Thioguanine

Catalog No.S1774

Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

Price Stock Quantity  
USD 97 In stock
USD 170 In stock
Bulk Inquiry

Massive Discount Available

Free Overnight Delivery on all orders over $ 500.

Thioguanine Chemical Structure

Thioguanine Chemical Structure
Molecular Weight: 167.19

Validation & Quality Control

MSDS

Related Compound Libraries

Thioguanine is available in the following compound libraries:

Product Information

  • Compare DNA Methyltransferase Inhibitors
    Compare DNA Methyltransferase Products
  • Research Area

Product Description

Biological Activity

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn’s disease, rheumatoid arthritis) and organ transplant recipients. [1]

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

SpeciesBaboonDogMonkeyRabbitGuinea pigRatHamsterMouse
Weight (kg)121031.80.40.150.080.02
Body Surface Area (m2)0.60.50.240.150.050.0250.020.007
Km factor202012128653
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Rat dose (mg/kg) = mouse dose (22.4 mg/kg) ×  mouse Km(3)  = 11.2 mg/kg
rat Km(6)

Clinical Trial Information( data from http://clinicaltrials.gov, updated on 2014-12-20)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT02101853 Recruiting Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acut  ...more Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia National Cancer Institute (NCI) December 2014 Phase 3
NCT02101853 Recruiting Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acut  ...more Adult B Acute Lymphoblastic Leukemia|Childhood B Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia National Cancer Institute (NCI) December 2014 Phase 3
NCT02112916 Recruiting Adult T Acute Lymphoblastic Leukemia|Childhood T Acute Lymphoblastic Leukemia|Stage II Childhood Lymphoblastic Lymphoma|Stage II Contiguous Adult L  ...more Adult T Acute Lymphoblastic Leukemia|Childhood T Acute Lymphoblastic Leukemia|Stage II Childhood Lymphoblastic Lymphoma|Stage II Contiguous Adult Lymphoblastic Lymphoma|Stage II Non-Contiguous Adult Lymphoblastic Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia National Cancer Institute (NCI) September 2014 Phase 3
NCT02112916 Recruiting Adult T Acute Lymphoblastic Leukemia|Childhood T Acute Lymphoblastic Leukemia|Stage II Childhood Lymphoblastic Lymphoma|Stage II Contiguous Adult L  ...more Adult T Acute Lymphoblastic Leukemia|Childhood T Acute Lymphoblastic Leukemia|Stage II Childhood Lymphoblastic Lymphoma|Stage II Contiguous Adult Lymphoblastic Lymphoma|Stage II Non-Contiguous Adult Lymphoblastic Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia National Cancer Institute (NCI) September 2014 Phase 3
NCT02141100 Not yet recruiting Non-Hodgkin Lymphoma Kjeld Schmiegelow|Aalborg Universitetshospital |Aarhus U  ...more Kjeld Schmiegelow|Aalborg Universitetshospital |Aarhus University Hospital Skejby|Odense University Hospital|Rigshospitalet, Denmark July 2014 Phase 1|Phase 2

view more

Chemical Information

Download Thioguanine SDF
Molecular Weight (MW) 167.19
Formula

C5H5N5S

CAS No. 154-42-7
Storage 3 years -20℃Powder
6 months-80℃in solvent (DMSO, water, etc.)
Synonyms
Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name 2-​amino-​1,​9-​dihydro-6H-​purine-​6-​thione

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:2

If you have any other enquiries, please leave a message.

* Indicates a Required Field

Related DNA Methyltransferase Products

  • OTX015

    OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. Phase 1.

  • MM-102

    MM-102 is a high-affinity peptidomimetic MLL1 inhibitor with IC50 of 0.4 μM.

  • JIB-04

    JIB-04 is a pan-selective Jumonji histone demethylase inhibitor with IC50 of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

  • Decitabine

    Decitabine is a potent inhibitor of DNA methylation with IC50 of 438 nM and 4.38 nM in HL-60 and KG1a cells, respectively.

  • Azacitidine

    Azacitidine is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases.

  • RG108

    RG108 is an inhibitor of DNA methyltransferase with IC50 of 115 nM, does not cause trapping of covalent enzymes.

  • Lomeguatrib

    Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.

  • Zebularine

    Zebularine is a DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases, also inhibits cytidinedeaminase with Ki of 2 μM.

    Features:Very stable with half-life of ~44 h at 37°C in PBS at pH 1.0 and approx. 508 h at pH 7.

  • SGI-1027

    SGI-1027 is a DNMT inhibitor with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.

    Features:Potential for use in epigenetic cancer therapy.

  • (+)-JQ1

    (+)-JQ1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for BRD4(1/2), binding to all bromodomains of the BET family, but not to bromodomains outside the BET family.

    Features:(+)-JQ1 is more effective than (-)-JQ1.

Recently Viewed Items

Tags: buy Thioguanine | Thioguanine ic50 | Thioguanine price | Thioguanine cost | Thioguanine solubility dmso | Thioguanine purchase | Thioguanine manufacturer | Thioguanine research buy | Thioguanine order | Thioguanine mouse | Thioguanine chemical structure | Thioguanine mw | Thioguanine molecular weight | Thioguanine datasheet | Thioguanine supplier | Thioguanine in vitro | Thioguanine cell line | Thioguanine concentration | Thioguanine nmr
Contact Us