AIM2

Other Immunology & Inflammation Related Inhibitors

CXCR AhR STING COX IL Receptor gp120/CD4 NOD NADPH-oxidase ROS Nrf2

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
E5801^New	NLRP3/AIM2-IN-3	NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis. It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 μM. It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC, effectively preventing ASC oligomerization and blocking inflammasome assembly.
E6574^New	NLRP3	NLRP3/aim2-in-2 (compound 8) is a novel potent inhibitor exhibiting species-specific effects on NLRP3 and AIM2 inflammasome-dependent cell death, with an IC₅₀ value of 0.2392 μM.