? NVuxO4R[OjV3OUe0N|M>
SH-SY5Y  MWDGeY5kfGmxbjDBd5NigQ>? M3WwNFExyqEQvF2= NH\DZ|IyyqCqwrC= NX7IfYhkcW6lcnXhd4V{KEGJQ{GgcXJPSSCuZY\lcC=> MmDXNlU2QTd2M{O=
hADSCs NUi4SmhiTnWwY4Tpc44hSXO|YYm= NVW4UY41PeLCidM1US=> NWLYXWU3OzBibXnu MUDpcoNz\WG|ZYOgZ2FOWCCuZY\lcJM> MYGyOVU6OTlyOB?=
HEK293  NFj1RpJHfW6ldHnvckBCe3OjeR?= Ml3POgKBkcL3TR?= NVTXSHhWOzBibXnu MmfLbY5kemWjc3XzJINCVVBibHX2[Yx{ NF3P[XAzPTV7MUmwPC=>
3T3-L1 M{\OSWZ2dmO2aX;uJGF{e2G7 MnvONk42NzVizszN M4DWe|I1KGkEoB?= M2rTO5Nq\26rZnnjZY51dHliZHXjdoVie2W|IFHUS2wheHKxdHXpckBmgHC{ZYPzbY9vKGG2IHHscEBld3OnczD0[ZN1\WR? M4nzUVI2PTlyNUm3
OCI-Ly1  MnzpSpVv[3Srb36gRZN{[Xl? M1PuN|QxyqEQvF2= MnLPNeKhcMLi NXK4UJhKTE2VTx?= MnnNbY5lfWOnczD0bIUhcW6lcnXt[Y51KG:oIHPBUXAh[2:wY3XueJJifGmxboO= NXzDZXF2OjV3N{[yNlA>
OCI-Ly18  NVHkSohMTnWwY4Tpc44hSXO|YYm= M3jGflQxyqEQvF2= NF:yfWEyyqCqwrC= NV;zOVV3TE2VTx?= NVnLO2lxcW6mdXPld{B1cGViaX7jdoVu\W62IH;mJINCVVBiY3;uZ4VvfHKjdHnvcpM> NVTCNmNiOjV3N{[yNlA>
BeWo MVTGeY5kfGmxbjDBd5NigQ>? MoW5NlDDqML3TR?= MnLGOFjDqGh? MYPEUXNQ Mlu1bY5kemWjc3XzJJRp\SCmaX\m[ZJmdnSrYYTpc44hd2ZiQnXXc{Bk\Wyucx?= Ml;KNlU2PjZ5NEC=
BeWo MlT1SpVv[3Srb36gRZN{[Xl? NVTMXmJNOjEEoNM1US=> NHrpTms1QMLiaB?= NE\lOY5FVVOR MmK1bY5kemWjc3XzJJRp\SCjZHjld4lwdiCxZjDUTHAuOSCvb37vZ5l1\XN? MUiyOVU3Pjd2MB?=
LNCaP  MYLGeY5kfGmxbjDBd5NigQ>? MoG0NVDDqM7:TR?= MV:xNkBpyqB? M1W4cmROW09? M3X4eYlv\HWlZYOgZUBlemGvYYTpZ{BqdmO{ZXHz[UBw\iCFUlXCNUBi[3Srdnn0fS=> NE\zVlUzPTV2OEC5PS=>
ThGCs  M4jYTmZ2dmO2aX;uJGF{e2G7 MnfmNVDjiIsQvF2= MUK05qCLcA>? NHzrTHZifWevZX70d{BJUUZzQTDs[ZZmdHNidHjheEB4\XKnIIP0bY12dGG2ZXSgZpkhS2:FbEK= NHO0VJMzPTR|M{CyOy=>
ThGCs  NES4foxHfW6ldHnvckBCe3OjeR?= MoPONVDjiIsQvF2= MUG05qCLcA>? NYjqT2V{cW6lcnXhd4V{KEOxQ3yyMYlv\HWlZXSgSWRPOsLiZ3Xu[UBmgHC{ZYPzbY9v NH;yco4zPTR|M{CyOy=>
ThGCs  MX\GeY5kfGmxbjDBd5NigQ>? NYexdpBMOTEkgJtOwG0> MlriN{Bp NWLmdVM3cW6qaXLpeJMhfGinIHXm[oVkfCCxZjDINm8zKG:wIFXEUlIhdVKQQR?= NWTCXmU3OjV2M{OwNlc>
RBMECs NIeyc|ZHfW6ldHnvckBCe3OjeR?= Mn7nNE4xPS9yLkWvOUDPxE1? MYGwMlI2KGh? MofHbY5kemWjc3XzJINCVVBiY3;uZ4VvfHKjdHnvci=> M1LMNVI2PDF4NkWx
RBMECs MlnaSpVv[3Srb36gRZN{[Xl? NIPHeGY2yqEQvF2= M4nFNlEhcA>? M3L3S4Jtd2OtczD0bIUh[WO2aY\heIlwdiCxZjDSbI9CN1KRQ1ugbY5lfWOnZDDifUBGVUGSLVnJ NWH0WGxSOjV2MU[2OVE>
RBMECs NWTMXnZmTnWwY4Tpc44hSXO|YYm= M{H0WFXDqM7:TR?= Mm\4NUBp MVvwdoV3\W62czD0bIUhTU2DUD3JTU1qdmS3Y3XkJHRGTVJidnHseYUh\GWlcnXhd4U> NETsW|EzPTRzNk[1NS=>
RBMECs NGj1NWNHfW6ldHnvckBCe3OjeR?= NWfPOpI3PcLizszN NVXhSpR1OSCq M{nXUJBz\X[nboTzJJRp\SCrbnPy[YF{\SCrbjDIVnAh\my3eDDhZ5Jwe3NidHjlJGJVSiCrbnT1Z4VlKGK7IDDFUWFRNUmL NWLTPG1[OjV2MU[2OVE>
RBMECs M1vEc2Z2dmO2aX;uJGF{e2G7 NYTGXHhJPcLizszN NUW1fFZoOSCq NV7QWnBOcW6qaXLpeJMhfGinIHTlZ5Jm[XOnZDDv[kBidW:3boSgc4YhYk9vMTDpckBOTnNiaX7keYNm\CCkeTDFUWFRNUmL MV2yOVQyPjZ3MR?=
RBMECs M1HOeWZ2dmO2aX;uJGF{e2G7 MXe1xsDPxE1? MlezNUBp MnLmdoV3\XK|ZYOgeIhmKGOqYX7n[ZMhcW5iWl:tNUBlcXO2cnnieZRqd25ic3XlckB4cXSqIFXNRXAuUUlidILlZZRu\W62 NIj5SJYzPTRzNk[1NS=>
RBMECs MmDFSpVv[3Srb36gRZN{[Xl? NV7heW4xPcLizszN Mk\6NUBp Mkj3Zoxw[2u|IITo[UBGVUGSLVnJMYlv\HWlZXSgZ4hidmenIHnuJG1NSyCyaH;zdIhwenmuYYTpc44> M2PLOlI2PDF4NkWx
RBMECs NFXhZotHfW6ldHnvckBCe3OjeR?= M2\2[VXDqM7:TR?= NEnQXYgyKGh? Mk[wZoxw[2u|IITo[UBi[3SrbjDjfZRwe2unbHX0c44hemWjcoLhcodmdWWwdDDz[YVvKHerdHigSW1CWC2LSTD0doVifG2nboVCpC=> M{D4O|I2PDF4NkWx
Primary bovine chondrocytes MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjnNJU2|ryP MljQOFghcA>? NG\6RW1z\X[ncoPld{B1cGViaX7obYJqfG:{eTDl[oZm[3Rib3[gZ4Vt\WOxeHniJI9vKHC{b3zp[oVz[XSrb36gbY4h\3Kxd4ToJJBt[XSnIHPoc45lem:leYTldy=> MkjZNlU1ODZyMU[=
EM1  MYDGeY5kfGmxbjDBd5NigQ>? M335b|E26oDMzszN NVHPT3JKPDhiaB?= MWLy[YR2[2W|IITo[UBmgHC{ZYPzbY9vKG:owrDMTWbDqG:{wrDQWGdUOsLiaX9CpGNCVFJvIH;yxsBGWEGFMj3zbYxmdmOnZDDFUVEh[2WubIRCpC=> NF:ycGMzPTN5OE[2NS=>
BeWo  MVXGeY5kfGmxbjDBd5NigQ>? MVGyNOKhyrWP M{frflQ5yqCqwrC= MlfESG1UV8Li NXzPSJJ5cW6lcnXhd4V{KHSqZTDi[ZRiNWiFRzDy[Yxm[XOn MXmyOVM3OjJ4MB?=
BeWo  NHGyRZpHfW6ldHnvckBCe3OjeR?= MmD0NlDDqML3TR?= NGXpZWw1QMLiaNMg NVq0O49jTE2VT9Mg NG\DZoVld3ewcnXneYxifGW|IITo[UBt\X[nbDDv[kBVVUWPRkG2 M{\rWVI2OzZ{Mk[w
BeWo  MX7GeY5kfGmxbjDBd5NigQ>? M4q3OVIxyqEEtV2= NY\KOppzPDkEoHlCpC=> NFjXeopFVVORwrC= MlXv[I94dnKnZ4XsZZRmeyC2aHWgcIV3\Wxib3[gS2NONTF? M3znOFI2OzZ{Mk[w
granulosa cells Mne0SpVv[3Srb36gRZN{[Xl? NVqwPZFNOTBizszN NVnJeGs3OTJxMkSgbC=> Ml6ybY5kemWjc3XzJJRp\SCuZY\lcJMhd2cEoGLHV|LDqG2UTlG= MoHENlU{OzlzMEW=
granulosa cells NUjVW3piTnWwY4Tpc44hSXO|YYm= MYKxNEDPxE1? NGjJbmwyOi9{NDDo MkK4bY5kemWjc3XzJJRp\SCuZY\lcJMhd2ZicnXwc5J1\XJiYXP0bZZqfHliZn;yJJRp\SCub37n[ZN1KG[{YXft[Y51KCkkiKK4OVQwMzF6UlfTNk5NXUNr Mnq4NlU{OzlzMEW=
granulosa cells NFS2W4JHfW6ldHnvckBCe3OjeR?= M131N|ExKM7:TR?= Ml3NNlQhcA>? MXrpcoNz\WG|ZYOgeIhmKGmwdHXud4l1gSCxZjDEUmEweHKxdHXpckBkd22ybHX4 NGDadlIzPTN|OUGwOS=>
granulosa cells MWLGeY5kfGmxbjDBd5NigQ>? MmLkNVAh|ryP NYGyOm11OjRiaB?= NVPiO45DcW6lcnXhd4V{KHSqZTDs[ZZmdHNib3[gVmdUOiCycn;tc5RmeiCjY4Tpeol1gQ>? MV2yOVM{QTFyNR?=
SK-N-AS  M2XLNGNmdGxiVnnhZoltcXS7IFHzd4F6 NUTTWYFXOTBizszNxsA> NGfOZVgzPC92ODDo MVrlcohidmOnczD0bY1mNWSncHXu[IVvfGy7IHPlcIx2dGG{II\pZYJqdGm2edMg NFyycpQzPTJ4NkC2Ny=>
SK-N-AS  NFPnXGtHfW6ldHnvckBCe3OjeR?= NHjyS2cyOCEQvF5CpC=> M3vCTVI1KGh? MnLQbY5kemWjc3XzJJRp\SClQV3QJIxmfmWuc9Mg MVKyOVI3PjB4Mx?=
SK-N-AS  NYjsT2d{TnWwY4Tpc44hSXO|YYm= NU\MV2JoOTBizszNxsA> NHTWeZMzPCCq MUjpcoNz\WG|ZYOgeIhmKGW6cILld5Nqd25ib3[gZ5lkdGmwIFSx NEPwfVQzPTJ4NkC2Ny=>
SK-N-AS  MUXGeY5kfGmxbjDBd5NigQ>? NV;vZnRXOTBizszNxsA> MkP4N|AhdWmw NHrleZNqdmS3Y3XzJJBpd3OyaH;yfYxifGmxbjDv[kDPui2lYYTlcolvKCi|ZYK2O|UqNCCyLVfTT|PPuiBqc3XyPUkh[W6mIHPvcoNwdWm2YX70JIhq\2incjDs[ZZmdHNib3[gZYN1cX[nLDD1cpBpd3OyaH;yfYxifGWmLDFOtk1k[XSnbnnu M4HOXlI2OjZ4ME[z
SK-N-AS  MX3GeY5kfGmxbjDBd5NigQ>? M3XvdFExKM7:TdMg M1\afFExNzNyL{[wJI1qdg>? NEj3fVVqdmO{ZXHz[ZMhdGW4ZXzzJI9nKHBvzsKtZ4F1\W6rbjCod4VzPjd3KTDhcoQhcW6mdXPld{Bi[2O3bYXsZZRqd25ib3[gdE3Pui2lYYTlcolvKCi|ZYK2O|UqKGmwIDjw[ZJqMW63Y3zlZZIhemWpaX;udy=> MmKyNlUzPjZyNkO=
SK-N-SH NFi4PGdE\WyuIG\pZYJqdGm2eTDBd5NigQ>? NFLvWlcyOCEQvF5CpC=> MV[0PEBp MX3lcohidmOnczDTT{1PNVOKIH7leZJw[myjc4TvcYEh[2WubDD2bYFjcWyrdIm= M1TQR|I2OjZ4ME[z
HEK‐CFTR NVixTotwTnWwY4Tpc44hSXO|YYm= NWnUZlV4OuLCk{WwxsDPxE1? NH;t[GoxNTF{IH3pci=> M1m3fmROW00EoB?= NHfrZZlqdmS3Y3XzJIEh\G:|ZfMAlIRmeGWwZHXueEBqd2SrZHWg[YZndHW6wrC= MUWyOVI3OzJyNx?=
L6 M1qzSGZ2dmO2aX;uJGF{e2G7 M4\mNFQxKML3TR?= NXzxb|dWOjRiaB?= MYrpcohq[mm2czDEUWgyNWmwZIXj[YQhSWu2IHHjeIl3[XSrb36= NIXWR5QzPTJ2N{W1NC=>
MIN6  NIPvZ5ZHfW6ldHnvckBCe3OjeR?= NYDxW5VVOTBizszNxsA> MYSzJIg> MlPxbY5kemWjc3XzJGQ{KG2UTlGg[ZhxemW|c3nvci=> M33HXVI2OjRzMUK0
ventricular cardiomyocytes  Mn;xSpVv[3Srb36gRZN{[Xl? NIrWcWoxNjBzLUGwJO69VQ>? MmWzbY5kemWjc3XzJEBkSU2SIHHjZ5VufWyjdHnvci=> M2HRRlI2OjB|MUGz
ventricular cardiomyocytes  NYm5cYJoTnWwY4Tpc44hSXO|YYm= M4e1RlAvODFvMUCg{txO M2TlbYV3d2unczDhckBqdm:2cn;wbYMhemW|cH;ud4UhOTJywsGxOUUh[WKxdnWgZoF{[Wxid3n0bEBidiCHQ{WwxsBw\iB{LkKgxtVO MknFNlUzODNzMUO=
BeWo  MXLGeY5kfGmxbjDBd5NigQ>? M2nI[VIxKML3TR?= NIPSZYU1QCCq MlXPSG1UV8Li NEnNRVBqdmS3Y3XzJINmdGxiZoXzbY9v MVqyOVE5PDR5Nx?=
THP-1  Mmr1SpVv[3Srb36gRZN{[Xl? NGH3W3QyNzFyIN88US=> MlzFNuKhcA>? M4rNb2ROW00EoB?= MXnzeZBxemW|c3XzJG1EWC1zIIDyc4R2[3Srb39CpC=> M1TZOlI2OTV2OEiy
Huh-7 M2LaZWZ2dmO2aX;uJGF{e2G7 NELZN|AxNTJyIN88US=> NXv0WpNFOiCqwrC= NYq1SIN5emW|dXz0d{BqdiCjIHTvd4Uu\GWyZX7k[Y51KGmwY4LlZZNmKGmwIHOtUZlkKGW6cILld5Nqd25iYYSgeIhmKHC{b4TlbY4h[W6mIH3SUmEhdGW4ZXzz MlHiNlUyODl6M{S=
C6 M2fLWmZ2dmO2aX;uJGF{e2G7 M4S1[FExKM7:TdMg MUmyNEBucW5? MmjsbY5kemWjc3XzJINCVVBiYXPjeY12dGG2aX;u M4exb|I2ODZ7NEG3
SW480 M33iN2Z2dmO2aX;uJGF{e2G7 M{LtSlQxyqEQvF2= MX:0POKhcA>? NXPzT4JXTE2VTx?= NH60b4hi[3SrdnH0[ZMhWFB{QR?= NYG4XmpkOjR7OUe0OVE>
HT-29  M4HDcWZ2dmO2aX;uJGF{e2G7 NWLhPHZUPDEEoN88US=> M1rRXlQ5yqCq MlXkSG1UVw>? M2nwNoFkfGm4YYTld{BRWDKD MkjQNlQ6QTd2NUG=
SW480 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV:0NOKh|ryP NGjFU2wxNTd{IHi= MVfEUXNQ NWDje5RXcW6qaXLpeJMh[2WubDDndo94fGhidHnt[UBl\XCnbnTlcpRtgQ>? NX:2T41[OjR7OUe0OVE>
HT-29  M4HJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S1[VQxyqEQvF2= M1\S[FAuPzJiaB?= MY\EUXNQ MYfpcohq[mm2czDj[YxtKGe{b4f0bEB1cW2nIHTldIVv\GWwdHz5 M1zQOFI1QTl5NEWx
SW480 NXXrfVJYTnWwY4Tpc44hSXO|YYm= M2S5XFQxyqEQvF2= NIS3PJE4KGR? M2D5bmROW09? M13QfZJm\HWlZYOgZ49td26xc4Do[ZJmKG[xcn3heIlwdiClYYDhZoltcXS7wrC= NVfJWnJ{OjR7OUe0OVE>
HT-29  NU\HOIlRTnWwY4Tpc44hSXO|YYm= NYO1TXBSPDEEoN88US=> MonTO{Bl NYXpcHVGTE2VTx?= MVjy[YR2[2W|IHPvcI9vd3OyaHXy[UBnd3KvYYTpc44h[2GyYXLpcIl1gcLi MmHJNlQ6QTd2NUG=
SW480 MXTBdI9xfG:|aYOgRZN{[Xl? NF;jOmU1OMLizszN Mme4OFjDqGh? M1TqdGROW09? M13lSIlv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> NIHnO|IzPDl7N{S1NS=>
HT-29  MnjlRZBweHSxc3nzJGF{e2G7 NYDRfZg4PDEEoN88US=> MVi0POKhcA>? NF3SWmZFVVOR M13IeYlv\HWlZYOgZY4h[WO2aY\heIlwdiCxZjDjZZNx[XOnIEOvOy=> MmDBNlQ6QTd2NUG=
SW480 NW\nRmtXSXCxcITvd4l{KEG|c3H5 NGW2UJA1OMLizszN M4G1[VQ5yqCq NXKzOWJ1TE2VTx?= M4rRZolv\HWlZYOgZ4hidmenczDpckB1cGVicHjvd5Bpd3K7bHH0bY9vKHO2YYT1d{Bw\iCSUELBJJRiemendIO= Ml2yNlQ6QTd2NUG=
HT-29  NFuwOWVCeG:ydH;zbZMhSXO|YYm= MVO0NOKh|ryP NWfGOFJXPDkEoHi= Mkn2SG1UVw>? NFXSNXJqdmS3Y3XzJINp[W6pZYOgbY4hfGinIIDoc5NxcG:{eXzheIlwdiC|dHH0eZMhd2ZiUGCyRUB1[XKpZYTz Mn7jNlQ6QTd2NUG=

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 82 mg/mL (199.75 mM)
Ethanol 37 mg/mL (90.13 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 410.5
Formula

C22H34O7

CAS No. 66575-29-9
Storage powder
Synonyms Coleonol

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01254006 Completed Glaucoma University of Roma La Sapienza|vingolo enzo maria|domanico daniela|salvatore serena null --

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

cAMP Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID