DNA Methyltransferase

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DNA Methyltransferase Inhibitors (8)


Cat.No. Product Name Information Product Use Citation Customer Product Validation
S1200 Decitabine Decitabine is a potent inhibitor of DNA methylation, used to treat myelodysplastic syndrome (MDS).
  • J Immunol, 2015, 10.4049/jimmunol.1403196
  • Mol Cell Biol, 2014, 34(22):4143-64
  • Cell Cycle, 2015, 10.1080/15384101.2015.1044174
S1782 Azacitidine Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.
  • Epigenetics, 2015, 10.1080/15592294.2015.1039216
S2821 RG108 RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM in a cell-free assay, does not cause trapping of covalent enzymes.
  • Biosensors and Bioelectronics, 2014, 66:109-14
  • Lab Chip, 2014, 14(13):2354-62
S1774 Thioguanine Thioguanine, a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.
S7113 Zebularine Zebularine is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM in a cell-free assay.
S7276 SGI-1027 SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B in cell-free assays, respectively.
  • Lab Chip, 2014, 14(13):2354-62
S8056 Lomeguatrib Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
  • Mol Cancer Ther, 2015, 14(5):1236-46
S4294 Procainamide HCl Procainamide HCl is a sodium channel blocker, and also a DNA methyltransferase inhibitor, used in the treatment of cardiac arrhythmias.

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Cat.No. Product Name Solubility (25°C)
Water DMSO Ethanol
S1200 Decitabine 10 mg/mL 45 mg/mL <1 mg/mL
S1782 Azacitidine <1 mg/mL 48 mg/mL <1 mg/mL
S2821 RG108 <1 mg/mL 67 mg/mL 67 mg/mL
S1774 Thioguanine <1 mg/mL <1 mg/mL <1 mg/mL
S7113 Zebularine 46 mg/mL 46 mg/mL <1 mg/mL
S7276 SGI-1027 <1 mg/mL 92 mg/mL <1 mg/mL
S8056 Lomeguatrib <1 mg/mL 65 mg/mL <1 mg/mL
S4294 Procainamide HCl 54 mg/mL 54 mg/mL 54 mg/mL
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