CAS No. 14663-23-1
Batch:
Purity:99.32
Chemical Structure
Check the
Dantrolene sodium
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | sodium 3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate | |
|---|---|---|
| CAS Number | 14663-23-1 | |
| Molecular Formula |
C14H9N4NaO5 |
|
| Molecular Weight (MW) | 336.23 | |
| SMILES | C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].[Na+] | |
| InChIKey | KSRLIXGNPXAZHD-HAZZGOGXSA-M |
Biological Activity
Dantrolene sodium is a postsynaptic muscle relaxant and ryanodine receptor antagonist that selectively inhibits calcium ion release from sarcoplasmic reticulum stores. By targeting ryanodine receptor channels, it modulates intracellular calcium signaling pathways, preventing excess cytoplasmic calcium accumulation. Consequently, this inhibition disrupts excitation-contraction coupling in skeletal muscle cells and suppresses hypermetabolic responses associated with impaired calcium homeostasis. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
10 mg/mL
(29.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.