AZD7762

Catalog No.S1532

AZD7762 Chemical Structure

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

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In DMSO USD 192 In stock
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USD 120 In stock
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9 Customer Reviews

  • CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and/or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

    B, time course analysis of the mitotic index after CHK1 or WEE1 inhibition in gemcitabine-arrested CAL120 cells. C, mitotic index of CAL120 and MCF7 cells treated with AZD7762, MK-1775, or the combination for 8 h. Treatment with combination AZD7762 and MK-1775 induces unscheduled mitotic entry in cells with <4N DNA content. D, representative cell-cycle profiles of CAL120 cells treated with AZD7762, MK-1775, or the combination for 8 h assessed by pH3/PI FACS.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

  • E, CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and /or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control. F, induction of the intra–S-phase checkpoint was not affected by WEE1 inhibition. CAL120 cells were pulse-labeled with 10 μmol/L BrdU for 30 minutes, washed (W), and then treated with 1 μmol/L camptothecin (CPT) for 30 minutes. After CPT removal (0 hours), BrdU-labeled S-phase cells (BrdU+ , indicated by boxed area) were monitored at the indicated time points in the absence (iii) or presence of MK-1775 (iv) or AZD7762 as a positive control (v). Control cells (ctr) were not exposed to CPT and cultured in the absence (i) or presence of MK-1775 (ii). Arrowheads indicate delayed S-phase progression.

    Cancer Discov 2012 2, 524-39. AZD7762 purchased from Selleck.

    HNSCC cell lines have in vitro diverse sensitivities to drugs that affect mitotic progression. Fifty-nine HNSCC cell lines were treated with volasertib, AZD1775, or AZD7762 at seven concentrations ranging from 0.018 to 9.613 μM for 72 h, and their viability was estimated using a CellTiter-Glo assay. (A) Representative dose-response curves for cell lines sensitive and resistant to the drugs. (B) Distributions of the IC80 values for the 59 cell lines. The vertical orange line is the Cmax values for each drug.

    Cancer Lett, 2017, 392:71-82. AZD7762 purchased from Selleck.

  • Photomicrographs showing characteristic morphological changes in T24 cells treated with gemcitabine and AZD7762 (24 and 48 h) (c). Scale bar = 100 μm

    J Exp Clin Cancer Res, 2017, 36(1):1. AZD7762 purchased from Selleck.

    (A) GBM6 and GBM12 cells and (B) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion based cell staining (±SE M, n= 3) *p < 0.05 greater than CHK1 inhibitor value. (C) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 +AZD0530 for 24 h and cell lysates were immunoblotted against cleaved caspase 3, PARP 1 and P-ERK1/2. (D) Medulloblastoma cell lines DAOY, VC312 and D283 were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48 h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion (±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value. The cell lysates were immunoblotted against cleaved caspases-3, cleaved caspases-7 and P-ER K1/2.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

  • GBM5, 6, 12 and 14 cells were treated with AZD7762 (300nM), AZD6244 (500nM) or AZD7762 + AZD6244 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion(±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

    MCF7 cells were plated in triplicate and treated with vehicle (VEH, DMSO) , AZD0530 (125 nM), AZD7762 (50 nM) or AZD7762 and AZD0530. Cells were isolated 48 h after exposure and subjected to the indicated various cell viability assays. Data for each assay is the mean of all data points from two studies(* p < 0.05 greater than CHK1 inhibitor value).

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

  • SRC family kinases play a key role in the regulation of the ERK1/2 pathway by CHK1 inhibitors. (A) Transformed mouse embryonic fibroblasts, MEF (wild type, WT; deleted for SRC/FYN/Y es , SYF) were treated with vehicle (VE, DMSO) , UCN-01 (100 nM) or AZD7762 (50 nM). Cells were isolated at the indicated time points and subjected to SDS PAGE followed by immunoblotting to determine the phosphorylation of ERK1/2 (p-ERK1/2), the phosphorylation of SRCY461 (p -Y 416 Src ) or the expression of GAPDH . Data are from a representative of three separate studies. (B) MCF7 cells were treated with vehicle (V eh, DMSO) , UCN-01 (100 nM), pp2 (10 μM), AZD7762 (50 nM) or UCN-01+ pp2 or AZD7762+ pp2. Cells were isolated 2 h after drug exposure and subjected to SDS PAGE f ollowed by immunoblotting to determine the phosphorylation of ERK1/2 ( p-ERK1/2) or the expression of e RK2 protein. Data are from a representative of two separate studies.

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYmzVW1CUUN3ME2wMlAxODJ|NDFOwG0> NX6xOHRmW0GQR1XS
NKM-1 NVfJfpA5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jRXGlEPTB;MD6wNFA1OTVizszN M{TQU3NCVkeHUh?=
MV-4-11 MkWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWKyVZFKUUN3ME2wMlAxODR{NTFOwG0> M1\1[nNCVkeHUh?=
NCI-H1703 NF7Xe5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTBwMEC2OFMh|ryP MnfRV2FPT0WU
A204 M{nOOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrINmpKSzVyPUCuNFA5PTZizszN NIPQeWZUSU6JRWK=
CGTH-W-1 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEG0NkDPxE1? NUTvW|A4W0GQR1XS
MLMA MnHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPJTWM2OD1yLkCyPFQ6KM7:TR?= NXL2O2xvW0GQR1XS
GOTO NF32SmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTUTWM2OD1yLkCzNVIh|ryP NWTub5J3W0GQR1XS
KE-37 M{DReGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMEOxOFIh|ryP NEDucWxUSU6JRWK=
ES4 NVixO2RnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMEOyOVEh|ryP MXTTRW5ITVJ?
ATN-1 MkXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfsfJVPUUN3ME2wMlA{PDF5IN88US=> NYTI[nNpW0GQR1XS
MHH-PREB-1 NXnDOllbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1voc2lEPTB;MD6wN|Q1OiEQvF2= NGS1[JpUSU6JRWK=
SW756 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;5N4RKSzVyPUCuNFM2PzlizszN NI\JSXZUSU6JRWK=
CTV-1 NEfHNWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWj5TYRsUUN3ME2wMlA{QDl4IN88US=> MkXaV2FPT0WU
HCC1806 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NETXOGlKSzVyPUCuNFQxOjJizszN NHT0fXZUSU6JRWK=
NEC8 MmjmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMESyNFMh|ryP NEHG[lBUSU6JRWK=
P12-ICHIKAWA MkfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGX3bnJKSzVyPUCuNFQ{OTZizszN MorWV2FPT0WU
DEL MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jZXmlEPTB;MD6wOFU6OiEQvF2= NYPvSnZKW0GQR1XS
KM12 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1zQcGlEPTB;MD6wOVE2QCEQvF2= MXnTRW5ITVJ?
LB1047-RCC NFvkcndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;vVHp2UUN3ME2wMlA3ODJ3IN88US=> NFzxOWxUSU6JRWK=
LB2241-RCC NV7XT4loT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFqxNFFKSzVyPUCuNFYyODJizszN M{SyOXNCVkeHUh?=
NOMO-1 NFnGeIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonXTWM2OD1yLkC2NVE2KM7:TR?= NVzvR49mW0GQR1XS
NB14 M1vrOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfrTWM2OD1yLkC2NVM3KM7:TR?= M1foZnNCVkeHUh?=
ONS-76 MnfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwME[xPVYh|ryP NF;6bJpUSU6JRWK=
HD-MY-Z NHvYbWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwME[yOVUh|ryP M{HTRnNCVkeHUh?=
G-402 NYTN[2N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vRdGlEPTB;MD6wOlQ3KM7:TR?= M1jKT3NCVkeHUh?=
ES1 NFXnVWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fDfmlEPTB;MD6wO|E1PiEQvF2= NGq1WZpUSU6JRWK=
L-363 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorNTWM2OD1yLkC3N|kh|ryP MVjTRW5ITVJ?
A4-Fuk MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXy0SYlbUUN3ME2wMlA4PDh4IN88US=> M2DEUXNCVkeHUh?=
OC-314 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMEe4NFch|ryP MWDTRW5ITVJ?
SK-LU-1 NIPrOJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\MemlEPTB;MD6wPFQzOSEQvF2= M{T6S3NCVkeHUh?=
MDA-MB-157 NGrmcoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDETWM2OD1yLkC4OlU6KM7:TR?= NInLSoFUSU6JRWK=
HuP-T3 NF\yXndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjhVVVvUUN3ME2wMlA5PzFizszN MYDTRW5ITVJ?
A3-KAW M1;TSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\NTWM2OD1yLkC4PFA3KM7:TR?= MWnTRW5ITVJ?
MOLT-16 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz6SWhKSzVyPUCuNFg5ODdizszN NHHoUJFUSU6JRWK=
COLO-679 NWTxZXJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEX4Sm9KSzVyPUCuNFkxQTFizszN MUHTRW5ITVJ?
EM-2 M4LTOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mlr2TWM2OD1yLkC5PVA{KM7:TR?= NVjBSpdqW0GQR1XS
ES8 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOwbGZSUUN3ME2wMlA6QTF6IN88US=> MWHTRW5ITVJ?
SK-MEL-2 NGe2OYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHaUGlKSzVyPUCuNVAxOzNizszN NWSxdlJIW0GQR1XS
ES3 Moi3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYH1WldmUUN3ME2wMlExOiEQvF2= MXzTRW5ITVJ?
HSC-4 M1fjNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPUZ|NjUUN3ME2wMlExPTV2IN88US=> NHm4OXBUSU6JRWK=
697 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fRXWlEPTB;MD6xNVA3OyEQvF2= MlnDV2FPT0WU
TGBC11TKB NELtclBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMUGwPVMh|ryP NYnGRmhrW0GQR1XS
SK-PN-DW MkfWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrFVHFyUUN3ME2wMlEyQDZizszN NG\0T2xUSU6JRWK=
H9 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MofBTWM2OD1yLkGyNVY2KM7:TR?= NWO0fFVpW0GQR1XS
NCI-H2122 NWPOeplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFmxWoZKSzVyPUCuNVIzPSEQvF2= MVfTRW5ITVJ?
ML-2 NHnpPGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWL1OY13UUN3ME2wMlEzPDh2IN88US=> MYrTRW5ITVJ?
MC-IXC NYPvdlJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXvDVVZOUUN3ME2wMlEzQDR|IN88US=> M1zPTXNCVkeHUh?=
KYSE-140 Ml3MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrFR2JKUUN3ME2wMlE{ODRzIN88US=> NUXHdIRRW0GQR1XS
DOHH-2 NHm0cIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWP5V5NMUUN3ME2wMlE{ODZ2IN88US=> M176TnNCVkeHUh?=
MEL-JUSO M1nTdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\NSlZMUUN3ME2wMlE{OTJ6IN88US=> NH3MOHNUSU6JRWK=
P30-OHK M2T5W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTBwMUOxOkDPxE1? Mm\KV2FPT0WU
CTB-1 M{T2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrMXnVKSzVyPUCuNVM{OjVizszN MnG5V2FPT0WU
ACHN MkPtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fkTWlEPTB;MD6xN|M3QSEQvF2= MV7TRW5ITVJ?
ES5 MormS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMUO0O|Yh|ryP NEDCTXRUSU6JRWK=
SF539 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3BOVRKSzVyPUCuNVM3QCEQvF2= MYjTRW5ITVJ?
D-283MED NV3yWFJsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrBR3BuUUN3ME2wMlE{Pjh5IN88US=> MoPkV2FPT0WU
OVCAR-5 NHTQW4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XBZmlEPTB;MD6xN|g6PCEQvF2= NHjYdJJUSU6JRWK=
RPMI-8866 NXHqS3p3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMUO5NlUh|ryP NH\B[XpUSU6JRWK=
PANC-03-27 M4rJb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVzWSmxuUUN3ME2wMlE1Ojh6IN88US=> MVXTRW5ITVJ?
M14 MlvxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfqfVNZUUN3ME2wMlE1PDZ|IN88US=> MkC1V2FPT0WU
D-566MG MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTBwMUS2PUDPxE1? NHXCd3ZUSU6JRWK=
Ramos-2G6-4C10 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnyzTWM2OD1yLkG0PFQzKM7:TR?= M4TwbnNCVkeHUh?=
NOS-1 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHuzfllKSzVyPUCuNVQ6PjdizszN M3rheHNCVkeHUh?=
YH-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHMcXFKSzVyPUCuNVU3PzRizszN Mn\rV2FPT0WU
NB17 Mn3lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjaZlFKSzVyPUCuNVU4QDZizszN MYHTRW5ITVJ?
U-2-OS NXPJOpV[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlruTWM2OD1yLkG1PFQ4KM7:TR?= NWLmWJJnW0GQR1XS
ES7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTVTWM2OD1yLkG2NFEyKM7:TR?= NUnuT2FQW0GQR1XS
LoVo M13FXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1POZWlEPTB;MD6xOlE3PiEQvF2= M3PO[nNCVkeHUh?=
QIMR-WIL MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zBfWlEPTB;MD6xOlMyOSEQvF2= Mn\pV2FPT0WU
ESS-1 NYrBW5N7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzTTWM2OD1yLkG2OFE{KM7:TR?= M2faU3NCVkeHUh?=
LAMA-84 NX3oemNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXadWRKSzVyPUCuNVY2ODNizszN MkjGV2FPT0WU
TGBC24TKB MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHFTWM2OD1yLkG2OVM2KM7:TR?= MU\TRW5ITVJ?
KU812 NYrZOZFwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjVTWM2OD1yLkG2PFMh|ryP M1jCXXNCVkeHUh?=
KARPAS-45 NEjmSHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMU[4OFch|ryP NHPCWGZUSU6JRWK=
ACN NHy2SmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDHR3hDUUN3ME2wMlE4OTdzIN88US=> MkPlV2FPT0WU
RPMI-8226 M4fST2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUjJR|UxRTBwMUe0OlQh|ryP NWDBXFZyW0GQR1XS
GR-ST MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEW4VIlKSzVyPUCuNVc5OjdizszN NFrrd3RUSU6JRWK=
SK-UT-1 NIXl[2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7sTWM2OD1yLkG4OVk6KM7:TR?= NIfqb4xUSU6JRWK=
SK-N-AS Mki5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWf5fW9CUUN3ME2wMlE5QDF3IN88US=> MlzaV2FPT0WU
EW-1 NF25[29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GzV2lEPTB;MD6xPFkxPSEQvF2= NFvPbXNUSU6JRWK=
5637 NWTVUZliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\kRZJQUUN3ME2wMlE6Ojd6IN88US=> NX3I[o92W0GQR1XS
GI-1 Mom0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TQWWlEPTB;MD6xPVU3OSEQvF2= M3LkOXNCVkeHUh?=
NCI-H1395 NXPTfmRwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DmcmlEPTB;MD6xPVc3OSEQvF2= MWDTRW5ITVJ?
CHP-212 NHe2Z49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwMUm3PFIh|ryP M{nVdnNCVkeHUh?=
A427 M3rJXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4q1fGlEPTB;MD6xPVg{OiEQvF2= MVrTRW5ITVJ?
BE-13 M2XuWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jWZ2lEPTB;MD6yNFEyPyEQvF2= MonBV2FPT0WU
RS4-11 NUG1W2VbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33PUGlEPTB;MD6yNFMyQCEQvF2= MnPsV2FPT0WU
TI-73 NFnLZnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X3T2lEPTB;MD6yNFg4OyEQvF2= M3\3V3NCVkeHUh?=
HAL-01 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;FbWlEPTB;MD6yNFk4KM7:TR?= MnzGV2FPT0WU
KY821 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUnaUG53UUN3ME2wMlIyPDJ7IN88US=> NYHXfVNSW0GQR1XS
H4 NW\yfYg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;r[ppKSzVyPUCuNlIxPjJizszN MV3TRW5ITVJ?
EPLC-272H NX74VoJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrOVm5KSzVyPUCuNlIxPjhizszN NFP1SFJUSU6JRWK=
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ABC-1 NIf2S2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzpNIZ4UUN3ME2wMlI3ODZ2IN88US=> NH;EUWFUSU6JRWK=
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Mewo MlfSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV[yRYZkUUN3ME2wMlMxPDNzIN88US=> M2PGTXNCVkeHUh?=
HCC70 NVW2foYxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPL[I84UUN3ME2wMlMxPjZ3IN88US=> MlXLV2FPT0WU
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LCLC-97TM1 NGDLSXpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKydY1wUUN3ME2wMlMyPTZ4IN88US=> NV;qSnM3W0GQR1XS
HCC2998 NInH[Y5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnKPHRKSzVyPUCuN|E3PSEQvF2= M1zVfHNCVkeHUh?=
NBsusSR MoO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwM{G4NVkh|ryP NVLTUol2W0GQR1XS
OVCAR-4 NEjzeWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLrVXg6UUN3ME2wMlMzODJzIN88US=> NYf5[3g6W0GQR1XS
NCI-H209 NYDoWlZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmq0TWM2OD1yLkOyN|U{KM7:TR?= NG\PeGpUSU6JRWK=
ChaGo-K-1 M2mzd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\sSWlEPTB;MD6zNlQ5QSEQvF2= NXvF[4NHW0GQR1XS
KALS-1 NXfCVplbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\UTWM2OD1yLkOyOVk1KM7:TR?= MoL0V2FPT0WU
D-423MG NIjQNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2Dr[WlEPTB;MD6zN|E1OiEQvF2= MXfTRW5ITVJ?
Detroit562 NWHWPWg{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HESGlEPTB;MD6zN|M1OyEQvF2= NVnFR4x{W0GQR1XS
HT-144 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnaV2hKSzVyPUCuN|M5OSEQvF2= MWHTRW5ITVJ?
MEG-01 NICyTVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\3VndKSzVyPUCuN|Q2QDRizszN M2XoTHNCVkeHUh?=
BV-173 NHPSOmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1exNmlEPTB;MD6zOFU6PiEQvF2= NIHVcXhUSU6JRWK=
MZ7-mel MmXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwM{S2O|ch|ryP NUjNRoJUW0GQR1XS
C32 M{\iUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7oRWtKSzVyPUCuN|Q3QDJizszN MVvTRW5ITVJ?
DU-4475 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwM{S4O|Uh|ryP M1\rRXNCVkeHUh?=
KP-N-YN MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXRcIFnUUN3ME2wMlM1QDh5IN88US=> NYfPNHN5W0GQR1XS
MKN1 NYHpcHFqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTQTWM2OD1yLkO1NFAzKM7:TR?= NEf1RYtUSU6JRWK=
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OVCAR-8 M4r2OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvFb2JSUUN3ME2wMlM2PTh2IN88US=> MXLTRW5ITVJ?
NH-12 M3OxO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmrTTWM2OD1yLkO1Olk3KM7:TR?= NH24c2FUSU6JRWK=
COR-L88 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\2W2hKSzVyPUCuN|Y1QDJizszN M1TLVnNCVkeHUh?=
T-24 NVTHcYY3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfMWYxKSzVyPUCuN|Y6QDVizszN NXv3U4xHW0GQR1XS
MIA-PaCa-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3f4VmlEPTB;MD6zO|Q6PyEQvF2= M13SR3NCVkeHUh?=
LS-411N NFHVSo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PYTWlEPTB;MD6zO|YxPiEQvF2= NXm5O2tiW0GQR1XS
TK10 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v6UGlEPTB;MD6zO|k1QCEQvF2= NV\LXIRIW0GQR1XS
SW1990 NYLNUmtNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\pcVlvUUN3ME2wMlM5OzV|IN88US=> M4LQbHNCVkeHUh?=
GAMG M2O3cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXVdpRKSzVyPUCuN|g2PjdizszN M{T6b3NCVkeHUh?=
G-361 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXveHB6UUN3ME2wMlM5PzF{IN88US=> NEXOXnRUSU6JRWK=
Ca-Ski MkC2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwM{i3PVIh|ryP M4TtXXNCVkeHUh?=
786-0 M336OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\tbnVEUUN3ME2wMlM5QDJ|IN88US=> MUnTRW5ITVJ?
MHH-NB-11 NXPzeopQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYPST2hWUUN3ME2wMlM5QTdizszN M1L5XnNCVkeHUh?=
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SW954 M{XuUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNECxN|Eh|ryP NFjJflJUSU6JRWK=
KYSE-180 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPqPY9KSzVyPUCuOFAyPTFizszN NGHPepZUSU6JRWK=
NCI-H720 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwNECxPVEh|ryP MV;TRW5ITVJ?
COR-L23 Mme2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD0TWM2OD1yLkSwNlg3KM7:TR?= NEfR[3dUSU6JRWK=
PFSK-1 M3OyTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fTVGlEPTB;MD60NVA6OiEQvF2= NVvwZo04W0GQR1XS
FADU NW\wNIVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fPW2lEPTB;MD60NVE4OiEQvF2= MXrTRW5ITVJ?
GP5d NHzKZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwNEGyNlUh|ryP M4\nPHNCVkeHUh?=
PC-14 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvmO3JkUUN3ME2wMlQyPjZzIN88US=> MlHDV2FPT0WU
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D-336MG MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfwTWM2OD1yLkSyNVM5KM7:TR?= M1HGcHNCVkeHUh?=
LOXIMVI NVPFOGtGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\LNYVFUUN3ME2wMlQzQDh3IN88US=> NV;RNmh7W0GQR1XS
EFO-27 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXXZ|FKSzVyPUCuOFMxPDlizszN NEPQbm9USU6JRWK=
A2780 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwNEOxOlIh|ryP NEi4VHFUSU6JRWK=
CAL-12T NXmxXZFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK2UJpKSzVyPUCuOFMzQDhizszN M1vUc3NCVkeHUh?=
ES6 MnPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfUTWM2OD1yLkS0NVg2KM7:TR?= M3TlcHNCVkeHUh?=
HCE-T M1nn[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIH0SmFKSzVyPUCuOFQyQDdizszN M2jFNnNCVkeHUh?=
SK-MES-1 M{Oxfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfE[pFJUUN3ME2wMlQ1Ojl|IN88US=> M{fEPHNCVkeHUh?=
Daoy NIPZW2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrmTlNMUUN3ME2wMlQ2OTB|IN88US=> NW[xNoZDW0GQR1XS
A2058 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwNEWxN|Yh|ryP MXnTRW5ITVJ?
Hs-578-T MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwNEWyO|gh|ryP MnXEV2FPT0WU
TE-11 MlLaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfJUVRQUUN3ME2wMlQ2Ojl|IN88US=> M2noTnNCVkeHUh?=
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MOLT-13 Mor1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXKwcI1IUUN3ME2wMlQ3Ojl2IN88US=> MX\TRW5ITVJ?
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HuP-T4 Mn:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDtTY5iUUN3ME2wMlQ3QDZ6IN88US=> MmP0V2FPT0WU
NCI-H1563 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrXTWM2OD1yLkS3NFM2KM7:TR?= MlPyV2FPT0WU
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HSC-3 NYDEO4luT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTXTWM2OD1yLkS4OlI3KM7:TR?= MmXGV2FPT0WU
HT-3 NFrQWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHLPb2FKSzVyPUCuOFkxOyEQvF2= MnrmV2FPT0WU
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HT-1080 NYrHOmJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwNEmyO{DPxE1? M1j3WXNCVkeHUh?=
RT-112 MnfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M122c2lEPTB;MD60PVkzOSEQvF2= MlLEV2FPT0WU
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SW626 Ml\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvJOYtCUUN3ME2wMlUxPjN|IN88US=> MVjTRW5ITVJ?
SBC-5 MnTTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnITWM2OD1yLkWxN|Q1KM7:TR?= Ml7qV2FPT0WU
CAL-51 NUf2UVJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPuWY5KSzVyPUCuOVE1OzdizszN MoX5V2FPT0WU
RKO Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrpTWM2OD1yLkWyNFE6KM7:TR?= NV;n[5lbW0GQR1XS
HC-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7hO3M{UUN3ME2wMlUzOTF2IN88US=> NV;GOG45W0GQR1XS
CHL-1 M364ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfUdYhKSzVyPUCuOVI2PTFizszN M2HueHNCVkeHUh?=
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SW13 MonDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoixTWM2OD1|LkKzNlYh|ryP MYnTRW5ITVJ?
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HT-1197 NXmyOHNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD3e3FKSzVyPUOuNlkyPzlizszN NVXzfVg{W0GQR1XS
HLE MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\MRWlEPTB;Mz6zNlgyKM7:TR?= MYPTRW5ITVJ?
NUGC-3 MlzzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3zTWM2OD1|LkS0O|YyKM7:TR?= Mny3V2FPT0WU
UACC-257 NWXURmRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\XTWM2OD1|LkWyOFE4KM7:TR?= NFTDZnFUSU6JRWK=
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KNS-81-FD NHfuPWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTNwNU[yJO69VQ>? Ml;1V2FPT0WU
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NCI-H1838 M{XiWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTNwOEGxNVkh|ryP M4HrO3NCVkeHUh?=
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CP66-MEL NIfr[m1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\uXWlEPTB;ND6yOVE6OSEQvF2= NHLuSGRUSU6JRWK=
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LU-99A NUT3ZnlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRTRwM{GzOFUh|ryP M37sfXNCVkeHUh?=
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KURAMOCHI NHvnUZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G1V2lEPTB;ND60OVUzQCEQvF2= M4PlNHNCVkeHUh?=
BEN NH[3VmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTRwNUKzOlIh|ryP Mnv5V2FPT0WU
NCI-H226 M2TUd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PxTmlEPTB;ND61OFg4OSEQvF2= NIrq[JpUSU6JRWK=
CAL-27 MmfaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPyeZZKSzVyPUSuO|E3QTRizszN M13mdnNCVkeHUh?=
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DMS-114 M{e1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3mTWM2OD13LkG0OVA3KM7:TR?= NID2PFBUSU6JRWK=
KYSE-70 NGiyZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTVwMUS4OVkh|ryP NHTnTmxUSU6JRWK=
NCI-H1648 NH;6Ro5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjFd|htUUN3ME21MlI6Pzh{IN88US=> NXf6RXdEW0GQR1XS
MDA-MB-175-VII NWm0S3Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIK5O5hKSzVyPUWuOFQxOTRizszN NUjwRlhUW0GQR1XS
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LS-1034 M{LBeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HjVmlEPTB;NT62Olg5QSEQvF2= NWfCV|FCW0GQR1XS
LB831-BLC MmLZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4i0T2lEPTB;NT63NFM1PSEQvF2= MoXDV2FPT0WU
MDA-MB-415 NUfESXFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vn[GlEPTB;NT63NFgyKM7:TR?= NF;ySnJUSU6JRWK=
TE-6 M2LnNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGzfVV3UUN3ME21Mlc1OTh{IN88US=> MYjTRW5ITVJ?
SK-MEL-24 Moq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzycWtKSzVyPUWuO|Q2PjRizszN MU\TRW5ITVJ?
HUTU-80 MlTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTVwN{WzN|Mh|ryP MWjTRW5ITVJ?
OCUB-M NXnCWVM1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTVwN{e1OlMh|ryP NXftXpAzW0GQR1XS
IGR-1 M1LsW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjkW4NKSzVyPUWuPFY5QTRizszN MULTRW5ITVJ?
NCI-H747 MnmzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\aTWM2OD14LkK0OVg2KM7:TR?= NEG2bWpUSU6JRWK=
COLO-680N M3WxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTZwM{m0NFMh|ryP M{PTVnNCVkeHUh?=
NB12 NFnjV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3GTWM2OD14Lke5O|IzKM7:TR?= NGr5SXRUSU6JRWK=
SNU-449 MlrtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\ud4F3UUN3ME22Mlk6PTlzIN88US=> MnS5V2FPT0WU
D-542MG NVLESlhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXGTWM2OD15LkGyNlk6KM7:TR?= M4XYZnNCVkeHUh?=
COLO-792 MoDIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkWxTWM2OD15Lki3NVI4KM7:TR?= Mn7UV2FPT0WU
NCI-H810 NEXp[FdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK4dYJKSzVyPUiuNFI6QDRizszN NHPyTG9USU6JRWK=
T47D NWG0N|BjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRThwMU[wNlQh|ryP MU\TRW5ITVJ?
Calu-3 M{PkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\qRWpKSzVyPUiuNlg5QDZizszN M16zbHNCVkeHUh?=
COLO-741 M3PmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzpSVVKSzVyPUiuPVMxQTNizszN NWXtOnZzW0GQR1XS
LU-135 NFnpc3RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVf2VW83UUN3ME25MlA{PDV{IN88US=> MXfTRW5ITVJ?
COLO-678 M3H5NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTE[nk2UUN3ME25MlI5QDR2IN88US=> NVP4WmVHW0GQR1XS
NCI-H2126 Mlq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPP[5RKSzVyPUmuN|M6OTlizszN NGLxWI1USU6JRWK=
SK-MEL-28 NIrWNpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4e1cWlEPTB;OT61N|U6PiEQvF2= NEO1bHdUSU6JRWK=
MFE-280 M{D1[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTFyLkCyNlkh|ryP MlXFV2FPT0WU
DBTRG-05MG MnzpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTFyLkSzOlkh|ryP M3X2NnNCVkeHUh?=
RCC10RGB NFXUS4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWe5fHJtUUN3ME2xNE42OjV3IN88US=> M3\QZ3NCVkeHUh?=
NTERA-S-cl-D1 M37jN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK5RYVKSzVyPUGwMlY5PTJizszN NF\JfohUSU6JRWK=
C3A NUDDdopXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDPV2VGUUN3ME2xNk4{OTd{IN88US=> NFT5elVUSU6JRWK=
MHH-ES-1 NV73THNpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXITWM2OD1zMj61Nlg1KM7:TR?= M3nCTXNCVkeHUh?=
LU-139 MoKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL4TWM2OD1zMj62N|M{KM7:TR?= M4LudnNCVkeHUh?=
KNS-42 NFy4VJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTF{Lki3O|Eh|ryP MljKV2FPT0WU
MCF7 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGj5Wm9KSzVyPUGzMlI{PjVizszN NWTib2dpW0GQR1XS
SW872 NFPsN|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3LTfmlEPTB;MUSuOVQ3OSEQvF2= M4OxZXNCVkeHUh?=
HT-1376 NEDQWVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jBd2lEPTB;MUSuPFU5OiEQvF2= MXPTRW5ITVJ?
NCI-SNU-5 M1vnW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGC2e5NKSzVyPUG1MlE4PDFizszN MYLTRW5ITVJ?
NCI-H2405 M2nJcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7mPG9KSzVyPUG1MlQ1PzRizszN NWrLN5NVW0GQR1XS
KYSE-150 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\PWIhKSzVyPUG1Mlc3OTFizszN NWLiUGhwW0GQR1XS
SW837 NGDrWXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTF4LkCxNlQh|ryP NVe0N3U3W0GQR1XS
LU-65 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HyS2lEPTB;MUmuO|I3KM7:TR?= NVHVTYVqW0GQR1XS
JEG-3 M{\aemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXXIU2VqUUN3ME2yNE4{PTd5IN88US=> M2jYPHNCVkeHUh?=
SK-MEL-1 NU[wTlRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjwO4tNUUN3ME2yNE44QDN4IN88US=> MVzTRW5ITVJ?
SK-HEP-1 NWPuOFNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnBRY84UUN3ME2yNU42PTRzIN88US=> NXnNRmpHW0GQR1XS
NCI-H1770 NXrwZ29PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1P5ZmlEPTB;MkOuOFA5PiEQvF2= NXzVUVFyW0GQR1XS
MG-63 NEDwNY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XMemlEPTB;MkOuO|Y4OyEQvF2= NYP6RWJmW0GQR1XS
ECC10 M2DiWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTJ3LkW3NUDPxE1? MUTTRW5ITVJ?
SW1463 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT1TWM2OD1{Nz64N|E3KM7:TR?= NH;SV|hUSU6JRWK=
JVM-2 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLrTWM2OD1{OD6zNlQ5KM7:TR?= M3zOR3NCVkeHUh?=
HCT-15 NYTHNIhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoC4TWM2OD1{OD60NVkzKM7:TR?= M3fEW3NCVkeHUh?=
CAL-72 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvPS3NoUUN3ME2zNU41QTF{IN88US=> M3nKOHNCVkeHUh?=
HCC2218 NGTBPGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2yTWM2OD1|Mj64PFU5KM7:TR?= MXnTRW5ITVJ?
BT-474 M2LaW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU[4UY1jUUN3ME2zN{4xQDR|IN88US=> NInheVVUSU6JRWK=
NCI-H1092 NHTJSVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\lemlEPTB;M{OuOVE1PSEQvF2= NI\JfIJUSU6JRWK=
Mo-T M{Xv[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTN5LkO1PFUh|ryP MXXTRW5ITVJ?
DU-145 MoHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTMTWM2OD12MD62Nlk2KM7:TR?= NXPHTXZXW0GQR1XS
NCI-H1666 NXfZfox5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\6TWM2OD12Mj60OFg5KM7:TR?= NVS3SWZEW0GQR1XS
IST-MES1 M4Hqc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\ib|BKSzVyPUS2MlQyQTZizszN MX\TRW5ITVJ?
SW1116 M3u2XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nOZWlEPTB;NEiuNVc2PiEQvF2= M2\S[HNCVkeHUh?=
MZ2-MEL MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NID0TXBKSzVyPUS4MlUxOjZizszN MVLTRW5ITVJ?

... Click to View More Cell Line Experimental Data

In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Chk1 Kinase Assay:

Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:[1]
+ Expand
  • Cell lines: HT29, SW620 and MDA-MB-231 cells
  • Concentrations: Dissolved in DMSO, final concentration ~12.5 μM
  • Incubation Time: 20 or 48 hours
  • Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells
  • Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin
  • Dosages: ~25 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (137.96 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.42
Formula

C17H19FN4O2S

CAS No. 860352-01-8
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

  • Answer:

    Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID