Home Endocrinology & Hormones Adrenergic Receptor

Adrenergic Receptor Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S4076 Propranolol HCl Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selective beta-adrenergic receptors inhibitor.
Cell Res, 2024, 10.1038/s41422-024-00946-z
J Immunother Cancer, 2024, 12(11)e009805
Sci Rep, 2024, 14(1):4178
S1206 Bisoprolol fumarate Bisoprolol fumarate (EMD33512) is a selective type β1 adrenergic receptor blocker.
J Immunother Cancer, 2024, 12(11)e009805
J Pathol, 2022, 10.1002/path.6020
Front Nutr, 2022, 9:907986
S1324 Doxazosin Mesylate Doxazosin, a quinazoline-derivative, selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia.
J Physiol Sci, 2025, 75(2):100016
J Exp Clin Cancer Res, 2023, 10.1186/s13046-023-02866-z
J Ocul Pharmacol Ther, 2017, 33(1):50-56
Verified customer review of Doxazosin Mesylate
S5739 Nebivolol Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.
Int J Mol Sci, 2023, 24(11)9708
Front Pharmacol, 2022, 13:1049640
Front Pharmacol, 2021, 12:691998
S5703 Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
Res Pharm Sci, 2016, 11(5):419-427
Res Pharm Sci, 2015, 10(5):388-96
S5787 Dronedarone Dronedarone (SR33589) is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).
Korean Circ J, 2024, 54(4):172-186
Chem Res Toxicol, 2021, 10.1021/acs.chemrestox.1c00127
S2086 Ivabradine HCl Ivabradine HCl (S 16257-2,S-18982 D6 hydrochloride), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
Cell Rep, 2022, 38(10):110468
J Pain, 2018, 19(6):626-634
S2113 Cisatracurium Besylate Cisatracurium Besylate(51W89) is a nondepolarizing neuromuscular blocking agent, antagonizing the action of acetylcholine by inhibiting neuromuscular transmission.
Biosci Trends, 2021, 15(1):50-54
S5088 Labetalone hydrochloride Labetalone hydrochloride (Benzoic amide) is hydrochloride form of labetalone, a blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.
S6345 3-Nitro-L-tyrosine 3-Nitro-L-tyrosine (3-NT, N-Tyr, MNT), synthesized from L-tyrosine by peroxynitrite, is a product of nitric oxide and superoxide. This compound inhibits the hemodynamic responses to angiotensin II, possibly through the inhibition of alpha 1-adrenoceptor-mediated events.
S9470 Penbutolol Sulfate Penbutolol sulfate ((-)-Terbuclomine) is an effective beta-adrenergic receptor blocker and diuretic that is used as an antihypertensive agent.
E0949 Mebicar Mebicar, a derivative of bicyclic bis-ureas, inhibits the orientation reaction in albino mice, potentiates the action of narcotic hypnotics, abolishes the conditioned reflex reaction of avoidance, displays central adrenolytic activity, interferes with the norepinephrine metabolism in the brain stem.
S5496 Guanethidine Monosulfate Guanethidine monosulfate is an antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves.
S0896 DSP-4 HCl DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, which exclusively affects the noradrenergic fibers from the LC (locus coeruleus).
S5723 Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF).
S4113 Desvenlafaxine Desvenlafaxine (WY 45233 Succinate) is a serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor with Ki of 40.2 nM and 558.4 nM, respectively.
Am J Cancer Res, 2024, 14(3):1087-1100
Drug Metab Dispos, 2020, 48(10):1044-1052
S1642 Methyldopa Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
J Immunother Cancer, 2024, 12(11)e009805
S4112 Desvenlafaxine Succinate hydrate Desvenlafaxine Succinate hydrate (WY 45233) is a new serotonin (5-HT) transporter and norepinephrine (NE) transporter reuptake inhibitor with Ki of 40.2 nM and 558.4 nM respectively.
Drug Metab Dispos, 2020, 48(10):1044-1052
S3913 Pimethixene maleate Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7.30, 7.28, 7.61, 6.37, 8.19, 7.54, 10.14, 8.61 and 9.38, respectively.
S9560 Anisodamine Hydrobromide Anisodamine (6-Hydroxyhyoscyamine) is a naturally occurring atropine derivative and exhibits anti-inflammatory activity. It also inhibits α1-adrenergic receptors and muscarinic acetylcholine receptors (mAChRs).