cAMP

Sigaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2449 Forskolin <1 mg/mL 82 mg/mL 37 mg/mL
S8414 PACAP 1-27 100 mg/mL -1 mg/mL -1 mg/mL
S7499 ESI-09 <1 mg/mL 66 mg/mL 20 mg/mL
S8415 PACAP 1-38 100 mg/mL -1 mg/mL -1 mg/mL
S8416 PACAP 6-38 100 mg/mL -1 mg/mL -1 mg/mL
S8283 SQ22536 41 mg/mL 41 mg/mL 41 mg/mL
S7500 HJC0350 <1 mg/mL 52 mg/mL <1 mg/mL
S4552 Bithionol <1 mg/mL 71 mg/mL 22 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S8414New

PACAP 1-27

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.

S7499

ESI-09

ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.

S8416New

PACAP 6-38

PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.

S8283New

SQ22536

SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.

S7500

HJC0350

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.

S4552

Bithionol

Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.

S8415New

PACAP 1-38

PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.

S2449

Forskolin

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

Catalog No. Information Product Use Citations Product Validations
S8414New

PACAP 1-27

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.

S7499

ESI-09

ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 μM and 1.4 μM for EPAC1 and EPAC2, respectively, >100-fold selectivity over PKA.

S8416New

PACAP 6-38

PACAP 6-38 is a PACAP (pituitary adenylate cyclase-activating polypeptide) non-stimulating competitive antagonist with an IC50 value of 2 nM. It also acts as a functional CARTp antagonist in vivo.

S8283New

SQ22536

SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.

S7500

HJC0350

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.

S4552

Bithionol

Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.

Catalog No. Information Product Use Citations Product Validations
S2449

Forskolin

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

2016, 143(12):2103-10

2014, 50(7):1310-20

2016, 237:98-108

Catalog No. Information Product Use Citations Product Validations
S8415New

PACAP 1-38

PACAP 1-38 is a highly potent PACAP receptor agonist (Kd = 100 pM). It stimulates adenylate cyclase and phagocytosis.