M4076

Catalog No.E1057

For research use only.

M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.

M4076 Chemical Structure

CAS No. 2495096-26-7

Purity & Quality Control

Choose Selective ATM/ATR Inhibitors

Other ATM/ATR Products

Biological Activity

Description M4076 inhibits Ataxia telangiectasia-mutated (ATM) kinase activity with a sub-nanomolar potency and shows remarkable selectivity against other protein kinases, suppresses DSB repair, clonogenic cancer cell growth, and potentiates antitumor activity of ionizing radiation in cancer cell lines.
Targets
ATM [1]
0.2 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 448.45
Formula

C23H21FN6O3

CAS No. 2495096-26-7
Storage 3 years -20°C powder
2 years -80°C in solvent

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04882917 Recruiting Drug: M4076 Advanced Solid Tumors EMD Serono Research & Development Institute Inc.|Merck KGaA Darmstadt Germany|EMD Serono May 24 2021 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-11-29)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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