Clinical Trials

Numerous clinical trials evaluate the biological role and pharmacologic modulation of serotonin across diverse conditions, including major depressive disorder, obsessive-compulsive disorder, eating disorders, coronary artery disease, ischemic stroke, and cocaine-related disorders. Spanning Phase 1 through Phase 4, these completed, active, terminated, and withdrawn studies are sponsored by academic institutions, hospital networks, and government entities such as the National Institute on Drug Abuse. Specific protocols include serotonin receptor modulation studies and PET imaging assessments of serotonin transporter dynamics.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07716982 NOT_YET_RECRUITING
Depression Disorder
Hôpital le Vinatier
 2026-09
NCT07189299 NOT_YET_RECRUITING
PMS; PMDD
Friederike Holze
 2025-10-01
NCT06704594 RECRUITING
Premenstrual Dysphoric Disorder (PMDD)
Johns Hopkins University
 2025-05-14 PHASE4
NCT07390981 NOT_YET_RECRUITING
Major Depressive Disorder
First People's Hospital of Hangzhou
 2026-03-01
NCT07651293 NOT_YET_RECRUITING
Depression - Major Depressive Disorder
Imperial College Healthcare NHS Trust
 2026-07-01
NCT06592833 RECRUITING
Major Depressive Disorder
Icahn School of Medicine at Mount Sinai
 2025-02-25 PHASE2
NCT07013331 RECRUITING
Epilepsy; Dravet Syndrome; Drug Resistant Epilepsy; Healthy Controls
Hospices Civils de Lyon
 2026-05-04
NCT04336228 ACTIVE_NOT_RECRUITING
Obsessive-Compulsive Disorder/High Compulsive Individuals; Healthy Individuals
Rigshospitalet, Denmark
 2020-04-01 PHASE4
NCT07359482 RECRUITING
Post-COVID; POST-Covid 19; Post-COVID Conditions
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2026-06-04 PHASE3
NCT05953038 ACTIVE_NOT_RECRUITING
Basic Science
Rigshospitalet, Denmark
 2023-11-08 EARLY_PHASE1
NCT07318181 RECRUITING
Post Traumatic Stress Disorder; Post Traumatic Stress Disorder PTSD; Post-Traumatic Stress Disorder, PTSD
University of Luxembourg
 2026-01-01
NCT07703722 RECRUITING
Major Depressive Disorder; Post-Traumatic Stress Disorder (PTSD)
Khyber Medical University Peshawar
 2026-04-01 PHASE3
NCT06225011 RECRUITING
Colorectal Adenocarcinoma
Jonsson Comprehensive Cancer Center
 2025-03-20 PHASE1
NCT04123314 RECRUITING
Depressive Symptoms; Depression; Alzheimer Disease; Mild Cognitive Impairment
Johns Hopkins University
 2021-03-24 EARLY_PHASE1
NCT05357612 RECRUITING
Neurodegenerative Diseases; Parkinson Disease; Parkinson Disease Psychosis
Vanderbilt University Medical Center
 2023-01-23 PHASE4
NCT06512220 RECRUITING
Treatment Resistant Depression
Centre for Addiction and Mental Health
 2025-04-21 PHASE2
NCT07602387 RECRUITING
Patients With Taxane-induced Chronic Neuropathic Pain
Hospital Ambroise Paré Paris
 2024-03-12
NCT07452341 NOT_YET_RECRUITING
Depression
Cairo University
 2026-08-01
NCT06545474 NOT_YET_RECRUITING
Major Depressive Disorder
University Hospital Tuebingen
 2024-09-15
NCT06559306 RECRUITING
Depressive Disorder, Major
Janssen Research & Development, LLC
 2024-07-25 PHASE3
NCT07067970 NOT_YET_RECRUITING
Premature Ejaculation
Medipol University
 2025-10-01
NCT07708428 NOT_YET_RECRUITING
Healthy Volunteers (HV)
LinGang Laboratory
 2026-07-24 PHASE1
NCT03228732 RECRUITING
Type 1 Diabetes Mellitus
University of Maryland, Baltimore
 2017-12-19 EARLY_PHASE1
NCT07153406 NOT_YET_RECRUITING
Depressive Disorder
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
 2025-09-15 PHASE3
NCT06008704 RECRUITING
Parkinson Disease
University Hospital, Toulouse
 2024-01-01
NCT05469165 RECRUITING
Ischemic Mitral Regurgitation
Laval University
 2023-06-20 PHASE2
NCT06796361 RECRUITING
Healthy
University Hospital, Basel, Switzerland
 2025-04-21 PHASE1
NCT07329621 TERMINATED
Healthy Volunteers
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2026-01-15 PHASE1
NCT04520178 RECRUITING
Spinal Cord Injuries
University of Alberta
 2020-07-01 PHASE2; PHASE3
NCT07017478 COMPLETED
LSD; Major Depressive Disorder; Depression
University of Chicago
 2025-06-09 EARLY_PHASE1
NCT07404813 ENROLLING_BY_INVITATION
Patient Engagement; Intensive Care (ICU); Family Members' Voices
Zeliha CENGİZ
 2025-02-20
NCT07057011 NOT_YET_RECRUITING
Premature Ejaculation
South Valley University
 2025-07-01
NCT06955845 COMPLETED
PTSD; PTSD - Post Traumatic Stress Disorder
Asad Ullah Jan
 2025-05-06
NCT05705830 UNKNOWN
Anxiety Disorder; Insomnia
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2022-11-01
NCT06081179 COMPLETED
Healthy
University of Zurich
 2023-10-24 PHASE1
NCT06363968 RECRUITING
PTSD; Posttraumatic Stress Disorder
VA Puget Sound Health Care System
 2024-02-12
NCT00285935 COMPLETED
Major Depressive Disorder
University of California, San Francisco
 2010-12-16
NCT05155280 TERMINATED
Anorexia Nervosa
Centre Hospitalier Universitaire de Saint Etienne
 2021-12-10
NCT06476509 COMPLETED
Major Depressive Disorder
Vigonvita Life Sciences
 2024-05-30 PHASE1
NCT06211140 UNKNOWN
Major Depressive Disorder
Xuanwu Hospital, Beijing
 2024-01-31
NCT03994965 WITHDRAWN
Schizophrenia; Psychosis
Bjorn H. Ebdrup
 2024-12-01 PHASE2
NCT04977271 WITHDRAWN
Depressive Disorder; Head and Neck Cancer
University of Alabama at Birmingham
 2024-01-05 PHASE4
NCT05651126 COMPLETED
Autism Spectrum Disorder
King's College London
 2022-12-12
NCT04597190 COMPLETED
PTSD
University of Washington
 2020-06-01 PHASE4
NCT05957094 UNKNOWN
Depression; Serotonin Deficiency
University of British Columbia
 2023-08
NCT06457581 UNKNOWN
Pain; Fibromyalgia
Superior University
 2023-11-01
NCT03222570 COMPLETED
Depressive Disorder
University of Minnesota
 2018-02-26 PHASE2
NCT06185361 UNKNOWN
Nocturnal Enuresis; Enuresis; Enuresis, Nocturnal
Fayoum University Hospital
 2022-12-01
NCT05175430 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2022-10-24 PHASE1
NCT04653337 UNKNOWN
Suicidal Ideation; Depression
Xijing Hospital
 2020-09-28 PHASE2
NCT05181527 COMPLETED
Major Depressive Disorder
All India Institute of Medical Sciences, Bhubaneswar
 2022-02-10 PHASE4
NCT04216329 ACTIVE_NOT_RECRUITING
Gliosarcoma; Newly Diagnosed; Glioblastoma
National Cancer Institute (NCI)
 2020-07-07 PHASE1
NCT05470465 COMPLETED
Hypercapnia; Ventilatory Depression
Food and Drug Administration (FDA)
 2022-09-01 PHASE1
NCT04218123 COMPLETED
Meniere Disease
Medical University of South Carolina
 2020-02-05 PHASE2; PHASE3
NCT05786677 UNKNOWN
Fibromyalgia; Depression
Cairo University
 2023-04-01
NCT06451406 COMPLETED
Selective Serotonin Reuptake Inhibitor; Hyaluronic Acid; Glans Penis; Lifelong Premature
New Valley University
 2022-10-01
NCT05588102 COMPLETED
Geriatric Depression; Cognitive Impairment
Capital Medical University
 2021-05-18
NCT03993535 COMPLETED
Obsessive-Compulsive Disorder
University of Sao Paulo
 2018-10-10 PHASE4
NCT05481294 UNKNOWN
HIV
Muh. Yusuf Tahir
 2021-12-16
NCT05357547 COMPLETED
Anhedonia
University of Oxford
 2022-05-13 PHASE2
NCT04849013 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2021-08-11 PHASE1
NCT05594667 WITHDRAWN
Depression; Major Depressive Disorder; Mild Depression; Moderate Depression; Depressive Disorder
Cybin Therapeutics Inc.
 2023-01-01 PHASE2
NCT03790358 COMPLETED
Healthy
University of Chicago
 2018-05-01 PHASE1
NCT05647148 UNKNOWN
Sleep Disturbance; Nursing Care
Ataturk University
 2022-05-09
NCT04209166 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2019-08-12
NCT04676139 UNKNOWN
Nocturnal Enuresis
Mansoura University
 2020-07-01 PHASE3
NCT04528628 UNKNOWN
Major Depressive Disorder
Shanghai Mental Health Center
 2020-10
NCT03910387 COMPLETED
Locally Advanced Unresectable Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Recurrent Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8
Emory University
 2019-04-17 PHASE2
NCT04873648 UNKNOWN
Eating Disorders; Intermittent Fasting; Obesity
University of Jordan
 2021-06-20
NCT04101227 COMPLETED
Alcohol Use Disorder
Adial Pharmaceuticals
 2020-02-01 PHASE3
NCT03970239 UNKNOWN
Parkinson Disease; Impulse Control Disorders
Hospices Civils de Lyon
 2019-05-13
NCT02767999 COMPLETED
Stroke
University Hospital, Toulouse
 2017-02-27 PHASE4
NCT04338321 COMPLETED
Depressive Disorder, Major
Janssen-Cilag International NV
 2020-08-21 PHASE3
NCT04904952 UNKNOWN
OCD
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2020-03-13
NCT04880460 COMPLETED
MDD
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2021-03-18 PHASE2
NCT02359513 COMPLETED
Bulimia Nervosa
Centre Hospitalier Universitaire de Saint Etienne
 2015-11-09 PHASE4
NCT04917458 UNKNOWN
Diabetes Mellitus, Type 2; Depressive Symptoms
Indonesia University
 2021-01-18 PHASE2
NCT02466685 COMPLETED
Bipolar Disorder
Herbert Meltzer
 2015-09 PHASE2
NCT04690270 UNKNOWN
Overweight
Cambridge University Hospitals NHS Foundation Trust
 2021-01-04 EARLY_PHASE1
NCT03934710 COMPLETED
Healthy
University of Chicago
 2019-04-20 PHASE1
NCT04478526 COMPLETED
Generalized Anxiety Disorder
Dr. Nazanin Alavi
 2020-04-29
NCT05659472 COMPLETED
Depression
Health Technology Institute of Cendekia Utama Kudus
 2020-12-12
NCT04221256 WITHDRAWN
Stroke, Ischemic
Burke Medical Research Institute
 2020-03-11 PHASE1; PHASE2
NCT03527316 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2019-10-18 EARLY_PHASE1
NCT02715232 UNKNOWN
Gender Dysphoria
Medical University of Vienna
 2017-02-06 PHASE4
NCT01568307 COMPLETED
Major Depressive Disorder
Baker Heart and Diabetes Institute
 2012-05 PHASE4
NCT03912974 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2019-07-04 PHASE1
NCT02865642 UNKNOWN
Stroke
Insel Gruppe AG, University Hospital Bern
 2016-08 PHASE2
NCT04482296 COMPLETED
MDD
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2019-09-15
NCT07644065 COMPLETED
Impacted Third Molar; Postoperative Pain; Neuroinflammation; Anxiety
Plovdiv Medical University
 2019-09-30
NCT04192162 UNKNOWN
Osteoarthritis of Multiple Joints
Specialized Rehabilitation Hospital Banja Koviljaca
 2019-12-18
NCT01975480 COMPLETED
Generalized Anxiety Disorder
START Clinic for Mood and Anxiety Disorders
 2013-01 PHASE4
NCT02717052 UNKNOWN
Depression; Ketamine
Medical University of Vienna
 2016-05 PHASE2
NCT03973567 UNKNOWN
Therapeutic Mechanism of Antidepressants for Refractory FD
Second Affiliated Hospital, Zhejiang University, School of Medicine
 2017-01-01
NCT03249311 UNKNOWN
None (i.e. Healthy Volunteers)
University of Ottawa
 2018-03-02 PHASE4
NCT03943251 COMPLETED
Healthy
Sunshine Lake Pharma Co., Ltd.
 2019-07-04 PHASE1
NCT03679702 UNKNOWN
Sexual Dysfunction
Michael Krychman, MD
 2018-12-15
NCT02473250 COMPLETED
Bipolar Disorder
New York State Psychiatric Institute
 2015-01 PHASE4
NCT02137369 COMPLETED
Depression
Emory University
 2014-09 PHASE4
NCT02753738 UNKNOWN
Ssri; Neuronal Plasticity
Medical University of Vienna
 2016-08 PHASE4
NCT03576053 COMPLETED
Itch; Thermal Stimulation; Histamine; Cowhage; Serotonine
Aalborg University
 2018-07-01
NCT03321136 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2017-11-28 EARLY_PHASE1
NCT03041870 COMPLETED
Healthy Volunteers
Hospices Civils de Lyon
 2017-11-14
NCT03577457 UNKNOWN
Healthy
University of Electronic Science and Technology of China
 2018-02-01
NCT03426176 UNKNOWN
Healthy
University of Electronic Science and Technology of China
 2018-02-01
NCT03321526 COMPLETED
Depressive Disorder, Major
Janssen Research & Development, LLC
 2017-12-12 PHASE2
NCT02851914 COMPLETED
Depression; Amyotrophic Lateral Sclerosis
St. Louis University
 2015-07-21 EARLY_PHASE1
NCT03754647 UNKNOWN
OCD
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2017-12-14
NCT03754712 UNKNOWN
MDD
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
 2018-03-10
NCT00182520 COMPLETED
Obsessive Compulsive Disorder
McMaster University
 2002-01 PHASE4
NCT00994786 COMPLETED
Obsessive-Compulsive Disorder
McMaster University
 2009-01 PHASE4
NCT02153567 COMPLETED
Dyspepsia; Anxiety; Depression
Chinese University of Hong Kong
 2013-12-06 PHASE3
NCT01674686 UNKNOWN
Variant Angina
Samsung Medical Center
 2012-08-01 PHASE4
NCT00182455 TERMINATED
Social Phobia
McMaster University
 2004-03-01 PHASE4
NCT06212284 COMPLETED
Healthy
University of Sussex
 2018-02-18
NCT01208324 COMPLETED
Menopause
University of Colorado, Denver
 2010-03-04
NCT03019822 COMPLETED
Healthy
University Hospital, Basel, Switzerland
 2017-02-01 EARLY_PHASE1
NCT01811147 COMPLETED
Bipolar Disorder; Major Depression
The Cleveland Clinic
 2011-11 PHASE4
NCT03364075 TERMINATED
Low Back Pain
Mark Ware
 2017-09-01 PHASE2
NCT03233906 UNKNOWN
Obesity; Eating Behavior; Mood; Glucose; Dietary Modification
California State Polytechnic University, Pomona
 2017-05-20
NCT02895932 COMPLETED
Parkinson's Disease
University of Michigan
 2015-01
NCT02858635 UNKNOWN
Suicidal Behaviour
University Hospital, Montpellier
 2001-09
NCT02492347 COMPLETED
Qt Interval, Variation in; Adverse Effect of Selective Serotonin Reuptake Inhibitors
University of Southampton
 2016-02-18
NCT02825342 TERMINATED
Chest Pain Rule Out Myocardial Infarction
Evangelismos Hospital
 2014-03 PHASE4
NCT02824081 UNKNOWN
Major Depressive Episode; Suicidal Behavior
University Hospital, Montpellier
 2015-11
NCT03638908 COMPLETED
Pulmonary Arterial Hypertension
University of Texas Southwestern Medical Center
 2013-11 PHASE2
NCT01695291 COMPLETED
Obsessive Compulsive Disorder
New York State Psychiatric Institute
 2012-05 PHASE2
NCT01450826 COMPLETED
Nausea; Vomiting; Glioma
Katy Peters
 2014-06-24 PHASE2
NCT02386475 COMPLETED
Stroke
Hospital de Granollers
 2015-01 PHASE4
NCT02916628 TERMINATED
Smoking
Inha University Hospital
 2013-07
NCT02228005 COMPLETED
Depression
University Health Network, Toronto
 2014-07 PHASE4
NCT01535573 COMPLETED
Cocaine Dependence
Joy Schmitz
 2010-12 PHASE2
NCT02285699 COMPLETED
Obsessive-Compulsive Disorder
McMaster University
 2014-11-01
NCT02333487 COMPLETED
Schizophrenia
H. Lundbeck A/S
 2014-12-30 PHASE1
NCT02607436 COMPLETED
Coronary Artery Disease
Seoul National University Bundang Hospital
 2015-07 PHASE4
NCT02463110 TERMINATED
Depression; Coronary Artery Disease
Assistance Publique - Hôpitaux de Paris
 2015-07 PHASE4
NCT02014363 COMPLETED
Major Depressive Disorder
e-Therapeutics PLC
 2013-10 PHASE2
NCT01275248 TERMINATED
Obsessive-compulsive Disorder
Transcept Pharmaceuticals
 2011-01 PHASE2
NCT00523718 COMPLETED
Obsessive-compulsive Disorder; Ocd
Yale University
 2006-09 PHASE2
NCT02038608 COMPLETED
Parkinson's Disease
Hospices Civils de Lyon
 2014-12
NCT01674361 COMPLETED
Obsessive-Compulsive Disorder
Hoffmann-La Roche
 2012-12-31 PHASE2
NCT03209427 COMPLETED
Pruritus
Assiut University
 2014-04-02 PHASE4
NCT01617070 COMPLETED
Phenylketonuria (PKU)
University of Southern California
 2012-05 PHASE4
NCT01361815 COMPLETED
Major Depressive Disorder, Recurrent, Unspecified; Major Depressive Disorder, Single Episode, Unspecified
Brainsway
 2011-07
NCT02092974 COMPLETED
Healthy Young and Older Adults
Charite University, Berlin, Germany
 2014-04 PHASE1
NCT01813019 TERMINATED
Patient Diagnosed With OCD and Resistant to SSRI Treatment; Failed SSRI Over 12 Weeks at Appropriate Doses
Novartis Pharmaceuticals
 2013-11 PHASE2
NCT02963545 COMPLETED
Cerebral Infarction
Versailles Hospital
 2012-10
NCT01160263 COMPLETED
Amyotrophic Lateral Sclerosis
Assistance Publique - Hôpitaux de Paris
 2012-10 PHASE3
NCT01555970 COMPLETED
Obsessive-Compulsive Disorder
University of Sao Paulo
 2012-03 PHASE2
NCT02262156 COMPLETED
Depression; Epilepsy, Temporal Lobe
El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
 2014-08
NCT02230371 COMPLETED
Myofascial Pain; Temporomandibular Disorders
Karolinska Institutet
 2007-03 PHASE4
NCT01148979 COMPLETED
Major Depressive Disorder
Mclean Hospital
 2010-09 PHASE4
NCT02175602 COMPLETED
Hepatitis C Infection
Bristol-Myers Squibb
 2014-06 PHASE1
NCT02314195 COMPLETED
Obsessive-Compulsive Disorder; Anxiety; Depression
Islamic Azad University, Marvdasht
 2014-04
NCT01178671 COMPLETED
Posttraumatic Stress Disorder
Research Foundation for Mental Hygiene, Inc.
 2010-07 PHASE4
NCT01175616 WITHDRAWN
Major Depressive Disorder
University of Utah
 2012-09 PHASE4
NCT00633399 COMPLETED
Major Depressive Disorder
Massachusetts General Hospital
 2008-07 PHASE2
NCT02051530 COMPLETED
Mood; Social Behavior
University of Groningen
 2012-04 EARLY_PHASE1
NCT01370499 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2011-08 PHASE3
NCT02051569 COMPLETED
Social Behaviour
University of Groningen
 2012-08 EARLY_PHASE1
NCT01065220 COMPLETED
Transsexualism
Medical University of Vienna
 2010-02 PHASE4
NCT01364649 COMPLETED
Treatment Outcome
Takeda
 2011-06 PHASE3
NCT02015546 COMPLETED
Major Depressive Disorder (MDD)
Duke University
 2012-12 PHASE3
NCT01173601 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2010-11 PHASE3
NCT01456052 COMPLETED
Ulcerative Colitis
Lexicon Pharmaceuticals
 2012-01-30 PHASE2
NCT01187407 COMPLETED
Major Depressive Disorder (MDD)
Eli Lilly and Company
 2011-03 PHASE3
NCT00517764 COMPLETED
Depression
Centre for Addiction and Mental Health
 2006-12
NCT01185340 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2011-03 PHASE3
NCT00732901 COMPLETED
Cocaine Dependence
Virginia Commonwealth University
 2008-06 PHASE2; PHASE3
NCT01318434 COMPLETED
Major Depressive Disorder
Euthymics BioScience, Inc.
 2011-02 PHASE2; PHASE3
NCT00955474 TERMINATED
Major Depressive Disorder With Psychotic Features
Massachusetts General Hospital
 2008-09 PHASE4
NCT01155661 COMPLETED
Depressive Disorder, Major
Eli Lilly and Company
 2010-10 PHASE3
NCT02473783 COMPLETED
Major Depressive Disorder
Tri-Service General Hospital (TSGH)
 2011-10 PHASE2
NCT01461083 COMPLETED
Parkinson Disease
Institute for Neurodegenerative Disorders
 2011-09 PHASE1
NCT01548937 COMPLETED
Melancholia
Chang Gung Memorial Hospital
 2010-05 PHASE2
NCT02833090 COMPLETED
Aortic Stenosis
University Hospital, Toulouse
 2010-02
NCT04352686 COMPLETED
Gastroesophageal Reflux
Universitaire Ziekenhuizen KU Leuven
 2012-02
NCT01297738 COMPLETED
Obesity; Diabetes Mellitus Type 2
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
 2011-02
NCT01531972 COMPLETED
Healthy
Sumitomo Pharma America, Inc.
 2012-02 PHASE1
NCT01313403 WITHDRAWN
Major Depression; Unipolar Depression; Depression; Anxiety Disorder
National Institute of Mental Health (NIMH)
 2011-02-10
NCT02132286 COMPLETED
Major Depressive Disorder
University of Calgary
 2008-12 PHASE4
NCT01097980 COMPLETED
Sexual Dysfunction
Beitou Armed Forces Hospital, Taipei, Taiwan
 2010-04
NCT01264861 TERMINATED
Parkinson Disease
Newron Pharmaceuticals SPA
 2011-03 PHASE2
NCT00641108 COMPLETED
Depression
University of Pennsylvania
 2008-01 PHASE2; PHASE3
NCT01517438 COMPLETED
Agitation
Seoul National University Hospital
 2011-03
NCT01101152 UNKNOWN
Healthy
University of Ottawa
 2010-04 PHASE1
NCT04355455 COMPLETED
Gastroesophageal Reflux
Universitaire Ziekenhuizen KU Leuven
 2011-07
NCT02172859 COMPLETED
Healthy
dsm-firmenich Switzerland AG
 2010-11 PHASE2
NCT01045083 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2010-01 PHASE1
NCT01189825 COMPLETED
Sexual Dysfunction
University of Texas at Austin
 2009-06
NCT00539513 TERMINATED
Obsessive-Compulsive Disorder
Yale University
 2006-06 PHASE2
NCT01358006 COMPLETED
Healthy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2010-11 PHASE1
NCT01263223 COMPLETED
Major Depressive Disorder
Eli Lilly and Company
 2010-12 PHASE1
NCT01101685 COMPLETED
Dysphoria
University of Oxford
 2010-02 PHASE4
NCT01638689 COMPLETED
Healthy
Karolinska Institutet
 2010-09 PHASE1
NCT00254020 COMPLETED
Depression
Sunnybrook Health Sciences Centre
 2005-06 PHASE4
NCT01040208 TERMINATED
Sexual Dysfunctions, Psychological; Depression
Sprout Pharmaceuticals, Inc
 2010-01 PHASE3
NCT00657163 COMPLETED
Ischemic Stroke; Motor Impairment
University Hospital, Toulouse
 2005-03 PHASE2
NCT01018108 COMPLETED
Breast Cancer
Abramson Cancer Center at Penn Medicine
 2009-03 PHASE1
NCT00894543 COMPLETED
Hot Flashes; Menopause; Vasomotor Symptoms
Fred Hutchinson Cancer Center
 2009-07
NCT00411398 COMPLETED
General Anxiety Disorder, Social Anxiety Disorder
State University of New York - Upstate Medical University
 2006-12 PHASE3
NCT00086307 COMPLETED
Major Depression
National Institute of Mental Health (NIMH)
 2004-06 PHASE2
NCT00840034 COMPLETED
Depressive Disorder, Major
Eli Lilly and Company
 2009-02 PHASE2
NCT00145132 COMPLETED
Depression
Ludwig-Maximilians - University of Munich
 2005-06 PHASE4
NCT00838305 COMPLETED
MDMA Mechanism of Action
California Pacific Medical Center Research Institute
 2009-02
NCT00704860 COMPLETED
Major Depression
University of Ottawa
 2005-02 PHASE4
NCT00074815 COMPLETED
Obsessive-Compulsive Disorder
Duke University
 2003-09 PHASE3
NCT01153802 COMPLETED
Depressive Disorder
GlaxoSmithKline
 2009-04-03 PHASE1
NCT00129467 COMPLETED
Depression; Palliative Care; Cancer; Mental Disorder
US Department of Veterans Affairs
 2005-02
NCT00427674 TERMINATED
Parkinson Disease
Institute for Neurodegenerative Disorders
 2007-01 PHASE1
NCT00902421 COMPLETED
Overactive Bladder
Samsung Medical Center
 2007-01 PHASE4
NCT00211809 TERMINATED
Body Dysmorphic Disorder
Icahn School of Medicine at Mount Sinai
 2008-09 PHASE4
NCT00043550 COMPLETED
Depression
University of Pennsylvania
 2001-11 PHASE3
NCT00093847 COMPLETED
Depression
Massachusetts General Hospital
 2004-05 PHASE2
NCT00603018 COMPLETED
Anorexia Nervosa
University of Pittsburgh
 2007-06
NCT00361218 COMPLETED
Major Depressive Disorder
Massachusetts General Hospital
 2005-10 PHASE3
NCT00168493 UNKNOWN
Major Depression
Baker Heart Research Institute
 2000-06
NCT01296802 COMPLETED
Amphetamine-Related Disorders; Amphetamine Abuse
University of Zurich
 2006-04
NCT00056472 COMPLETED
Major Depressive Disorder With Psychotic Features
Weill Medical College of Cornell University
 2003-01 PHASE3
NCT00343928 COMPLETED
Anorexia Nervosa
Beth Israel Deaconess Medical Center
 2006-06 PHASE2
NCT00611975 COMPLETED
Healthy
Weill Medical College of Cornell University
 2005-10 PHASE4
NCT00331799 COMPLETED
Major Depressive Disorder
Duke University
 2007-04 PHASE2
NCT00296517 COMPLETED
Depressive Disorder
GlaxoSmithKline
 2006-01-19 PHASE3
NCT00556140 COMPLETED
Psychotic Depression
Massachusetts General Hospital
 2003-06 PHASE3
NCT00564564 COMPLETED
Obsessive Compulsive Disorder
University of Sao Paulo
 2006-01 PHASE4
NCT00733668 COMPLETED
Major Depressive Disorder
AstraZeneca
 2006-03 PHASE2
NCT00228943 COMPLETED
Breast Cancer
Indiana University
 2005-07
NCT00456430 COMPLETED
Depression
Indiana University
 2003-07 PHASE4
NCT00249847 TERMINATED
Hot Flashes
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
 2005-10
NCT01059591 COMPLETED
Depressive Disorder and Anxiety Disorders
GlaxoSmithKline
 2006-05-25 PHASE1
NCT01059578 COMPLETED
Depressive Disorder and Anxiety Disorders
GlaxoSmithKline
 2006-05-23 PHASE1
NCT01160991 COMPLETED
Schizophrenia; Diabetes; Insulin Resistance
Central Institute of Mental Health, Mannheim
 2004-05
NCT00157547 COMPLETED
Major Depressive Disorder
Massachusetts General Hospital
 2003-04 PHASE4
NCT00142779 COMPLETED
Cocaine-Related Disorders; Opioid-Related Disorders
National Institute on Drug Abuse (NIDA)
 2001-04
NCT00254007 COMPLETED
Depression; Traumatic Brain Injury
Sunnybrook Health Sciences Centre
 2003-07 PHASE4
NCT00178971 COMPLETED
Schizophrenia; Schizoaffective Disorder
Northwestern University
 2003-01 PHASE3
NCT01282632 COMPLETED
Subjects Had Unipolar, Non-psychotic Major Depression
Sunnybrook Health Sciences Centre
 2002-08 PHASE1; PHASE2
NCT00100464 COMPLETED
Obstructive Sleep Apnea
US Department of Veterans Affairs
 2000-11 PHASE4
NCT00049972 COMPLETED
Major Depressive Disorder
GlaxoSmithKline
 2002-09 PHASE4
NCT00000309 TERMINATED
Cocaine-Related Disorders
Butler Hospital
 1994-08 PHASE2
NCT00000310 TERMINATED
Cocaine-Related Disorders
National Institute on Drug Abuse (NIDA)
 1996-01 PHASE2
NCT00115362 COMPLETED
Dyspepsia
Radboud University Medical Center
 2005-07
NCT00229645 COMPLETED
Major Depression With Comorbid Anxiety Symptoms
Dr Alexander McIntyre Inc.
 2003-11 PHASE4
NCT00219505 TERMINATED
Irritable Bowel Syndrome
Penn State University
 2001-08
NCT00532519 UNKNOWN
Prurigo Nodularis
Hadassah Medical Organization
NCT00025740 COMPLETED
Post Traumatic Stress Disorder
National Institute of Mental Health (NIMH)
 2001-10 PHASE4
NCT00031317 COMPLETED
Panic Disorder
National Institute of Mental Health (NIMH)
 2002-02 PHASE4
NCT00363506 UNKNOWN
Migraine Disorders
Dynamic Health Resources
 2006-01 PHASE4
NCT00226642 UNKNOWN
Depression
Ludwig-Maximilians - University of Munich
 PHASE4
NCT00086294 COMPLETED
Parkinson's Disease; Dyskinesias
National Institute of Neurological Disorders and Stroke (NINDS)
 2004-06-25 PHASE2
NCT00297505 COMPLETED
Cocaine Dependence
National Institute on Drug Abuse (NIDA)
 2001-04 PHASE2

(data from https://clinicaltrials.gov, updated on 2026-07-21)

Check the Serotonin product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Serotonin functions as an endogenous agonist that selectively binds to 5-hydroxytryptamine (5-HT) receptors while concurrently inhibiting catechol O-methyltransferase, thereby modulating downstream G-protein-coupled intracellular signaling cascades and regulating central monoaminergic neurotransmission. This control over neural circuitry and vascular reactivity underpins its primary physiological impact, directly relating to clinical trial indications such as major depressive disorder, obsessive-compulsive disorder, and ischemic stroke.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.