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Tuvusertib (M1774) ATR Inhibitor

Name: Tuvusertib (M1774)
Brand: Selleck Chemicals
SKU: E1411
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1411

Tuvusertib (M1774, ATR inhibitor 1) is a potent ATR inhibitor, which exhibits anti-proliferative and anti-tumor effects in cancer cell lines.

Chemical Structure

Molecular Weight: 370.32

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Quality Control

Batch: Purity: 99.70%

99.70

Related Targets	HDAC PARP DNA-PK WRN DNA/RNA Synthesis Topoisomerase PPAR Sirtuin Casein Kinase eIF
Other ATM/ATR Inhibitors	Ceralasertib (AZD6738) AZD1390 Berzosertib (VE-822) Lartesertib (M4076) Camonsertib (RP-3500) KU-60019 KU-55933 VE-821 AZ20 AZD0156

Q&A of Tuvusertib (M1774): Insights Rooted in Extensive Publications, Every Answer Cited

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Solubility in DMSO or Water

In vitro
Batch:

DMSO : 11 mg/mL (29.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 12 mg/mL (32.4 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

DMSO : 11 mg/mL (29.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

The solubility data above are all experimental results (not literature values).

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Search directly for a cell line, or select a cell line to find matched working concentrations

Mechanism of Action

Information	Tuvusertib (M1774) is a potent, highly selective, ATP-competitive ATR kinase inhibitor. It affects the DNA damage response (DDR) signaling pathway by blocking ATR-mediated Chk1 phosphorylation, effectively inhibiting DNA repair and promoting apoptosis in cancer cells.
Primary Applications and Mechanism of Action

Chemical Information, Storage & Stability

Molecular Weight	370.32	Formula	C₁₆H₁₂F₂N₈O	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1613200-51-3	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Tuvusertib (M1774) ATR Inhibitor

Molecular Weight: 370.32

Quality Control

Solubility in DMSO or Water

Molarity Calculator

In vivo Formulation Calculator (Clear solution)

Working Concentrations for Cell Culture Treatment

Search directly for a cell line, or select a cell line to find matched working concentrations

Mechanism of Action

Chemical Information, Storage & Stability

Tech Support