Riluzole (Rilutek) Chemical Structure
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Riluzole(Rilutek) is a drug used to treat amyotrophic lateral sclerosis. It delays the onset of ventilator-dependence or tracheostomy in selected patients and may increase the survival approximately 3–5 months. [1] Its pharmacological activities in motor neurons include the following: 1) an inhibitory effect on glutamate release 2) inactivation of voltage-dependent sodium channels 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors. In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission. [1]
| Molecular Weight (WM): | 234.2 |
|---|---|
| Formula: | C8H5F3N2OS |
| CAS No.: | 1744-22-5 |
| Synonyms: |
PK-26124, RP-54274, Rilutek
|
| Dissolve in (25°C): | DMSO ≥47mg/mL |
| Water <1mg/mL | |
| Ethanol ≥47mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
A collection of 864 bioactive compounds
A collection of 481 inhibitors
A collection of 194 kinase inhibitors
A collection of 85 tyrosine kinase inhibitors.
A collection of 426 FDA approved drugs
A collection of 139 natural products
A collection of 40 chemotherapeutic agents
A unique collection of 17 small molecule modulators
A unique collection of 47 small molecule inhibitors
A unique collection of 63 GPCR small molecules
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