Pyrimethamine

Catalog No.S2006

Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM.

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In DMSO USD 130 In stock
USD 97 In stock
USD 310 In stock
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Pyrimethamine Chemical Structure

Pyrimethamine Chemical Structure
Molecular Weight: 248.71

Validation & Quality Control

Quality Control & MSDS

Related Compound Libraries

Pyrimethamine is available in the following compound libraries:

Product Information

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Product Description

Biological Activity

Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. It is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immune-compromised patients, such as HIV-positive individuals. It interferes with folic acid synthesis by inhibiting the enzyme dihydrofolate reductase (DHFR). Folic acid is needed for DNA and RNA synthesis in many species, including protozoa. [1]

Chemical Information

Download Pyrimethamine SDF
Molecular Weight (MW) 248.71
Formula

C12H13ClN4

CAS No. 58-14-0
Storage 3 years -20℃Powder
6 months-80℃in DMSO
Syonnyms Daraprim
Solubility (25°C) * In vitro DMSO 10 mg/mL (40 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Name

Preparing Stock Solutions

Stock Solution (1ml DMSO) 1mM 10mM 20mM 30mM
Mass(mg) 0.24871 2.4871 4.9742 7.4613

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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