CAS No. 522650-83-5
Batch:
Purity:99.63
Chemical Structure
Check the
SW-044248
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(5-ethyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-N-(2-methoxyphenyl)butanamide | |
|---|---|---|
| CAS Number | 522650-83-5 | |
| Molecular Formula |
C22H23N5O2S |
|
| Molecular Weight (MW) | 421.52 | |
| SMILES | CCC(C(=O)NC1=CC=CC=C1OC)SC2=NC3=C(C4=CC=CC=C4N3CC)N=N2 | |
| InChIKey | PEVRGVRHMMZNGI-UHFFFAOYSA-N |
SW-044248 is a non-canonical topoisomerase I (Top1) inhibitor that exhibits selective cytotoxicity against non-small cell lung cancer (NSCLC) cells. By targeting Top1, it disrupts DNA replication and transcription integrity, inducing DNA damage pathways and promoting apoptotic cell death. This selective toxicity renders SW-044248 a useful chemical probe for dissecting Top1-dependent signaling mechanisms and targeted therapeutic strategies in NSCLC model systems. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
14 mg/mL
(33.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
84 mg/mL
(199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.