Serine Protease Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
E7249	Ulinastatin	Ulinastatin (Uristatin) is the main inhibitor of a hydrolase protein and serine protease suppresses trypsin, chymotrypsin, and other pancreatic proteases. It can inhibit the production and release of inflammatory factors through mediating inflammatory pathways, while modulating apoptosis, enzyme activity, coagulation, and immune responses. It is effective in preventing and managing conditions like pancreatitis, cerebral edema, acute respiratory distress, circulatory failure, sepsis, and systemic inflammatory response syndrome.
S0042	Fulacimstat	Fulacimstat (BAY1142524) is an orally available inhibitor of chymase with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively.
S3511	FOY251	FOY251, an active metabolite of camostat mesilate, is an inhibitor of synthetic serine protease. This compound inhibits SARS-CoV-2 infection.
E1342	Sebetralstat	Sebetralstat(KVD900) is a plasma kallikrien inhibitor.
E6013	Sivelestat sodium	Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in COVID-19.
E1014	Upamostat (WX-671)	Upamostat (WX-671), a novel serine protease urokinase (uPA) inhibitor by inhibiting the urokinase-type plasminogen activator (uPA) system.
S0479	ZK824859	ZK824859 is a potent, selective and orally bioavailable inhibitor of urokinase plasminogen activator (uPA) with IC50 of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
S1811	Amiloride HCl	Amiloride HCl is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA)(Ki=7 μM).	J Extracell Vesicles, 2024, 13(4):e12426 Virus Res, 2024, 339:199258 J Clin Invest, 2023, 10.1172/JCI163402