cAMP

Sigaling Pathway Map

Research Area

Inhibitory Selectivity

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Notes:
2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations
S8414New

PACAP 1-27

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.

S7500

HJC0350

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.

S8283New

SQ22536

SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.

S4552New

Bithionol

Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.

S2449

Forskolin

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

Catalog No. Information Product Use Citations Product Validations
S8414New

PACAP 1-27

Pituitary adenylate cyclase activating polypeptide (PACAP 1-27) is a potent PACAP receptor antagonist.

S7500

HJC0350

HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.

S8283New

SQ22536

SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.

S4552New

Bithionol

Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity.

Catalog No. Information Product Use Citations Product Validations
S2449

Forskolin

Forskolin is a ubiquitous activator of eukaryotic adenylyl cyclase (AC) in a wide variety of cell types, commonly used to raise levels of cAMP in the study and research of cell physiology.

2016, 143(12):2103-10

2014, 50(7):1310-20

2016, 237:98-108