Research Area
Product Type
United States ( Change Country )
LY2603618 (IC-83) Chemical Structure
Recommended Products
AZD7762
AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively.
CHIR-124
CHIR-124 is a novel and potent chk1 inhibitor with an IC50 of 0.3 nM.
SCH 900776
SCH 900776 is a potent and functionally selective targeting cell cycle checkpoint kinase 1 (CHK1) inhibitor with IC50 of 3 nM, 0.16 and 1.5 μM for CHK1, CDK2 and CHK2, respectively.
ABT-888 (Veliparib)
ABT-888 (Veliparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor of PARP-1 and PARP-2 with Ki of 5.2 nM and 2.9 nM, respectively.
Olaparib (AZD2281)
Olaparib(AZD2281, KU0059436) is a selective inhibitor of PARP-1 and PARP-2 enzymes with IC50 of 5 nM and 1 nM, respectively.
Y-27632 2HCl
Y-27632 2HCl is ROCK inhibitor, as a novel bronchodilator. Y27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.
Rucaparib (AG-014699 , PF-01367338)
AG-014699 (Rucaparib, PF-01367338) is an inhibitor of PARP with a Ki of 1.4 nM.
BI 2536
BI 2536 is a Plk1 inhibitor with an IC50 of 0.83 nM.
PD 0332991 HCl
PD 0332991 is a highly selective inhibitor of Cdk4/cyclin D1 and Cdk6/cyclin D2 with IC50 of 11 nM and 16 nM, respectively.
BSI-401
PARP-1 inhibitor with an IC50<15μm
Biological Activity
LY2603618 (IC-83) is a highly selective Chk 1 inhibitor with potential antitumor activity. LY2603618 (IC-83) binds to and inhibits the activity of chk1, which may prevent the repair of DNA caused by DNA-damaging agents, thus potentiating the antitumor efficacies of various chemotherapeutic agents. Chk1, an ATP-dependent serine-threonine kinase, is a key component in the DNA replication-monitoring checkpoint system and is activated by double-stranded breaks (DSBs); activated chk1 is overexpressed by a variety of cancer cell types. [1][2]
References on LY2603618 (IC-83)
- [1] Clin Cancer Res. 2010 Jan 15;16(2):376-83.
- [2] http://www.springer.com/biomed/cancer/book/978-1-60761-177-6 ;
Chemical Information
| Molecular Weight (WM): | 436.3 |
|---|---|
| Formula: | C18H22BrN5O3 |
| CAS No.: | 911222-45-2 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥21mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
Related Inhibitors
Recommended Screening Libraries
Chemical Library
A collection of 864 bioactive compounds
Inhibitor Library
A collection of 481 inhibitors
Kinase Inhibitor Library
A collection of 194 kinase inhibitors
Tyrosine Kinase Inhibitor Library
A collection of 85 tyrosine kinase inhibitors.
FDA Approved Drug Library
A collection of 426 FDA approved drugs
Natural Product Library
A collection of 139 natural products
Chemotherapeutic Agent Library
A collection of 40 chemotherapeutic agents
Epigenetics Compound library
A unique collection of 17 small molecule modulators
Stem Cell Compound library
A unique collection of 47 small molecule inhibitors
GPCR Compound library
A unique collection of 63 GPCR small molecules
Keywords:buy LY2603618 (IC-83) | LY2603618 (IC-83) supplier | purchase LY2603618 (IC-83) | LY2603618 (IC-83) cost | LY2603618 (IC-83) manufacturer | order LY2603618 (IC-83) | LY2603618 (IC-83) distributor