Gemcitabine

Gemcitabine belongs to the group of medicines called antimetabolites.Phase 3.

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In DMSO USD 130 In stock
USD 97 In stock
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Gemcitabine  Chemical Structure

Gemcitabine Chemical Structure
Molecular Weight: 263.2

Validation & Quality Control

Customer Reviews(1)

Quality Control & MSDS

Related Compound Libraries

Gemcitabine is available in the following compound libraries:

Product Information

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  • Research Area

Product Description

Biological Activity

Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites. It is used alone or in combination with other medicines to treat cancer of the breast, ovary, pancreas, and lung. Gemcitabine interferes with the growth of cancer cells, which are eventually destroyed. [1, 2]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01956812 Not yet recruiting Metastatic Pancreatic Cancer|Pancreatic Cancer Immunomedics, Inc. 2013-12 Phase 3
NCT01964430 Not yet recruiting Pancreatic Neoplasms|Digestive System Neoplasms|Neoplasms by Site|Neoplasms|Endocrine Gland Neoplasms|Pancreatic Diseases|Digestive System Diseases|Endocrine System Diseases|Gemcitabine|Antimetabolite Celgene Corporation 2014-01 Phase 3
NCT01830322 Withdrawn Metastatic Pancreatic Adenocarcinoma Cornerstone Pharmaceuticals, Inc. 2014-01 Phase 2
NCT02016417 Not yet recruiting Nasopharyngeal Carcinoma Cancer Hospital of Guangxi Medical University 2014-01 Phase 2
NCT01852890 Not yet recruiting Pancreatic Neoplasms University of Iowa|Joseph J. Cullen 2014-02 Phase 1

Chemical Information

Download Gemcitabine SDF
Molecular Weight (MW) 263.2
Formula

C9H11F2N3O4

CAS No. 95058-81-4
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms Gemzar
Solubility (25°C) * In vitro DMSO 15 mg/mL (56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol, 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.2632 2.632 5.264 7.896

Research Area

Customer Reviews (1)


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Rating
Source Dr. Helen Sadik of Johns Hopkins University. Gemcitabine purchased from Selleck
Method MTT assays
Cell Lines MCF7 cells, MCF10A cells
Concentrations 0.01-100 μM
Incubation Time 48 h
Results Gemcitabine potently inhibited the survival of MCF10A cells in a dose-dependent manner. The highest level of inhibition was observed with Gemcitabine HCl in concentration of 0.01 μM in MCF7 cells

Product Citations (2)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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