Dexamethasone (DHAP)

Catalog No.S1322

Dexamethasone (DHAP) Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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In DMSO USD 130 In stock
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2 Customer Reviews

  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

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Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells M1fucmZ2dmO2aX;uJIF{e2G7 MmXORYN1cX[rdImgZZQhcHWvYX6g[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiZYjwdoV{e2WmIHnuJGNXOSClZXzsd{Bie3Onc4Pl[EBieyC{ZYDy[ZN{cW:wIH;mJHRPTiCjbnSgTWwuOS2kZYThMYlv\HWlZXSgSU1{\WynY4TpckBo\W6nIHX4dJJme3Orb36gZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFSFUxRTBwMTDuUS=> MmfXNVgxOzJ4MUC=
HEK293 cells MWjGeY5kfGmxbjDhd5NigQ>? MX7EbZNxdGGlZX3lcpQhd2ZiW{PIYU1idGSxc4Tldo9v\SCocn;tJIh2dWGwIH3pcoVz[WyxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBJTUt{OUOgZ4VtdHNuIFvpQVAvOzZibl2= MXWyOFQ1Pjd{OB?=
human PBMC MUnGeY5kfGmxbjDhd5NigQ>? MXHBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGDCUWMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBidnSrLVPEN{1qdmS3Y3XkJGdONUOVRjDwdo9lfWO2aX;uJIFnfGW{IES4JIhzeyxiRVO1NF0xNjR5IH7N NVf5RlZLOjNzOUm0PFU>
HFF cells MmTmSpVv[3Srb36gZZN{[Xl? NFzjUHVCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gTWwyKHO2aX31cIF1\WRiSVy2JJBzd2S3Y4Tpc44hcW5iSF\GJINmdGy|IHL5JJRz[W6|cnXwdoV{e2mxbjDhd5NigSxiRVO1NF0xNjVibl2= NFjuVpMyPzZ7MkWxPS=>
human A549 cells MWTGeY5kfGmxbjDhd5NigQ>? NELsfVdC[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBqdiCqdX3hckBCPTR7IHPlcIx{KGG|c3Xzd4VlKGG|IHXm[oVkfCCxbjDHVmUheHKxbX;0[ZIhemW|cH;ud4Uh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDhd5NigSxiRVO1NF0yKG6P NGm1e5YyPjZ2M{C2NC=>
NHDFneo cells MoPRSpVv[3Srb36gZZN{[Xl? NGDEd5hC[3Srdnn0fUBifCCqdX3hckBIWiCneIDy[ZN{\WRiaX6gUmhFTm6nbzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKEmOLU[gdJJw\HWldHnvckwhUUN3ME2xMlQhdk1? MUixO|cxPTN4Mh?=
human HeLa cells NWizZZRvTnWwY4Tpc44h[XO|YYm= MV3UdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgZ49tdGGpZX7hd4UheHKxbX;0[ZIh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUGuOVghdk1? MWKyNFczPzd2Mx?=
human SW1353 cells MXTGeY5kfGmxbjDhd5NigQ>? M37ZTHRz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDTW|E{PTNiY3XscJMh[XO|ZYPz[YQh[XNicnXwdoV{e2mxbjDv[kBKVC1zLXnu[JVk\WRiTV3QMVE{KHC{b3T1Z5Rqd25iYX\0[ZIhOjRiaILzJIJ6KEWOSWPBMEBKSzVyPUGuPEBvVQ>? M1T2UVI2PzB4MUCw
rat polymorphonuclear leukocytes MkPmSpVv[3Srb36gZZN{[Xl? MkG5NlAhdWmwcx?= MkLmRY51cWmwZnzhcY1ifG:{eTDhZ5Rqfmm2eTDpckBz[XRicH;sfY1wenCqb371Z4xm[XJibHX1b49kgXSnczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1{fGmvdXzheIVlKG6rdILpZ{BwgGmmZTDwdo9lfWO2aX;uJIFnfGW{IEKwJI1qdnNiYomgS5Jq\XO|IH3leIhw\CxiSVO1NF0zNjNibl2= M4TyV|IzPTB4NkKw
human THP1 cells NED6U5FHfW6ldHnvckBie3OjeR?= M2fFR3Rz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVC16IIDyc4R2[3Srb36sJGlEPTB;Mj61NUBvVQ>? MkHzNlA4Ojd5NEO=
human NP1 cells NHvEXVlHfW6ldHnvckBie3OjeR?= NH;WNnBC\2:waYP0JIFkfGm4aYT5JIF1KEeUIHzp[4Fv\CCkaX7kbY5oKGSxbXHpckBmgHC{ZYPz[YQhcW5iaIXtZY4hVlBzIHPlcIx{KGG|c3Xzd4VlKGG|IHfseYNw[2:{dHnjc4llKHKnc4DvcpNmKGWuZX3lcpQhfHKjboPhZ5RqfmG2aX;uJIJ6KEeDTESgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVQvOiCwTR?= MmnGNVk{OjF|NEG=
human HeLa cells MkTySpVv[3Srb36gZZN{[Xl? M1XyeXRz[W6|YXP0bZZifGmxbjDv[kBIWi2OQlSg[ZhxemW|c3XkJIlvKGi3bXHuJGhmVGFiY3XscJMh[29vZYjwdoV{e2mwZzDHRWw1NUSERDDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:PC5{IH7N M4f4bVI1ODFzNkS0
human 13D3/Huh7 cells NHq3eVdHfW6ldHnvckBie3OjeR?= M{DHTFI1KGh? NYP5N3AzXHKjboPhZ5RqfmG2aX;uJIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJIlvKGi3bXHuJFE{TDNxSIXoO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmS3Y4Tpc44hd2ZidInyc5NqdmViYX3pco91emGwc3\ldoF{\SCjY4Tpeol1gSCjZoTldkAzPCCqcoOsJGVEPTB;NTDuUS=> M2m2NVIyODd|MUmw
rat R1 cells MYHGeY5kfGmxbjDhd5NigQ>? M2HqdFExKM7:TR?= M1j3bFI1KGh? MYTJcohq[mm2aX;uJI9nKGeudXPvZ49zfGmlb3nkJJJm[2WydH;yMYdtfWOxY3;yeIlkd2mmIHPvcZBt\XhidILhcpNn\WO2ZXSgbY4hemG2IGKxJINmdGy|IHHzd4V{e2WmIHHzJIRwf25vcnXneYxifGmxbjDv[kBVWEFvcnXzdI9ve2m4ZTDlcIVu\W62IIDyc4lv\myjbX3heI9zgSCpZX7lJIV5eHKnc4Ppc44h[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JIJmfGFvZ3HsZYN1d3OrZHHz[UBie3OjeTygTWM2OD13IH7N NXLvPVZOOTh2MUKzPVc>
human RPMI8226 cells NIfZWIlRem:uaX\ldoF1cW:wIHHzd4F6 NGTzSWg1KGSjeYO= MoDWRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCUUF3JPFIzPiClZXzsd{Bi\nSncjC0JIRigXNuIFnDOVA:Pi53IH7N NHTZRpcyPzdyNUO2Ni=>
african green monkey COS7 cells NX:ye2p{TnWwY4Tpc44h[XO|YYm= M1X5cGFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDh[pJq[2GwIHfy[YVvKG2xbnvlfUBEV1N5IHPlcIx{KGOxLYTyZY5{\mWldHXkJJdqfGhiR3HsOE1NSkRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVcvOiCwTR?= M{SzfFE6QDZ|MEiz
human PBMC NXzBXopETnWwY4Tpc44h[XO|YYm= NH33fZEzPCCq MWDBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGDCUWMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRUEFvaX7keYNm\CCLRl7nZY1u[SCycn;keYN1cW:wIHHmeIVzKDJ2IHjydy=> Mmf4NlMyQTl2OEW=
human H13 cells MmLkSpVv[3Srb36gZZN{[Xl? M4fKPWlvcGmkaYTpc44hd2ZiZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUDF|IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yh\2y3Y3;jc5J1cWOxaXStbY5lfWOnZDDj[YxtKHC{b3zp[oVz[XSrb36gZYZ1\XJiMzDodpMh[nliW{PIYU11cHmvaXTpcoUhcW6lb4Lwc5JifGmxbjDhd5NigSxiRVO1NF06Njdibl2= M1yyc|I{OTl7NEi1
mouse RAW264.7 cells NW\SZ5ZLTnWwY4Tpc44h[XO|YYm= MUmxPEBp NWfDSFlFSW62aXnu[oxidW2jdH;yfUBi[3Srdnn0fUBqdiCvb4Xz[UBTSVd{NkSuO{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oIFzQV{1qdmS3Y3XkJHRPTi2jbIDoZUB{\WO{ZYTpc44h[W[2ZYKgNVghcHK|LDDJR|UxRTBwMEGg{txO MmfaNlE{PTN3NEO=
293 MSR cells MVHGeY5kfGmxbjDhd5NigQ>? Ml7zOlAhdWmwcx?= NV;2eGpITGm|cHzhZ4Vu\W62IH;mJHs{UF1vZHX4ZY1mfGijc3;u[UBpfW2jbjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCjbIDoZUBmgHC{ZYPz[YQhcW5iMkmzJG1UWiClZXzsd{Bi\nSncjC2NEBucW6|IHL5JJNkcW62aXzsZZRqd25iY3;1cpRqdmduIFXDOVA:OTJwNTDuUS=> MkL1NlMyQTl2OEW=
Sf9 cells MVTGeY5kfGmxbjDhd5NigQ>? MWLCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlZ49u[mmwYX70JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgZ4VtdHN? M{T3b|IxPzJ5N{Sz
RAW 264.7 cells MW\GeY5kfGmxbjDhd5NigQ>? MmXoNlQhcA>? NX64OmpLUW6qaXLpeIlwdiCxZjDpcpRmem[ncn;uJIdidW2jLYP0bY12dGG2ZXSgUm8heHKxZIXjeIlwdiCrbjDSRXchOjZ2LkegZ4VtdHNiYX\0[ZIhOjRiaILzMEBKSzVyPUCuNFIh|ryP Mn3INVc{PjdzMkS=
mouse J774A.1 cells Mle3SpVv[3Srb36gZZN{[Xl? M3nk[mlvcGmkaYTpc44hd2ZiTGDTMYlv\HWlZXSgWG5H[WyyaHGgdJJw\HWldHnvckBqdiCvb4Xz[UBLPzd2QT6xJINmdGy|LDDJR|UxRTR6IH7N M{PrdVE4QDl{OUSx
human HepG2 cells MlmzSpVv[3Srb36gZZN{[Xl? Mk\NNlQhcA>? NHPkOXhC[3SrdnH0bY9vKG:oIILheEBRYFJiZYjwdoV{e2WmIHnuJIh2dWGwIFjldGczKGOnbHzzJIFnfGW{IEK0JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYnHz[YQhdHWvaX7ld4NmdnRiYX7hcJl{cXNuIFXDOVA:Oi54IN88US=> MkXENlA6PjZyNEO=
human U2OS cells M{L6dmZ2dmO2aX;uJIF{e2G7 M1;1[FE5KGh? NUjCUZJ7SWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1NSkRiaX6gbJVu[W5iVULPV{Bk\WyuczD0doFve2[nY4Tl[EB4cXSqIFfhcFQuTEKGIHHzd4V{e2WmIHHzJIlv[3KnYYPlJI9nKHS{YX7zZYN1cX[jdHnvckBi[3Srdnn0fUBi\nSncjCxPEBpenNiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVE2Njh2OEmg{txO M3y4dVIxQDF{Nkix
mouse thymocytes NFvxPZJHfW6ldHnvckBie3OjeR?= NHPhTFUyKM7:TR?= M{fUW|I1KGh? MoHGTY5lfWO2aX;uJI9nKGGyb4D0c5NqeyCrbjDtc5V{\SC2aIntc4N6fGW|IHHzd4V{e2WmIHHzJIlvfGW{boXjcIVwe2:vYXygSG5CKG[{YXft[Y51[XSrb36gZZQhOSC3TTDh[pRmeiB{NDDodpMh[nliYXfhdo9{\SCpZXyg[Yxm[3S{b4Doc5Jme2m| MXGyOFc6PDd2OB?=
human HMC1 cells MVLGeY5kfGmxbjDhd5NigQ>? NHvuS28yKGh? NYHub5ZQdW23bn;tc4R2dGG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJGhOSzFiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBxcG:{Yn;sJFEzNW27cnnzeIF1\SBzMz3hZ4V1[XSnL1GyN|E5Py2|dHnteYxifGWmIFnMNU1j\XSjIIPlZ5JmfGmxbjD0doVifGWmIEGgbJIheHKrb4KgeI8hOzBibXnud{BxcG:{Yn;sJFEzNW27cnnzeIF1\SBzMz3hZ4V1[XSnL1GyN|E5PyClaHHscIVv\2ViYomgW4V{fGW{bjDicI91fGmwZzDhcoFtgXOrcx?= M1zUd|IyOzB{OU[3
human monocytes NXKxOIdITnWwY4Tpc44h[XO|YYm= Ml[5OUDPxE1? NITRUnczOCCq M{LTPGFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gcY9vd2O7dHXzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gUHBUNWmwZIXj[YQhS0:[MjDlfJBz\XO|aX;uJIF1KDVidV2gZYZ1\XJiMkCgbJJ{KHW|aX7nJJJi[mKrdDDwc4x6[2yxbnHsJIFvfGmkb3T5JGloTyCkeTDTSHMuWEGJRTDhcoFtgXOrcx?= MUiyNVg1Ozl|NR?=
COS7 cells MmjpSpVv[3Srb36gZZN{[Xl? NF3EUXEyKM7:TR?= NVPTPWJQSWexbnnzeEBi[3Srdnn0fUBifCCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBSPTdyQTDteZRidnRiaX6gR29UPyClZXzsd{BifCBzIIXNJIJ6KE6ILXvhdJBiSi2udXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYm= NYPWVYhMOThyM{i5O|A>
human MDA-kb2 cells MmLTSpVv[3Srb36gZZN{[Xl? NXPiXXA5SWexbnnzeEBi[3Srdnn0fUBifCCjbnTyc4dmdiC{ZXPldJRweiCrbjDoeY1idiCPRFGtb4IzKGOnbHzzJIF{e2W|c3XkJIF{KHO2aX31cIF1cW:wIH;mJIx2[2moZYLhd4Uh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 MkXRNVk2QTJ{NEW=
human HeLaS3 cells MlnkSpVv[3Srb36gZZN{[Xl? NGX0ZZkzKGh? NUT1WIhwTGm|cHzhZ4Vu\W62IH;mJHs{UF2GZYjhcYV1cGG|b37lJIZzd21iZ3z1Z49kd3K2aXPvbYQhemWlZYD0c5IhcW5iaIXtZY4hUGWOYWOzJINmdGy|IHHmeIVzKDJiaILz NUPQXIFiOjN2MEOwPFI>

... Click to View More Cell Line Experimental Data

In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents individually and in order:
5% DMSO+45% PEG 300+H2O
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01236586 Withdrawn Lymphoma|Brain Neoplasms|Sarcoma|Osteosarcoma|Wilms Tumor National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 8, 2010 Phase 1
NCT03040011 Not yet recruiting Pelvic Organ Prolapse|Surgery|Postoperative Pain University of Pittsburgh|Magee-Womens Research Institute March 6, 2017 Phase 1|Phase 2
NCT01553214 Recruiting Blood Donor|Leukocyte Transfusion|Granulocyte Colony-Stimulation Factor|Blood Component Removal National Institutes of Health Clinical Center (CC) March 6, 2012 Phase 1
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID