Thioguanine

Catalog No.S1774

Thioguanine is a purine antimetabolite widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients.

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Thioguanine Chemical Structure

Thioguanine Chemical Structure
Molecular Weight: 167.19

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Thioguanine is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn’s disease, rheumatoid arthritis) and organ transplant recipients. [1]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number Recruitment Conditions Sponsor
/Collaborators
Start Date Phases
NCT01406756 Recruiting B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|Cognitive/Functional Effects|Neurotoxicity|Pain|Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia|Therapy-related Toxicity|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia Children's Oncology Group|National Cancer Institute (NCI) 2012-02 Phase 3
NCT01451515 Recruiting Lymphoblastic Lymphoma St. Jude Children's Research Hospital|National University, Singapore 2012-05 Phase 2
NCT01770444 Recruiting Acute Chest Pain Seoul National University Hospital 2012-12
NCT02112916 Not yet recruiting Contiguous Stage II Adult Lymphoblastic Lymphoma|Noncontiguous Stage II Adult Lymphoblastic Lymphoma|Stage II Childhood Lymphoblastic Lymphoma|Stage III Adult Lymphoblastic Lymphoma|Stage III Childhood Lymphoblastic Lymphoma|Stage IV Adult Lymphoblastic Lymphoma|Stage IV Childhood Lymphoblastic Lymphoma|T-cell Adult Acute Lymphoblastic Leukemia|T-cell Childhood Acute Lymphoblastic Leukemia|Untreated Adult Acute Lymphoblastic Leukemia|Untreated Childhood Acute Lymphoblastic Leukemia National Cancer Institute (NCI) 2014-04 Phase 3
NCT02101853 Not yet recruiting B-cell Adult Acute Lymphoblastic Leukemia|B-cell Childhood Acute Lymphoblastic Leukemia|Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia|Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Childhood Acute Lymphoblastic Leukemia National Cancer Institute (NCI) 2014-04 Phase 3

Chemical Information

Download Thioguanine SDF
Molecular Weight (MW) 167.19
Formula

C5H5N5S

CAS No. 154-42-7
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Synonyms
Solubility (25°C) * In vitro DMSO <1 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name

Research Area

Tech Support & FAQs

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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