SW-044248

Catalog No.S6747 Batch:S674702

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Technical Data

Formula

C22H23N5O2S

Molecular Weight 421.52 CAS No. 522650-83-5
Solubility (25°C)* In vitro DMSO 84 mg/mL (199.27 mM)
Ethanol 4 mg/mL (9.48 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells.
Targets
Topo1 [1]
In vitro

SW044248 is selectively toxic for some NSCLC cell lines. SW044248 rapidly inhibits transcription, translation and DNA synthesis in sensitive cells but not insensitive cells. The acute transcriptional response to SW044248 correlates with the response to agents that cause DNA damage[1].

Protocol (from reference)

Cell Assay:

[1]

  • Cell lines

    NSCLC cell lines

  • Concentrations

    --

  • Incubation Time

    96 h

  • Method

    Cell viability assay

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.