Dexamethasone (DHAP)

Catalog No.S1322

Dexamethasone (DHAP) Chemical Structure

Molecular Weight(MW): 392.46

Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.

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In DMSO USD 130 In stock
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  • Dexamethasone and largazole cooperate to suppress invasion and to restore E-cadherin localization to the cell peripher y. ( a) Phase contrast micrographs showing morphological changes in MDA-MB-231 cells induced by E-cadherin expression combined with 100 nM dexamethasone and 10 nM largazole treatments. Insets show the cells at higher magnification. (b ) Fluorescence (E-Cad-GFP) or immunofluorescence microscopy (g -catenin (g-Cat.)) of 231/E-Cad-GFP cells treated for 72 h with vehicle (Control), 100 n M dexamethasone, 10 nM largazole or 100 nM dexamethasone + 10 nM largazole (Dex. + Larg.). (c ) Invasion assays were per formed with the indicated cell lines treated for 72 h with or without 100 nM dexamethasone + 10 nM largazole using modified Boyden chambers impregnated with matrigel. The results are presented as the average number of cells that invaded through the membrane per field s.d. of five randomly chosen fields, and are representative of three independently per formed experiments.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

    (d) BT549 cells were treated and analyzed by immunofluorescence microscopy as in Figure b. (e) BT549 cells were treated as described in Figure b and analyzed for invasion as in Figure 3c. (f) Quantitation of junctional E-cadherin staining of the indicated cell lines treated with DMSO vehicle or Dex.+ Larg. as described in Figure b. Results are presented as the mean of analyses of three different fields of cells for each sample±s.d. Statistical significance was assessed using Student’s t -test.

    Oncogene 2013 32, 1316-29. Dexamethasone (DHAP) purchased from Selleck.

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Choose Selective IL Receptor Inhibitors

Biological Activity

Description Dexamethasone (DHAP) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
Targets
interleukin receptor [1]
(Cell-free assay)
In vitro

Dexamethasone results in decrease in transmonolayer paracellular permeability mainly to sucrose, fluorescein and dextrans of up to 20 KDa in an immortalised rat brain endothelial cell line (GPNT). Dexamethasone results in filamentous actin and the cytoskeleton associated protein cortactin being highly concentrated in the regions of cell-cell contact with few F-actin stress fibres visible within the cytoplasm in cultured rat brain endothelial cells, an observation consistent with a more differentiated barrier phenotype induced by dexamethasone. Dexamethasone treatment has been shown to strongly stimulate the level of the Id-1 protein, which is a serum-inducible helix-loop-helix transcriptional repressor, involved in cell differentiation, and this effect was shown to be associated with reorganisation of ZO-1 to the cell periphery in Con8 mammary epithelial tumor cells. Dexamethasone prevents cytokine-induced enhanced expression of MMP-9 and alterations in the expression of ZO-1 in untreated GPNT monolayers. [1] Dexamethasone depletes both basal and TNF-alpha-stimulated GSH levels by down-regulating the gamma-GCS-heavy subunit transcription via a mechanism involving AP-1 (c-Jun) in alveolar epithelial cells. Dexamethasone decreases both basal and stimulated GSH levels (TNF-α-treated) in alveolar epithelial cells (A549), without any change in GSSG. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CV1 cells MknZSpVv[3Srb36gZZN{[Xl? M1ziWGFkfGm4aYT5JIF1KGi3bXHuJIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBEXjFiY3XscJMh[XO|ZYPz[YQh[XNicnXwdoV{e2mxbjDv[kBVVkZiYX7kJGlNNTFvYnX0ZU1qdmS3Y3XkJGUue2WuZXP0bY4h\2WwZTDlfJBz\XO|aX;uJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWQ2OD1yLkGgcm0> M13oOlE5ODN{NkGw
HEK293 cells Ml;SSpVv[3Srb36gZZN{[Xl? NVXRPYxxTGm|cHzhZ4Vu\W62IH;mJHs{UF1vYXzkc5N1\XKxbnWg[pJwdSCqdX3hckBucW6ncnHsc4NwenSrY3;p[EBz\WOncITvdkBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzMEBMcT1yLkO2JI5O MmHyNlQ1PDZ5Mki=
human PBMC MWHGeY5kfGmxbjDhd5NigQ>? NHf4UXlCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJHBDVUNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCjboTpMWNFOy2rbnT1Z4VlKEePLVPTSkBxem:mdXP0bY9vKGGodHXyJFQ5KGi{czygSWM2OD1yLkS3JI5O NYfyOVNEOjNzOUm0PFU>
HFF cells NXqzU2ZqTnWwY4Tpc44h[XO|YYm= M{HtdWFvfGmrbn\sZY1u[XSxcomgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDJUFEhe3SrbYXsZZRm\CCLTE[gdJJw\HWldHnvckBqdiCKRl[gZ4VtdHNiYomgeJJidnO{ZYDy[ZN{cW:wIHHzd4F6NCCHQ{WwQVAvPSCwTR?= MmWzNVc3QTJ3MUm=
human A549 cells NXjNNWVnTnWwY4Tpc44h[XO|YYm= MVzBZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDBOVQ6KGOnbHzzJIF{e2W|c3XkJIF{KGWoZnXjeEBwdiCJUlWgdJJwdW:2ZYKgdoV{eG:wc3WgZpkhdHWlaX\ldoF{\SC{ZYDvdpRmeiCjc4PhfUwhTUN3ME2xJI5O NFq3[2syPjZ2M{C2NC=>
NHDFneo cells M3S1b2Z2dmO2aX;uJIF{e2G7 MXjBZ5Rqfmm2eTDheEBpfW2jbjDHVkBmgHC{ZYPz[YQhcW5iTljESo5mdyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGlNNTZicILv[JVkfGmxbjygTWM2OD1zLkSgcm0> NWnHV|dMOTd5MEWzOlI>
human HeLa cells M1;zRWZ2dmO2aX;uJIF{e2G7 MVfUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JvbXXkbYF1\WRiYX70bYlv\myjbX3heI9zgSCjY4Tpeol1gSCrbjDoeY1idiCKZVzhJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiVGDBMYlv\HWlZXSgZ49tdGGpZX7hd4UheHKxbX;0[ZIh[WO2aY\peJkh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBKSzVyPUGuOVghdk1? NFLRdYkzODd{N{e0Ny=>
human SW1353 cells NX33O3kyTnWwY4Tpc44h[XO|YYm= MXjUdoFve3KncILld5Nqd25iYXP0bZZqfHliYYSg[4x2[2:lb4L0bYNwcWRicnXj[ZB1d3JiaX6gbJVu[W5iU2exN|U{KGOnbHzzJIF{e2W|c3XkJIF{KHKncILld5Nqd25ib3[gTWwuOS2rbnT1Z4VlKE2PUD2xN{Bxem:mdXP0bY9vKGGodHXyJFI1KGi{czDifUBGVEmVQTygTWM2OD1zLkigcm0> MWWyOVcxPjFyMB?=
rat polymorphonuclear leukocytes NGe4RlJHfW6ldHnvckBie3OjeR?= MYKyNEBucW6| MUjBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJJJifCCyb3z5cY9zeGixboXjcIVieiCuZYXrc4N6fGW|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZiTGDTMZN1cW23bHH0[YQhdmm2cnnjJI95cWSnIIDyc4R2[3Srb36gZYZ1\XJiMkCgcYlveyCkeTDHdolme3NibXX0bI9lNCCLQ{WwQVIvOyCwTR?= NX\5NWRzOjJ3ME[2NlA>
human THP1 cells Mo[wSpVv[3Srb36gZZN{[Xl? M3nQNHRz[W6|cnXwdoV{e2mxbjDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcj3t[YRq[XSnZDDhcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGTIVFEh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDMVHMucW6mdXPl[EBKVC16IIDyc4R2[3Srb36sJGlEPTB;Mj61NUBvVQ>? NEfXWW0zODd{N{e0Ny=>
human NP1 cells M1yxeGZ2dmO2aX;uJIF{e2G7 M3vJcWFod26rc4SgZYN1cX[rdImgZZQhT1JibHnnZY5lKGKrbnTpcoch\G:vYXnuJIV5eHKnc4Pl[EBqdiCqdX3hckBPWDFiY3XscJMh[XO|ZYPz[YQh[XNiZ3z1Z49kd3K2aXPvbYQhemW|cH;ud4Uh\WynbXXueEB1emGwc3HjeIl3[XSrb36gZpkhT0GONDDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9OE4zKG6P NUH6XnYxOTl|MkGzOFE>
human HeLa cells NIfwWWdHfW6ldHnvckBie3OjeR?= MV;UdoFve2GldHn2ZZRqd25ib3[gS3IuVEKGIHX4dJJme3OnZDDpckBpfW2jbjDI[WxiKGOnbHzzJINwNWW6cILld5NqdmdiR1HMOE1FSkRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVQvOiCwTR?= NYPydFczOjRyMUG2OFQ>
human 13D3/Huh7 cells NEXEc2lHfW6ldHnvckBie3OjeR?= NIDBfIYzPCCq MoGyWJJidnOjY4TpeoF1cW:wIHHjeIl3cXS7IHH0JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHnuJIh2dWGwIEGzSFMwUHWqNzDj[YxteyCjc4Pld5Nm\CCjczDpcoR2[3Srb36gc4YhfHm{b4PpcoUh[W2rbn;0doFve2[ncnHz[UBi[3Srdnn0fUBi\nSncjCyOEBpenNuIFXDOVA:PSCwTR?= MonCNlExPzNzOUC=
rat R1 cells M3y3U2Z2dmO2aX;uJIF{e2G7 M1m3blExKM7:TR?= M1TR[FI1KGh? MoH5TY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[EBz\WOncITvdk1odHWlb3PvdpRq[2:rZDDjc41xdGW6IITyZY5{\mWldHXkJIlvKHKjdDDSNUBk\WyuczDhd5Nme3OnZDDhd{Bld3ewLYLl[5Vt[XSrb36gc4YhXFCDLYLld5BwdnOrdnWg[YxmdWWwdDDwdo9qdm[uYX3tZZRwenliZ3Xu[UBmgHC{ZYPzbY9vKGG2IEGwJJVOKGGodHXyJFI1KGi{czDifUBj\XSjLXfhcIFkfG:|aXThd4Uh[XO|YYmsJGlEPTB;NTDuUS=> NXnFT2Y3OTh2MUKzPVc>
human RPMI8226 cells M2G5WXBzd2yrZnXyZZRqd25iYYPzZZk> M3LF[VQh\GG7cx?= M4rwT2FvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iUmDNTVgzOjZiY3XscJMh[W[2ZYKgOEBl[Xm|LDDJR|UxRTZwNTDuUS=> MVyxO|cxPTN4Mh?=
african green monkey COS7 cells NILIXZVHfW6ldHnvckBie3OjeR?= MlzmRYdwdmm|dDDhZ5Rqfmm2eTDheEBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDsbYdidmRiYnnu[Ilv\yCmb33hbY4h\XiycnXzd4VlKGmwIHHmdolk[W5iZ4Ll[Y4hdW:wa3X5JGNQWzdiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJYXy0MWxDTCCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9O{4zKG6P NX34c|c2OTl6NkOwPFM>
human PBMC Mlf3SpVv[3Srb36gZZN{[Xl? MnfsNlQhcA>? MVTBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJIh2dWGwIGDCUWMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBRUEFvaX7keYNm\CCLRl7nZY1u[SCycn;keYN1cW:wIHHmeIVzKDJ2IHjydy=> NWTDRo5XOjNzOUm0PFU>
human H13 cells M{jVO2Z2dmO2aX;uJIF{e2G7 NUHsU|ZDUW6qaXLpeIlwdiCxZjDncJVkd2OxcoTpZ49q\CC{ZXPldJRweiCrbjDoeY1idiCKMUOgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iCpbIXjc4NwenSrY3;p[E1qdmS3Y3XkJINmdGxicILvcIln\XKjdHnvckBi\nSncjCzJIhzeyCkeTDbN2heNXSqeX3p[Ilv\SCrbnPvdpBwemG2aX;uJIF{e2G7LDDFR|UxRTlwNzDuUS=> MkiwNlMyQTl2OEW=
mouse RAW264.7 cells NUXMXo43TnWwY4Tpc44h[XO|YYm= MomxNVghcA>? MVTBcpRqcW6obHHtcYF1d3K7IHHjeIl3cXS7IHnuJI1wfXOnIGLBW|I3PC55IHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhVFCVLXnu[JVk\WRiVF7GMYFteGijIIPlZ5JmfGmxbjDh[pRmeiBzODDodpMtKEmFNUC9NE4xOSEQvF2= M1Pme|IyOzV|NUSz
293 MSR cells MV7GeY5kfGmxbjDhd5NigQ>? NH\1fXI3OCCvaX7z MmTNSIl{eGyjY3Xt[Y51KG:oIGuzTH0u\GW6YX3leIhie2:wZTDoeY1idiCpbIXjc4NwenSrY3;p[EBz\WOncITvdkBidHCqYTDlfJBz\XO|ZXSgbY4hOjl|IF3TVkBk\WyuczDh[pRmeiB4MDDtbY5{KGK7IIPjbY51cWyuYYTpc44h[2:3boTpcoctKEWFNUC9NVIvPSCwTR?= MWSyN|E6QTR6NR?=
Sf9 cells NYLCTlluTnWwY4Tpc44h[XO|YYm= MXTCbY5lcW6pIHHm[olvcXS7IITvJIh2dWGwIILlZ49u[mmwYX70JIdtfWOxY3;yeIlkd2mmIILlZ4VxfG:{IHX4dJJme3OnZDDpckBj[WO3bH;2bZJ2eyCrbn\lZ5Rm\CCVZkmgZ4VtdHN? Mo\2NlA4Ojd5NEO=
RAW 264.7 cells MoP1SpVv[3Srb36gZZN{[Xl? M1j4UVI1KGh? Mn3HTY5pcWKrdHnvckBw\iCrboTldoZmem:wIHfhcY1iNXO2aX31cIF1\WRiTl:gdJJw\HWldHnvckBqdiCUQWegNlY1NjdiY3XscJMh[W[2ZYKgNlQhcHK|LDDJR|UxRTBwMEKg{txO NXHadVNjOTd|NkexNlQ>
mouse J774A.1 cells MoCwSpVv[3Srb36gZZN{[Xl? MmfoTY5pcWKrdHnvckBw\iCOUGOtbY5lfWOnZDDUUmZidHCqYTDwdo9lfWO2aX;uJIlvKG2xdYPlJGo4PzSDLkGgZ4VtdHNuIFnDOVA:PDhibl2= NELWWnQyPzh7Mkm0NS=>
human HepG2 cells MXzGeY5kfGmxbjDhd5NigQ>? Ml:4NlQhcA>? M2nqSmFkfGm4YYTpc44hd2ZicnH0JHBZWiCneIDy[ZN{\WRiaX6gbJVu[W5iSHXwS|Ih[2WubIOgZYZ1\XJiMkSgbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCkYYPl[EBtfW2rbnXzZ4VvfCCjbnHsfZNqeyxiRVO1NF0zNjZizszN M1H6eVIxQTZ4MESz
human U2OS cells NUXJeVRvTnWwY4Tpc44h[XO|YYm= M1HsblE5KGh? M1XNfmFod26rc4SgZYN1cX[rdImgZZQh\2y3Y3;jc5J1cWOxaXSgdoVk\XC2b4KtUGJFKGmwIHj1cYFvKFV{T2OgZ4VtdHNidILhcpNn\WO2ZXSge4l1cCCJYXy0MWRDTCCjc4Pld5Nm\CCjczDpcoNz\WG|ZTDv[kB1emGwc3HjeIl3[XSrb36gZYN1cX[rdImgZYZ1\XJiMUigbJJ{KGK7IHz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2xOU45PDh7IN88US=> MWeyNFgyOjZ6MR?=
mouse thymocytes MWnGeY5kfGmxbjDhd5NigQ>? MnfYNUDPxE1? M2PuVVI1KGh? M3XjcWlv\HWldHnvckBw\iCjcH;weI9{cXNiaX6gcY92e2VidHj5cY9kgXSnczDhd5Nme3OnZDDhd{BqdnSncn71Z4xmd3OxbXHsJGRPSSCocnHncYVvfGG2aX;uJIF1KDFidV2gZYZ1\XJiMkSgbJJ{KGK7IHHnZZJwe2ViZ3XsJIVt\WO2cn;wbI9z\XOrcx?= NUfZO3h1OjR5OUS3OFg>
human HMC1 cells M{XWR2Z2dmO2aX;uJIF{e2G7 NYrXdnNvOSCq NEjOdopudXWwb33v[JVt[XSxcomgZYN1cX[rdImgbY4hcHWvYX6gTG1EOSClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJBpd3Kkb3ygNVIudXm{aYP0ZZRmKDF|LXHj[ZRifGVxQUKzNVg4NXO2aX31cIF1\WRiSVyxMYJmfGFic3XjdoV1cW:wIITy[YF1\WRiMTDodkBxemmxcjD0c{A{OCCvaX7zJJBpd3Kkb3ygNVIudXm{aYP0ZZRmKDF|LXHj[ZRifGVxQUKzNVg4KGOqYXzs[Y5o\SCkeTDX[ZN1\XKwIHLsc5R1cW6pIHHuZYx6e2m| Mk[zNlE{ODJ7Nke=
human monocytes NGK0OVVHfW6ldHnvckBie3OjeR?= MlfOOUDPxE1? NWH2ZmM3OjBiaB?= NEexPYhCdnSraX7mcIFudWG2b4L5JIFkfGm4aYT5JIlvKGi3bXHuJI1wdm:leYTld{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJGxRWy2rbnT1Z4VlKEORWEKg[ZhxemW|c3nvckBifCB3IIXNJIFnfGW{IEKwJIhzeyC3c3nu[{Bz[WKkaYSgdI9tgWOub37hcEBidnSrYn;kfUBK\0diYomgV2RUNVCDR1WgZY5idHm|aYO= MlnsNlE5PDN7M{W=
COS7 cells NHHpfJpHfW6ldHnvckBie3OjeR?= M4PLUVEh|ryP NF7q[JBC\2:waYP0JIFkfGm4aYT5JIF1KGeudXPvZ49zfGmlb3nkJJJm[2WydH;yJHE2PzCDIH31eIFvfCCrbjDDU3M4KGOnbHzzJIF1KDFidV2gZpkhVkZva3HwdIFDNWy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeR?= MV2xPFA{QDl5MB?=
human MDA-kb2 cells MWHGeY5kfGmxbjDhd5NigQ>? NH;ZeYdC\2:waYP0JIFkfGm4aYT5JIF1KGGwZILv[4VvKHKnY3XweI9zKGmwIHj1cYFvKE2GQT3rZlIh[2WubIOgZZN{\XO|ZXSgZZMhe3SrbYXsZZRqd25ib3[gcJVkcW[ncnHz[UBi[3Srdnn0fUBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYm= MYmxPVU6OjJ2NR?=
human HeLaS3 cells Mni1SpVv[3Srb36gZZN{[Xl? MlLrNkBp MYnEbZNxdGGlZX3lcpQhd2ZiW{PIYWRmgGGvZYToZZNwdmViZoLvcUBodHWlb3PvdpRq[2:rZDDy[YNmeHSxcjDpckBpfW2jbjDI[WxiWzNiY3XscJMh[W[2ZYKgNkBpenN? NWSxOWhIOjN2MEOwPFI>

... Click to View More Cell Line Experimental Data

In vivo Dexamethasone is administered i.m. to pregnant ewes, leads to the following results (1) blood pressure is unchanged; (2) as previously reported in the fetus, sensitivity to endothelin-1 (ET) is increased; (3) acetylcholine-induced relaxation is increased; (4) L-NAME suppressible vasodilatory response to ET is abolished; (5) there is no change in endothelium-independent vasodilatation; and (6) there is no change in eNOS RNA and protein levels, when compared to saline treated controls. [3]

Protocol

Solubility (25°C)

In vitro DMSO 79 mg/mL (201.29 mM)
Ethanol 6 mg/mL (15.28 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
5% DMSO+45% PEG 300+H2O
For best results, use promptly after mixing.
13mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 392.46
Formula

C22H29FO5

CAS No. 50-02-2
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01236586 Withdrawn Lymphoma|Brain Neoplasms|Sarcoma|Osteosarcoma|Wilms Tumor National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) October 8, 2010 Phase 1
NCT03040011 Not yet recruiting Pelvic Organ Prolapse|Surgery|Postoperative Pain University of Pittsburgh|Magee-Womens Research Institute March 6, 2017 Phase 1|Phase 2
NCT01553214 Recruiting Blood Donor|Leukocyte Transfusion|Granulocyte Colony-Stimulation Factor|Blood Component Removal National Institutes of Health Clinical Center (CC) March 6, 2012 Phase 1
NCT02802163 Not yet recruiting Multiple Myeloma H. Lee Moffitt Cancer Center and Research Institute|Novartis|Amgen April 30, 2017 Phase 1|Phase 2
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NCT01660997 Withdrawn Multiple Myeloma National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) July 30, 2012 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Frequently Asked Questions

  • Question 1:

    I'm loonkig for Dexamethasone to use in cell culture, would it be better to use the Dexamethasone S1322, the sodiume phosphate S4028 or the acetate S3124?

  • Answer:

    S1322 is the free base form of Dexamethasone, S4028 is the sodium phosphate form and S3124 is the acetate salt. All of them have similar biological activity in tissue culture, however, their suitabilities vary in different solvents. As free base, S1322 has high solubility in DMSO (79mg/ml), poor solubility in water (<1mg/ml), and moderate solubility in ethanol (6mg/ml). As sodium phosphate salt, S4028 has high solubility in water (103mg/ml) but is insoluble in DMSO and ethanol (<1mg/ml). The solubility of S3124 is 87mg/ml in DMSO, <1mg/ml in water, and 20mg/ml in ethanol. Selection can be made based on the customer's experimental setup.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID