CAS No. 1613200-51-3

Batch: Purity:99.70
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Tuvusertib (M1774) Chemical Structure
Chemical Structure
Check the Tuvusertib (M1774) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-6-fluoro-N-[5-fluoro-4-(3-methylimidazol-4-yl)-3-pyridinyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
CAS Number 1613200-51-3
Molecular Formula

C16H12F2N8O
Molecular Weight (MW) 370.32
InChIKey RBQPCTBFIPVIJN-UHFFFAOYSA-N

Ordering Information

Biological Activity

Tuvusertib (M1774) is a potent, selective, orally bioavailable inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. By suppressing the ATR/CHK1 signaling pathway, tuvusertib blocks DNA damage repair mechanisms triggered by replication stress. This disruption leads to unscheduled DNA replication, elevated genomic instability, and attenuated cancer cell viability, demonstrating robust anti-proliferative and anti-tumor activity in cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 11 mg/mL (29.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.