Amiloride HCl

Catalog No.S1811 1 Product Citations

Amiloride HCl, a pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.

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In DMSO USD 130 In stock
USD 97 In stock
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Amiloride HCl  Chemical Structure

Amiloride HCl Chemical Structure
Molecular Weight: 266.09

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Amiloride HCl is available in the following compound libraries:

Product Information

Product Description

Biological Activity

Amiloride hydrochloride(Midamor), a pyrazine compound inhibit sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.
Body Surface Area (m2)
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from, updated on 2014-11-22)

NCT Number Recruitment Conditions Sponsor
Start Date Phases
NCT01879527 Recruiting Acute Autoimmune Optic Neuritis Medical University of Vienna March 2014 Phase 2
NCT01918488 Enrolling by invitation Diabetic Nephropathies|Hypertension University of Southern Denmark|Odense University Hospital  ...more University of Southern Denmark|Odense University Hospital|Region Southern Denmark|Ministry of Science, Innovation and Higher Education (Denmark)|Danish Heart Foundation October 2013 --
NCT01910259 Not yet recruiting Secondary Progressive Multiple Sclerosis University College, London|Medical Research Council|Natio  ...more University College, London|Medical Research Council|National Institute for Health Research, United Kingdom|MS Society|University of Edinburgh|Queen Mary University of London|Keele University|University of Sheffield|University of Leeds|University of Warwick October 2013 Phase 2
NCT01896661 Not yet recruiting Hypertension|Obstructive Sleep Apnea Hospital de Clinicas de Porto Alegre August 2013 Phase 3
NCT01804777 Terminated Proteinuria|Hypertension|Type II Diabetes University of New Mexico|Dialysis Clinic, Inc.|University  ...more University of New Mexico|Dialysis Clinic, Inc.|University of Pittsburgh March 2013 Phase 0

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Chemical Information

Download Amiloride HCl SDF
Molecular Weight (MW) 266.09


CAS No. 2016-88-8
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Solubility (25°C) * In vitro DMSO 53 mg/mL (199.18 mM)
Water 6 mg/mL (22.54 mM)
Ethanol 5 mg/mL (18.79 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 1-(3,5-diamino-2-chloropyrazine-6-carbonyl)guanidine hydrochloride

Research Area

Product Citations (1)

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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