Transferase

  • Compare Transferase Inhibitors
  • Research Area

Transferase Inhibitors (8)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S1453 Tipifarnib Tipifarnib (R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.
  • Clin Cancer Res, 2012, 18(13):3524-31
  • J Clin Endocrinol Metab, 2013, 98(6):2502-12
  • Transl Res, 2014, 10.1016/j.trsl.2014.06.005
S2797 Lonafarnib Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Phase 3.
  • Biores Open Access, 2014, 3(4):176-82
S2799 FK866 (APO866, Daporinad) FK866 (APO866, Daporinad) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM. Phase 1/2.
  • Mol Endocrinol, 2014, 28(3):395-405
S2821 RG108 RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes.
  • Biosensors and Bioelectronics, 2014, 10.1016/j.bios.2014.11.015
  • Lab Chip, 2014, 14(13):2354-62
S2674 A922500 A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.
S7192 PF-04620110 PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.
S7467 LB42708 LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.
S4021 Tolcapone Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.
Contact Us