SB 200646

Catalog No.S2649 Batch:S264901

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Technical Data

Formula

C15H14N4O

Molecular Weight 266.30 CAS No. 143797-63-1
Solubility (25°C)* In vitro DMSO 53 mg/mL (199.02 mM)
Ethanol 2 mg/mL (7.51 mM)
Water ˂1 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
Targets
5-HT2B (rat) [1]
(Cell-free assay)
5-HT2C (Rat) [1]
(Cell-free assay)
5-HT2A (rat) [1]
(Cell-free assay)
7.5(pKi) 6.9(pKi) 5.2(pKi)

Protocol (from reference)

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.