AZD7762

Catalog No.S1532

AZD7762 Chemical Structure

Molecular Weight(MW): 362.42

AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.

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In DMSO USD 192 In stock
USD 70 In stock
USD 120 In stock
USD 370 In stock
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9 Customer Reviews

  • CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and/or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

    B, time course analysis of the mitotic index after CHK1 or WEE1 inhibition in gemcitabine-arrested CAL120 cells. C, mitotic index of CAL120 and MCF7 cells treated with AZD7762, MK-1775, or the combination for 8 h. Treatment with combination AZD7762 and MK-1775 induces unscheduled mitotic entry in cells with <4N DNA content. D, representative cell-cycle profiles of CAL120 cells treated with AZD7762, MK-1775, or the combination for 8 h assessed by pH3/PI FACS.

    Cancer Discov, 2012, 2: 524-539. AZD7762 purchased from Selleck.

  • E, CAL120 cells were either untreated or pretreated with gemcitabine for 24 hours followed by treatment with AZD7762 and /or MK-1775 for an additional 2 hours (top) or 8 hours (bottom), before lysis. Western blot analysis of Cyclin B1, CDK1 (phospho-Y15 and total) expression, and β-tubulin as loading control. F, induction of the intra–S-phase checkpoint was not affected by WEE1 inhibition. CAL120 cells were pulse-labeled with 10 μmol/L BrdU for 30 minutes, washed (W), and then treated with 1 μmol/L camptothecin (CPT) for 30 minutes. After CPT removal (0 hours), BrdU-labeled S-phase cells (BrdU+ , indicated by boxed area) were monitored at the indicated time points in the absence (iii) or presence of MK-1775 (iv) or AZD7762 as a positive control (v). Control cells (ctr) were not exposed to CPT and cultured in the absence (i) or presence of MK-1775 (ii). Arrowheads indicate delayed S-phase progression.

    Cancer Discov 2012 2, 524-39. AZD7762 purchased from Selleck.

    HNSCC cell lines have in vitro diverse sensitivities to drugs that affect mitotic progression. Fifty-nine HNSCC cell lines were treated with volasertib, AZD1775, or AZD7762 at seven concentrations ranging from 0.018 to 9.613 μM for 72 h, and their viability was estimated using a CellTiter-Glo assay. (A) Representative dose-response curves for cell lines sensitive and resistant to the drugs. (B) Distributions of the IC80 values for the 59 cell lines. The vertical orange line is the Cmax values for each drug.

    Cancer Lett, 2017, 392:71-82. AZD7762 purchased from Selleck.

  • Photomicrographs showing characteristic morphological changes in T24 cells treated with gemcitabine and AZD7762 (24 and 48 h) (c). Scale bar = 100 μm

    J Exp Clin Cancer Res, 2017, 36(1):1. AZD7762 purchased from Selleck.

    (A) GBM6 and GBM12 cells and (B) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion based cell staining (±SE M, n= 3) *p < 0.05 greater than CHK1 inhibitor value. (C) GBM5 and GBM14 cells were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 +AZD0530 for 24 h and cell lysates were immunoblotted against cleaved caspase 3, PARP 1 and P-ERK1/2. (D) Medulloblastoma cell lines DAOY, VC312 and D283 were treated with AZD7762 (300 nM), AZD0530 (100 nM), or AZD7762 + AZD0530 for 48 h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion (±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value. The cell lysates were immunoblotted against cleaved caspases-3, cleaved caspases-7 and P-ER K1/2.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

  • GBM5, 6, 12 and 14 cells were treated with AZD7762 (300nM), AZD6244 (500nM) or AZD7762 + AZD6244 for 48h. Floating and attached cells were isolated after drug exposure, cell viability was measured by trypan blue exclusion(±SE M, n = 3) *p < 0.05 greater than CHK1 inhibitor value.

    Cancer Biol Ther 2012 13. AZD7762 purchased from Selleck.

    MCF7 cells were plated in triplicate and treated with vehicle (VEH, DMSO) , AZD0530 (125 nM), AZD7762 (50 nM) or AZD7762 and AZD0530. Cells were isolated 48 h after exposure and subjected to the indicated various cell viability assays. Data for each assay is the mean of all data points from two studies(* p < 0.05 greater than CHK1 inhibitor value).

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

  • SRC family kinases play a key role in the regulation of the ERK1/2 pathway by CHK1 inhibitors. (A) Transformed mouse embryonic fibroblasts, MEF (wild type, WT; deleted for SRC/FYN/Y es , SYF) were treated with vehicle (VE, DMSO) , UCN-01 (100 nM) or AZD7762 (50 nM). Cells were isolated at the indicated time points and subjected to SDS PAGE followed by immunoblotting to determine the phosphorylation of ERK1/2 (p-ERK1/2), the phosphorylation of SRCY461 (p -Y 416 Src ) or the expression of GAPDH . Data are from a representative of three separate studies. (B) MCF7 cells were treated with vehicle (V eh, DMSO) , UCN-01 (100 nM), pp2 (10 μM), AZD7762 (50 nM) or UCN-01+ pp2 or AZD7762+ pp2. Cells were isolated 2 h after drug exposure and subjected to SDS PAGE f ollowed by immunoblotting to determine the phosphorylation of ERK1/2 ( p-ERK1/2) or the expression of e RK2 protein. Data are from a representative of two separate studies.

    Cancer Biol Ther 2011 12, 215-28. AZD7762 purchased from Selleck.

Purity & Quality Control

Choose Selective Chk Inhibitors

Biological Activity

Description AZD7762 is a potent and selective inhibitor of Chk1 with IC50 of 5 nM in a cell-free assay. It is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. Phase 1.
Targets
Chk1 [1]
(Cell-free assay)
Chk2 [1]
(Cell-free assay)
5 nM <10 nM
In vitro

AZD7762, a more selective Chk1 inhibitor, inhibits Chk1 phosphorylation of a cdc25C peptide by reversibly binding to the ATP-binding site of Chk1, with IC50 of 5 nM and Ki of 3.6 nM. AZD7762 induces cell arrest with EC50 of 0.620 μM, and significantly abrogates the camptothecin induced G2 arrest with an EC50 of 10 nM, by blocking the chk1 dependent degradation of Cdc25A and activation of Cyclin A. AZD7762 (300 nM) enhances the antitumor efficacy of gemcitabine against SW620 and topotecan against MDA-MB-231 by reducing the GI50 values from 24.1 nM and 2.25 μM to 1.08 nM and 0.15 μM, respectively. [1] AZD7762 shows cytotoxicity against a variety of neuroblastoma cell lines bearing p53 wild type, p53 mutation, Mdm2 amplification or p14 deletion with IC50 values ranging from 82.6-505.9 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
KASUMI-1 M1jNVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoK4TWM2OD1yLkCwNFI{PCEQvF2= MXzTRW5ITVJ?
NKM-1 NYC5NmtxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILvVo5KSzVyPUCuNFAxPDF3IN88US=> Ml24V2FPT0WU
MV-4-11 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH2yRnhKSzVyPUCuNFAxPDJ3IN88US=> NGOyRpVUSU6JRWK=
NCI-H1703 NHfTc2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfT[HNKSzVyPUCuNFA3PDNizszN M4XKVnNCVkeHUh?=
A204 NWPCdI9zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDVNXFyUUN3ME2wMlAxQDV4IN88US=> NE\5NnRUSU6JRWK=
CGTH-W-1 NVrUWZFHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVrsR204UUN3ME2wMlAyPDJizszN NVmxbGNJW0GQR1XS
MLMA M2LFXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7X[4toUUN3ME2wMlAzQDR7IN88US=> M{TsbXNCVkeHUh?=
GOTO NHTKXI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnVSHJKSzVyPUCuNFMyOiEQvF2= M1rBUHNCVkeHUh?=
KE-37 MkS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\aXWlEPTB;MD6wN|E1OiEQvF2= MV3TRW5ITVJ?
ES4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rPe2lEPTB;MD6wN|I2OSEQvF2= MXjTRW5ITVJ?
ATN-1 MoHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnkTWM2OD1yLkCzOFE4KM7:TR?= NFyzOFZUSU6JRWK=
MHH-PREB-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrvTWM2OD1yLkCzOFQzKM7:TR?= NH23TYZUSU6JRWK=
SW756 NFL1V4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nsR2lEPTB;MD6wN|U4QSEQvF2= MYnTRW5ITVJ?
CTV-1 NYP0SHJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMEO4PVYh|ryP MnLxV2FPT0WU
HCC1806 NUPaNZgxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moq5TWM2OD1yLkC0NFIzKM7:TR?= NH7hTpdUSU6JRWK=
NEC8 NYDCSFZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTYSZVoUUN3ME2wMlA1OjB|IN88US=> NHXyR5hUSU6JRWK=
P12-ICHIKAWA M1zSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfrWpNKSzVyPUCuNFQ{OTZizszN NVPXe3JEW0GQR1XS
DEL M1;FU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzMblV5UUN3ME2wMlA1PTl{IN88US=> MWPTRW5ITVJ?
KM12 NFPHWpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEWxOVgh|ryP NH\VPYFUSU6JRWK=
LB1047-RCC M1WwNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjhV3JIUUN3ME2wMlA3ODJ3IN88US=> MoXrV2FPT0WU
LB2241-RCC MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf6TXVKSzVyPUCuNFYyODJizszN M1vyUnNCVkeHUh?=
NOMO-1 M17Ncmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HicGlEPTB;MD6wOlEyPSEQvF2= NFz5OnJUSU6JRWK=
NB14 NVfr[lBmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGD1bnRKSzVyPUCuNFYyOzZizszN NYTDUopiW0GQR1XS
ONS-76 MoezS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTBwME[xPVYh|ryP MoTVV2FPT0WU
HD-MY-Z MkK5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTBwME[yOVUh|ryP NFniOYtUSU6JRWK=
G-402 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjPdGpPUUN3ME2wMlA3PDZizszN M33ZWnNCVkeHUh?=
ES1 MnS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f5TmlEPTB;MD6wO|E1PiEQvF2= M3TzcnNCVkeHUh?=
L-363 NU\INXY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13zUWlEPTB;MD6wO|M6KM7:TR?= NYrhTYJFW0GQR1XS
A4-Fuk MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PlWmlEPTB;MD6wO|Q5PiEQvF2= NUXycI9jW0GQR1XS
OC-314 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmriTWM2OD1yLkC3PFA4KM7:TR?= NX3SWnVuW0GQR1XS
SK-LU-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwMEi0NlEh|ryP NGPzOmhUSU6JRWK=
MDA-MB-157 Mn\oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwMEi2OVkh|ryP NVrLUYNRW0GQR1XS
HuP-T3 M{SwcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHO3fFlKSzVyPUCuNFg4OSEQvF2= M2j0PHNCVkeHUh?=
A3-KAW M2DhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETLfoJKSzVyPUCuNFg5ODZizszN Ml[2V2FPT0WU
MOLT-16 NUDBRXpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMEi4NFch|ryP M332RnNCVkeHUh?=
COLO-679 NH7VOGZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFnMT3hKSzVyPUCuNFkxQTFizszN MnfzV2FPT0WU
EM-2 NGH1R3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkO3TWM2OD1yLkC5PVA{KM7:TR?= MYHTRW5ITVJ?
ES8 M3H5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3He5ZOUUN3ME2wMlA6QTF6IN88US=> MkjyV2FPT0WU
SK-MEL-2 NULpeIxxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\jUJhWUUN3ME2wMlExODN|IN88US=> NGT0TWZUSU6JRWK=
ES3 NULHUGQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEP3VlZKSzVyPUCuNVAzKM7:TR?= M4foNnNCVkeHUh?=
HSC-4 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHflNW9KSzVyPUCuNVA2PTRizszN MVTTRW5ITVJ?
697 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[wbmp3UUN3ME2wMlEyODZ|IN88US=> M1nFW3NCVkeHUh?=
TGBC11TKB NEjaOIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zKNWlEPTB;MD6xNVA6OyEQvF2= MYXTRW5ITVJ?
SK-PN-DW M17yWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\WXGlEPTB;MD6xNVg3KM7:TR?= NXv5SXlsW0GQR1XS
H9 NGG2dVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHYXoNHUUN3ME2wMlEzOTZ3IN88US=> MYfTRW5ITVJ?
NCI-H2122 MlvPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7XTWM2OD1yLkGyNlUh|ryP MYjTRW5ITVJ?
ML-2 NYDneZJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfsemdKSzVyPUCuNVI1QDRizszN NFnHd5hUSU6JRWK=
MC-IXC M{XFeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDSXHRKSzVyPUCuNVI5PDNizszN MXHTRW5ITVJ?
KYSE-140 NVnRToZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmyZ3BKSzVyPUCuNVMxPDFizszN NX7hfIFtW0GQR1XS
DOHH-2 NUXuW5o1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjkUWpKSzVyPUCuNVMxPjRizszN M1GyNnNCVkeHUh?=
MEL-JUSO MmLUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;nTWM2OD1yLkGzNVI5KM7:TR?= MlvSV2FPT0WU
P30-OHK M2DycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMUOxOkDPxE1? NX3IWYhOW0GQR1XS
CTB-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXPR5dKSzVyPUCuNVM{OjVizszN Mk\lV2FPT0WU
ACHN M4PhUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTBwMUOzOlkh|ryP MonUV2FPT0WU
ES5 NHnjUYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4PMVWlEPTB;MD6xN|Q4PiEQvF2= NUnKb3o4W0GQR1XS
SF539 M4Tt[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX:2Zm1lUUN3ME2wMlE{PjhizszN NV3yNHA3W0GQR1XS
D-283MED NX3CboRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M135RWlEPTB;MD6xN|Y5PyEQvF2= MYnTRW5ITVJ?
OVCAR-5 NUnoTo93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMUO4PVQh|ryP NH3yWmJUSU6JRWK=
RPMI-8866 M1fZb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDyfJB7UUN3ME2wMlE{QTJ3IN88US=> NFvDbVZUSU6JRWK=
PANC-03-27 M361N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMUSyPFgh|ryP MXrTRW5ITVJ?
M14 NYTWcY52T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;BfJVKSzVyPUCuNVQ1PjNizszN MnjwV2FPT0WU
D-566MG NIToO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWPJR|UxRTBwMUS2PUDPxE1? NFmwdFFUSU6JRWK=
Ramos-2G6-4C10 M1TnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PhZmlEPTB;MD6xOFg1OiEQvF2= Ml3KV2FPT0WU
NOS-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\B[JZKSzVyPUCuNVQ6PjdizszN NWe1WoxjW0GQR1XS
YH-13 Mmr1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMUW2O|Qh|ryP MXXTRW5ITVJ?
NB17 NV\iVXd2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMUW3PFYh|ryP MV;TRW5ITVJ?
U-2-OS MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXyTWM2OD1yLkG1PFQ4KM7:TR?= NWDFR4hCW0GQR1XS
ES7 M3n3R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIXJXXBKSzVyPUCuNVYxOTFizszN MUXTRW5ITVJ?
LoVo MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMU[xOlYh|ryP MXXTRW5ITVJ?
QIMR-WIL NFXlbpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\4TWM2OD1yLkG2N|EyKM7:TR?= NWD1dGVCW0GQR1XS
ESS-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMU[0NVMh|ryP M2nmU3NCVkeHUh?=
LAMA-84 NVfqWWlZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX23b|NVUUN3ME2wMlE3PTB|IN88US=> M{GzO3NCVkeHUh?=
TGBC24TKB NHLrNHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XBSmlEPTB;MD6xOlU{PSEQvF2= MnKyV2FPT0WU
KU812 M4\EXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS0N4RsUUN3ME2wMlE3QDNizszN M1\RZXNCVkeHUh?=
KARPAS-45 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17OPGlEPTB;MD6xOlg1PyEQvF2= NHPpSFdUSU6JRWK=
ACN NVv3c29NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\4VWlEPTB;MD6xO|E4OSEQvF2= NUXW[FJXW0GQR1XS
RPMI-8226 M1eyWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzsR4hKSzVyPUCuNVc1PjRizszN NGH1c4tUSU6JRWK=
GR-ST MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGe4U3NKSzVyPUCuNVc5OjdizszN M3nLdHNCVkeHUh?=
SK-UT-1 NVXx[JVnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjRTWM2OD1yLkG4OVk6KM7:TR?= MoLCV2FPT0WU
SK-N-AS MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\pdmlEPTB;MD6xPFgyPSEQvF2= MXPTRW5ITVJ?
EW-1 NVHtWJBZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;Ub2lEPTB;MD6xPFkxPSEQvF2= M2fxb3NCVkeHUh?=
5637 NXG4eXdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrNTWM2OD1yLkG5Nlc5KM7:TR?= NGH3PJRUSU6JRWK=
GI-1 M33zWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjCOINSUUN3ME2wMlE6PTZzIN88US=> MWDTRW5ITVJ?
NCI-H1395 Mlr2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3hOmw4UUN3ME2wMlE6PzZzIN88US=> NV\vU5NsW0GQR1XS
CHP-212 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLLTWM2OD1yLkG5O|gzKM7:TR?= NX7TcZZbW0GQR1XS
A427 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnDO3puUUN3ME2wMlE6QDN{IN88US=> Ml\zV2FPT0WU
BE-13 M2iwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[weJdwUUN3ME2wMlIxOTF5IN88US=> MoTGV2FPT0WU
RS4-11 M{KxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVP0fGpWUUN3ME2wMlIxOzF6IN88US=> MofzV2FPT0WU
TI-73 M1TzWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTBwMkC4O|Mh|ryP NFTk[XZUSU6JRWK=
HAL-01 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnPtTWM2OD1yLkKwPVch|ryP NFzSOW1USU6JRWK=
KY821 NV;3WldTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TVPGlEPTB;MD6yNVQzQSEQvF2= NYjVOXFPW0GQR1XS
H4 NVn2fGpjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwMkKwOlIh|ryP NX7Ec5FbW0GQR1XS
EPLC-272H NGTpPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnvS4xKSzVyPUCuNlIxPjhizszN MoqwV2FPT0WU
COR-L105 M{npd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\FcGxmUUN3ME2wMlIzOjN3IN88US=> NHm2ZnhUSU6JRWK=
769-P M1rnd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkG3TWM2OD1yLkKyNlk5KM7:TR?= NEfKPHVUSU6JRWK=
HEL MmSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;1TWM2OD1yLkKyOFU1KM7:TR?= M132fXNCVkeHUh?=
VA-ES-BJ MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUCwc4M5UUN3ME2wMlIzPTV5IN88US=> MmPPV2FPT0WU
IST-MEL1 M4TZemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGyTWM2OD1yLkKyOVch|ryP NXTQVYVNW0GQR1XS
KYSE-270 NYfvZlcxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjnSJo1UUN3ME2wMlIzPjN|IN88US=> MmKxV2FPT0WU
RH-1 NY\mRpRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTBwMkK2OlYh|ryP MX\TRW5ITVJ?
JVM-3 MnfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnZTXRWUUN3ME2wMlI{ODN4IN88US=> NVT5WWd3W0GQR1XS
RPMI-7951 NH\1SHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXiTHBKSzVyPUCuNlMxPTZizszN NEPrco1USU6JRWK=
JAR NV:yeYw4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHBdYdVUUN3ME2wMlI{OjN6IN88US=> MlT6V2FPT0WU
MOLT-4 NYHabIZ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmq2TWM2OD1yLkKzPFUh|ryP NVvaR2JMW0GQR1XS
ALL-PO Ml;ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXmSnBDUUN3ME2wMlI1OjR|IN88US=> NGfSWmZUSU6JRWK=
SNU-387 NYTK[ndIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIGzcGZKSzVyPUCuNlQ{OzlizszN M1\ybXNCVkeHUh?=
IGROV-1 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMkS0NFEh|ryP NEfIXGZUSU6JRWK=
MPP-89 NInNdlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMkS0OVEh|ryP NH;hZ4tUSU6JRWK=
T98G MnvJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TF[mlEPTB;MD6yOFU3QCEQvF2= M4T1ZXNCVkeHUh?=
NCI-H510A MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMkS2NlYh|ryP NFjF[3dUSU6JRWK=
KOSC-2 NWnGUlFZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWO1Z41LUUN3ME2wMlI1PjdzIN88US=> M2nDUnNCVkeHUh?=
NCI-H23 NX7uTW9ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrWUXJKSzVyPUCuNlQ4PjFizszN Ml3LV2FPT0WU
MC116 NXjzV3V1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIfBV4dKSzVyPUCuNlU3PTRizszN MXnTRW5ITVJ?
8-MG-BA MnrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMkW3Olgh|ryP M2jDXHNCVkeHUh?=
ABC-1 Mo\SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTBwMk[wOlQh|ryP MVvTRW5ITVJ?
J-RT3-T3-5 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTBwMk[2O|gh|ryP NHXjeIFUSU6JRWK=
NCI-SNU-1 MmfuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDkVINsUUN3ME2wMlI4ODV7IN88US=> NIXCOXpUSU6JRWK=
HCC1395 NIO1bIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf6N|Z{UUN3ME2wMlI4ODh7IN88US=> MlftV2FPT0WU
BB65-RCC NX\1VoY1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEmzUXhKSzVyPUCuNlcxQTdizszN MYjTRW5ITVJ?
NCI-H1755 M2nyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXewc5dGUUN3ME2wMlI4OzB2IN88US=> NWD6R4FvW0GQR1XS
OVCAR-3 M3\DVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHyyRo1KSzVyPUCuNlc{QDVizszN NEL5Wo5USU6JRWK=
MKN45 MkO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzjOFFWUUN3ME2wMlI4QThizszN M1zod3NCVkeHUh?=
TYK-nu M1e2Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXrqXFl5UUN3ME2wMlI5ODZizszN NFPvTW9USU6JRWK=
SNU-C2B NIjJc2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jISGlEPTB;MD6yPFE{PCEQvF2= M3HvZnNCVkeHUh?=
H-EMC-SS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUK2foZrUUN3ME2wMlI5OzV2IN88US=> MnXxV2FPT0WU
CAKI-1 M{DlOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7HTWM2OD1yLkK4Olgh|ryP MWnTRW5ITVJ?
EW-24 MnTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm0TWM2OD1yLkK4PVEh|ryP M{nmcnNCVkeHUh?=
RXF393 NVHJbpZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDhZoVKSzVyPUCuNlkxODhizszN M1PNSHNCVkeHUh?=
CCRF-CEM MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXSXFQ2UUN3ME2wMlI6OTV2IN88US=> Mn7sV2FPT0WU
HOP-92 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4X0bWlEPTB;MD6yPVI4QSEQvF2= MVvTRW5ITVJ?
COLO-684 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzmOZhKSzVyPUCuNlk1ODZizszN MWLTRW5ITVJ?
NCI-H28 NVXIbmd5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPuNI1KSzVyPUCuNlk4ODRizszN Mli4V2FPT0WU
HuO9 M3XaS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUK2UIVNUUN3ME2wMlI6Pzl|IN88US=> M1nFeHNCVkeHUh?=
SF295 M1u2VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMkm4NFIh|ryP NEOwbHpUSU6JRWK=
COLO-829 NVn4e2E6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTBwMkm4OFUh|ryP NF7tTm9USU6JRWK=
MSTO-211H MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfye4dKSzVyPUCuNlk5PTVizszN M4HJVnNCVkeHUh?=
MDA-MB-361 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ezO2lEPTB;MD6yPVg6PiEQvF2= MWLTRW5ITVJ?
FTC-133 NEjjRXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33OZ2lEPTB;MD6zNFI3PSEQvF2= NEfxdWFUSU6JRWK=
Mewo NIqwV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwM{C0N|Eh|ryP NXHm[HJTW0GQR1XS
HCC70 NH[3R2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwM{C2OlUh|ryP NYjme2o2W0GQR1XS
BB30-HNC NEDlVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7rTWM2OD1yLkOxOVI2KM7:TR?= MVjTRW5ITVJ?
LCLC-97TM1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jNcGlEPTB;MD6zNVU3PiEQvF2= NVrNTXVHW0GQR1XS
HCC2998 NVHpcoc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwM{G2OUDPxE1? NFLoUnVUSU6JRWK=
NBsusSR MnrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYe3cYpkUUN3ME2wMlMyQDF7IN88US=> NUnhOI5tW0GQR1XS
OVCAR-4 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XQSmlEPTB;MD6zNlAzOSEQvF2= Ml35V2FPT0WU
NCI-H209 NGHQNlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7U[WZNUUN3ME2wMlMzOzV|IN88US=> M{S3WHNCVkeHUh?=
ChaGo-K-1 NGHFRWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHXHfllKSzVyPUCuN|I1QDlizszN MVfTRW5ITVJ?
KALS-1 M3i2TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDLTWM2OD1yLkOyOVk1KM7:TR?= NIPMTpBUSU6JRWK=
D-423MG Mn;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn2yTWM2OD1yLkOzNVQzKM7:TR?= M4PLSnNCVkeHUh?=
Detroit562 M{\Oemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljpTWM2OD1yLkOzN|Q{KM7:TR?= Mm[3V2FPT0WU
HT-144 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzuNWlKSzVyPUCuN|M5OSEQvF2= MYPTRW5ITVJ?
MEG-01 M3TPe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OwfmlEPTB;MD6zOFU5PCEQvF2= NYTwT5UzW0GQR1XS
BV-173 M1zXdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwM{S1PVYh|ryP NULBUFhtW0GQR1XS
MZ7-mel NXr3R2d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H3NWlEPTB;MD6zOFY4PyEQvF2= M3flenNCVkeHUh?=
C32 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\6VGlEPTB;MD6zOFY5OiEQvF2= NWrSdYFFW0GQR1XS
DU-4475 NIDuV2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV;JR|UxRTBwM{S4O|Uh|ryP MoHzV2FPT0WU
KP-N-YN MoOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL5TWM2OD1yLkO0PFg4KM7:TR?= M4HHNnNCVkeHUh?=
MKN1 M1HMT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonNTWM2OD1yLkO1NFAzKM7:TR?= MVjTRW5ITVJ?
8505C NGTKXXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\4VlVKSzVyPUCuN|UxODJizszN MUHTRW5ITVJ?
OVCAR-8 NVnZbmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnLU4dKSzVyPUCuN|U2QDRizszN M4DFV3NCVkeHUh?=
NH-12 M{ToRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVG0dHVpUUN3ME2wMlM2Pjl4IN88US=> M2PTOXNCVkeHUh?=
COR-L88 M1\Sd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTBwM{[0PFIh|ryP NH7HS3JUSU6JRWK=
T-24 MnPuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwM{[5PFUh|ryP MkHvV2FPT0WU
MIA-PaCa-2 M{LjPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHWTWM2OD1yLkO3OFk4KM7:TR?= NEXLUFZUSU6JRWK=
LS-411N MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13BXWlEPTB;MD6zO|YxPiEQvF2= MofJV2FPT0WU
TK10 NHW2OGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXmTWM2OD1yLkO3PVQ5KM7:TR?= NGrxTIZUSU6JRWK=
SW1990 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DocmlEPTB;MD6zPFM2OyEQvF2= NWjme|VCW0GQR1XS
GAMG NEHaOHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXlSYdKSzVyPUCuN|g2PjdizszN MXfTRW5ITVJ?
G-361 NWTG[lg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ITWM2OD1yLkO4O|EzKM7:TR?= MWHTRW5ITVJ?
Ca-Ski MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwM{i3PVIh|ryP M3rxUHNCVkeHUh?=
786-0 M135bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LCNmlEPTB;MD6zPFgzOyEQvF2= M3ezfXNCVkeHUh?=
MHH-NB-11 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwM{i5O{DPxE1? Mk\TV2FPT0WU
OE33 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHjTWM2OD1yLkO5NVE5KM7:TR?= MU\TRW5ITVJ?
SW954 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnIeXNmUUN3ME2wMlQxOTNzIN88US=> MlnoV2FPT0WU
KYSE-180 NEm4eWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwNECxOVEh|ryP NGnmdo9USU6JRWK=
NCI-H720 MmHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4\yPWlEPTB;MD60NFE6OSEQvF2= NIjXUoVUSU6JRWK=
COR-L23 NWjHNVZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3NTWM2OD1yLkSwNlg3KM7:TR?= NEXD[WdUSU6JRWK=
PFSK-1 MlfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnCTmxYUUN3ME2wMlQyODl{IN88US=> NXexWIlnW0GQR1XS
FADU MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPNTWM2OD1yLkSxNVczKM7:TR?= NIPnc5hUSU6JRWK=
GP5d MmHwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7rUWRVUUN3ME2wMlQyOjJ3IN88US=> M{jDenNCVkeHUh?=
PC-14 M2nnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vF[WlEPTB;MD60NVY3OSEQvF2= Mn72V2FPT0WU
SJSA-1 M2jsT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwNEG3NVQh|ryP NX7Id4tVW0GQR1XS
D-336MG M4jCOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFvY[VRKSzVyPUCuOFIyOzhizszN NGDNSm9USU6JRWK=
LOXIMVI MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwNEK4PFUh|ryP M13nRXNCVkeHUh?=
EFO-27 NFXJXZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwNEOwOFkh|ryP NFjtenpUSU6JRWK=
A2780 M3vDd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlP1TWM2OD1yLkSzNVYzKM7:TR?= Ml;hV2FPT0WU
CAL-12T NHfFT5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3WWpVVUUN3ME2wMlQ{Ojh6IN88US=> NIHITopUSU6JRWK=
ES6 NV\iNpJNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXoTWM2OD1yLkS0NVg2KM7:TR?= NUnaRplTW0GQR1XS
HCE-T M2Xq[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPQWWdRUUN3ME2wMlQ1OTh5IN88US=> MVvTRW5ITVJ?
SK-MES-1 NXjRZnVxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{W5TGlEPTB;MD60OFI6OyEQvF2= NXPlWHYyW0GQR1XS
Daoy NXrUepN5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYjJUpBFUUN3ME2wMlQ2OTB|IN88US=> MWTTRW5ITVJ?
A2058 NXjlbpZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmLXTWM2OD1yLkS1NVM3KM7:TR?= NHfpUXJUSU6JRWK=
Hs-578-T NInXW|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4[0R2lEPTB;MD60OVI4QCEQvF2= M1rxN3NCVkeHUh?=
TE-11 M2LnUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvmTWM2OD1yLkS1Nlk{KM7:TR?= MXrTRW5ITVJ?
GI-ME-N MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzHc2k6UUN3ME2wMlQ2PDZizszN MnP6V2FPT0WU
D-392MG M4rQcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXXdYNKSzVyPUCuOFU3OTJizszN M4Hme3NCVkeHUh?=
MOLT-13 MoLMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvEWYFKSzVyPUCuOFYzQTRizszN NH[xSm9USU6JRWK=
SK-NEP-1 NEfUNHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{XjOmlEPTB;MD60OlQyQSEQvF2= MWDTRW5ITVJ?
KS-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXmyUo1wUUN3ME2wMlQ3PjB|IN88US=> NXTWVWlmW0GQR1XS
HuP-T4 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPsTWM2OD1yLkS2PFY5KM7:TR?= Mo\WV2FPT0WU
NCI-H1563 Ml\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVHabZpUUUN3ME2wMlQ4ODN3IN88US=> MnPuV2FPT0WU
U031 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXF[ZdjUUN3ME2wMlQ5OjN2IN88US=> MVHTRW5ITVJ?
HSC-3 NGr3fWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3W3VWlEPTB;MD60PFYzPiEQvF2= MlK1V2FPT0WU
HT-3 NYDwZVI1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LhbmlEPTB;MD60PVA{KM7:TR?= NV;sZ3FEW0GQR1XS
HGC-27 NFzDNpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmW2TWM2OD1yLkS5NVE2KM7:TR?= Mo\5V2FPT0WU
HT-1080 NIiyc2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzV[pI{UUN3ME2wMlQ6OjdizszN NXjXW5BTW0GQR1XS
RT-112 NV7lRnZsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnJTWM2OD1yLkS5PVIyKM7:TR?= M1;BXnNCVkeHUh?=
A375 Ml\DS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUnJR|UxRTBwNEm5NlIh|ryP NH:wZ5FUSU6JRWK=
SW626 Mn3KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PXWmlEPTB;MD61NFY{OyEQvF2= MlLkV2FPT0WU
SBC-5 NXHtco93T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTBwNUGzOFQh|ryP MlXyV2FPT0WU
CAL-51 NUjNcoc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXCS4FtUUN3ME2wMlUyPDN5IN88US=> MXfTRW5ITVJ?
RKO NEXBPZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{X6bWlEPTB;MD61NlAyQSEQvF2= M4G5UXNCVkeHUh?=
HC-1 NEHXO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF60Z2ZKSzVyPUCuOVIyOTRizszN MmjsV2FPT0WU
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NCI-H2342 M1nWS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwM{S2NFMh|ryP M3fBfHNCVkeHUh?=
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NCI-H441 M4TlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJwNUCzNFUh|ryP MmnSV2FPT0WU
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CAL-85-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFm5eVhKSzVyPUKuOlYyPjFizszN Mn;LV2FPT0WU
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D-247MG MlzGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV71[5g4UUN3ME2yMlc{PzV4IN88US=> NWn2TVJLW0GQR1XS
CAL-39 NV7PTYxST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwOE[zPFkh|ryP MUfTRW5ITVJ?
NCI-H2087 M3;GeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETGUJpKSzVyPUKuPFg1OzFizszN MnXuV2FPT0WU
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NCI-H1437 M2XLWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXG3XlZsUUN3ME2yMlkzOjV5IN88US=> NEXJNpZUSU6JRWK=
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NCI-H596 M3PsZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XjXmlEPTB;Mz6wOlcyKM7:TR?= MXTTRW5ITVJ?
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C3A MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PlbGlEPTB;MUKuN|E4OiEQvF2= NVvJdZBZW0GQR1XS
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LU-139 NFz2VGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHBSFlKSzVyPUGyMlY{OzNizszN NYTreHB{W0GQR1XS
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MCF7 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoK0TWM2OD1zMz6yN|Y2KM7:TR?= M{nUbXNCVkeHUh?=
SW872 M3XpS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTF2LkW0OlEh|ryP NX;FWmVjW0GQR1XS
HT-1376 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXyc3pKSzVyPUG0Mlg2QDJizszN NYPFPIFSW0GQR1XS
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NCI-H2405 NFO2RmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPaPIlKSzVyPUG1MlQ1PzRizszN M1:4VnNCVkeHUh?=
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HCT-15 Mk\GS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7XNZpKSzVyPUK4MlQyQTJizszN NH\iN2JUSU6JRWK=
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NCI-H1092 MkXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jD[mlEPTB;M{OuOVE1PSEQvF2= M{fycXNCVkeHUh?=
Mo-T NHTSZ|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUGwS|FPUUN3ME2zO{4{PTh3IN88US=> NYjnNWFHW0GQR1XS
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IST-MES1 NFr5V5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC1TWM2OD12Nj60NVk3KM7:TR?= MmnKV2FPT0WU
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MZ2-MEL NUnFNnFKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmn1TWM2OD12OD61NFI3KM7:TR?= NVXYfVVjW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo AZD7762 alone at 25 mg/kg shows little antitumor activity in the H460-DNp53 xenograft mice and SW620 xenograft mice, but when administrated in combination with gemcitabine (60 mg/kg), AZD7762 shows significant antitumor efficacy in the two xenografts mice with a log cell kill of 0.9 or percent treated/control (%T/C) of 26 even at low dose of 12.5 mg. Dosing of AZD7762 in combination with gemcitabine (10 mg/kg) in the H460-DNp53 xenograft rat inhibits the tumor volume in a dose-dependent manner with the %T/C values of 48 and 32 for 10 and 20 mg/kg AZD7762, respectively. AZD7762 (25 mg/kg) in combination with irinotecan (25 or 50 mg/kg) causes complete tumor regression in the SW620 xenograft mice with the %T/C increasing significantly to -66% and -67%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Chk1 Kinase Assay:

Recombinant human Chk1 is expressed as a glutathione S-transferase fusion in insect cells using a baculovirus vector and purified by glutathione affinity chromatography. A synthetic peptide substrate (N-biotinylaminohexanoyl-KKVSRSGLYRSPMPENLNRPR) for Chk1 is synthesized. Final assay concentrations of peptide and ATP (cold + 40 nCi [33P]ATP) are 0.8 and 1 μM, respectively. Different concentrations of AZD7762, buffer containing peptide and chk1 kinase and ATP, are added sequentially to a 384-well assay plate. The plate is incubated for 2 hours, reaction is stopped by the addition of buffer containing EDTA and scintillation proximity assay beads, and plates are read using a TopCount reader. Data analysis is carried out to determinate a dose response (IC50).
Cell Research:[1]
+ Expand
  • Cell lines: HT29, SW620 and MDA-MB-231 cells
  • Concentrations: Dissolved in DMSO, final concentration ~12.5 μM
  • Incubation Time: 20 or 48 hours
  • Method: For the checkpoint abrogation assay, HT29 cells are treated for 2 hours with camptothecin (topoisomerase I inhibitor; 0.07 μg/mL) to induce the G2 checkpoint. Cells are then treated for 20 hours with a 12-point titration of AZD7762 (12.5 μM to 6 nM) plus nocodazole. Cells are fixed with 3.7% formaldehyde for 1 hour, permeabilized with PBS containing 0.05% Triton X, and incubated with anti-phH3 antibody for 1 hour followed by Alexa Fluor 488 anti-rabbit and Hoechst stain for 1 hour. Mitotic index is determined on the ArrayScan and expressed as the percentage of cells undergoing mitosis. For the potentiation assays, SW620 or MDA-MB-231 cells are dosed for 24 hours with a 9-point titration of gemcitabine ranging from 0.01 to 100 nM with a constant dose of AZD7762 (300 nM). After 24 hours, medium is removed and AZD7762 alone is added back to the wells for an additional 24 hours. Cells are then incubated in AZD7762-free medium for an additional 72 hours. The effect on cell proliferation is determined by MTT.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Male NCr mice implanted s.c. with H460-DNp53 cells or SW620, and male rnu rats implanted s.c. with H460-DNp53 cells
  • Formulation: Formulated in 11.3% hydroxyproplyl-β-cyclodextrin
  • Dosages: ~25 mg/kg
  • Administration: Injection i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 50 mg/mL (137.96 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 362.42
Formula

C17H19FN4O2S

CAS No. 860352-01-8
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00937664 Terminated Cancer|Solid Tumors|Advanced Solid Malignancies AstraZeneca July 2009 Phase 1
NCT00473616 Terminated Advanced Solid Tumors|Cancer|Advanced Solid Malignancies AstraZeneca May 2007 Phase 1
NCT00413686 Completed Solid Tumors AstraZeneca December 2006 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    If I want to use the inhibitor for i.p. injection, can I use DMSO to dissolve it?

  • Answer:

    Since DMSO has low toxicity with i.p. injection, hydroxyproplyl-β-cyclodextrin is consider a safer co-solvent in compound formulation. In a previous literature report, 11.3% hydroxyproplyl-β-cyclodextrin was used to formulate this compound for i.v. injection.

Chk Signaling Pathway Map

Chk Inhibitors with Unique Features

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID