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Dapagliflozin Chemical Structure
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Biological Activity
Dapagliflozin(BMS-512148) is a potent sodium-glucose transport proteins inhibitor with IC50 of 1.1 nM and 1.4 μM for SGLT2 and SGLT1, respectively. Dapagliflozin (BMS-512148) inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Symptoms of hypoglycaemia occurred in similar proportions of patients in the dapagliflozin (2~4%) and placebo groups (3%). Signs, symptoms, and other reports suggestive of genital infections were more frequent in the dapagliflozin groups (2•5 mg, [8%]; 5 mg, [13%]; 10 mg, [9%]) than in the placebo group ( [5%]). [1][2]
References on Dapagliflozin
- [1] Lancet 2010;375: 2223–2233
- [2] DMD 2010;38:405–414
Chemical Information
| Molecular Weight (WM): | 408.87 |
|---|---|
| Formula: | C21H25ClO6 |
| CAS No.: | 461432-26-8 |
| Synonyms: |
BMS-512148
|
| Dissolve in (25°C): | DMSO ≥82mg/mL |
| Water <1mg/mL | |
| Ethanol ≥82mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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