Dexamethasone (DHAP)

Catalog No.S1322

Dexamethasone (DHAP) Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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In DMSO USD 130 In stock
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2 Customer Reviews

  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

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Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells NYPNXVY4TnWwY4Tpc44h[XO|YYm= MWXBZ5Rqfmm2eTDheEBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCneIDy[ZN{\WRiaX6gR3YyKGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gWG5HKGGwZDDJUE0yNWKndHGtbY5lfWOnZDDFMZNmdGWldHnuJIdmdmViZYjwdoV{e2mxbjDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXEOVA:OC5zIH7N MWexPFA{OjZzMB?=
HEK293 cells NV\EWYlGTnWwY4Tpc44h[XO|YYm= MmDySIl{eGyjY3Xt[Y51KG:oIGuzTH0u[Wymb4P0[ZJwdmViZoLvcUBpfW2jbjDtbY5memGub3PvdpRq[2:rZDDy[YNmeHSxcjDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|LDDLbV0xNjN4IH7N MX6yOFQ1Pjd{OB?=
human PBMC MlvFSpVv[3Srb36gZZN{[Xl? MXfBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGDCUWMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBidnSrLVPEN{1qdmS3Y3XkJGdONUOVRjDwdo9lfWO2aX;uJIFnfGW{IES4JIhzeyxiRVO1NF0xNjR5IH7N NV;uUFdFOjNzOUm0PFU>
HFF cells M2HsV2Z2dmO2aX;uJIF{e2G7 MlrHRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFnMNUB{fGmvdXzheIVlKEmONjDwdo9lfWO2aX;uJIlvKEiIRjDj[YxteyCkeTD0doFve3KncILld5Nqd25iYYPzZZktKEWFNUC9NE42KG6P NFT1WncyPzZ7MkWxPS=>
human A549 cells M3jmcWZ2dmO2aX;uJIF{e2G7 M1Xqd2FkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJGE2PDliY3XscJMh[XO|ZYPz[YQh[XNiZX\m[YN1KG:wIFfSSUBxem:vb4TldkBz\XOyb37z[UBjgSCudXPp[oVz[XOnIILldI9zfGW{IHHzd4F6NCCHQ{WwQVEhdk1? MnjoNVY3PDNyNkC=
NHDFneo cells NIjkUlJHfW6ldHnvckBie3OjeR?= MV7BZ5Rqfmm2eTDheEBpfW2jbjDHVkBmgHC{ZYPz[YQhcW5iTljESo5mdyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNNTZicILv[JVkfGmxbjygTWM2OD1zLkSgcm0> MXSxO|cxPTN4Mh?=
human HeLa cells NWfHcGFmTnWwY4Tpc44h[XO|YYm= MlrhWJJidnO{ZYDy[ZN{cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{LX3l[IlifGWmIHHueIlqdm[uYX3tZZRwenliYXP0bZZqfHliaX6gbJVu[W5iSHXMZUBk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIGTQRU1qdmS3Y3XkJINwdGyjZ3XuZZNmKHC{b33veIVzKGGldHn2bZR6KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhUUN3ME2xMlU5KG6P NY\CbY5TOjB5Mke3OFM>
human SW1353 cells MnG2SpVv[3Srb36gZZN{[Xl? M4Lje3Rz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDTW|E{PTNiY3XscJMh[XO|ZYPz[YQh[XNicnXwdoV{e2mxbjDv[kBKVC1zLXnu[JVk\WRiTV3QMVE{KHC{b3T1Z5Rqd25iYX\0[ZIhOjRiaILzJIJ6KEWOSWPBMEBKSzVyPUGuPEBvVQ>? NHzqOYwzPTdyNkGwNC=>
rat polymorphonuclear leukocytes MXzGeY5kfGmxbjDhd5NigQ>? M{X4cFIxKG2rboO= NWSyNVc{SW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiC{YYSgdI9tgW2xcoDoc452[2ynYYKgcIV2c2:leYTld{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2|dHnteYxifGWmIH7peJJq[yCxeHnk[UBxem:mdXP0bY9vKGGodHXyJFIxKG2rboOgZpkhT3KrZYPzJI1mfGixZDygTWM2OD1{LkOgcm0> MkHzNlI2ODZ4MkC=
human THP1 cells NIj0W5NHfW6ldHnvckBie3OjeR?= MWHUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCWSGCxJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgTWwuQCCycn;keYN1cW:wLDDJR|UxRTJwNUGgcm0> NGLkOm8zODd{N{e0Ny=>
human NP1 cells NFn5enBHfW6ldHnvckBie3OjeR?= NUHnXVZuSWexbnnzeEBi[3Srdnn0fUBifCCJUjDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHj1cYFvKE6SMTDj[YxteyCjc4Pld5Nm\CCjczDncJVkd2OxcoTpZ49q\CC{ZYPwc45{\SCnbHXt[Y51KHS{YX7zZYN1cX[jdHnvckBjgSCJQVy0JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF01NjJibl2= M3zWU|E6OzJzM{Sx
human HeLa cells Mn7ySpVv[3Srb36gZZN{[Xl? NFmydmZVemGwc3HjeIl3[XSrb36gc4YhT1JvTFLEJIV5eHKnc4Pl[EBqdiCqdX3hckBJ\UyjIHPlcIx{KGOxLXX4dJJme3OrbnegS2FNPC2GQlSgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTRwMjDuUS=> M1\xTlI1ODFzNkS0
human 13D3/Huh7 cells MWrGeY5kfGmxbjDhd5NigQ>? MnPmNlQhcA>? NHrVbIRVemGwc3HjeIl3[XSrb36gZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgbY4hcHWvYX6gNVNFOy:KdXi3JINmdGy|IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iC2eYLvd4lv\SCjbXnuc5Rz[W6|ZnXyZZNmKGGldHn2bZR6KGGodHXyJFI1KGi{czygSWM2OD13IH7N MUOyNVA4OzF7MB?=
rat R1 cells NV;3cXdlTnWwY4Tpc44h[XO|YYm= MYOxNEDPxE1? Mn7INlQhcA>? NFWw[mRKdmirYnn0bY9vKG:oIHfseYNw[2:{dHnjc4llKHKnY3XweI9zNWeudXPvZ49zfGmlb3nkJINwdXCuZYigeJJidnOoZXP0[YQhcW5icnH0JHIyKGOnbHzzJIF{e2W|c3XkJIF{KGSxd36tdoVofWyjdHnvckBw\iCWUFGtdoV{eG:wc3n2[UBmdGWvZX70JJBzd2mwZnzhcY1ifG:{eTDn[Y5mKGW6cILld5Nqd25iYYSgNVAhfU1iYX\0[ZIhOjRiaILzJIJ6KGKndHGt[4Ft[WO2b4Pp[IF{\SCjc4PhfUwhUUN3ME21JI5O M33rW|E5PDF{M{m3
human RPMI8226 cells NETUS4tRem:uaX\ldoF1cW:wIHHzd4F6 MmLlOEBl[Xm| M1LjTWFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUmDNTVgzOjZiY3XscJMh[W[2ZYKgOEBl[Xm|LDDJR|UxRTZwNTDuUS=> MYCxO|cxPTN4Mh?=
african green monkey COS7 cells NFHROI9HfW6ldHnvckBie3OjeR?= MYnB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHzp[4Fv\CCkaX7kbY5oKGSxbXHpckBmgHC{ZYPz[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR29UPyClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbEStUGJFKGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME23MlIhdk1? M3L1WFE6QDZ|MEiz
human PBMC NEnNN21HfW6ldHnvckBie3OjeR?= NFSzTVIzPCCq MVHBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGDCUWMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRUEFvaX7keYNm\CCLRl7nZY1u[SCycn;keYN1cW:wIHHmeIVzKDJ2IHjydy=> NHfMSXUzOzF7OUS4OS=>
human H13 cells NWfYUIRuTnWwY4Tpc44h[XO|YYm= M3;mW2lvcGmkaYTpc44hd2ZiZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUDF|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\2y3Y3;jc5J1cWOxaXStbY5lfWOnZDDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiMzDodpMh[nliW{PIYU11cHmvaXTpcoUhcW6lb4Lwc5JifGmxbjDhd5NigSxiRVO1NF06Njdibl2= MWiyN|E6QTR6NR?=
mouse RAW264.7 cells MVnGeY5kfGmxbjDhd5NigQ>? NWHnOIZVOThiaB?= NYPhcIxZSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTi2jbIDoZUB{\WO{ZYTpc44h[W[2ZYKgNVghcHK|LDDJR|UxRTBwMEGg{txO NEK5SYozOTN3M{W0Ny=>
293 MSR cells NXq1fI03TnWwY4Tpc44h[XO|YYm= NWT5RnE6PjBibXnudy=> M4fWXmRqe3CuYXPlcYVvfCCxZjDbN2heNWSneHHt[ZRp[XOxbnWgbJVu[W5iZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5Ih[WyyaHGg[ZhxemW|c3XkJIlvKDJ7MzDNV3Ih[2WubIOgZYZ1\XJiNkCgcYlveyCkeTDzZ4lvfGmubHH0bY9vKGOxdX70bY5oNCCHQ{WwQVEzNjVibl2= NH35c5UzOzF7OUS4OS=>
Sf9 cells MX\GeY5kfGmxbjDhd5NigQ>? NVPUVGhmSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckBz\WOxbXLpcoFvfCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBmgHC{ZYPz[YQhcW5iYnHjeYxwfmm{dYOgbY5n\WO2ZXSgV4Y6KGOnbHzz MVqyNFczPzd2Mx?=
RAW 264.7 cells NHW5WZpHfW6ldHnvckBie3OjeR?= MYCyOEBp NYi0cYVNUW6qaXLpeIlwdiCxZjDpcpRmem[ncn;uJIdidW2jLYP0bY12dGG2ZXSgUm8heHKxZIXjeIlwdiCrbjDSRXchOjZ2LkegZ4VtdHNiYX\0[ZIhOjRiaILzMEBKSzVyPUCuNFIh|ryP MYWxO|M3PzF{NB?=
mouse J774A.1 cells NXfNWHFNTnWwY4Tpc44h[XO|YYm= MYnJcohq[mm2aX;uJI9nKEySUz3pcoR2[2WmIGTOSoFteGijIIDyc4R2[3Srb36gbY4hdW:3c3WgTlc4PEFwMTDj[YxteyxiSVO1NF01QCCwTR?= M4HRTlE4QDl{OUSx
human HepG2 cells NGDJeZBHfW6ldHnvckBie3OjeR?= MUWyOEBp MVvBZ5RqfmG2aX;uJI9nKHKjdDDQXHIh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHmeIVzKDJ2IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[mG|ZXSgcJVucW6nc3PlcpQh[W6jbInzbZMtKEWFNUC9Nk43KM7:TR?= M33scVIxQTZ4MESz
human U2OS cells MoLUSpVv[3Srb36gZZN{[Xl? M{LydFE5KGh? MVnB[49vcXO2IHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{LVzCSEBqdiCqdX3hckBWOk:VIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghT2GuND3ERmQh[XO|ZYPz[YQh[XNiaX7jdoVie2Vib3[geJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7IHHmeIVzKDF6IHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MUWuPFQ5QSEQvF2= M33TVlIxQDF{Nkix
mouse thymocytes MnzmSpVv[3Srb36gZZN{[Xl? MV6xJO69VQ>? M2DkV|I1KGh? NH\BeppKdmS3Y4Tpc44hd2ZiYYDvdJRwe2m|IHnuJI1wfXOnIITofY1w[3m2ZYOgZZN{\XO|ZXSgZZMhcW62ZYLueYNt\W:|b33hcEBFVkFiZoLh[41mdnSjdHnvckBifCBzIIXNJIFnfGW{IEK0JIhzeyCkeTDh[4Fzd3OnIHflcEBmdGWldILvdIhwemW|aYO= M2PMSVI1Pzl2N{S4
human HMC1 cells MX3GeY5kfGmxbjDhd5NigQ>? M3W1TFEhcA>? M2e2fo1ufW6xbX;keYxifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDIUWMyKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gdIhwemKxbDCxNk1ugXKrc4TheIUhOTNvYXPleIF1\S:DMkOxPFcue3SrbYXsZZRm\CCLTEGtZoV1[SC|ZXPy[ZRqd25idILlZZRm\CBzIHjyJJBzcW:{IITvJFMxKG2rboOgdIhwemKxbDCxNk1ugXKrc4TheIUhOTNvYXPleIF1\S:DMkOxPFch[2ijbHzlcodmKGK7IGfld5Rmem5iYnzveJRqdmdiYX7hcJl{cXN? MWKyNVMxOjl4Nx?=
human monocytes M1fWUWZ2dmO2aX;uJIF{e2G7 NITySlY2KM7:TR?= MVuyNEBp MkKzRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBpfW2jbjDtc45w[3m2ZYOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBEV1h{IHX4dJJme3Orb36gZZQhPSC3TTDh[pRmeiB{MDDodpMhfXOrbnegdoFj[mm2IIDvcJlkdG:wYXygZY51cWKxZImgTYdIKGK7IGPEV{1RSUeHIHHuZYx6e2m| MUSyNVg1Ozl|NR?=
COS7 cells MU\GeY5kfGmxbjDhd5NigQ>? NVXE[5kyOSEQvF2= MlzWRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDROVcxSSCvdYThcpQhcW5iQ1;TO{Bk\WyuczDheEAyKHWPIHL5JG5HNWujcIDhRk1tfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[Xl? NFzIW|YyQDB|OEm3NC=>
human MDA-kb2 cells M{PUNGZ2dmO2aX;uJIF{e2G7 NWnoe4ZYSWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtb4IzKGOnbHzzJIF{e2W|c3XkJIF{KHO2aX31cIF1cW:wIH;mJIx2[2moZYLhd4Uh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 MUKxPVU6OjJ2NR?=
human HeLaS3 cells NUf0O492TnWwY4Tpc44h[XO|YYm= Mn70NkBp NXXHSm05TGm|cHzhZ4Vu\W62IH;mJHs{UF2GZYjhcYV1cGG|b37lJIZzd21iZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUGWOYWOzJINmdGy|IHHmeIVzKDJiaILz NUDJV45tOjN2MEOwPFI>

... Click to View More Cell Line Experimental Data

In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents individually and in order:
5% DMSO+45% PEG 300+H2O
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01236586 Withdrawn Lymphoma|Brain Neoplasms|Sarcoma|Osteosarcoma|Wilms Tumor National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 8, 2010 Phase 1
NCT03040011 Not yet recruiting Pelvic Organ Prolapse|Surgery|Postoperative Pain University of Pittsburgh|Magee-Womens Research Institute March 6, 2017 Phase 1|Phase 2
NCT01553214 Recruiting Blood Donor|Leukocyte Transfusion|Granulocyte Colony-Stimulation Factor|Blood Component Removal National Institutes of Health Clinical Center (CC) March 6, 2012 Phase 1
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID