Home Endocrinology & Hormones Adrenergic Receptor

Adrenergic Receptor Agonists

Cat.No. Product Name Information Product Use Citations Product Validations
S4009 Mirabegron Mirabegron (YM 178) is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.
Biomed Pharmacother, 2025, 183:117816
iScience, 2024, 27(10):110862
J Pers Med, 2022, 12(2)258
S2521 Epinephrine bitartrate Epinephrine bitartrate (Adrenalinium) is an alpha- and beta-adrenergic receptor stimulator.
iScience, 2024, 27(10):110862
Sci Adv, 2024, 10(33):eado1533
Int J Biol Sci, 2023, 19(7):2006-2019
S2569 Phenylephrine HCl Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
J Am Heart Assoc, 2025, 14(1):e037400
NPJ Regen Med, 2023, 8(1):9
Front Immunol, 2022, 13:1090773
Verified customer review of Phenylephrine HCl
S2516 Xylazine HCl Xylazine(BAY 1470 hydrochloride) is an α2-Adrenergic receptor agonist, used as a sedative and muscle relaxant.
J Immunother Cancer, 2024, 12(11)e009805
Cell Death Dis, 2023, 14(5):318
Eur J Pharmacol, 2021, 911:174522
S2507 Salbutamol (Albuterol) Sulfate Salbutamol (Albuterol) Sulfate is a short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM.
Front Pharmacol, 2025, 16:1621775
Front Physiol, 2022, 13:800055
cell, 2020, 180(1):64-78.e16
Verified customer review of Salbutamol (Albuterol) Sulfate
S9507 (−)-Norepinephrine (−)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.This compound can be used to induce animal models of Cardiomyopathy.
Drug Des Devel Ther, 2025, 19:4585-4603
BMC Nephrol, 2025, 26(1):498
bioRxiv, 2025, 2025.03.30.646252
S7974 L755507 L-755,507 is characterized as a potent and selective β3 adrenergic receptor partial agonist with EC50 of 0.43 nM. It is also recently identified to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs) and other cell types.
Nucleic Acids Res, 2024, 52(22):13757-13774
Front Cell Dev Biol, 2023, 11:1276890
bioRxiv, 2023, 10.1101/2023.10.03.560773
S2566 Isoprenaline (Isoproterenol) HCl Isoprenaline (Isoproterenol) HCl is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
Stem Cell Res Ther, 2022, 13(1):287
BMC Cancer, 2022, 22(1):213
J Dairy Sci, 2022, 105-10:8426-8438
S2090 Dexmedetomidine HCl Dexmedetomidine HCl((+)-Medetomidine Hydrochloride) is a highly selective and potent alpha-2 adrenoceptor agonist, which reduces anesthetic requirements for patients by providing significant sedation.
Oral Dis, 2022, 10.1111/odi.14286
JHEP Rep, 2021, 3(4):100296
Sci Rep, 2021, 11(1):13345
S2458 Clonidine HCl Clonidine HCl(Kapvay) is a direct-acting α2 adrenergic agonist with an ED50 of 0.02±0.01 mg/kg.
J Control Release, 2025, 379:120-134
J Immunother Cancer, 2024, 12(11)e009805
Mol Pain, 2022, 18:17448069221107810
S5527 Salmeterol Salmeterol (Astmerole, GR-33343X, SN408D) is a long-acting beta2-adrenergic receptor agonist with Ki value of 1.5 nM for WT β2AR and shows very high selectivity for the WT β2AR(β1Ki/β2Ki ratio of approximately 1500).
Front Pharmacol, 2022, 13:865715
Mol Syst Biol, 2021, 17(8):e10239
Drug Test Anal, 2020, 10.1002/dta.2917
S5564 Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals.
Cell Death Dis, 2023, 14(5):318
Cell Death Differ, 2020, 10.1038
Mol Med Rep, 2017, 16(2):1911-1919
S5683 Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity.Isoproterenol sulfate dihydrate can be used to induce animal models of Angina Pectoris.
Stem Cell Res Ther, 2022, 13(1):287
Cell Biol Toxicol, 2021, 10.1007/s10565-021-09615-y
Biochim Biophys Acta Mol Cell Res, 2021, 1868(10):119080
S3727 Vilanterol Trifenate Vilanterol trifenatate (GW642444M) is a novel inhaled long-acting beta2 adrenoceptor agonist with inherent 24-hour activity for once daily treatment of COPD and asthma.
Biomed Pharmacother, 2025, 187:118100
Toxicol In Vitro, 2021, 77:105251
J Neuroimmunol, 2019, 332:37-48
S5654 Indacaterol Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
J Cell Mol Med, 2025, 29(1):e70335
Drug Test Anal, 2020, 10.1002/dta.2917
J Neuroimmunol, 2019, 332:37-48
S4065 Guanabenz Acetate Guanabenz Acetate (WY-8678) is an selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively.
Cell Stem Cell, 2020, 27(6):876-889.e12
Thyroid, 2019, 29(6):809-823
S3061 Epinephrine HCl Epinephrine HCl (Adrenaline) is a hormone and a neurotransmitter.
Cell Rep Methods, 2023, 3(10):100599
J Immunother Cancer, 2021, 9(1)e001466
S2092 Detomidine HCl Detomidine HCl(MPV 253AII) produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors.
J Immunother Cancer, 2024, 12(11)e009805
Nature, 2018, 560(7718):372-376
S4296 Salmeterol Xinafoate Salmeterol Xinafoate(GR 33343X xinafoate,Salmetedur) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
ACS Pharmacol Transl Sci, 2019, 2(3):148-154
Commun Biol, 2018, 1:106
S3960 Higenamine hydrochloride Higenamine (Norcoclaurine, (+-)-Demethylcoclaurine), also known as Norcoclaurine HCl, is a non-selective β2 adrenoceptor agonist which is a chemical compound naturally occurring in a number of plants.
Mol Cell Biochem, 2021, 10.1007/s11010-021-04197-z
Oncol Rep, 2021, 46(3)202
S4127 Terbutaline Sulfate Terbutaline Sulfate(Terbutaline hemisulfate) is a selective β2-adrenergic receptor agonist with IC50 of 53 nM.
BMC Pharmacol Toxicol, 2020, 21(1):61
Hum Reprod, 2016, 31(11):2506-2519
S5494 Salbutamol Salbutamol (Albuterol) is a short-acting, selective beta2-adrenergic receptor agonist used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases.
Front Physiol, 2022, 13:800055
BMC Pharmacol Toxicol, 2020, 21(1):61
S3083 Indacaterol Maleate Indacaterol (QAB149) is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.
J Allergy Clin Immunol, 2021, S0091-6749(21)00979-9
S3041 Droxidopa Droxidopa (L-DOPS) is a psychoactive drug and acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline).
bioRxiv, 2024, 2024.07.30.605812
S2522 L-Adrenaline L-Adrenaline (Epinephrine) belongs to a group of the compounds known as catecholamines.This compound can be used to induce animal models of Arrhythmias.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
J Immunother Cancer, 2024, 12(11)e009805
S3060 Medetomidine HCl Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
Micromachines, 2018, 9(6)
S1437 Tizanidine HCl Tizanidine HCl (DS 103-282) is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
Drug Metab Dispos, 2021, 49(8):638-647
S3294 Demethyl-Coclaurine Demethyl-Coclaurine (Higenamine, Norcoclaurine), the key component of the Chinese herb aconite root, is a beta-2 adrenergic receptor (β2-AR) agonist. This compound stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes.
Signal Transduct Target Ther, 2024, 9(1):243
S5537 Tizanidine Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
Drug Metab Dispos, 2021, 49(8):638-647
S5768 Fenoterol hydrobromide Fenoterol hydrobromide (Phenoterol) is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity.
Toxicol In Vitro, 2021, 77:105251
S4693 Guanfacine Hydrochloride Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.
J Immunother Cancer, 2024, 12(11)e009805
S5925 Olodaterol hydrochloride Olodaterol hydrochloride (BI-1744) is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist.
Front Pharmacol, 2025, 16:1621775
S5750 DL-Norepinephrine hydrochloride Norepinephrine (noradrenaline) is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors.
J Ethnopharmacol, 2025, 344:119517
S6487 fluticasone furoate Fluticasone furoate (GW685698) is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.
Front Pharmacol, 2025, 16:1621775
S3185 Adrenalone HCl Adrenalone is an adrenergic agonist used as a topical vasoconstrictor and hemostatic, mainly acts on alpha-1 adrenergic receptors.
J Immunother Cancer, 2024, 12(11)e009805
S2020 Formoterol Hemifumarate Formoterol Hemifumarate (Eformoterol, CGP 25827A, NSC 299587, YM 08316,Formoterol fumarate) is a potent, selective and long-acting β2-adrenoceptor agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD).
S2519 Naphazoline HCl Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.
S2533 Ritodrine HCl Ritodrine HCl (NSC 291565,DU 21220, Ritodrine) is a hydrochloride salt of ritodrine which is a β-2 adrenergic receptor agonist.
S2438 Synephrine HCl SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.
S2545 Scopine Scopine(6,7-Epoxytropine) is the metabolite of anisodine, which is a α1-adrenergic receptor agonist and used in the treatment of acute circulatory shock.
S2523 DL-Adrenaline DL-Adrenaline(dl-Epinephrine) is a hormone and a neurotransmitter secreted by the medulla of the adrenal glands.
S4266 Brimonidine Tartrate Brimonidine Tartrate(UK 1434 Tartrate) is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.
S2615 Noradrenaline bitartrate monohydrate Norepinephrine (Levarterenol; L-Noradrenaline) bitartrate monohydrate is a potent adrenergic receptor (AR) agonist that primarily targets α1, α2, and β1 adrenergic receptors, with Ki values of 330 nM for α1 and 56 nM for α2 receptors.
E4888 Guanabenz hydrochloride Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease.
E4825 Naphazoline (nitrate) Naphazoline (nitrate) is a agonist of peripheral α2-adrenergic receptor and used as a topical decongestant. It also acts as a vasoconstrictor that effectively reduces intraoperative bleeding and enhances postoperative analgesia. When used in conjunction with intranasal lidocaine, it significantly reduces both intra- and postoperative pain, thereby decreasing the need for rescue analgesics in the postoperative period following septorhinoplasty.
S5769 Fenoterol Fenoterol (Phenoterol) is a β2 adrenoreceptor agonist with bronchodilator activity.
S4135 Clorprenaline HCl Clorprenaline HCl (NSC 334693) is a β2-receptor agonist, it has a significant expansion of the bronchial effect.
S4043 Tetrahydrozoline HCl Tetrahydrozoline (Tetryzoline) HCl is an imidazoline derivative with alpha receptor agonist activity.
E7904 Ritodrine Ritodrine (DU21220) is a potent and selective agonist of β2-adrenergic. It rapidly inhibits recurrent uterine contractions and can be used in research to study the prevention of preterm labor and prolong pregnancy.
E4963 Clonidine Clonidine (Clonidin) is a direct-acting α2-adrenergic agonist. It is potentially used in the treatment of attention-deficit hyperactivity disorder (ADHD) in children and adolescents.
S5217 Arformoterol Tartrate Arformoterol Tartrate is the tartrate salt of arformoterol, a long-acting beta-2 adrenergic agonist with bronchodilator activity.
E8311New Isoprenaline Isoprenaline is a synthetic, non-selective agonist of beta-adrenergic receptor and is used for the treatment of bradycardia, heart block, and congestive heart failure.
S5734 Midodrine hydrochloride Midodrine hydrochloride is the hydrochloride salt form of midodrine, an adrenergic alpha-1 agonist used as a vasopressor.
S5735 Midodrine Midodrine belongs to the class of medications known as vasopressors. It is an adrenergic alpha-1 agonist.
S5727 Tetryzoline Tetryzoline (Tetrahydrozoline) is an alpha-adrenergic agonist used in some over-the-counter eye drops and nasal sprays.
S5954 L-(-)-α-Methyldopa hydrate L-(-)-α-Methyldopa (Methyldopa, MK-351) hydrate, a potent antihypertensive drug, is a selective agonist for α2-adrenergic receptors.
E4842 Vilanterol Vilanterol (GW642444) is a potent and selective agonist of β2-adrenoceptor (β2-AR) with pEC50 of β2-AR, β1-AR, and β3-AR is 10.37, 6.98 and 7.36 respectively in cAMP detection assays.
S2576 Xylometazoline HCl Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM.
S3640 Methoxyphenamine Hydrochloride Methoxyphenamine Hydrochloride (2-methoxy-N-methylamphetamine, OMMA) is a β-adrenergic receptor agonist of the amphetamine class used as a bronchodilator.
S1423 Dobutamine HCl Dobutamine(Dobutrex) hydrochloride is a selective potent agonist of β1-AR (β-1 adrenergic receptor) and exhibits weak activity at α1-AR and β2-AR. Dobutamine is a sympathomimetic compound that effectively restores blood pressure in hypotensive dogs and human patients by improving myocardial contractility and increasing cardiac output (CO).
S6583 Apraclonidine HCl Apraclonidine (Iopidine,ALO 2145) is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
S4485 Olodaterol Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/this compound) for treating patients with chronic obstructive pulmonary disease (COPD).
S5669 Isoxsuprine hydrochloride Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity.
E1049 CL316243 CL316243 is a highly potent and selective agonist of β3-adrenoceptor with an EC50 value of 3 nM, respectively but is an extremely poor to β1/2- receptors.It effectively stimulates adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate.
S6407 Tulobuterol hydrochloride Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities.
E6068New levosalbutamol hydrochloride levosalbutamol hydrochloride ((R)-Salbutamol hydrochloride, (R)-Salbutamol hydrochloride) is a short-acting agonist of the β2 adrenergic receptor used to treat asthma and chronic obstructive pulmonary disease (COPD). It is the active (R)-enantiomer of salbutamol.
E4892 Formoterol Formoterol is a highly selective and potent long-acting beta2-adrenergic agonist that functions by binding to and activating beta2-adrenergic receptors on the smooth muscle cells of the airways. It is used in the treatment of patients with chronic obstructive pulmonary disease (COPD).
E2944 Norepinephrine hydrochloride Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.
E4849 Terbutaline Terbutaline(Brican, Brethine), an active metabolite of bambuterol is an orally active agonist of β2-adrenergic receptor, that increases MKP-1 expression. This compound is used in the treatment of obstructive lung diseases as a bronchodilator remedy. It also exhibits anti-inflammatory effects.
S2083 Procaterol HCl Procaterol HCl (OPC-2009) is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma
E7406 Tulobuterol Tulobuterol (C-78 free base) is a long-acting and selective agonist of β2-adrenoceptor . It can be used as a transdermal patch, increases normal diaphragm muscle strength and aids in bronchial asthma treatment, and may protect against endotoxins in inhaled house dust.
E2964 Norepinephrine tartrate Norepinephrine tartrate is a potent agonist of adrenergic receptor (AR). Norepinephrine activates α1, α2, β1 receptors.
S4277 Bambuterol HCl Bambuterol HCl(Bambuterol hydrochloride,KWD-2183 hydrochloride) is a potent β-adrenoceptor agonist, used in the treatment of asthma.
E1746 Protokylol hydrochloride Protokylol hydrochloride(Caytine hydrochloride, JB-251 hydrochloride) is a salt form of protokylol and is an agonist of β-adrenergic receptor. This compound is also used as a bronchodilator.
S2362 Synephrine Synephrine (Oxedrine), a natural protoalkaloid in the extract of bitter orange and other citrus species, is commonly used for weight loss.
S9508 Brimonidine Brimonidine (Bromoxidine, UK 1430) is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure.
S5267 Nylidrin Hydrochloride Nylidrin Hydrochloride (Buphenine), a β-adrenergic agonist, is used therapeutically for its vasodilating effect on the peripheral circulation and possibly on the cerebral circulation as well.
S4481 Guanabenz Guanabenz (GBZ, GA, Wytensin, Wy-8678,BR-750) is an orally active central alpha 2-adrenoceptor (α2 adrenergic receptor) agonist with antihypertensive action.
S0032 Batefenterol  Batefenterol (GSK961081, TD-5959) is both a muscarinic receptor antagonist and a β2-adrenoceptor agonist with Ki of 1.4 nM, 1.3 nM and 3.7 nM for hM2, hM3 muscarinic receptors and hβ2-adrenoceptor, respectively.
S2304 Gramine Gramine (Donaxine) is a natural indole alkaloid isolated from giant reed, acts as an active adiponectin receptor (AdipoR) agonist, with IC50 of 3.2 µM and 4.2 µM for AdipoR2 and AdipoR1, respectively. This compound is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist.