FXR

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2782 GW4064 <1 mg/mL 100 mg/mL <1 mg/mL
S2694 Turofexorate Isopropyl (XL335) <1 mg/mL 33 mg/mL 2 mg/mL
S1843 Chenodeoxycholic Acid <1 mg/mL 79 mg/mL 79 mg/mL
S4003 Lithocholic acid <1 mg/mL 75 mg/mL 47 mg/mL
S7660 Obeticholic Acid <1 mg/mL 84 mg/mL 84 mg/mL
Catalog No. Information Product Use Citations Product Validations
S2782

GW4064

GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM.

S2694

Turofexorate Isopropyl (XL335)

Turofexorate Isopropyl (XL335) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.

S1843

Chenodeoxycholic Acid

Chenodeoxycholic Acid is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines.

S4003

Lithocholic acid

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.

S7660

Obeticholic Acid

Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Phase 3.

Catalog No. Information Product Use Citations Product Validations
S2782

GW4064

GW4064 is an agonist of farnesoid X receptor (FXR) with EC50 of 65 nM in CV1 cell line and displays no activity at other nuclear receptors at concentrations up to 1 μM.

2015, 6(6):4226-38

2016, 68(5):376-87

S2694

Turofexorate Isopropyl (XL335)

Turofexorate Isopropyl (XL335) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.

2015, 6(6):4226-38

S1843

Chenodeoxycholic Acid

Chenodeoxycholic Acid is a naturally occurring human bile acid, and inhibits production of cholesterol in the liver and absorption in the intestines.

S4003

Lithocholic acid

Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR.

S7660

Obeticholic Acid

Obeticholic Acid is a potent and selective farnesoid X receptor (FXR) agonist with EC50 of 99 nM. Phase 3.

2017, 10.1039/c7ib00027h

2017, 315:23-34